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Protein

Anaphase-promoting complex subunit 13

Gene

Anapc13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, Mitosis, Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Anaphase-promoting complex subunit 13
Short name:
APC13
Alternative name(s):
Cyclosome subunit 13
Gene namesi
Name:Anapc13
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1916260 Anapc13

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002539811 – 74Anaphase-promoting complex subunit 13Add BLAST74

Proteomic databases

MaxQBiQ8R034
PaxDbiQ8R034
PeptideAtlasiQ8R034
PRIDEiQ8R034

PTM databases

PhosphoSitePlusiQ8R034

Expressioni

Gene expression databases

BgeeiENSMUSG00000035048 Expressed in 289 organ(s), highest expression level in lens of camera-type eye
CleanExiMM_ANAPC13
GenevisibleiQ8R034 MM

Interactioni

Subunit structurei

The mammalian APC/C is composed at least of 14 distinct subunits ANAPC1, ANAPC2, CDC27/APC3, ANAPC4, ANAPC5, CDC16/APC6, ANAPC7, CDC23/APC8, ANAPC10, ANAPC11, CDC26/APC12, ANAPC13, ANAPC15 and ANAPC16 that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa; APC/C interacts with FZR1 and FBXO5.By similarity

Protein-protein interaction databases

BioGridi213171, 28 interactors
IntActiQ8R034, 25 interactors
STRINGi10090.ENSMUSP00000039761

Structurei

3D structure databases

ProteinModelPortaliQ8R034
SMRiQ8R034
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the APC13 family.Curated

Phylogenomic databases

eggNOGiENOG410J0AV Eukaryota
ENOG4111UJR LUCA
GeneTreeiENSGT00390000008673
HOGENOMiHOG000220858
HOVERGENiHBG079845
InParanoidiQ8R034
KOiK12456
OMAiLHENTPN
OrthoDBiEOG091G176S
PhylomeDBiQ8R034
TreeFamiTF105448

Family and domain databases

InterProiView protein in InterPro
IPR008401 Apc13p
PfamiView protein in Pfam
PF05839 Apc13p, 1 hit

Sequencei

Sequence statusi: Complete.

Q8R034-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDSEVQRDGR ILDLIDDAWR EDKLPYEDVA IPLSELPEPE QDNGGTTESV
60 70
KEQEMKWTDL ALQGLHENVP PAGN
Length:74
Mass (Da):8,346
Last modified:June 1, 2002 - v1
Checksum:iE84F16A13821CB3B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007332 mRNA Translation: BAC25171.1
BC028526 mRNA Translation: AAH28526.1
CCDSiCCDS40744.1
RefSeqiNP_852059.1, NM_181394.3
XP_006511869.1, XM_006511806.3
XP_006511870.1, XM_006511807.3
UniGeneiMm.2000

Genome annotation databases

EnsembliENSMUST00000038673; ENSMUSP00000039761; ENSMUSG00000035048
ENSMUST00000186693; ENSMUSP00000139762; ENSMUSG00000035048
ENSMUST00000188398; ENSMUSP00000140325; ENSMUSG00000035048
ENSMUST00000190279; ENSMUSP00000140967; ENSMUSG00000035048
GeneIDi69010
KEGGimmu:69010
UCSCiuc009rft.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007332 mRNA Translation: BAC25171.1
BC028526 mRNA Translation: AAH28526.1
CCDSiCCDS40744.1
RefSeqiNP_852059.1, NM_181394.3
XP_006511869.1, XM_006511806.3
XP_006511870.1, XM_006511807.3
UniGeneiMm.2000

3D structure databases

ProteinModelPortaliQ8R034
SMRiQ8R034
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi213171, 28 interactors
IntActiQ8R034, 25 interactors
STRINGi10090.ENSMUSP00000039761

PTM databases

PhosphoSitePlusiQ8R034

Proteomic databases

MaxQBiQ8R034
PaxDbiQ8R034
PeptideAtlasiQ8R034
PRIDEiQ8R034

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038673; ENSMUSP00000039761; ENSMUSG00000035048
ENSMUST00000186693; ENSMUSP00000139762; ENSMUSG00000035048
ENSMUST00000188398; ENSMUSP00000140325; ENSMUSG00000035048
ENSMUST00000190279; ENSMUSP00000140967; ENSMUSG00000035048
GeneIDi69010
KEGGimmu:69010
UCSCiuc009rft.2 mouse

Organism-specific databases

CTDi25847
MGIiMGI:1916260 Anapc13

Phylogenomic databases

eggNOGiENOG410J0AV Eukaryota
ENOG4111UJR LUCA
GeneTreeiENSGT00390000008673
HOGENOMiHOG000220858
HOVERGENiHBG079845
InParanoidiQ8R034
KOiK12456
OMAiLHENTPN
OrthoDBiEOG091G176S
PhylomeDBiQ8R034
TreeFamiTF105448

Enzyme and pathway databases

UniPathwayi
UPA00143

ReactomeiR-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

ChiTaRSiAnapc13 mouse
PROiPR:Q8R034
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000035048 Expressed in 289 organ(s), highest expression level in lens of camera-type eye
CleanExiMM_ANAPC13
GenevisibleiQ8R034 MM

Family and domain databases

InterProiView protein in InterPro
IPR008401 Apc13p
PfamiView protein in Pfam
PF05839 Apc13p, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAPC13_MOUSE
AccessioniPrimary (citable) accession number: Q8R034
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: June 1, 2002
Last modified: October 10, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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