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Protein

Organic solute transporter subunit alpha

Gene

Slc51a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently transports the major species of bile acids.4 Publications

GO - Molecular functioni

  • bile acid transmembrane transporter activity Source: UniProtKB
  • protein heterodimerization activity Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB
  • transmembrane transporter activity Source: MGI

GO - Biological processi

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Organic solute transporter subunit alpha
Short name:
OST-alpha
Alternative name(s):
Solute carrier family 51 subunit alpha
Gene namesi
Name:Slc51a
Synonyms:Osta
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:2146634 Slc51a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 48ExtracellularSequence analysisAdd BLAST48
Transmembranei49 – 69HelicalSequence analysisAdd BLAST21
Topological domaini70 – 87CytoplasmicSequence analysisAdd BLAST18
Transmembranei88 – 108HelicalSequence analysisAdd BLAST21
Topological domaini109 – 114ExtracellularSequence analysis6
Transmembranei115 – 135HelicalSequence analysisAdd BLAST21
Topological domaini136 – 181CytoplasmicSequence analysisAdd BLAST46
Transmembranei182 – 202HelicalSequence analysisAdd BLAST21
Topological domaini203 – 219ExtracellularSequence analysisAdd BLAST17
Transmembranei220 – 240HelicalSequence analysisAdd BLAST21
Topological domaini241 – 255CytoplasmicSequence analysisAdd BLAST15
Transmembranei256 – 276HelicalSequence analysisAdd BLAST21
Topological domaini277 – 297ExtracellularSequence analysisAdd BLAST21
Transmembranei298 – 317HelicalSequence analysisAdd BLAST20
Topological domaini318 – 340CytoplasmicSequence analysisAdd BLAST23

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice are physically indistinguishable from wild-type mice but display strongly reduced transileal transport of taurocholate. Moreover, the bile acid pool size is significantly reduced, but fecal bile acid excretion is not elevated.1 Publication

Chemistry databases

ChEMBLiCHEMBL2073723

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003315441 – 340Organic solute transporter subunit alphaAdd BLAST340

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi25N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei330PhosphoserineCombined sources1

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ8R000
PRIDEiQ8R000

PTM databases

iPTMnetiQ8R000
PhosphoSitePlusiQ8R000

Expressioni

Tissue specificityi

Present at high levels in ileum. In ileum, it is restricted to the apical domain on the mature villus enterocytes with little detectable expression in the goblet cells or crypt enterocytes (at protein level). Expressed in kidney but not in heart, brain, liver, spleen, embryo, lung, thymus, ovary nor testis.2 Publications

Inductioni

Positively regulated via the bile acid-activated nuclear receptor farnesoid X receptor (NR1H4/FXR). Up-regulated in mice lacking Mrp4, but it is unable to compensate for the absence of Mrp4.2 Publications

Gene expression databases

BgeeiENSMUSG00000035699 Expressed in 43 organ(s), highest expression level in ileum
GenevisibleiQ8R000 MM

Interactioni

Subunit structurei

Interacts with SLC51B. The Ost-alpha/Ost-beta complex is a heterodimer composed of alpha (SLC51A) and beta (SLC51B) subunit.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046286

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi160 – 167Poly-Cys8

Sequence similaritiesi

Belongs to the OST-alpha family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKZG Eukaryota
ENOG410XW07 LUCA
GeneTreeiENSGT00640000091510
HOGENOMiHOG000115297
HOVERGENiHBG098275
InParanoidiQ8R000
KOiK14360
OMAiLNTPPCC
OrthoDBiEOG091G0CFZ
PhylomeDBiQ8R000
TreeFamiTF316050

Family and domain databases

InterProiView protein in InterPro
IPR005178 Ostalpha/TMEM184C
PANTHERiPTHR23423 PTHR23423, 1 hit
PfamiView protein in Pfam
PF03619 Solute_trans_a, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8R000-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPGRTHIKL DPRYTAELLE LLETNYSISP ACFSHPPTAA QLLRALGPVD
60 70 80 90 100
IALTIILTFL TTGSVAIFLE DAVYLYKNTL CPIKKRTLIW SSSAPTVVSV
110 120 130 140 150
FCCFGLWIPR ALTLVEMAIT SFYAVCFYLL MMVMVEGFGG KKAVLRTLKD
160 170 180 190 200
TPMRVHTGPC CCCCPCCPPL ILTRKKLQLL LLGPFQYAFF KITLSIVGLF
210 220 230 240 250
LIPDGIYDPG EISEKSAALW INNLLAVSTL LALWSLAILF RQAKMHLGEQ
260 270 280 290 300
NMGSKFALFQ VLVILTALQP AIFSILANSG QIACSPPYSS KIRSQVMNCH
310 320 330 340
MLILETFLMT VLTRMYYRRK DDKVGYEACS LPDLDSALKA
Length:340
Mass (Da):37,759
Last modified:June 1, 2002 - v1
Checksum:i5A072346AB5402F7
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A338P6E4A0A338P6E4_MOUSE
Organic solute transporter subunit ...
Slc51a
178Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK052725 mRNA Translation: BAC35116.1
AK147155 mRNA Translation: BAE27722.1
BC024441 mRNA Translation: AAH24441.1
BC025912 mRNA Translation: AAH25912.1
BC031178 mRNA Translation: AAH31178.1
CCDSiCCDS28121.1
RefSeqiNP_666044.1, NM_145932.3
UniGeneiMm.476915

Genome annotation databases

EnsembliENSMUST00000042042; ENSMUSP00000046286; ENSMUSG00000035699
GeneIDi106407
KEGGimmu:106407
UCSCiuc007yyx.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK052725 mRNA Translation: BAC35116.1
AK147155 mRNA Translation: BAE27722.1
BC024441 mRNA Translation: AAH24441.1
BC025912 mRNA Translation: AAH25912.1
BC031178 mRNA Translation: AAH31178.1
CCDSiCCDS28121.1
RefSeqiNP_666044.1, NM_145932.3
UniGeneiMm.476915

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046286

Chemistry databases

ChEMBLiCHEMBL2073723

PTM databases

iPTMnetiQ8R000
PhosphoSitePlusiQ8R000

Proteomic databases

PaxDbiQ8R000
PRIDEiQ8R000

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000042042; ENSMUSP00000046286; ENSMUSG00000035699
GeneIDi106407
KEGGimmu:106407
UCSCiuc007yyx.1 mouse

Organism-specific databases

CTDi200931
MGIiMGI:2146634 Slc51a

Phylogenomic databases

eggNOGiENOG410IKZG Eukaryota
ENOG410XW07 LUCA
GeneTreeiENSGT00640000091510
HOGENOMiHOG000115297
HOVERGENiHBG098275
InParanoidiQ8R000
KOiK14360
OMAiLNTPPCC
OrthoDBiEOG091G0CFZ
PhylomeDBiQ8R000
TreeFamiTF316050

Miscellaneous databases

PROiPR:Q8R000
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000035699 Expressed in 43 organ(s), highest expression level in ileum
GenevisibleiQ8R000 MM

Family and domain databases

InterProiView protein in InterPro
IPR005178 Ostalpha/TMEM184C
PANTHERiPTHR23423 PTHR23423, 1 hit
PfamiView protein in Pfam
PF03619 Solute_trans_a, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiOSTA_MOUSE
AccessioniPrimary (citable) accession number: Q8R000
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: June 1, 2002
Last modified: September 12, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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