UniProtKB - Q8QZV7 (INT13_MOUSE)
Protein
Integrator complex subunit 13
Gene
IntS13
Organism
Mus musculus (Mouse)
Status
Functioni
Crucial regulator of the mitotic cell cycle and development. At prophase, required for dynein anchoring to the nuclear envelope important for proper centrosome-nucleus coupling. At G2/M phase, may be required for proper spindle formation and execution of cytokinesis. Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing.By similarity
GO - Biological processi
- cell division Source: UniProtKB-KW
- centrosome localization Source: MGI
- flagellated sperm motility Source: UniProtKB
- mitotic spindle organization Source: MGI
- protein localization to nuclear envelope Source: MGI
- regulation of fertilization Source: UniProtKB
- regulation of mitotic cell cycle Source: UniProtKB
Keywordsi
Biological process | Cell cycle, Cell division, Mitosis |
Enzyme and pathway databases
Reactomei | R-MMU-6807505, RNA polymerase II transcribes snRNA genes |
Names & Taxonomyi
Protein namesi | Recommended name: Integrator complex subunit 13ImportedAlternative name(s): Cell cycle regulator Mat89Bb homolog Protein asunder homolog Spermatogenesis-associated protein 30 |
Gene namesi | Name:IntS13Imported Synonyms:Asun, Spata30 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1918427, Ints13 |
Subcellular locationi
Nucleus
- integrator complex Source: GO_Central
- nuclear body Source: MGI
- nucleoplasm Source: MGI
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
- intracellular membrane-bounded organelle Source: MGI
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 577 – 582 | REDRED → AAAAAA: Loss of nuclear location. Location is mainly cytoplasmic or diffuse. 1 Publication | 6 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000089846 | 1 – 732 | Integrator complex subunit 13Add BLAST | 732 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 611 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 623 | PhosphoserineBy similarity | 1 | |
Modified residuei | 626 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q8QZV7 |
jPOSTi | Q8QZV7 |
MaxQBi | Q8QZV7 |
PaxDbi | Q8QZV7 |
PeptideAtlasi | Q8QZV7 |
PRIDEi | Q8QZV7 |
PTM databases
iPTMneti | Q8QZV7 |
PhosphoSitePlusi | Q8QZV7 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000040250, Expressed in saccule of membranous labyrinth and 285 other tissues |
ExpressionAtlasi | Q8QZV7, baseline and differential |
Genevisiblei | Q8QZV7, MM |
Interactioni
Subunit structurei
Interacts with PAFAH1B1; this interaction may be required for proper recruitment of dynein complexes to the nuclear envelope at prophase.
1 PublicationProtein-protein interaction databases
BioGRIDi | 214533, 3 interactors |
IntActi | Q8QZV7, 1 interactor |
MINTi | Q8QZV7 |
STRINGi | 10090.ENSMUSP00000032427 |
Miscellaneous databases
RNActi | Q8QZV7, protein |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 572 – 582 | Nuclear localization signal (NLS)1 PublicationAdd BLAST | 11 |
Sequence similaritiesi
Belongs to the asunder family.Curated
Phylogenomic databases
eggNOGi | KOG3711, Eukaryota |
GeneTreei | ENSGT00390000002793 |
InParanoidi | Q8QZV7 |
OMAi | KQDEVRC |
OrthoDBi | 676663at2759 |
TreeFami | TF105815 |
Family and domain databases
InterProi | View protein in InterPro IPR019355, Cell_cycle_regulator_Mat89Bb |
PANTHERi | PTHR12955, PTHR12955, 1 hit |
Pfami | View protein in Pfam PF10221, DUF2151, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
Q8QZV7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKIFSESHKT VFVVDHCPYM AESCRQHVEF DMLVKNRTQG IIPLAPISKS
60 70 80 90 100
LWTCSVESSM EYCRIMYDIF PFKKLVNFIV SDSGAHVLNS WTQEDQNLQE
110 120 130 140 150
LMAALATVGP PNPRADPECC SILHGLVAAV ETLCKITEYQ HEARTLLMEN
160 170 180 190 200
AERVGNRGRI ICITNAKSDS HVRMLEDCVQ ETIHEHNKLA ANSDHLMQIQ
210 220 230 240 250
KCELVLIHTY PVGEDSLVSD RPKKELSPVL TSEVHSVRAG RHLATKLNVL
260 270 280 290 300
VQQHFDLAST TITNIPMKEE QHANTSANYD VELLHHKDAH VDFLRSGDSH
310 320 330 340 350
SGSSSREGPF KETVTLKWCT PRTNSIELHY CTGAYRISPV DVNSRPSSCL
360 370 380 390 400
TNFLLNGRSV LLEQPRKSGS KVISHMLSSH GGEIFLHVLS SSRSILEDPP
410 420 430 440 450
SISEGCGGRV TDYRITDFGE FMRENRLTPF LDPRYKIDAS LEIPLERAKD
460 470 480 490 500
QLEKHTRYWP MIISQTTIFN MQAVVPLAGV IVKESLTEED VLNCQKTIYN
510 520 530 540 550
LVDMERKNDP LPVSTVGTRG KGPKRDEQYR IMWNELETLV RAHISNSEKH
560 570 580 590 600
QRVLECLMAC RSKPPEEEER KKRGRKREDR EDKSEQAGKE HGTEKARPDA
610 620 630 640 650
DRLKGILERG KEELAEAEVI KDSPDSPEPP NKKPLVETDE TPHMEKSKGP
660 670 680 690 700
VSLLSLWSNR INTANSRKHQ EFAGRLNSVN NRAELYQHLK EENGEEVGLT
710 720 730
GGPRTAIPFL KCPRSPVVNR METTENGKAS RQ
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF7BP94 | F7BP94_MOUSE | Integrator complex subunit 13 | Ints13 Asun, Spata30 | 230 | Annotation score: | ||
A0A0N4SVS8 | A0A0N4SVS8_MOUSE | Integrator complex subunit 13 | Ints13 Asun | 327 | Annotation score: | ||
F6W761 | F6W761_MOUSE | Integrator complex subunit 13 | Ints13 Asun, Spata30 | 395 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 303 | S → G in AAH26851 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 303 | S → G in AAH27229 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 605 | G → R in AAH05696 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC124128 Genomic DNA No translation available. BC005696 mRNA Translation: AAH05696.1 BC026851 mRNA Translation: AAH26851.1 BC027229 mRNA Translation: AAH27229.1 |
CCDSi | CCDS39710.1 |
RefSeqi | NP_620096.2, NM_138757.2 |
Genome annotation databases
Ensembli | ENSMUST00000032427; ENSMUSP00000032427; ENSMUSG00000040250 |
GeneIDi | 71177 |
KEGGi | mmu:71177 |
UCSCi | uc009esb.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC124128 Genomic DNA No translation available. BC005696 mRNA Translation: AAH05696.1 BC026851 mRNA Translation: AAH26851.1 BC027229 mRNA Translation: AAH27229.1 |
CCDSi | CCDS39710.1 |
RefSeqi | NP_620096.2, NM_138757.2 |
3D structure databases
SMRi | Q8QZV7 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 214533, 3 interactors |
IntActi | Q8QZV7, 1 interactor |
MINTi | Q8QZV7 |
STRINGi | 10090.ENSMUSP00000032427 |
PTM databases
iPTMneti | Q8QZV7 |
PhosphoSitePlusi | Q8QZV7 |
Proteomic databases
EPDi | Q8QZV7 |
jPOSTi | Q8QZV7 |
MaxQBi | Q8QZV7 |
PaxDbi | Q8QZV7 |
PeptideAtlasi | Q8QZV7 |
PRIDEi | Q8QZV7 |
Protocols and materials databases
Antibodypediai | 42367, 59 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000032427; ENSMUSP00000032427; ENSMUSG00000040250 |
GeneIDi | 71177 |
KEGGi | mmu:71177 |
UCSCi | uc009esb.1, mouse |
Organism-specific databases
CTDi | 55726 |
MGIi | MGI:1918427, Ints13 |
Phylogenomic databases
eggNOGi | KOG3711, Eukaryota |
GeneTreei | ENSGT00390000002793 |
InParanoidi | Q8QZV7 |
OMAi | KQDEVRC |
OrthoDBi | 676663at2759 |
TreeFami | TF105815 |
Enzyme and pathway databases
Reactomei | R-MMU-6807505, RNA polymerase II transcribes snRNA genes |
Miscellaneous databases
BioGRID-ORCSi | 71177, 9 hits in 20 CRISPR screens |
ChiTaRSi | Ints13, mouse |
PROi | PR:Q8QZV7 |
RNActi | Q8QZV7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000040250, Expressed in saccule of membranous labyrinth and 285 other tissues |
ExpressionAtlasi | Q8QZV7, baseline and differential |
Genevisiblei | Q8QZV7, MM |
Family and domain databases
InterProi | View protein in InterPro IPR019355, Cell_cycle_regulator_Mat89Bb |
PANTHERi | PTHR12955, PTHR12955, 1 hit |
Pfami | View protein in Pfam PF10221, DUF2151, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | INT13_MOUSE | |
Accessioni | Q8QZV7Primary (citable) accession number: Q8QZV7 Secondary accession number(s): E9QLV7, Q99JT8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 19, 2005 |
Last sequence update: | July 27, 2011 | |
Last modified: | February 10, 2021 | |
This is version 110 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families