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Protein

Ras-related protein Rab-38

Gene

Rab38

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and Mycobacterium (By similarity). May be involved in melanosomal transport and docking. Involved in the proper sorting of TYRP1. Involved in peripheral melanosomal distribution of TYRP1 in melanocytes; the function, which probably is implicating vesicle-trafficking, includes cooperation with ANKRD27 and VAMP7 (PubMed:21187289). Plays an important role in the control of melanin production and melanosome biogenesis (By similarity). In concert with RAB32, regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes (PubMed:26620560).By similarity2 Publications

Activity regulationi

Regulated by a guanine nucleotide-exchange factor (GEF) and a GTPase-activating protein (GAP) and alternates between an inactive GDP-bound and an active GTP-bound form. The BLOC-3 complex composed of HPS1 and HPS4 acts as its GEF, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form. SGSM2 acts as its GAP and inactivates it by stimulating its GTPase activity (PubMed:26620560).1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi16 – 23GTPBy similarity8
Nucleotide bindingi65 – 69GTPBy similarity5
Nucleotide bindingi127 – 130GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-8873719 RAB geranylgeranylation
R-MMU-8876198 RAB GEFs exchange GTP for GDP on RABs

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-38
Gene namesi
Name:Rab38
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1919683 Rab38

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Involvement in diseasei

Defects in Rab38 are the cause of a form of oculocutaneous albinism known as the chocolate (cht) phenotype. Mice exhibit a brown coat similar in color to mice with a mutation in tyrosinase-related protein 1 (TYRP1). The targeting of TYRP1 protein to the melanosome is impaired in Rab38(cht)/Rab38(cht) melanocytes.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi69Q → L: Inhibits the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes. 1 Publication1
Mutagenesisi78V → A: Disrupts interaction with ANKRD27; inhibits peripheral distribution of TYRP1 in melanocytes. 1 Publication1

Keywords - Diseasei

Albinism, Disease mutation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001212521 – 211Ras-related protein Rab-38Add BLAST211

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi205S-palmitoyl cysteineSequence analysis1
Lipidationi208S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Palmitate, Prenylation

Proteomic databases

MaxQBiQ8QZZ8
PaxDbiQ8QZZ8
PRIDEiQ8QZZ8

PTM databases

iPTMnetiQ8QZZ8
PhosphoSitePlusiQ8QZZ8

Expressioni

Gene expression databases

BgeeiENSMUSG00000030559 Expressed in 200 organ(s), highest expression level in skin epidermis
CleanExiMM_RAB38
ExpressionAtlasiQ8QZZ8 baseline and differential
GenevisibleiQ8QZZ8 MM

Interactioni

Subunit structurei

Interacts with ANKRD27 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Ankrd27Q3UMR05EBI-1993463,EBI-1993429

GO - Molecular functioni

Protein-protein interaction databases

BioGridi215371, 6 interactors
DIPiDIP-46949N
IntActiQ8QZZ8, 64 interactors
STRINGi10090.ENSMUSP00000102877

Structurei

3D structure databases

ProteinModelPortaliQ8QZZ8
SMRiQ8QZZ8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi38 – 46Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG4423 Eukaryota
ENOG410YITC LUCA
GeneTreeiENSGT00760000119125
HOGENOMiHOG000233968
HOVERGENiHBG009351
InParanoidiQ8QZZ8
KOiK07923
OMAiKRYVHHN
OrthoDBiEOG091G0K53
PhylomeDBiQ8QZZ8
TreeFamiTF324491

Family and domain databases

CDDicd04107 Rab32_Rab38, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR030697 Rab29/Rab38/Rab32
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8QZZ8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQTPHKEHLY KLLVIGDLGV GKTSIIKRYV HQNFSSHYRA TIGVDFALKV
60 70 80 90 100
LHWDPETVVR LQLWDIAGQE RFGNMTRVYY REAMGAFIVF DVTRPATFEA
110 120 130 140 150
VAKWKNDLDS KLTLPNGKPV SVVLLANKCD QGKDVLMNNG LKMDQFCKEH
160 170 180 190 200
GFVGWFETSA KENINIDEAS RCLVKHILAN ECDLLESIEP DIVKPHLTSP
210
KVVSCSGCAK S
Length:211
Mass (Da):23,776
Last modified:June 1, 2002 - v1
Checksum:i61F84A88CDACC486
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A140LHK2A0A140LHK2_MOUSE
Ras-related protein Rab-38
Rab38
121Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti149 – 150EH → DD in BAB26198 (PubMed:16141072).Curated2
Sequence conflicti161 – 162KE → QR in BAB26198 (PubMed:16141072).Curated2
Sequence conflicti173 – 175LVK → RGQ in BAB26198 (PubMed:16141072).Curated3

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti19G → V in cht. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY062237 mRNA Translation: AAL38663.1
AF448443, AF448441, AF448442 Genomic DNA Translation: AAM12528.1
AK009296 mRNA Translation: BAB26198.1
AK044783 mRNA Translation: BAC32089.1
AK054253 mRNA Translation: BAC35704.1
CCDSiCCDS21439.1
RefSeqiNP_082514.4, NM_028238.7
UniGeneiMm.276669

Genome annotation databases

EnsembliENSMUST00000107256; ENSMUSP00000102877; ENSMUSG00000030559
GeneIDi72433
KEGGimmu:72433
UCSCiuc009ifv.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY062237 mRNA Translation: AAL38663.1
AF448443, AF448441, AF448442 Genomic DNA Translation: AAM12528.1
AK009296 mRNA Translation: BAB26198.1
AK044783 mRNA Translation: BAC32089.1
AK054253 mRNA Translation: BAC35704.1
CCDSiCCDS21439.1
RefSeqiNP_082514.4, NM_028238.7
UniGeneiMm.276669

3D structure databases

ProteinModelPortaliQ8QZZ8
SMRiQ8QZZ8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi215371, 6 interactors
DIPiDIP-46949N
IntActiQ8QZZ8, 64 interactors
STRINGi10090.ENSMUSP00000102877

PTM databases

iPTMnetiQ8QZZ8
PhosphoSitePlusiQ8QZZ8

Proteomic databases

MaxQBiQ8QZZ8
PaxDbiQ8QZZ8
PRIDEiQ8QZZ8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000107256; ENSMUSP00000102877; ENSMUSG00000030559
GeneIDi72433
KEGGimmu:72433
UCSCiuc009ifv.1 mouse

Organism-specific databases

CTDi23682
MGIiMGI:1919683 Rab38

Phylogenomic databases

eggNOGiKOG4423 Eukaryota
ENOG410YITC LUCA
GeneTreeiENSGT00760000119125
HOGENOMiHOG000233968
HOVERGENiHBG009351
InParanoidiQ8QZZ8
KOiK07923
OMAiKRYVHHN
OrthoDBiEOG091G0K53
PhylomeDBiQ8QZZ8
TreeFamiTF324491

Enzyme and pathway databases

ReactomeiR-MMU-8873719 RAB geranylgeranylation
R-MMU-8876198 RAB GEFs exchange GTP for GDP on RABs

Miscellaneous databases

PROiPR:Q8QZZ8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030559 Expressed in 200 organ(s), highest expression level in skin epidermis
CleanExiMM_RAB38
ExpressionAtlasiQ8QZZ8 baseline and differential
GenevisibleiQ8QZZ8 MM

Family and domain databases

CDDicd04107 Rab32_Rab38, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR030697 Rab29/Rab38/Rab32
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRAB38_MOUSE
AccessioniPrimary (citable) accession number: Q8QZZ8
Secondary accession number(s): Q9D7E8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: June 1, 2002
Last modified: November 7, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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