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Protein

Protein FAM161A

Gene

Fam161a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in ciliogenesis.By similarity

GO - Molecular functioni

GO - Biological processi

  • cilium assembly Source: UniProtKB
  • cilium organization Source: MGI
  • positive regulation of protein acetylation Source: MGI

Keywordsi

Biological processCilium biogenesis/degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM161A
Gene namesi
Name:Fam161a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1921123 Fam161a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003290531 – 448Protein FAM161AAdd BLAST448

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki350Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiQ8QZV6
PaxDbiQ8QZV6
PRIDEiQ8QZV6

PTM databases

PhosphoSitePlusiQ8QZV6

Expressioni

Tissue specificityi

Expressed in the retina.2 Publications

Developmental stagei

Expressed at low levels from 12.5 to 16.5 dpc in the retinal progenitor cells of the optic cup, as well as in the posterior compartment of the lens. Expression drops in the retina at birth. At P5, highly expressed in the postmigratory photoreceptor precursors at the apical side of the outer nuclear layer. At P10, present in the outer nuclear layer and in the inner segments of photoreceptors and in the outer plexiform layer (at protein level). In adult animals, at P30, reaches a well-defined localization in the inner segment of photoreceptors, as well as in the outer plexiform layer (at protein level). Completely absent from the outer segment of photoreceptors (at protein level).2 Publications

Interactioni

Subunit structurei

Interacts (via C-terminus) with microtubules. Interacts with LCA5, CEP290 and SDCCAG8. Interacts with FAM161B. Interacts with POC1B. Interacts with CEP78.By similarity

GO - Molecular functioni

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili135 – 207Sequence analysisAdd BLAST73

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi27 – 61Ser-richAdd BLAST35

Sequence similaritiesi

Belongs to the FAM161 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IEKK Eukaryota
ENOG4111HTJ LUCA
HOVERGENiHBG107870
InParanoidiQ8QZV6
KOiK16772

Family and domain databases

InterProiView protein in InterPro
IPR019579 UPF0564
PfamiView protein in Pfam
PF10595 UPF0564, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q8QZV6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSKLEKMYQD KLNIKDIQAG FIRDGISDSS SSSASEKSCS HPALSVTSLS
60 70 80 90 100
EPDLDGSSSL STTTDEGLPD LEEKTPGESS AMVHAQELIN NMWNDFSVED
110 120 130 140 150
YIQYDSDSRT AKKKRKKAKS LTPKITVPVP FEMTVREQNR REKALSARSD
160 170 180 190 200
LETKLLKRDE DDAECKKKFR ANPVPSCVLL PLYEDLVKQS EERRKKARER
210 220 230 240 250
NRAALLASLK PFKFIAREEQ KQAVREKKLR DLFRAKRKTN QFKAKPVPRF
260 270 280 290 300
IYRPAASDKP KEEELYGDSR MLPKVRDLLQ NSPWPSRSAC RRFRDPRSPA
310 320 330 340 350
KPRGKHRRRC LRRDGDLEKW KEPFSEYSFL KCPMLCEECC LHESPCDSDK
360 370 380 390 400
RQKLLADIRA DEEILRETRR PGRSPRRKSP GRSSNPKPRP HECSPPMPTA
410 420 430 440
SSRGREQAIR RSEKARMREY WQELEEQEEK LQKRPMLFER VTQVVFIG
Length:448
Mass (Da):52,029
Last modified:June 1, 2002 - v1
Checksum:iFFADA9805D1CD115
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1AVK0B1AVK0_MOUSE
Protein FAM161A
Fam161a
475Annotation score:
B1AVK2B1AVK2_MOUSE
Protein FAM161A
Fam161a
287Annotation score:
A0A140LHD1A0A140LHD1_MOUSE
Protein FAM161A
Fam161a
562Annotation score:
F6XT74F6XT74_MOUSE
Protein FAM161A
Fam161a
236Annotation score:
A0A1B0GXD7A0A1B0GXD7_MOUSE
Protein FAM161A
Fam161a
137Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC024460 mRNA Translation: AAH24460.1
BC026495 mRNA Translation: AAH26495.1
RefSeqiNP_082948.2, NM_028672.2
UniGeneiMm.252406

Genome annotation databases

GeneIDi73873
KEGGimmu:73873
UCSCiuc007ies.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC024460 mRNA Translation: AAH24460.1
BC026495 mRNA Translation: AAH26495.1
RefSeqiNP_082948.2, NM_028672.2
UniGeneiMm.252406

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSitePlusiQ8QZV6

Proteomic databases

MaxQBiQ8QZV6
PaxDbiQ8QZV6
PRIDEiQ8QZV6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi73873
KEGGimmu:73873
UCSCiuc007ies.1 mouse

Organism-specific databases

CTDi84140
MGIiMGI:1921123 Fam161a

Phylogenomic databases

eggNOGiENOG410IEKK Eukaryota
ENOG4111HTJ LUCA
HOVERGENiHBG107870
InParanoidiQ8QZV6
KOiK16772

Miscellaneous databases

PROiPR:Q8QZV6
SOURCEiSearch...

Family and domain databases

InterProiView protein in InterPro
IPR019579 UPF0564
PfamiView protein in Pfam
PF10595 UPF0564, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiF161A_MOUSE
AccessioniPrimary (citable) accession number: Q8QZV6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: June 1, 2002
Last modified: February 28, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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