Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

HAUS augmin-like complex subunit 3

Gene

Haus3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.By similarity

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

ReactomeiR-MMU-2565942 Regulation of PLK1 Activity at G2/M Transition
R-MMU-380259 Loss of Nlp from mitotic centrosomes
R-MMU-380270 Recruitment of mitotic centrosome proteins and complexes
R-MMU-380320 Recruitment of NuMA to mitotic centrosomes
R-MMU-5620912 Anchoring of the basal body to the plasma membrane
R-MMU-8854518 AURKA Activation by TPX2

Names & Taxonomyi

Protein namesi
Recommended name:
HAUS augmin-like complex subunit 3
Gene namesi
Name:Haus3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2387633 Haus3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00003019522 – 570HAUS augmin-like complex subunit 3Add BLAST569

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ8QZX2
PaxDbiQ8QZX2
PeptideAtlasiQ8QZX2
PRIDEiQ8QZX2

PTM databases

PhosphoSitePlusiQ8QZX2

Expressioni

Gene expression databases

BgeeiENSMUSG00000079555 Expressed in 289 organ(s), highest expression level in oocyte
CleanExiMM_BC023882
ExpressionAtlasiQ8QZX2 baseline and differential
GenevisibleiQ8QZX2 MM

Interactioni

Subunit structurei

Component of the HAUS augmin-like complex. The complex interacts with the gamma-tubulin ring complex and this interaction is required for spindle assembly (By similarity).By similarity

Protein-protein interaction databases

BioGridi231085, 3 interactors
IntActiQ8QZX2, 5 interactors
MINTiQ8QZX2
STRINGi10090.ENSMUSP00000049973

Structurei

3D structure databases

ProteinModelPortaliQ8QZX2
SMRiQ8QZX2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili90 – 124Sequence analysisAdd BLAST35
Coiled coili154 – 178Sequence analysisAdd BLAST25
Coiled coili284 – 336Sequence analysisAdd BLAST53
Coiled coili458 – 495Sequence analysisAdd BLAST38

Sequence similaritiesi

Belongs to the HAUS3 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IG8W Eukaryota
ENOG4111N2F LUCA
GeneTreeiENSGT00390000011904
HOGENOMiHOG000054217
InParanoidiQ8QZX2
KOiK16586
OMAiEQFHQVE
OrthoDBiEOG091G0M4W
PhylomeDBiQ8QZX2
TreeFamiTF331151

Family and domain databases

InterProiView protein in InterPro
IPR026206 HAUS3
IPR032733 HAUS3_N
PANTHERiPTHR19378 PTHR19378, 1 hit
PfamiView protein in Pfam
PF14932 HAUS-augmin3, 1 hit
PRINTSiPR02089 HAUSAUGMINL3

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8QZX2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSCGNEFVET LKKIGYPKAD ILNGEDFDWL FEDVEDESFL KWFCGNVNEQ
60 70 80 90 100
NVLSEKELEA FSDLQRSGKP ILEGTALDEV LRTCKTFDLK TCKLDDKEIQ
110 120 130 140 150
ILEDEVQTLQ KLNNSKIQRR NKYQLMVSET SYRFLALNAK QEEATKKLKQ
160 170 180 190 200
KQGFLNSVNT KLSNELQGLT EEVNNLMIFF RNSNLSERTN PMVFLSQFPL
210 220 230 240 250
GKYISQEEQS TAALTLYTKK QFFQGMHEVV ESSNEDNFQL LDIQTPSICD
260 270 280 290 300
NEEILRERRL EMARLQMACI CVQKQIIYLK TSNLSMKSSI KWAEENLNRL
310 320 330 340 350
TNEVIDKENL DAEISSLNSE ILKLEEQITH IKDKVLPAVV KEYAQLLNMP
360 370 380 390 400
VVKGDFELQI AKQDYYTARQ ELVLNELIKQ KASFELVQLS YEIELRKHWD
410 420 430 440 450
TYRQLESLVQ QLSQRNTVLC QHLAVLSDIP ASEQLTSRTP IDTKDHSTHR
460 470 480 490 500
LYELLEGDNK KKELFITHEH LEEVAEKLKQ DVSVIQDQLA VSTQEHFFFL
510 520 530 540 550
SKLNNDVDML CDALYRGGNQ LLLCDQELKE HFHQVESQLN ELHHLLTDIL
560 570
ADVKTKRRIL ATNKLHQVER
Length:570
Mass (Da):66,308
Last modified:June 1, 2002 - v1
Checksum:iBAA32FB3003E3B3F
GO
Isoform 2 (identifier: Q8QZX2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     527-570: ELKEHFHQVESQLNELHHLLTDILADVKTKRRILATNKLHQVER → VSVYLKI

Note: No experimental confirmation available.
Show »
Length:533
Mass (Da):61,847
Checksum:iC4DD46DE66FF4E6F
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0J9YU78A0A0J9YU78_MOUSE
HAUS augmin-like complex subunit 3
Haus3
96Annotation score:
A0A0J9YVC8A0A0J9YVC8_MOUSE
HAUS augmin-like complex subunit 3
Haus3
25Annotation score:

Sequence cautioni

The sequence BAE36560 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti31F → L in AAH23882 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_027887527 – 570ELKEH…HQVER → VSVYLKI in isoform 2. 1 PublicationAdd BLAST44

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK049414 mRNA Translation: BAC33742.1
AK161756 mRNA Translation: BAE36560.1 Different initiation.
BC023882 mRNA Translation: AAH23882.1
BC025497 mRNA Translation: AAH25497.1
BC027393 mRNA Translation: AAH27393.1
CCDSiCCDS19211.1 [Q8QZX2-1]
RefSeqiNP_666271.1, NM_146159.1 [Q8QZX2-1]
UniGeneiMm.319286

Genome annotation databases

EnsembliENSMUST00000060049; ENSMUSP00000049973; ENSMUSG00000079555 [Q8QZX2-1]
GeneIDi231123
KEGGimmu:231123
UCSCiuc008xbv.3 mouse [Q8QZX2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK049414 mRNA Translation: BAC33742.1
AK161756 mRNA Translation: BAE36560.1 Different initiation.
BC023882 mRNA Translation: AAH23882.1
BC025497 mRNA Translation: AAH25497.1
BC027393 mRNA Translation: AAH27393.1
CCDSiCCDS19211.1 [Q8QZX2-1]
RefSeqiNP_666271.1, NM_146159.1 [Q8QZX2-1]
UniGeneiMm.319286

3D structure databases

ProteinModelPortaliQ8QZX2
SMRiQ8QZX2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi231085, 3 interactors
IntActiQ8QZX2, 5 interactors
MINTiQ8QZX2
STRINGi10090.ENSMUSP00000049973

PTM databases

PhosphoSitePlusiQ8QZX2

Proteomic databases

EPDiQ8QZX2
PaxDbiQ8QZX2
PeptideAtlasiQ8QZX2
PRIDEiQ8QZX2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000060049; ENSMUSP00000049973; ENSMUSG00000079555 [Q8QZX2-1]
GeneIDi231123
KEGGimmu:231123
UCSCiuc008xbv.3 mouse [Q8QZX2-1]

Organism-specific databases

CTDi79441
MGIiMGI:2387633 Haus3

Phylogenomic databases

eggNOGiENOG410IG8W Eukaryota
ENOG4111N2F LUCA
GeneTreeiENSGT00390000011904
HOGENOMiHOG000054217
InParanoidiQ8QZX2
KOiK16586
OMAiEQFHQVE
OrthoDBiEOG091G0M4W
PhylomeDBiQ8QZX2
TreeFamiTF331151

Enzyme and pathway databases

ReactomeiR-MMU-2565942 Regulation of PLK1 Activity at G2/M Transition
R-MMU-380259 Loss of Nlp from mitotic centrosomes
R-MMU-380270 Recruitment of mitotic centrosome proteins and complexes
R-MMU-380320 Recruitment of NuMA to mitotic centrosomes
R-MMU-5620912 Anchoring of the basal body to the plasma membrane
R-MMU-8854518 AURKA Activation by TPX2

Miscellaneous databases

PROiPR:Q8QZX2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000079555 Expressed in 289 organ(s), highest expression level in oocyte
CleanExiMM_BC023882
ExpressionAtlasiQ8QZX2 baseline and differential
GenevisibleiQ8QZX2 MM

Family and domain databases

InterProiView protein in InterPro
IPR026206 HAUS3
IPR032733 HAUS3_N
PANTHERiPTHR19378 PTHR19378, 1 hit
PfamiView protein in Pfam
PF14932 HAUS-augmin3, 1 hit
PRINTSiPR02089 HAUSAUGMINL3
ProtoNetiSearch...

Entry informationi

Entry nameiHAUS3_MOUSE
AccessioniPrimary (citable) accession number: Q8QZX2
Secondary accession number(s): Q3TSW5, Q8BQL2, Q8CIH1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: June 1, 2002
Last modified: November 7, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again