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Protein

Serine/threonine-protein kinase SBK1

Gene

Sbk1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in signal-transduction pathways related to the control of brain development.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei82ATPPROSITE-ProRule annotation1
Active sitei174Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi59 – 67ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase SBK1 (EC:2.7.11.1)
Alternative name(s):
SH3-binding kinase 1
Gene namesi
Name:Sbk1
Synonyms:Sbk
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2135937 Sbk1

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002384521 – 417Serine/threonine-protein kinase SBK1Add BLAST417

Proteomic databases

MaxQBiQ8QZX0
PaxDbiQ8QZX0
PRIDEiQ8QZX0

PTM databases

PhosphoSitePlusiQ8QZX0

Expressioni

Gene expression databases

BgeeiENSMUSG00000042978 Expressed in 285 organ(s), highest expression level in brain
CleanExiMM_SBK1
ExpressionAtlasiQ8QZX0 baseline and differential
GenevisibleiQ8QZX0 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000060907

Structurei

3D structure databases

ProteinModelPortaliQ8QZX0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini53 – 318Protein kinasePROSITE-ProRule annotationAdd BLAST266

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi363 – 393Pro-richAdd BLAST31

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1345 Eukaryota
ENOG41112JR LUCA
GeneTreeiENSGT00680000099954
HOGENOMiHOG000063666
HOVERGENiHBG108481
InParanoidiQ8QZX0
KOiK08858
OMAiEEMVKRC
OrthoDBiEOG091G0QNH
PhylomeDBiQ8QZX0
TreeFamiTF326736

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR008271 Ser/Thr_kinase_AS
IPR016234 Ser/Thr_kinase_Sbk1
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
PIRSFiPIRSF000566 Ser/Thr_PK_Sbk1, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8QZX0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSVGCPEPEP LHSLPCCGPG AAPVPGAGVP LLTEDMQALT LRTLAASDVT
60 70 80 90 100
KHYELVRELG KGTYGKVDLV AYKGTGTKMA LKFVNKSKTK LKNFLREVSI
110 120 130 140 150
TNSLSSSPFI IKVFDVVFET EECYVFAQEY APAGDLFDII PPQVGLPEDT
160 170 180 190 200
VKRCVQQLGL ALDFMHSRQL VHRDIKPENV LLFDRECRRV KLADFGMTRR
210 220 230 240 250
VGCRVKRVSG TIPYTAPEVC QAGRADGFAV DTGVDVWAFG VLIFCVLTGN
260 270 280 290 300
FPWEAASGAD AFFEEFVRWQ RGRLPGLPSQ WRRFTEPALR MFQRLLALEP
310 320 330 340 350
ERRGPAKEVF RFLKHELTSE LRRRPSHRAR KPPGDRLPGS LRLEAPGPLK
360 370 380 390 400
RTVLTESGSG SRPSPPSVGP VVPVPVPVPV PVPEAGLAPP APPGRTDGRT
410
DKSKGQVVLA TAIEICV
Length:417
Mass (Da):45,696
Last modified:June 1, 2002 - v1
Checksum:iC6A79A28EE6D2EC7
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0U1RNW9A0A0U1RNW9_MOUSE
Serine/threonine-protein kinase SBK...
Sbk1
22Annotation score:
A0A0U1RNY5A0A0U1RNY5_MOUSE
Serine/threonine-protein kinase SBK...
Sbk1
134Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC024114 mRNA Translation: AAH24114.1
BC025837 mRNA Translation: AAH25837.1
BC031759 mRNA Translation: AAH31759.1
CCDSiCCDS21824.1
RefSeqiNP_663562.1, NM_145587.2
XP_017177409.1, XM_017321920.1
UniGeneiMm.29660

Genome annotation databases

EnsembliENSMUST00000056028; ENSMUSP00000060907; ENSMUSG00000042978
GeneIDi104175
KEGGimmu:104175
UCSCiuc009jqw.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC024114 mRNA Translation: AAH24114.1
BC025837 mRNA Translation: AAH25837.1
BC031759 mRNA Translation: AAH31759.1
CCDSiCCDS21824.1
RefSeqiNP_663562.1, NM_145587.2
XP_017177409.1, XM_017321920.1
UniGeneiMm.29660

3D structure databases

ProteinModelPortaliQ8QZX0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000060907

PTM databases

PhosphoSitePlusiQ8QZX0

Proteomic databases

MaxQBiQ8QZX0
PaxDbiQ8QZX0
PRIDEiQ8QZX0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000056028; ENSMUSP00000060907; ENSMUSG00000042978
GeneIDi104175
KEGGimmu:104175
UCSCiuc009jqw.1 mouse

Organism-specific databases

CTDi388228
MGIiMGI:2135937 Sbk1

Phylogenomic databases

eggNOGiKOG1345 Eukaryota
ENOG41112JR LUCA
GeneTreeiENSGT00680000099954
HOGENOMiHOG000063666
HOVERGENiHBG108481
InParanoidiQ8QZX0
KOiK08858
OMAiEEMVKRC
OrthoDBiEOG091G0QNH
PhylomeDBiQ8QZX0
TreeFamiTF326736

Miscellaneous databases

ChiTaRSiSbk1 mouse
PROiPR:Q8QZX0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000042978 Expressed in 285 organ(s), highest expression level in brain
CleanExiMM_SBK1
ExpressionAtlasiQ8QZX0 baseline and differential
GenevisibleiQ8QZX0 MM

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR008271 Ser/Thr_kinase_AS
IPR016234 Ser/Thr_kinase_Sbk1
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
PIRSFiPIRSF000566 Ser/Thr_PK_Sbk1, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSBK1_MOUSE
AccessioniPrimary (citable) accession number: Q8QZX0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: June 1, 2002
Last modified: November 7, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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