UniProtKB - Q8R059 (GALE_MOUSE)

BLAST

>sp|Q8R059|GALE_MOUSE UDP-glucose 4-epimerase OS=Mus musculus OX=10090 GN=Gale PE=1 SV=1
MEKVLVTGGAGYIGSHTVLELLEAGYSPVVIDNFHNAIRGEDSMPESLRRVQELTGRSVE
FEEMDILDQAALQHLFKKHSFKAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMRA
HGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCRADTAWNAV
LLRYFNPIGAHASGRIGEDPQGIPNNLMPYVSQVAIGRREALNVFGDDYATEDGTGVRDY
IHVVDLAKGHIAALKKLKEQCGCRTYNLGTGTGYSVLQMVQAMEKASGKKIPYKVVARRE
GDVAACYANPSLAHEELGWTAALGLDRMCEDLWRWQKQNPSGFGAQA

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History
Entry version 129 (07 Nov 2018)
Sequence version 1 (01 Jun 2002)
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Protein

UDP-glucose 4-epimerase

Gene

Gale

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids.By similarity

Catalytic activityⁱ

UDP-alpha-D-glucose = UDP-alpha-D-galactose.By similarity

UDP-N-acetyl-alpha-D-glucosamine = UDP-N-acetyl-alpha-D-galactosamine.By similarity

Cofactorⁱ

NAD⁺By similarity

Pathwayⁱ: galactose metabolism

This protein is involved in the pathway galactose metabolism, which is part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the pathway galactose metabolism and in Carbohydrate metabolism.

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	87	NAD; via carbonyl oxygenBy similarity	1
Binding siteⁱ	91	NADBy similarity	1
Active siteⁱ	156	Proton acceptorBy similarity	1
Binding siteⁱ	160	NADBy similarity	1
Binding siteⁱ	184	NADBy similarity	1
Binding siteⁱ	238	SubstrateBy similarity	1

Regions

Feature key	Position(s)	DescriptionActions	Length
Nucleotide bindingⁱ	11 – 13	NADBy similarity	3
Nucleotide bindingⁱ	32 – 36	NADBy similarity	5
Nucleotide bindingⁱ	65 – 66	NADBy similarity	2

GO - Molecular functionⁱ

identical protein binding Source: MGI
protein homodimerization activity Source: MGI
UDP-glucose 4-epimerase activity
Source: MGI
Inferred from direct assayⁱ
- 14741191
UDP-N-acetylglucosamine 4-epimerase activity Source: UniProtKB-EC

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

galactose catabolic process Source: MGI
galactose catabolic process via UDP-galactose
Source: MGI
Inferred by curatorⁱ
- 14741191
galactose metabolic process
Source: MGI
Inferred from direct assayⁱ
- 14741191
glycolytic process from galactose
Source: MGI
Inferred by curatorⁱ
- 14741191

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Isomerase
Biological process	Carbohydrate metabolism, Galactose metabolism
Ligand	NAD

Enzyme and pathway databases

Reactomeⁱ	R-MMU-70370 Galactose catabolism
UniPathwayⁱ	UPA00214

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: UDP-glucose 4-epimeraseBy similarity (EC:5.1.3.2By similarity) Alternative name(s): GalactowaldenaseBy similarity UDP-N-acetylglucosamine 4-epimeraseBy similarity (EC:5.1.3.7By similarity) Short name: UDP-GlcNAc 4-epimeraseBy similarity UDP-galactosamine 4-epimeraseBy similarity Short name: UDP-GalNAc 4-epimeraseBy similarity UDP-galactose 4-epimeraseBy similarity
Gene namesⁱ	Name:Gale
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 4

Organism-specific databases

MGIⁱ	MGI:1921496 Gale

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000183190	1 – 347	UDP-glucose 4-epimeraseAdd BLAST		347

Proteomic databases

EPDⁱ	Q8R059
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8R059
PaxDbⁱ	Q8R059
PeptideAtlas More...PeptideAtlasⁱ	Q8R059
PRIDEⁱ	Q8R059

PTM databases

iPTMnetⁱ	Q8R059
PhosphoSitePlusⁱ	Q8R059
SwissPalmⁱ	Q8R059

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000028671 Expressed in 198 organ(s), highest expression level in ileum
CleanExⁱ	MM_GALE
ExpressionAtlasⁱ	Q8R059 baseline and differential
Genevisibleⁱ	Q8R059 MM

Interactionⁱ

Subunit structureⁱ

Homodimer.By similarity

GO - Molecular functionⁱ

identical protein binding Source: MGI
protein homodimerization activity Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

IntActⁱ	Q8R059, 2 interactors
Molecular INTeraction database More...MINTⁱ	Q8R059
STRINGⁱ	10090.ENSMUSP00000099599

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8R059
SMRⁱ	Q8R059
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	131 – 133	Substrate bindingBy similarity	3
Regionⁱ	184 – 186	Substrate bindingBy similarity	3
Regionⁱ	205 – 207	Substrate bindingBy similarity	3
Regionⁱ	223 – 225	Substrate bindingBy similarity	3
Regionⁱ	299 – 302	Substrate bindingBy similarity	4

Sequence similaritiesⁱ

Belongs to the NAD(P)-dependent epimerase/dehydratase family.Curated

Phylogenomic databases

eggNOGⁱ	KOG1371 Eukaryota COG1087 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063128
HOGENOMⁱ	HOG000168001
HOVERGENⁱ	HBG001396
InParanoidⁱ	Q8R059
OMAⁱ	SCTVYGQ
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0ACI
PhylomeDBⁱ	Q8R059
TreeFamⁱ	TF105800

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd05247 UDP_G4E_1_SDR_e, 1 hit
InterProⁱ	View protein in InterPro IPR016040 NAD(P)-bd_dom IPR036291 NAD(P)-bd_dom_sf IPR005886 UDP_G4E
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF16363 GDP_Man_Dehyd, 1 hit
SUPFAMⁱ	SSF51735 SSF51735, 1 hit
TIGRFAMsⁱ	TIGR01179 galE, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

Q8R059-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MEKVLVTGGA GYIGSHTVLE LLEAGYSPVV IDNFHNAIRG EDSMPESLRR 
        60         70         80         90        100
VQELTGRSVE FEEMDILDQA ALQHLFKKHS FKAVIHFAGL KAVGESVQKP 
       110        120        130        140        150
LDYYRVNLTG TIQLLEIMRA HGVKNLVFSS SATVYGNPQY LPLDEAHPTG 
       160        170        180        190        200
GCTNPYGKSK FFIEEMIRDL CRADTAWNAV LLRYFNPIGA HASGRIGEDP 
       210        220        230        240        250
QGIPNNLMPY VSQVAIGRRE ALNVFGDDYA TEDGTGVRDY IHVVDLAKGH 
       260        270        280        290        300
IAALKKLKEQ CGCRTYNLGT GTGYSVLQMV QAMEKASGKK IPYKVVARRE 
       310        320        330        340 
GDVAACYANP SLAHEELGWT AALGLDRMCE DLWRWQKQNP SGFGAQA

Length:347

Mass (Da):38,225

Last modified:June 1, 2002 - v1

Checksum:ⁱ8EAE03B38040CED5

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

B1AV53	B1AV53_MOUSE	UDP-glucose 4-epimerase UDP-glucose 4-epimerase	Gale	57	Annotation score:
B1AV54	B1AV54_MOUSE	UDP-glucose 4-epimerase UDP-glucose 4-epimerase	Gale	60	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC027438 mRNA Translation: AAH27438.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS18796.1
NCBI Reference Sequences More...RefSeqⁱ	NP_848476.1, NM_178389.3 XP_006539280.1, XM_006539217.1 XP_006539281.1, XM_006539218.3 XP_006539282.1, XM_006539219.3
UniGeneⁱ	Mm.247946

Genome annotation databases

Ensemblⁱ	ENSMUST00000102540; ENSMUSP00000099599; ENSMUSG00000028671 ENSMUST00000102541; ENSMUSP00000099600; ENSMUSG00000028671
GeneIDⁱ	74246
UCSC genome browser More...UCSCⁱ	uc008vhk.1 mouse

Protein	Similar proteins		Species	Score	Length	Source
Q8R059	UDP-glucose 4-epimerase (Fragment)		MOUSE		57	UniRef100_Q8R059
UDP-glucose 4-epimerase (Fragment)		MOUSE		60
UPI0003D6E5C0		MOUSE		230

Protein	Similar proteins		Species	Score	Length	Source
Q8R059	UDP-glucose 4-epimerase (Fragment)		MOUSE		57	UniRef90_Q8R059
Putative udp-glucose 4-epimerase/udp-sulfoquinovose synthase (Fragment)		DESRO		353
UDP-galactose-4-epimerase		LOXAF		348
UDP-galactose-4-epimerase		SHEEP		348
UDP-galactose-4-epimerase		CAVPO		348
+36

Protein	Similar proteins		Species	Score	Length	Source
Q8R059	UDP-glucose 4-epimerase	)	HUMAN		348	UniRef50_Q14376
UDP-glucose 4-epimerase		PONAB		348
UDP-glucose 4-epimerase		BOVIN		348
Uncharacterized protein (Fragment)		AILME		349
UDP-galactose-4-epimerase		SAIBB		348
+201

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC027438 mRNA Translation: AAH27438.1
CCDSⁱ	CCDS18796.1
RefSeqⁱ	NP_848476.1, NM_178389.3 XP_006539280.1, XM_006539217.1 XP_006539281.1, XM_006539218.3 XP_006539282.1, XM_006539219.3
UniGeneⁱ	Mm.247946

3D structure databases

ProteinModelPortalⁱ	Q8R059
SMRⁱ	Q8R059
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	Q8R059, 2 interactors
MINTⁱ	Q8R059
STRINGⁱ	10090.ENSMUSP00000099599

PTM databases

iPTMnetⁱ	Q8R059
PhosphoSitePlusⁱ	Q8R059
SwissPalmⁱ	Q8R059

Proteomic databases

EPDⁱ	Q8R059
MaxQBⁱ	Q8R059
PaxDbⁱ	Q8R059
PeptideAtlasⁱ	Q8R059
PRIDEⁱ	Q8R059

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000102540; ENSMUSP00000099599; ENSMUSG00000028671 ENSMUST00000102541; ENSMUSP00000099600; ENSMUSG00000028671
GeneIDⁱ	74246
UCSCⁱ	uc008vhk.1 mouse

Organism-specific databases

CTDⁱ	2582
MGIⁱ	MGI:1921496 Gale

Phylogenomic databases

eggNOGⁱ	KOG1371 Eukaryota COG1087 LUCA
GeneTreeⁱ	ENSGT00530000063128
HOGENOMⁱ	HOG000168001
HOVERGENⁱ	HBG001396
InParanoidⁱ	Q8R059
OMAⁱ	SCTVYGQ
OrthoDBⁱ	EOG091G0ACI
PhylomeDBⁱ	Q8R059
TreeFamⁱ	TF105800

Enzyme and pathway databases

UniPathwayⁱ	UPA00214
Reactomeⁱ	R-MMU-70370 Galactose catabolism

Miscellaneous databases

ChiTaRSⁱ	Gale mouse
Protein Ontology More...PROⁱ	PR:Q8R059
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000028671 Expressed in 198 organ(s), highest expression level in ileum
CleanExⁱ	MM_GALE
ExpressionAtlasⁱ	Q8R059 baseline and differential
Genevisibleⁱ	Q8R059 MM

Family and domain databases

CDDⁱ	cd05247 UDP_G4E_1_SDR_e, 1 hit
InterProⁱ	View protein in InterPro IPR016040 NAD(P)-bd_dom IPR036291 NAD(P)-bd_dom_sf IPR005886 UDP_G4E
Pfamⁱ	View protein in Pfam PF16363 GDP_Man_Dehyd, 1 hit
SUPFAMⁱ	SSF51735 SSF51735, 1 hit
TIGRFAMsⁱ	TIGR01179 galE, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	GALE_MOUSE
Accessionⁱ	Q8R059Primary (citable) accession number: Q8R059
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 19, 2003
	Last sequence update:	June 1, 2002
	Last modified:	November 7, 2018
	This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
PATHWAY comments
Index of metabolic and biosynthesis pathways

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UniParc

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Supporting data

UniProtKB - Q8R059 (GALE_MOUSE)

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UDP-glucose 4-epimerase

Gale

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: galactose metabolism

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

Pathwayⁱ: galactose metabolism

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ