UniProtKB - Q8R081 (HNRPL_MOUSE)

BLAST

>sp|Q8R081|HNRPL_MOUSE Heterogeneous nuclear ribonucleoprotein L OS=Mus musculus OX=10090 GN=Hnrnpl PE=1 SV=2
MSRRLLPRAEKRRRRLEQRQQPDEQLRRAGAMVKMAAAGGGGGGGRYYGGGNEGGRAPKR
LKTENAGDQHGGGGGGGSGAAGGGGGENYDDPHKTPASPVVHIRGLIDGVVEADLVEALQ
EFGPISYVVVMPKKRQALVEFEDVLGACNAVNYAADNQIYIAGHPAFVNYSTSQKISRPG
DSDDSRSVNSVLLFTILNPIYSITTDVLYTICNPCGPVQRIVIFRKNGVQAMVEFDSVQS
AQRAKASLNGADIYSGCCTLKIEYAKPTRLNVFKNDQDTWDYTNPNLSGQGDPGSNPNKR
QRQPPLLGDHPAEYGGPHGGYHSHYHDEGYGPPPPHYEGRRMGPPVGGHRRGPSRYGPQY
GHPPPPPPPPDYGPHADSPVLMVYGLDQSKMNCDRVFNVFCLYGNVEKVKFMKSKPGAAM
VEMADGYAVDRAITHLNNNFMFGQKMNVCVSKQPAIMPGQSYGLEDGSCSYKDFSESRNN
RFSTPEQAAKNRIQHPSNVLHFFNAPLEVTEENFFEICDELGVKRPTSVKVFSGKSERSS
SGLLEWDSKSDALETLGFLNHYQMKNPNGPYPYTLKLCFSTAQHAS

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History
Entry version 150 (07 Nov 2018)
Sequence version 2 (25 Nov 2008)
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Protein

Heterogeneous nuclear ribonucleoprotein L

Gene

Hnrnpl

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion (PubMed:22523384). Exhibits a binding preference for CA-rich elements. Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts. Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter.By similarity1 Publication

GO - Molecular functionⁱ

mRNA 3'-UTR binding Source: MGI
mRNA CDS binding Source: MGI
pre-mRNA intronic binding Source: UniProtKB
transcription regulatory region DNA binding Source: UniProtKB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular response to amino acid starvation Source: MGI
circadian rhythm Source: Ensembl
mRNA processing Source: InterPro
negative regulation of mRNA splicing, via spliceosome Source: MGI
positive regulation of mRNA binding Source: MGI
positive regulation of translation Source: MGI
regulation of alternative mRNA splicing, via spliceosome
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 22523384
response to peptide Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Ribonucleoprotein, RNA-binding

Molecular function

Ribonucleoprotein, RNA-binding

Enzyme and pathway databases

Reactomeⁱ	R-MMU-72163 mRNA Splicing - Major Pathway

Reactomeⁱ

R-MMU-72163 mRNA Splicing - Major Pathway

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Heterogeneous nuclear ribonucleoprotein L Short name: hnRNP L
Gene namesⁱ	Name:Hnrnpl Synonyms:Hnrpl
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 7

Organism-specific databases

MGIⁱ	MGI:104816 Hnrnpl

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Disruption phenotypeⁱ

Complete lethality during early embryonic development.1 Publication

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000081863	1 – 586	Heterogeneous nuclear ribonucleoprotein LAdd BLAST		586

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Cross-linkⁱ	59	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linkⁱ	62	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	98	PhosphoserineBy similarity	1
Cross-linkⁱ	133	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	182	PhosphoserineBy similarity	1
Modified residueⁱ	266	N6-acetyllysineBy similarity	1
Modified residueⁱ	288	PhosphoserineBy similarity	1
Modified residueⁱ	295	PhosphoserineBy similarity	1
Cross-linkⁱ	299	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	351	Asymmetric dimethylarginineCombined sources	1
Modified residueⁱ	355	Asymmetric dimethylarginineCombined sources	1
Modified residueⁱ	378	PhosphoserineCombined sources	1
Modified residueⁱ	541	Phosphoserine; by CaMK4By similarity	1
Cross-linkⁱ	565	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Post-translational modificationⁱ

Phosphorylation at Ser-541 by CaMK4 enhances interaction with a CaMK4-responsive RNA element (CaRRE1), and prevents inclusion of the stress axis-regulated exon (STREX) of the KCNMA1 potassium channel transcripts upon membrane depolarization.By similarity

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q8R081
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8R081
PaxDbⁱ	Q8R081
PeptideAtlas More...PeptideAtlasⁱ	Q8R081
PRIDEⁱ	Q8R081

2D gel databases

REPRODUCTION-2DPAGE More...REPRODUCTION-2DPAGEⁱ	Q8R081

REPRODUCTION-2DPAGEⁱ

Q8R081

PTM databases

iPTMnetⁱ	Q8R081
PhosphoSitePlusⁱ	Q8R081
SwissPalmⁱ	Q8R081

Expressionⁱ

Tissue specificityⁱ

Detected in hematopoietic cells, including lymphoid progenitor cells.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000015165 Expressed in 296 organ(s), highest expression level in fibroblast
CleanExⁱ	MM_HNRNPL
ExpressionAtlasⁱ	Q8R081 baseline and differential
Genevisibleⁱ	Q8R081 MM

Interactionⁱ

Subunit structureⁱ

Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with HNRNPLL. Interacts with APEX1; the interaction is DNA-dependent. Component of a complex with SETD2 (By similarity). Interacts with ELAVL1 (By similarity).By similarity

Protein-protein interaction databases

BioGridⁱ	200360, 9 interactors
IntActⁱ	Q8R081, 12 interactors
Molecular INTeraction database More...MINTⁱ	Q8R081
STRINGⁱ	10090.ENSMUSP00000049407

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	379 – 384	Combined sources	6
Turnⁱ	388 – 390	Combined sources	3
Helixⁱ	393 – 400	Combined sources	8
Turnⁱ	401 – 403	Combined sources	3
Beta strandⁱ	406 – 411	Combined sources	6
Beta strandⁱ	419 – 425	Combined sources	7
Helixⁱ	426 – 436	Combined sources	11
Beta strandⁱ	447 – 450	Combined sources	4
Beta strandⁱ	452 – 455	Combined sources	4
Beta strandⁱ	469 – 473	Combined sources	5
Helixⁱ	485 – 488	Combined sources	4
Beta strandⁱ	498 – 505	Combined sources	8
Helixⁱ	511 – 521	Combined sources	11
Beta strandⁱ	527 – 531	Combined sources	5
Beta strandⁱ	536 – 545	Combined sources	10
Helixⁱ	549 – 559	Combined sources	11
Beta strandⁱ	567 – 571	Combined sources	5
Beta strandⁱ	576 – 578	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	Q8R081
SMRⁱ	Q8R081
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	99 – 173	RRM 1PROSITE-ProRule annotationAdd BLAST	75
Domainⁱ	190 – 267	RRM 2PROSITE-ProRule annotationAdd BLAST	78
Domainⁱ	379 – 476	RRM 3PROSITE-ProRule annotationAdd BLAST	98
Domainⁱ	492 – 580	RRM 4PROSITE-ProRule annotationAdd BLAST	89

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	39 – 86	Gly-richAdd BLAST		48
Compositional biasⁱ	332 – 379	Pro-richAdd BLAST		48

Domainⁱ

RRM domain 2 has moderate RNA-binding affinity. RRM domains 3 and 4 may facilitate RNA looping when binding to two appropriately separated binding sites within the same target pre-mRNA.By similarity

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	KOG1456 Eukaryota ENOG410XQHN LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074508
HOGENOMⁱ	HOG000293298
HOVERGENⁱ	HBG105786
InParanoidⁱ	Q8R081
KEGG Orthology (KO) More...KOⁱ	K13159
PhylomeDBⁱ	Q8R081

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd12780 RRM1_hnRNPL, 1 hit cd12785 RRM2_hnRNPL, 1 hit cd12699 RRM3_hnRNPL, 1 hit cd12704 RRM4_hnRNPL, 1 hit
Gene3Dⁱ	3.30.70.330, 4 hits
InterProⁱ	View protein in InterPro IPR006536 HnRNP-L/PTB IPR034816 hnRNP-L_RRM3 IPR035005 hnRNPL_RRM1 IPR035008 hnRNPL_RRM2 IPR034817 hnRNPL_RRM4 IPR012677 Nucleotide-bd_a/b_plait_sf IPR035979 RBD_domain_sf IPR000504 RRM_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00076 RRM_1, 2 hits
SMARTⁱ	View protein in SMART SM00360 RRM, 3 hits
SUPFAMⁱ	SSF54928 SSF54928, 3 hits
TIGRFAMsⁱ	TIGR01649 hnRNP-L_PTB, 1 hit
PROSITEⁱ	View protein in PROSITE PS50102 RRM, 3 hits

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show all Align All

Q8R081-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MSRRLLPRAE KRRRRLEQRQ QPDEQLRRAG AMVKMAAAGG GGGGGRYYGG 
        60         70         80         90        100
GNEGGRAPKR LKTENAGDQH GGGGGGGSGA AGGGGGENYD DPHKTPASPV 
       110        120        130        140        150
VHIRGLIDGV VEADLVEALQ EFGPISYVVV MPKKRQALVE FEDVLGACNA 
       160        170        180        190        200
VNYAADNQIY IAGHPAFVNY STSQKISRPG DSDDSRSVNS VLLFTILNPI 
       210        220        230        240        250
YSITTDVLYT ICNPCGPVQR IVIFRKNGVQ AMVEFDSVQS AQRAKASLNG 
       260        270        280        290        300
ADIYSGCCTL KIEYAKPTRL NVFKNDQDTW DYTNPNLSGQ GDPGSNPNKR 
       310        320        330        340        350
QRQPPLLGDH PAEYGGPHGG YHSHYHDEGY GPPPPHYEGR RMGPPVGGHR 
       360        370        380        390        400
RGPSRYGPQY GHPPPPPPPP DYGPHADSPV LMVYGLDQSK MNCDRVFNVF 
       410        420        430        440        450
CLYGNVEKVK FMKSKPGAAM VEMADGYAVD RAITHLNNNF MFGQKMNVCV 
       460        470        480        490        500
SKQPAIMPGQ SYGLEDGSCS YKDFSESRNN RFSTPEQAAK NRIQHPSNVL 
       510        520        530        540        550
HFFNAPLEVT EENFFEICDE LGVKRPTSVK VFSGKSERSS SGLLEWDSKS 
       560        570        580 
DALETLGFLN HYQMKNPNGP YPYTLKLCFS TAQHAS

Length:586

Mass (Da):63,964

Last modified:November 25, 2008 - v2

Checksum:ⁱBB56D3D6A8553F7E

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

G3UY38	G3UY38_MOUSE	Heterogeneous nuclear ribonucleopro... Heterogeneous nuclear ribonucleoprotein L	Hnrnpl	456	Annotation score:
G5E924	G5E924_MOUSE	Heterogeneous nuclear ribonucleopro... Heterogeneous nuclear ribonucleoprotein L	Hnrnpl	615	Annotation score:
G3UY56	G3UY56_MOUSE	Heterogeneous nuclear ribonucleopro... Heterogeneous nuclear ribonucleoprotein L	Hnrnpl	201	Annotation score:
G3UYY3	G3UYY3_MOUSE	Heterogeneous nuclear ribonucleopro... Heterogeneous nuclear ribonucleoprotein L	Hnrnpl	112	Annotation score:

Sequence cautionⁱ

The sequence AAH27206 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	388	Q → E in BAA24237 (Ref. 2) Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC027206 mRNA Translation: AAH27206.1 Different initiation. BC030461 mRNA Translation: AAH30461.1 BC099683 mRNA Translation: AAH99683.1 AB009392 mRNA Translation: BAA24237.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS39864.2
NCBI Reference Sequences More...RefSeqⁱ	NP_796275.3, NM_177301.5 XP_006539621.1, XM_006539558.2
UniGeneⁱ	Mm.9043

Genome annotation databases

Ensemblⁱ	ENSMUST00000038572; ENSMUSP00000049407; ENSMUSG00000015165 ENSMUST00000174548; ENSMUSP00000133728; ENSMUSG00000015165
GeneIDⁱ	15388
KEGGⁱ	mmu:15388
UCSC genome browser More...UCSCⁱ	uc009fzz.2 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8R081	Heterogeneous nuclear ribonucleoprotein L		RAT		586	UniRef100_Q8R081
Heterogeneous nuclear ribonucleoprotein L		MOUSE		456

Protein	Similar proteins		Species	Score	Length	Source
Q8R081	Heterogeneous nuclear ribonucleoprotein L	)	HUMAN		589	UniRef90_P14866
HNRNPL isoform 1		PANTR		589
Heterogeneous nuclear ribonucleoprotein L isoform a		MACMU		589
Uncharacterized protein		CERAT		589
Uncharacterized protein		RHIRO		589
+79

Protein	Similar proteins		Species	Score	Length	Source
Q8R081	Heterogeneous nuclear ribonucleoprotein L	)	HUMAN		589	UniRef50_P14866
HNRNPL isoform 1		PANTR		589
Heterogeneous nuclear ribonucleoprotein L isoform a		MACMU		589
Uncharacterized protein		CERAT		589
Uncharacterized protein		RHIRO		589
+145

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC027206 mRNA Translation: AAH27206.1 Different initiation. BC030461 mRNA Translation: AAH30461.1 BC099683 mRNA Translation: AAH99683.1 AB009392 mRNA Translation: BAA24237.1
CCDSⁱ	CCDS39864.2
RefSeqⁱ	NP_796275.3, NM_177301.5 XP_006539621.1, XM_006539558.2
UniGeneⁱ	Mm.9043

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3S01	X-ray	2.15	A	376-586	[»]
	3TYT	X-ray	1.60	A	376-579	[»]
ProteinModelPortalⁱ	Q8R081
SMRⁱ	Q8R081
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	200360, 9 interactors
IntActⁱ	Q8R081, 12 interactors
MINTⁱ	Q8R081
STRINGⁱ	10090.ENSMUSP00000049407

PTM databases

iPTMnetⁱ	Q8R081
PhosphoSitePlusⁱ	Q8R081
SwissPalmⁱ	Q8R081

2D gel databases

REPRODUCTION-2DPAGEⁱ	Q8R081

REPRODUCTION-2DPAGEⁱ

Q8R081

Proteomic databases

EPDⁱ	Q8R081
MaxQBⁱ	Q8R081
PaxDbⁱ	Q8R081
PeptideAtlasⁱ	Q8R081
PRIDEⁱ	Q8R081

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000038572; ENSMUSP00000049407; ENSMUSG00000015165 ENSMUST00000174548; ENSMUSP00000133728; ENSMUSG00000015165
GeneIDⁱ	15388
KEGGⁱ	mmu:15388
UCSCⁱ	uc009fzz.2 mouse

Organism-specific databases

CTDⁱ	3191
MGIⁱ	MGI:104816 Hnrnpl

Phylogenomic databases

eggNOGⁱ	KOG1456 Eukaryota ENOG410XQHN LUCA
GeneTreeⁱ	ENSGT00550000074508
HOGENOMⁱ	HOG000293298
HOVERGENⁱ	HBG105786
InParanoidⁱ	Q8R081
KOⁱ	K13159
PhylomeDBⁱ	Q8R081

Enzyme and pathway databases

Reactomeⁱ	R-MMU-72163 mRNA Splicing - Major Pathway

Reactomeⁱ

R-MMU-72163 mRNA Splicing - Major Pathway

Miscellaneous databases

ChiTaRSⁱ	Hnrnpl mouse
Protein Ontology More...PROⁱ	PR:Q8R081
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000015165 Expressed in 296 organ(s), highest expression level in fibroblast
CleanExⁱ	MM_HNRNPL
ExpressionAtlasⁱ	Q8R081 baseline and differential
Genevisibleⁱ	Q8R081 MM

Family and domain databases

CDDⁱ	cd12780 RRM1_hnRNPL, 1 hit cd12785 RRM2_hnRNPL, 1 hit cd12699 RRM3_hnRNPL, 1 hit cd12704 RRM4_hnRNPL, 1 hit
Gene3Dⁱ	3.30.70.330, 4 hits
InterProⁱ	View protein in InterPro IPR006536 HnRNP-L/PTB IPR034816 hnRNP-L_RRM3 IPR035005 hnRNPL_RRM1 IPR035008 hnRNPL_RRM2 IPR034817 hnRNPL_RRM4 IPR012677 Nucleotide-bd_a/b_plait_sf IPR035979 RBD_domain_sf IPR000504 RRM_dom
Pfamⁱ	View protein in Pfam PF00076 RRM_1, 2 hits
SMARTⁱ	View protein in SMART SM00360 RRM, 3 hits
SUPFAMⁱ	SSF54928 SSF54928, 3 hits
TIGRFAMsⁱ	TIGR01649 hnRNP-L_PTB, 1 hit
PROSITEⁱ	View protein in PROSITE PS50102 RRM, 3 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	HNRPL_MOUSE
Accessionⁱ	Q8R081Primary (citable) accession number: Q8R081 Secondary accession number(s): O54789, Q499X2, Q8K0S7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 26, 2004
	Last sequence update:	November 25, 2008
	Last modified:	November 7, 2018
	This is version 150 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - Q8R081 (HNRPL_MOUSE)

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Heterogeneous nuclear ribonucleoprotein L

Hnrnpl

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Cytosol

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ