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Protein

Small ubiquitin-related modifier 1

Gene

SUMO1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-GGA-3065676 SUMO is conjugated to E1 (UBA2:SAE1)
R-GGA-3065678 SUMO is transferred from E1 to E2 (UBE2I, UBC9)
R-GGA-3065679 SUMO is proteolytically processed
R-GGA-3108214 SUMOylation of DNA damage response and repair proteins
R-GGA-3232118 SUMOylation of transcription factors
R-GGA-3899300 SUMOylation of transcription cofactors
R-GGA-4551638 SUMOylation of chromatin organization proteins
R-GGA-4570464 SUMOylation of RNA binding proteins
R-GGA-4615885 SUMOylation of DNA replication proteins
R-GGA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-GGA-5693571 Nonhomologous End-Joining (NHEJ)
R-GGA-5696395 Formation of Incision Complex in GG-NER
R-GGA-69473 G2/M DNA damage checkpoint
R-GGA-877312 Regulation of IFNG signaling
R-GGA-8866904 Negative regulation of activity of TFAP2 (AP-2) family transcription factors

Names & Taxonomyi

Protein namesi
Recommended name:
Small ubiquitin-related modifier 1
Short name:
SUMO-1
Gene namesi
Name:SUMO1
ORF Names:RCJMB04_2j18
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002676141 – 97Small ubiquitin-related modifier 1Add BLAST97
PropeptideiPRO_000026761598 – 101By similarity4

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki97Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)PROSITE-ProRule annotation

Post-translational modificationi

Cleavage of precursor form by a sentrin-specific protease is necessary for function.By similarity

Keywords - PTMi

Isopeptide bond

Proteomic databases

PaxDbiQ8QGH2
PRIDEiQ8QGH2

Expressioni

Gene expression databases

BgeeiENSGALG00000008435

Interactioni

Subunit structurei

Interacts with SAE2, UBE2I, RANBP2, PIAS1 and PIAS2. Covalently attached to a number of proteins (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000013729

Structurei

3D structure databases

ProteinModelPortaliQ8QGH2
SMRiQ8QGH2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 97Ubiquitin-likePROSITE-ProRule annotationAdd BLAST78

Sequence similaritiesi

Belongs to the ubiquitin family. SUMO subfamily.Curated

Phylogenomic databases

eggNOGiKOG1769 Eukaryota
COG5227 LUCA
GeneTreeiENSGT00390000018808
HOGENOMiHOG000207495
HOVERGENiHBG053025
InParanoidiQ8QGH2
KOiK12160
OMAiTDNHTPK
OrthoDBiEOG091G10ZQ
PhylomeDBiQ8QGH2

Family and domain databases

CDDicd01763 Sumo, 1 hit
InterProiView protein in InterPro
IPR022617 Rad60/SUMO-like_dom
IPR033950 Sumo
IPR029071 Ubiquitin-like_domsf
IPR000626 Ubiquitin_dom
PfamiView protein in Pfam
PF11976 Rad60-SLD, 1 hit
SMARTiView protein in SMART
SM00213 UBQ, 1 hit
SUPFAMiSSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50053 UBIQUITIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8QGH2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDQEAKPSA EDLGDKKEGE YIKLKVIGQD SSEIHFKVKM TTHLKKLKES
60 70 80 90 100
YCQRQGVPMN SLRFLFEGQR ITDNHTPKEL GMEEEDVIEV YQEQTGGHST

V
Length:101
Mass (Da):11,557
Last modified:June 1, 2002 - v1
Checksum:i9415E7C69554FB33
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF461015 mRNA Translation: AAL85281.1
AJ719470 mRNA Translation: CAG31129.1
RefSeqiNP_989466.1, NM_204135.2
UniGeneiGga.8466

Genome annotation databases

EnsembliENSGALT00000013744; ENSGALP00000013729; ENSGALG00000008435
GeneIDi373930
KEGGigga:373930

Similar proteinsi

Entry informationi

Entry nameiSUMO1_CHICK
AccessioniPrimary (citable) accession number: Q8QGH2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: June 1, 2002
Last modified: May 23, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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