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Protein

Polycomb group RING finger protein 1

Gene

Pcgf1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Component of the Polycomb group (PcG) multiprotein BCOR complex, a complex required to maintain the transcriptionally repressive state of some genes, such as BCL6 and the cyclin-dependent kinase inhibitor, CDKN1A. Transcriptional repressor that may be targeted to the DNA by BCL6; this transcription repressor activity may be related to PKC signaling pathway. Represses CDKN1A expression by binding to its promoter, and this repression is dependent on the retinoic acid response element (RARE element). Promotes cell cycle progression and enhances cell proliferation as well. May have a positive role in tumor cell growth by down-regulating CDKN1A. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity. Regulates the expression of DPPA4 and NANOG in the NT2 embryonic carcinoma cells.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri47 – 86RING-typePROSITE-ProRule annotationAdd BLAST40

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • promoter-specific chromatin binding Source: GO_Central
  • protein C-terminus binding Source: MGI

GO - Biological processi

Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Polycomb group RING finger protein 1
Alternative name(s):
Nervous system Polycomb-1
Short name:
NSPc1
RING finger protein 68
Gene namesi
Name:Pcgf1
Synonyms:Nspc1, Rnf68
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1917087 Pcgf1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002778562 – 259Polycomb group RING finger protein 1Add BLAST258

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei3PhosphoserineBy similarity1
Cross-linki24Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki88Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8R023
MaxQBiQ8R023
PaxDbiQ8R023
PeptideAtlasiQ8R023
PRIDEiQ8R023

PTM databases

PhosphoSitePlusiQ8R023

Expressioni

Developmental stagei

Expressed in the otic vesicle, urogenital bud and dorsal root ganglia at 10.5 dpc, in the neural tube and neural crest cell derivatives of the peripheral nervous system at 11.5 dpc.1 Publication

Gene expression databases

BgeeiENSMUSG00000069678 Expressed in 58 organ(s), highest expression level in embryo
CleanExiMM_PCGF1
ExpressionAtlasiQ8R023 baseline and differential
GenevisibleiQ8R023 MM

Interactioni

Subunit structurei

Component of the repressive BCOR complex containing a Polycomb group subcomplex at least composed of RYBP, RING1 and RNF2/RING2. Specifically interacts with BCOR, RING1 and RNF2/RING2. Also interacts with BCORL1, the interaction is direct. Component of a PRC1-like complex. Interacts with CBX6, CBX7 and CBX8. Interacts with DPPA4, NANOG, POU5F1 and RYBP.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi213711, 31 interactors
IntActiQ8R023, 29 interactors
STRINGi10090.ENSMUSP00000090277

Structurei

3D structure databases

ProteinModelPortaliQ8R023
SMRiQ8R023
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni86 – 247Necessary for repressor activityBy similarityAdd BLAST162
Regioni167 – 255Sufficient for interaction with BCOR and BCORL1By similarityAdd BLAST89

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri47 – 86RING-typePROSITE-ProRule annotationAdd BLAST40

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG2660 Eukaryota
ENOG410XPCN LUCA
GeneTreeiENSGT00550000074463
HOGENOMiHOG000231946
HOVERGENiHBG052826
InParanoidiQ8R023
KOiK11487
OrthoDBiEOG091G0EC9
PhylomeDBiQ8R023
TreeFamiTF324206

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR039642 E3_Ub_ligase/polycomb_RING
IPR032443 RAWUL
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PANTHERiPTHR10825 PTHR10825, 1 hit
PfamiView protein in Pfam
PF16207 RAWUL, 1 hit
SMARTiView protein in SMART
SM00184 RING, 1 hit
PROSITEiView protein in PROSITE
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q8R023-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASPQGGQIA IAMRLRNQLQ SVYKMDPLRN EEEVRVKIKD LNEHIVCCLC
60 70 80 90 100
AGYFVDATTI TECLHTFCKS CIVKYLQTSK YCPMCNIKIH ETQPLLNLKL
110 120 130 140 150
DRVMQDIVYK LVPGLQDSEE KRIREFYQSR GLDRVSQPSG EEPALSNLGL
160 170 180 190 200
PFSSFDHSKA HYYRYDEQLS LCLERLSSGK DKNKNVLQNK YVRCSVRAEV
210 220 230 240 250
RHLRRVLCHR LMLNPQHVQL LFDNEVLPDH MTMKQLWLSR WFGKPSPLLL

QYSVKEKRR
Length:259
Mass (Da):30,318
Last modified:February 10, 2009 - v2
Checksum:iB631543B0DEA2954
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4J141A0A0R4J141_MOUSE
Polycomb group RING finger protein ...
Pcgf1
247Annotation score:
H3BK85H3BK85_MOUSE
Polycomb group RING finger protein ...
Pcgf1
176Annotation score:
H3BK63H3BK63_MOUSE
Polycomb group RING finger protein ...
Pcgf1
108Annotation score:
H3BL61H3BL61_MOUSE
Polycomb group RING finger protein ...
Pcgf1
106Annotation score:
H3BLR0H3BLR0_MOUSE
Polycomb group RING finger protein ...
Pcgf1
52Annotation score:

Sequence cautioni

The sequence AAH28560 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC104324 Genomic DNA No translation available.
BC028560 mRNA Translation: AAH28560.1 Different initiation.
RefSeqiNP_932109.1, NM_197992.1
UniGeneiMm.12261

Genome annotation databases

EnsembliENSMUST00000165164; ENSMUSP00000130614; ENSMUSG00000069678
GeneIDi69837
KEGGimmu:69837
UCSCiuc009cmg.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC104324 Genomic DNA No translation available.
BC028560 mRNA Translation: AAH28560.1 Different initiation.
RefSeqiNP_932109.1, NM_197992.1
UniGeneiMm.12261

3D structure databases

ProteinModelPortaliQ8R023
SMRiQ8R023
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi213711, 31 interactors
IntActiQ8R023, 29 interactors
STRINGi10090.ENSMUSP00000090277

PTM databases

PhosphoSitePlusiQ8R023

Proteomic databases

EPDiQ8R023
MaxQBiQ8R023
PaxDbiQ8R023
PeptideAtlasiQ8R023
PRIDEiQ8R023

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000165164; ENSMUSP00000130614; ENSMUSG00000069678
GeneIDi69837
KEGGimmu:69837
UCSCiuc009cmg.1 mouse

Organism-specific databases

CTDi84759
MGIiMGI:1917087 Pcgf1

Phylogenomic databases

eggNOGiKOG2660 Eukaryota
ENOG410XPCN LUCA
GeneTreeiENSGT00550000074463
HOGENOMiHOG000231946
HOVERGENiHBG052826
InParanoidiQ8R023
KOiK11487
OrthoDBiEOG091G0EC9
PhylomeDBiQ8R023
TreeFamiTF324206

Miscellaneous databases

PROiPR:Q8R023
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000069678 Expressed in 58 organ(s), highest expression level in embryo
CleanExiMM_PCGF1
ExpressionAtlasiQ8R023 baseline and differential
GenevisibleiQ8R023 MM

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR039642 E3_Ub_ligase/polycomb_RING
IPR032443 RAWUL
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PANTHERiPTHR10825 PTHR10825, 1 hit
PfamiView protein in Pfam
PF16207 RAWUL, 1 hit
SMARTiView protein in SMART
SM00184 RING, 1 hit
PROSITEiView protein in PROSITE
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPCGF1_MOUSE
AccessioniPrimary (citable) accession number: Q8R023
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: February 10, 2009
Last modified: November 7, 2018
This is version 116 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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