Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

E3 ubiquitin-protein ligase RNF183

Gene

Rnf183

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (PubMed:29300766). Triggers apoptosis in response to prolonged ER stress by mediating the polyubiquitination and subsequent proteasomal degradation of BCL2L1 (By similarity). May collaborate with FATE1 to restrain BIK protein levels thus regulating apoptotic signaling (By similarity).By similarity1 Publication

Catalytic activityi

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.1 Publication

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.1 Publication
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri13 – 60RING-typePROSITE-ProRule annotationAdd BLAST48

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • ubiquitin protein ligase activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processApoptosis, Ubl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase RNF183 (EC:2.3.2.271 Publication)
Gene namesi
Name:Rnf183
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1923322 Rnf183

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 159CytoplasmicCuratedAdd BLAST159
Transmembranei160 – 180Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21
Topological domaini181 – 190LumenalCurated10

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Lysosome, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi13C → S: Decrease in autoubiquitination; when associated with S-16. 1 Publication1
Mutagenesisi16C → S: Decrease in autoubiquitination; when associated with S-13. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002473591 – 190E3 ubiquitin-protein ligase RNF183Add BLAST190

Post-translational modificationi

Autoubiquitinated (in vitro).1 Publication

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiQ8QZS5
PRIDEiQ8QZS5

Expressioni

Tissue specificityi

Highly expressed in the kidney and testis.2 Publications

Gene expression databases

BgeeiENSMUSG00000063851 Expressed in 24 organ(s), highest expression level in late tubule (mouse)
CleanExiMM_RNF183
GenevisibleiQ8QZS5 MM

Interactioni

Subunit structurei

Interacts with FATE1 (By similarity). Interacts with SEC16A (PubMed:29300766). Interacts with BCL2L1 (By similarity).By similarity1 Publication

Protein-protein interaction databases

IntActiQ8QZS5, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliQ8QZS5
SMRiQ8QZS5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri13 – 60RING-typePROSITE-ProRule annotationAdd BLAST48

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiENOG410ITEM Eukaryota
ENOG4111Y1I LUCA
GeneTreeiENSGT00530000063798
HOGENOMiHOG000082461
HOVERGENiHBG093908
InParanoidiQ8QZS5
KOiK22157
OMAiCWNPFNN
OrthoDBiEOG091G0Q9E
PhylomeDBiQ8QZS5
TreeFamiTF337102

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PfamiView protein in Pfam
PF13639 zf-RING_2, 1 hit
SMARTiView protein in SMART
SM00184 RING, 1 hit
PROSITEiView protein in PROSITE
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8QZS5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSEPQGQELR AECPVCWNPF NNTFHTPKVL DCCHSFCVEC LAHLSLVTPA
60 70 80 90 100
RRRLLCPLCR QPTVLASGQP VTDLPTDTAM LTLLRLEPHH VILEGHQLCL
110 120 130 140 150
KDQPKSRYFL RQPRVYTLDL GAEPGSQTGL PQDTAPDTRP VPIPSHYSLR
160 170 180 190
ECVRNPHFRI FAYLMAVILS VTLLLIFSIF WTKQFFWGMG
Length:190
Mass (Da):21,625
Last modified:June 1, 2002 - v1
Checksum:i0671BD5D56DB7FB1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK017982 mRNA Translation: BAC25537.1
AL732594 Genomic DNA Translation: CAX15990.1
CH466527 Genomic DNA Translation: EDL31146.1
CH466527 Genomic DNA Translation: EDL31147.1
BC025512 mRNA Translation: AAH25512.1
CCDSiCCDS38775.1
RefSeqiNP_705724.1, NM_153504.3
XP_006538402.1, XM_006538339.3
UniGeneiMm.169565

Genome annotation databases

EnsembliENSMUST00000079420; ENSMUSP00000078389; ENSMUSG00000063851
ENSMUST00000107454; ENSMUSP00000103078; ENSMUSG00000063851
ENSMUST00000107455; ENSMUSP00000103079; ENSMUSG00000063851
GeneIDi76072
KEGGimmu:76072
UCSCiuc008tes.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK017982 mRNA Translation: BAC25537.1
AL732594 Genomic DNA Translation: CAX15990.1
CH466527 Genomic DNA Translation: EDL31146.1
CH466527 Genomic DNA Translation: EDL31147.1
BC025512 mRNA Translation: AAH25512.1
CCDSiCCDS38775.1
RefSeqiNP_705724.1, NM_153504.3
XP_006538402.1, XM_006538339.3
UniGeneiMm.169565

3D structure databases

ProteinModelPortaliQ8QZS5
SMRiQ8QZS5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8QZS5, 1 interactor

Proteomic databases

PaxDbiQ8QZS5
PRIDEiQ8QZS5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000079420; ENSMUSP00000078389; ENSMUSG00000063851
ENSMUST00000107454; ENSMUSP00000103078; ENSMUSG00000063851
ENSMUST00000107455; ENSMUSP00000103079; ENSMUSG00000063851
GeneIDi76072
KEGGimmu:76072
UCSCiuc008tes.1 mouse

Organism-specific databases

CTDi138065
MGIiMGI:1923322 Rnf183

Phylogenomic databases

eggNOGiENOG410ITEM Eukaryota
ENOG4111Y1I LUCA
GeneTreeiENSGT00530000063798
HOGENOMiHOG000082461
HOVERGENiHBG093908
InParanoidiQ8QZS5
KOiK22157
OMAiCWNPFNN
OrthoDBiEOG091G0Q9E
PhylomeDBiQ8QZS5
TreeFamiTF337102

Enzyme and pathway databases

UniPathwayi
UPA00143

Miscellaneous databases

PROiPR:Q8QZS5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000063851 Expressed in 24 organ(s), highest expression level in late tubule (mouse)
CleanExiMM_RNF183
GenevisibleiQ8QZS5 MM

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PfamiView protein in Pfam
PF13639 zf-RING_2, 1 hit
SMARTiView protein in SMART
SM00184 RING, 1 hit
PROSITEiView protein in PROSITE
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRN183_MOUSE
AccessioniPrimary (citable) accession number: Q8QZS5
Secondary accession number(s): B7ZCH3, Q5NBV8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: June 1, 2002
Last modified: November 7, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again