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Protein

U7 snRNA-associated Sm-like protein LSm10

Gene

Lsm10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Appears to function in the U7 snRNP complex that is involved in histone 3'-end processing (By similarity). Increases U7 snRNA levels but not histone 3'-end pre-mRNA processing activity, when overexpressed (By similarity). Required for cell cycle progression from G1 to S phases (By similarity). Binds specifically to U7 snRNA (By similarity). Binds specifically to U7 snRNA (By similarity). Binds to the downstream cleavage product (DCP) of histone pre-mRNA.By similarity

GO - Molecular functioni

  • histone pre-mRNA DCP binding Source: UniProtKB
  • snRNA binding Source: MGI
  • U7 snRNA binding Source: MGI

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding
Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-MMU-109688 Cleavage of Growing Transcript in the Termination Region
R-MMU-111367 SLBP independent Processing of Histone Pre-mRNAs
R-MMU-77588 SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs

Names & Taxonomyi

Protein namesi
Recommended name:
U7 snRNA-associated Sm-like protein LSm10
Gene namesi
Name:Lsm10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2151045 Lsm10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001255861 – 122U7 snRNA-associated Sm-like protein LSm10Add BLAST122

Post-translational modificationi

Not methylated. Methylation is not necessary for interaction with SMN (By similarity).By similarity

Proteomic databases

EPDiQ8QZX5
MaxQBiQ8QZX5
PaxDbiQ8QZX5
PRIDEiQ8QZX5

PTM databases

iPTMnetiQ8QZX5
PhosphoSitePlusiQ8QZX5

Expressioni

Gene expression databases

BgeeiENSMUSG00000050188 Expressed in 231 organ(s), highest expression level in oocyte
CleanExiMM_LSM10
ExpressionAtlasiQ8QZX5 baseline and differential
GenevisibleiQ8QZX5 MM

Interactioni

Subunit structurei

Component of the heptameric ring U7 snRNP complex, or U7 Sm protein core complex, at least composed of LSM10, LSM11, SNRPB, SNRPD3, SNRPE, SNRPF, SNRPG and U7 snRNA. Formation of the U7 snRNP is an ATP-dependent process mediated by a specialized SMN complex containing at least the Sm protein core complex and additionally, the U7-specific LSM10 and LSM11 proteins. Interacts with CLNS1A and SMN (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000061913

Structurei

3D structure databases

ProteinModelPortaliQ8QZX5
SMRiQ8QZX5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the snRNP Sm proteins family.Curated

Phylogenomic databases

eggNOGiKOG3428 Eukaryota
COG1958 LUCA
GeneTreeiENSGT00510000048364
HOGENOMiHOG000230640
HOVERGENiHBG052366
InParanoidiQ8QZX5
OMAiNTLNCWP
OrthoDBiEOG091G0TWE
PhylomeDBiQ8QZX5
TreeFamiTF332356

Family and domain databases

InterProiView protein in InterPro
IPR001163 LSM_dom_euk/arc
IPR010920 LSM_dom_sf
PfamiView protein in Pfam
PF01423 LSM, 1 hit
SMARTiView protein in SMART
SM00651 Sm, 1 hit
SUPFAMiSSF50182 SSF50182, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8QZX5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALSHSVKER TISENSLIIL LQGLQGQITT VDLRDESVAR GRIDNVDAFM
60 70 80 90 100
NIRLANVTYT DRWGHQVELD DLFVTGRNVR YVHIPDGVDI TATIEQQLQI
110 120
IHRVRNFGGK GQGRREFPSK RP
Length:122
Mass (Da):13,881
Last modified:June 1, 2002 - v1
Checksum:iB4614D960896B828
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A8Y5G9A8Y5G9_MOUSE
U7 snRNA-associated Sm-like protein...
Lsm10
93Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC024543 mRNA Translation: AAH24543.1
BC026476 mRNA Translation: AAH26476.1
CCDSiCCDS18642.1
RefSeqiNP_001156738.1, NM_001163266.1
NP_620046.1, NM_138721.2
XP_006502749.1, XM_006502686.2
XP_006502750.1, XM_006502687.2
UniGeneiMm.41865

Genome annotation databases

EnsembliENSMUST00000055575; ENSMUSP00000061913; ENSMUSG00000050188
ENSMUST00000179323; ENSMUSP00000136585; ENSMUSG00000050188
GeneIDi116748
KEGGimmu:116748
UCSCiuc008usk.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC024543 mRNA Translation: AAH24543.1
BC026476 mRNA Translation: AAH26476.1
CCDSiCCDS18642.1
RefSeqiNP_001156738.1, NM_001163266.1
NP_620046.1, NM_138721.2
XP_006502749.1, XM_006502686.2
XP_006502750.1, XM_006502687.2
UniGeneiMm.41865

3D structure databases

ProteinModelPortaliQ8QZX5
SMRiQ8QZX5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000061913

PTM databases

iPTMnetiQ8QZX5
PhosphoSitePlusiQ8QZX5

Proteomic databases

EPDiQ8QZX5
MaxQBiQ8QZX5
PaxDbiQ8QZX5
PRIDEiQ8QZX5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000055575; ENSMUSP00000061913; ENSMUSG00000050188
ENSMUST00000179323; ENSMUSP00000136585; ENSMUSG00000050188
GeneIDi116748
KEGGimmu:116748
UCSCiuc008usk.2 mouse

Organism-specific databases

CTDi84967
MGIiMGI:2151045 Lsm10

Phylogenomic databases

eggNOGiKOG3428 Eukaryota
COG1958 LUCA
GeneTreeiENSGT00510000048364
HOGENOMiHOG000230640
HOVERGENiHBG052366
InParanoidiQ8QZX5
OMAiNTLNCWP
OrthoDBiEOG091G0TWE
PhylomeDBiQ8QZX5
TreeFamiTF332356

Enzyme and pathway databases

ReactomeiR-MMU-109688 Cleavage of Growing Transcript in the Termination Region
R-MMU-111367 SLBP independent Processing of Histone Pre-mRNAs
R-MMU-77588 SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs

Miscellaneous databases

PROiPR:Q8QZX5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000050188 Expressed in 231 organ(s), highest expression level in oocyte
CleanExiMM_LSM10
ExpressionAtlasiQ8QZX5 baseline and differential
GenevisibleiQ8QZX5 MM

Family and domain databases

InterProiView protein in InterPro
IPR001163 LSM_dom_euk/arc
IPR010920 LSM_dom_sf
PfamiView protein in Pfam
PF01423 LSM, 1 hit
SMARTiView protein in SMART
SM00651 Sm, 1 hit
SUPFAMiSSF50182 SSF50182, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLSM10_MOUSE
AccessioniPrimary (citable) accession number: Q8QZX5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: June 1, 2002
Last modified: September 12, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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