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Entry version 122 (08 May 2019)
Sequence version 2 (26 Jul 2002)
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Protein

G2 and S phase-expressed protein 1

Gene

Gtse1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in p53-induced cell cycle arrest in G2/M phase by interfering with microtubule rearrangements that are required to enter mitosis. Overexpression delays G2/M phase progression.

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-69481 G2/M Checkpoints
R-MMU-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
G2 and S phase-expressed protein 1
Short name:
GTSE-1
Alternative name(s):
Protein B99
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Gtse1
Synonyms:B99
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1352755 Gtse1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000838761 – 741G2 and S phase-expressed protein 1Add BLAST741

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei73PhosphoserineBy similarity1
Modified residuei139PhosphoserineBy similarity1
Modified residuei153PhosphoserineBy similarity1
Modified residuei191PhosphoserineBy similarity1
Modified residuei245PhosphoserineBy similarity1
Modified residuei311PhosphoserineBy similarity1
Modified residuei460PhosphoserineCombined sources1
Modified residuei465PhosphothreonineCombined sources1
Modified residuei476PhosphoserineCombined sources1
Modified residuei493PhosphoserineBy similarity1
Modified residuei509PhosphoserineBy similarity1
Modified residuei514PhosphoserineBy similarity1
Modified residuei518PhosphothreonineBy similarity1
Modified residuei521PhosphoserineBy similarity1
Modified residuei541PhosphoserineBy similarity1
Modified residuei582PhosphoserineBy similarity1
Modified residuei599PhosphoserineBy similarity1
Modified residuei696PhosphothreonineBy similarity1
Modified residuei720PhosphoserineBy similarity1
Modified residuei726PhosphoserineBy similarity1
Modified residuei736PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated in mitosis.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8R080

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8R080

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8R080

PRoteomics IDEntifications database

More...
PRIDEi
Q8R080

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8R080

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8R080

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expression begins at S phase, accumulates in late S/G2 phase and disappears in G1 phase.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By p53 when exposed to different DNA damaging agents, including gamma irradiation and chemotherapeutic drugs.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000022385 Expressed in 127 organ(s), highest expression level in embryonic stem cell

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8R080 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8R080 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
205935, 4 interactors

Protein interaction database and analysis system

More...
IntActi
Q8R080, 1 interactor

Molecular INTeraction database

More...
MINTi
Q8R080

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000128759

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi23 – 28Poly-Ser6

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IHTJ Eukaryota
ENOG410ZUTK LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154189

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000294205

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8R080

KEGG Orthology (KO)

More...
KOi
K10129

Identification of Orthologs from Complete Genome Data

More...
OMAi
HLGQGKR

Database of Orthologous Groups

More...
OrthoDBi
1407808at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8R080

TreeFam database of animal gene trees

More...
TreeFami
TF332555

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026657 DDA3/GTSE-1
IPR026659 GTSE1
IPR032768 GTSE1_N

The PANTHER Classification System

More...
PANTHERi
PTHR21584 PTHR21584, 1 hit
PTHR21584:SF10 PTHR21584:SF10, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15259 GTSE1_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8R080-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDAGSKKEDF LLLEDEKFDF DLSLSSSSTN EDDEVFFGPV GHKERCIAAS
60 70 80 90 100
LDLNRRVPGQ PLAPGSGSPC TLSPLTGEKF VEVYKEAHLL ALQIESHSRR
110 120 130 140 150
EVAQAATPQN PVNQGKETFV QDSQLKVSLF EKEQKRDRSP MSLKRETFCL
160 170 180 190 200
PSSRVQPPMG EPQLLASPGL LSSPVSAGPA QTQSNQGLPC SSQPLPRESS
210 220 230 240 250
TSQPPSQAGP QKRITSKLQP PRALPVRGRN LHLATEKLKK EVPASIQRTK
260 270 280 290 300
LVNEKGSQSD VLQDKPSTAP DAASREGHPG KRSLPIPGKL GLKKTLLKPP
310 320 330 340 350
GYTGNLTRKS STSGSASSLE SGVYRSSVAG KAKSSEQRSS IPASGSQRRT
360 370 380 390 400
STSKSGRIGP AASRQALPAA PARVFGRQAN KADAAQTVAE QPKVPTLSPL
410 420 430 440 450
TQQPQTPEQR GPRLDPDTET PQLNKTVSIK RRDSYLSCKT EAVSTTTNPF
460 470 480 490 500
KVPQFSVGES PGGVTPKFSR THRLQSWTPA SRVVSSTPVR RSSGTTPQGL
510 520 530 540 550
PGSMRTPLST RRMSVLPTPA SRRLSSLPLM APQSMPRALV SPLCVPARRL
560 570 580 590 600
SSEPRRRSTV RAELTQESSG SGSGGQAQGL SSDESSSPPS SVPQALNFSP
610 620 630 640 650
EKSASPPPQG SSTGAAQGEA EPPEDTLPSE VHGGGCSHTP SEGLLLDLKL
660 670 680 690 700
DQLTITPEAG GRDLADCPLI DFSNTPESNT ALGPSSWPLI DLIMNTPDMG
710 720 730 740
RNDVGKPAKA ELGQLIDLGS PLIQLSPEAD KENVDSPLLK F
Length:741
Mass (Da):78,751
Last modified:July 26, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1C684D06EE9B7ACB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti153S → P in AAH27213 (PubMed:15489334).Curated1
Sequence conflicti246I → L in AAH27213 (PubMed:15489334).Curated1
Sequence conflicti252V → M in AAH27213 (PubMed:15489334).Curated1
Sequence conflicti274S → G in AAH27213 (PubMed:15489334).Curated1
Sequence conflicti398 – 399SP → IL in AAH27213 (PubMed:15489334).Curated2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ222580 mRNA Translation: CAA10848.1
BC027213 mRNA Translation: AAH27213.1
AK012870 mRNA Translation: BAB28524.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS27725.1

NCBI Reference Sequences

More...
RefSeqi
NP_001162143.1, NM_001168672.1
NP_038910.1, NM_013882.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000170629; ENSMUSP00000128759; ENSMUSG00000022385
ENSMUST00000231074; ENSMUSP00000155552; ENSMUSG00000022385

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
29870

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:29870

UCSC genome browser

More...
UCSCi
uc007xdp.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ222580 mRNA Translation: CAA10848.1
BC027213 mRNA Translation: AAH27213.1
AK012870 mRNA Translation: BAB28524.1
CCDSiCCDS27725.1
RefSeqiNP_001162143.1, NM_001168672.1
NP_038910.1, NM_013882.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi205935, 4 interactors
IntActiQ8R080, 1 interactor
MINTiQ8R080
STRINGi10090.ENSMUSP00000128759

PTM databases

iPTMnetiQ8R080
PhosphoSitePlusiQ8R080

Proteomic databases

EPDiQ8R080
MaxQBiQ8R080
PaxDbiQ8R080
PRIDEiQ8R080

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000170629; ENSMUSP00000128759; ENSMUSG00000022385
ENSMUST00000231074; ENSMUSP00000155552; ENSMUSG00000022385
GeneIDi29870
KEGGimmu:29870
UCSCiuc007xdp.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
51512
MGIiMGI:1352755 Gtse1

Phylogenomic databases

eggNOGiENOG410IHTJ Eukaryota
ENOG410ZUTK LUCA
GeneTreeiENSGT00940000154189
HOGENOMiHOG000294205
InParanoidiQ8R080
KOiK10129
OMAiHLGQGKR
OrthoDBi1407808at2759
PhylomeDBiQ8R080
TreeFamiTF332555

Enzyme and pathway databases

ReactomeiR-MMU-69481 G2/M Checkpoints
R-MMU-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q8R080

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000022385 Expressed in 127 organ(s), highest expression level in embryonic stem cell
ExpressionAtlasiQ8R080 baseline and differential
GenevisibleiQ8R080 MM

Family and domain databases

InterProiView protein in InterPro
IPR026657 DDA3/GTSE-1
IPR026659 GTSE1
IPR032768 GTSE1_N
PANTHERiPTHR21584 PTHR21584, 1 hit
PTHR21584:SF10 PTHR21584:SF10, 1 hit
PfamiView protein in Pfam
PF15259 GTSE1_N, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGTSE1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8R080
Secondary accession number(s): O89015, Q9CSG9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 26, 2002
Last sequence update: July 26, 2002
Last modified: May 8, 2019
This is version 122 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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