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Protein

Ribonuclease P protein subunit p21

Gene

Rpp21

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.By similarity

Catalytic activityi

Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi62ZincBy similarity1
Metal bindingi65ZincBy similarity1
Metal bindingi92ZincBy similarity1
Metal bindingi95ZincBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processtRNA processing
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease P protein subunit p21 (EC:3.1.26.5)
Short name:
RNaseP protein p21
Alternative name(s):
Ribonucleoprotein V
Gene namesi
Name:Rpp21
Synonyms:Cat60
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1914926 Rpp21

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001538462 – 150Ribonuclease P protein subunit p21Add BLAST149

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ8R040
PaxDbiQ8R040
PeptideAtlasiQ8R040
PRIDEiQ8R040

PTM databases

PhosphoSitePlusiQ8R040

Expressioni

Gene expression databases

BgeeiENSMUSG00000024446 Expressed in 211 organ(s), highest expression level in muscle tissue
CleanExiMM_RPP21
ExpressionAtlasiQ8R040 baseline and differential
GenevisibleiQ8R040 MM

Interactioni

Subunit structurei

RNase P consists of an RNA moiety and at least 9 protein subunits; POP1, RPP14, RPP20/POP7, RPP21, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025319

Structurei

3D structure databases

ProteinModelPortaliQ8R040
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4394 Eukaryota
COG2023 LUCA
GeneTreeiENSGT00390000003020
HOGENOMiHOG000231207
HOVERGENiHBG055987
InParanoidiQ8R040
KOiK03540
OMAiERMNFLY
OrthoDBiEOG091G12P3
PhylomeDBiQ8R040
TreeFamiTF323865

Family and domain databases

InterProiView protein in InterPro
IPR007175 Rpr2
PfamiView protein in Pfam
PF04032 Rpr2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8R040-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGPVKDREA FQRLSFLYQA AHCVLSQNPE NQALARFYCH TEKTIAKRLV
60 70 80 90 100
LRQDPSVKRT LCRSCSSLLI PGLTCTQRQR RRKGQRWTVQ TCLTCQRSQR
110 120 130 140 150
FLNDPKHLLW GDRPEAQLEN QADINPSEPL PNIADLPKEN IQTQALNTSE
Length:150
Mass (Da):17,243
Last modified:July 5, 2004 - v2
Checksum:iEDB5C52A6F2FF519
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3UWS0G3UWS0_MOUSE
Ribonuclease P protein subunit p21
Rpp21
51Annotation score:
Q80XY2Q80XY2_MOUSE
Ribonuclease P protein subunit p21
Rpp21
71Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti18Y → C in AAP03887 (PubMed:12671000).Curated1
Sequence conflicti47 – 53KRLVLRQ → NAGPPA in CAD44293 (Ref. 2) Curated7
Sequence conflicti141I → M in AAH28491 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY251016 mRNA Translation: AAP03887.1
AJ504717 mRNA Translation: CAD44293.1
AK002780 mRNA Translation: BAB22353.1
AK003455 mRNA Translation: BAB22800.1
BC028491 mRNA Translation: AAH28491.1
CCDSiCCDS28719.1
RefSeqiNP_080584.1, NM_026308.2
UniGeneiMm.27131

Genome annotation databases

EnsembliENSMUST00000025319; ENSMUSP00000025319; ENSMUSG00000024446
GeneIDi67676
KEGGimmu:67676
UCSCiuc008ckq.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY251016 mRNA Translation: AAP03887.1
AJ504717 mRNA Translation: CAD44293.1
AK002780 mRNA Translation: BAB22353.1
AK003455 mRNA Translation: BAB22800.1
BC028491 mRNA Translation: AAH28491.1
CCDSiCCDS28719.1
RefSeqiNP_080584.1, NM_026308.2
UniGeneiMm.27131

3D structure databases

ProteinModelPortaliQ8R040
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025319

PTM databases

PhosphoSitePlusiQ8R040

Proteomic databases

MaxQBiQ8R040
PaxDbiQ8R040
PeptideAtlasiQ8R040
PRIDEiQ8R040

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025319; ENSMUSP00000025319; ENSMUSG00000024446
GeneIDi67676
KEGGimmu:67676
UCSCiuc008ckq.1 mouse

Organism-specific databases

CTDi79897
MGIiMGI:1914926 Rpp21

Phylogenomic databases

eggNOGiKOG4394 Eukaryota
COG2023 LUCA
GeneTreeiENSGT00390000003020
HOGENOMiHOG000231207
HOVERGENiHBG055987
InParanoidiQ8R040
KOiK03540
OMAiERMNFLY
OrthoDBiEOG091G12P3
PhylomeDBiQ8R040
TreeFamiTF323865

Miscellaneous databases

ChiTaRSiRpp21 mouse
PROiPR:Q8R040
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024446 Expressed in 211 organ(s), highest expression level in muscle tissue
CleanExiMM_RPP21
ExpressionAtlasiQ8R040 baseline and differential
GenevisibleiQ8R040 MM

Family and domain databases

InterProiView protein in InterPro
IPR007175 Rpr2
PfamiView protein in Pfam
PF04032 Rpr2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRPP21_MOUSE
AccessioniPrimary (citable) accession number: Q8R040
Secondary accession number(s): Q80XY3, Q811B7, Q9CPX1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: July 5, 2004
Last modified: September 12, 2018
This is version 109 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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