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Protein

UDP-glucose 4-epimerase

Gene

Gale

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids.By similarity

Catalytic activityi

UDP-alpha-D-glucose = UDP-alpha-D-galactose.By similarity
UDP-N-acetyl-alpha-D-glucosamine = UDP-N-acetyl-alpha-D-galactosamine.By similarity

Cofactori

NAD+By similarity

Pathwayi: galactose metabolism

This protein is involved in the pathway galactose metabolism, which is part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the pathway galactose metabolism and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei87NAD; via carbonyl oxygenBy similarity1
Binding sitei91NADBy similarity1
Active sitei156Proton acceptorBy similarity1
Binding sitei160NADBy similarity1
Binding sitei184NADBy similarity1
Binding sitei238SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 13NADBy similarity3
Nucleotide bindingi32 – 36NADBy similarity5
Nucleotide bindingi65 – 66NADBy similarity2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processCarbohydrate metabolism, Galactose metabolism
LigandNAD

Enzyme and pathway databases

ReactomeiR-MMU-70370 Galactose catabolism
UniPathwayi
UPA00214

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucose 4-epimeraseBy similarity (EC:5.1.3.2By similarity)
Alternative name(s):
GalactowaldenaseBy similarity
UDP-N-acetylglucosamine 4-epimeraseBy similarity (EC:5.1.3.7By similarity)
Short name:
UDP-GlcNAc 4-epimeraseBy similarity
UDP-galactosamine 4-epimeraseBy similarity
Short name:
UDP-GalNAc 4-epimeraseBy similarity
UDP-galactose 4-epimeraseBy similarity
Gene namesi
Name:Gale
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1921496 Gale

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001831901 – 347UDP-glucose 4-epimeraseAdd BLAST347

Proteomic databases

EPDiQ8R059
MaxQBiQ8R059
PaxDbiQ8R059
PeptideAtlasiQ8R059
PRIDEiQ8R059

PTM databases

iPTMnetiQ8R059
PhosphoSitePlusiQ8R059
SwissPalmiQ8R059

Expressioni

Gene expression databases

BgeeiENSMUSG00000028671 Expressed in 198 organ(s), highest expression level in ileum
CleanExiMM_GALE
ExpressionAtlasiQ8R059 baseline and differential
GenevisibleiQ8R059 MM

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ8R059, 2 interactors
MINTiQ8R059
STRINGi10090.ENSMUSP00000099599

Structurei

3D structure databases

ProteinModelPortaliQ8R059
SMRiQ8R059
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni131 – 133Substrate bindingBy similarity3
Regioni184 – 186Substrate bindingBy similarity3
Regioni205 – 207Substrate bindingBy similarity3
Regioni223 – 225Substrate bindingBy similarity3
Regioni299 – 302Substrate bindingBy similarity4

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1371 Eukaryota
COG1087 LUCA
GeneTreeiENSGT00530000063128
HOGENOMiHOG000168001
HOVERGENiHBG001396
InParanoidiQ8R059
OMAiSCTVYGQ
OrthoDBiEOG091G0ACI
PhylomeDBiQ8R059
TreeFamiTF105800

Family and domain databases

CDDicd05247 UDP_G4E_1_SDR_e, 1 hit
InterProiView protein in InterPro
IPR016040 NAD(P)-bd_dom
IPR036291 NAD(P)-bd_dom_sf
IPR005886 UDP_G4E
PfamiView protein in Pfam
PF16363 GDP_Man_Dehyd, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR01179 galE, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8R059-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEKVLVTGGA GYIGSHTVLE LLEAGYSPVV IDNFHNAIRG EDSMPESLRR
60 70 80 90 100
VQELTGRSVE FEEMDILDQA ALQHLFKKHS FKAVIHFAGL KAVGESVQKP
110 120 130 140 150
LDYYRVNLTG TIQLLEIMRA HGVKNLVFSS SATVYGNPQY LPLDEAHPTG
160 170 180 190 200
GCTNPYGKSK FFIEEMIRDL CRADTAWNAV LLRYFNPIGA HASGRIGEDP
210 220 230 240 250
QGIPNNLMPY VSQVAIGRRE ALNVFGDDYA TEDGTGVRDY IHVVDLAKGH
260 270 280 290 300
IAALKKLKEQ CGCRTYNLGT GTGYSVLQMV QAMEKASGKK IPYKVVARRE
310 320 330 340
GDVAACYANP SLAHEELGWT AALGLDRMCE DLWRWQKQNP SGFGAQA
Length:347
Mass (Da):38,225
Last modified:June 1, 2002 - v1
Checksum:i8EAE03B38040CED5
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1AV53B1AV53_MOUSE
UDP-glucose 4-epimerase
Gale
57Annotation score:
B1AV54B1AV54_MOUSE
UDP-glucose 4-epimerase
Gale
60Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC027438 mRNA Translation: AAH27438.1
CCDSiCCDS18796.1
RefSeqiNP_848476.1, NM_178389.3
XP_006539280.1, XM_006539217.1
XP_006539281.1, XM_006539218.3
XP_006539282.1, XM_006539219.3
UniGeneiMm.247946

Genome annotation databases

EnsembliENSMUST00000102540; ENSMUSP00000099599; ENSMUSG00000028671
ENSMUST00000102541; ENSMUSP00000099600; ENSMUSG00000028671
GeneIDi74246
UCSCiuc008vhk.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC027438 mRNA Translation: AAH27438.1
CCDSiCCDS18796.1
RefSeqiNP_848476.1, NM_178389.3
XP_006539280.1, XM_006539217.1
XP_006539281.1, XM_006539218.3
XP_006539282.1, XM_006539219.3
UniGeneiMm.247946

3D structure databases

ProteinModelPortaliQ8R059
SMRiQ8R059
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8R059, 2 interactors
MINTiQ8R059
STRINGi10090.ENSMUSP00000099599

PTM databases

iPTMnetiQ8R059
PhosphoSitePlusiQ8R059
SwissPalmiQ8R059

Proteomic databases

EPDiQ8R059
MaxQBiQ8R059
PaxDbiQ8R059
PeptideAtlasiQ8R059
PRIDEiQ8R059

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000102540; ENSMUSP00000099599; ENSMUSG00000028671
ENSMUST00000102541; ENSMUSP00000099600; ENSMUSG00000028671
GeneIDi74246
UCSCiuc008vhk.1 mouse

Organism-specific databases

CTDi2582
MGIiMGI:1921496 Gale

Phylogenomic databases

eggNOGiKOG1371 Eukaryota
COG1087 LUCA
GeneTreeiENSGT00530000063128
HOGENOMiHOG000168001
HOVERGENiHBG001396
InParanoidiQ8R059
OMAiSCTVYGQ
OrthoDBiEOG091G0ACI
PhylomeDBiQ8R059
TreeFamiTF105800

Enzyme and pathway databases

UniPathwayi
UPA00214

ReactomeiR-MMU-70370 Galactose catabolism

Miscellaneous databases

ChiTaRSiGale mouse
PROiPR:Q8R059
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028671 Expressed in 198 organ(s), highest expression level in ileum
CleanExiMM_GALE
ExpressionAtlasiQ8R059 baseline and differential
GenevisibleiQ8R059 MM

Family and domain databases

CDDicd05247 UDP_G4E_1_SDR_e, 1 hit
InterProiView protein in InterPro
IPR016040 NAD(P)-bd_dom
IPR036291 NAD(P)-bd_dom_sf
IPR005886 UDP_G4E
PfamiView protein in Pfam
PF16363 GDP_Man_Dehyd, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR01179 galE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGALE_MOUSE
AccessioniPrimary (citable) accession number: Q8R059
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: June 1, 2002
Last modified: November 7, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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