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Protein

Sulfite oxidase, mitochondrial

Gene

Suox

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Sulfite + O2 + H2O = sulfate + H2O2.

Cofactori

Protein has several cofactor binding sites:
  • heme bBy similarityNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group non-covalently per subunit.By similarity
  • Mo-molybdopterinBy similarityNote: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.By similarity

Pathwayi: sulfur metabolism

This protein is involved in the pathway sulfur metabolism, which is part of Energy metabolism.
View all proteins of this organism that are known to be involved in the pathway sulfur metabolism and in Energy metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi119Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi144Iron (heme axial ligand)PROSITE-ProRule annotation1
Binding sitei146Heme bBy similarity1
Binding sitei148Heme bBy similarity1
Metal bindingi265MolybdenumBy similarity1
Binding sitei323MolybdopterinBy similarity1
Binding sitei362MolybdopterinBy similarity1
Binding sitei367MolybdopterinBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandHeme, Iron, Metal-binding, Molybdenum

Enzyme and pathway databases

ReactomeiR-MMU-1614517 Sulfide oxidation to sulfate
UniPathwayi
UPA00096

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfite oxidase, mitochondrial (EC:1.8.3.1)
Gene namesi
Name:Suox
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:2446117 Suox

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 80MitochondrionBy similarityAdd BLAST80
ChainiPRO_000000648381 – 546Sulfite oxidase, mitochondrialAdd BLAST466

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei124PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8R086
MaxQBiQ8R086
PaxDbiQ8R086
PeptideAtlasiQ8R086
PRIDEiQ8R086

2D gel databases

REPRODUCTION-2DPAGEiQ8R086

PTM databases

iPTMnetiQ8R086
PhosphoSitePlusiQ8R086
SwissPalmiQ8R086

Expressioni

Gene expression databases

BgeeiENSMUSG00000049858 Expressed in 256 organ(s), highest expression level in seminal vesicle
CleanExiMM_SUOX
GenevisibleiQ8R086 MM

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

BioGridi229229, 1 interactor
IntActiQ8R086, 5 interactors
MINTiQ8R086
STRINGi10090.ENSMUSP00000056195

Structurei

3D structure databases

ProteinModelPortaliQ8R086
SMRiQ8R086
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini83 – 162Cytochrome b5 heme-bindingPROSITE-ProRule annotationAdd BLAST80

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni166 – 175HingeBy similarity10
Regioni176 – 402Moco domainBy similarityAdd BLAST227
Regioni216 – 220Molybdopterin-bindingBy similarity5
Regioni378 – 380Molybdopterin-bindingBy similarity3
Regioni403 – 539HomodimerizationBy similarityAdd BLAST137

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0535 Eukaryota
KOG4576 Eukaryota
COG2041 LUCA
GeneTreeiENSGT00390000003749
HOGENOMiHOG000252609
HOVERGENiHBG017865
InParanoidiQ8R086
KOiK00387
OMAiAVGNAKW
OrthoDBiEOG091G0DBF
PhylomeDBiQ8R086
TreeFamiTF300905

Family and domain databases

Gene3Di3.10.120.10, 1 hit
3.90.420.10, 1 hit
InterProiView protein in InterPro
IPR001199 Cyt_B5-like_heme/steroid-bd
IPR036400 Cyt_B5-like_heme/steroid_sf
IPR018506 Cyt_B5_heme-BS
IPR014756 Ig_E-set
IPR005066 MoCF_OxRdtse_dimer
IPR008335 Mopterin_OxRdtase_euk
IPR000572 OxRdtase_Mopterin-bd_dom
IPR036374 OxRdtase_Mopterin-bd_sf
IPR022407 OxRdtase_Mopterin_BS
PfamiView protein in Pfam
PF00173 Cyt-b5, 1 hit
PF03404 Mo-co_dimer, 1 hit
PF00174 Oxidored_molyb, 1 hit
PRINTSiPR00363 CYTOCHROMEB5
PR00407 EUMOPTERIN
SMARTiView protein in SMART
SM01117 Cyt-b5, 1 hit
SUPFAMiSSF55856 SSF55856, 1 hit
SSF56524 SSF56524, 1 hit
SSF81296 SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS00191 CYTOCHROME_B5_1, 1 hit
PS50255 CYTOCHROME_B5_2, 1 hit
PS00559 MOLYBDOPTERIN_EUK, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8R086-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLLQLYRSVV VRLPQAIRVK STPLRLCIQA CSTNDSLEPQ HPSLTFSDDN
60 70 80 90 100
SRTRRWKVMG TLLGLGVVLV YHEHRCRASQ ESPRMYSKED VRSHNNPKTG
110 120 130 140 150
VWVTLGSEVF DVTKFVDLHP GGPSKLMLAA GGPLEPFWAL YAVHNQPHVR
160 170 180 190 200
ELLAEYKIGE LNPEDSMSPS VEASDPYADD PIRHPALRIN SQRPFNAEPP
210 220 230 240 250
PELLTEGYIT PNPIFFTRNH LPVPNLDPHT YRLHVVGAPG GQSLSLSLDD
260 270 280 290 300
LHKFPKHEVT VTLQCAGNRR SEMSKVKEVK GLEWRTGAIS TARWAGARLC
310 320 330 340 350
DVLAQAGHRL CDSEAHVCFE GLDSDPTGTA YGASIPLARA MDPEAEVLLA
360 370 380 390 400
YEMNGQPLPR DHGFPVRVVV PGVVGARHVK WLGRVSVESE ESYSHWQRRD
410 420 430 440 450
YKGFSPSVDW DTVNFDLAPS IQELPIQSAI TQPQDGAIVE SGEVTIKGYA
460 470 480 490 500
WSGGGRAVIR VDVSVDGGLT WQEAELEGEE QCPRKAWAWR IWQLKAQVPA
510 520 530 540
EQKELNIICK AVDDSYNVQP DTVAPIWNLR GVLSNAWHRV HVQVVP
Length:546
Mass (Da):60,756
Last modified:July 10, 2007 - v2
Checksum:iA10ADF73FFA8DE51
GO

Sequence cautioni

The sequence BAE32710 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti455G → S in BAE28865 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK149422 mRNA Translation: BAE28865.1
AK154608 mRNA Translation: BAE32710.1 Different initiation.
BC027197 mRNA Translation: AAH27197.2
CCDSiCCDS24285.1
RefSeqiNP_776094.2, NM_173733.3
UniGeneiMm.23352

Genome annotation databases

EnsembliENSMUST00000054764; ENSMUSP00000056195; ENSMUSG00000049858
GeneIDi211389
KEGGimmu:211389
UCSCiuc007hnt.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK149422 mRNA Translation: BAE28865.1
AK154608 mRNA Translation: BAE32710.1 Different initiation.
BC027197 mRNA Translation: AAH27197.2
CCDSiCCDS24285.1
RefSeqiNP_776094.2, NM_173733.3
UniGeneiMm.23352

3D structure databases

ProteinModelPortaliQ8R086
SMRiQ8R086
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi229229, 1 interactor
IntActiQ8R086, 5 interactors
MINTiQ8R086
STRINGi10090.ENSMUSP00000056195

PTM databases

iPTMnetiQ8R086
PhosphoSitePlusiQ8R086
SwissPalmiQ8R086

2D gel databases

REPRODUCTION-2DPAGEiQ8R086

Proteomic databases

EPDiQ8R086
MaxQBiQ8R086
PaxDbiQ8R086
PeptideAtlasiQ8R086
PRIDEiQ8R086

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000054764; ENSMUSP00000056195; ENSMUSG00000049858
GeneIDi211389
KEGGimmu:211389
UCSCiuc007hnt.2 mouse

Organism-specific databases

CTDi6821
MGIiMGI:2446117 Suox

Phylogenomic databases

eggNOGiKOG0535 Eukaryota
KOG4576 Eukaryota
COG2041 LUCA
GeneTreeiENSGT00390000003749
HOGENOMiHOG000252609
HOVERGENiHBG017865
InParanoidiQ8R086
KOiK00387
OMAiAVGNAKW
OrthoDBiEOG091G0DBF
PhylomeDBiQ8R086
TreeFamiTF300905

Enzyme and pathway databases

UniPathwayi
UPA00096

ReactomeiR-MMU-1614517 Sulfide oxidation to sulfate

Miscellaneous databases

PROiPR:Q8R086
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000049858 Expressed in 256 organ(s), highest expression level in seminal vesicle
CleanExiMM_SUOX
GenevisibleiQ8R086 MM

Family and domain databases

Gene3Di3.10.120.10, 1 hit
3.90.420.10, 1 hit
InterProiView protein in InterPro
IPR001199 Cyt_B5-like_heme/steroid-bd
IPR036400 Cyt_B5-like_heme/steroid_sf
IPR018506 Cyt_B5_heme-BS
IPR014756 Ig_E-set
IPR005066 MoCF_OxRdtse_dimer
IPR008335 Mopterin_OxRdtase_euk
IPR000572 OxRdtase_Mopterin-bd_dom
IPR036374 OxRdtase_Mopterin-bd_sf
IPR022407 OxRdtase_Mopterin_BS
PfamiView protein in Pfam
PF00173 Cyt-b5, 1 hit
PF03404 Mo-co_dimer, 1 hit
PF00174 Oxidored_molyb, 1 hit
PRINTSiPR00363 CYTOCHROMEB5
PR00407 EUMOPTERIN
SMARTiView protein in SMART
SM01117 Cyt-b5, 1 hit
SUPFAMiSSF55856 SSF55856, 1 hit
SSF56524 SSF56524, 1 hit
SSF81296 SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS00191 CYTOCHROME_B5_1, 1 hit
PS50255 CYTOCHROME_B5_2, 1 hit
PS00559 MOLYBDOPTERIN_EUK, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSUOX_MOUSE
AccessioniPrimary (citable) accession number: Q8R086
Secondary accession number(s): Q3U3S5, Q3UEP6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: July 10, 2007
Last modified: September 12, 2018
This is version 130 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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