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Protein

Mothers against decapentaplegic homolog

Gene

Smad8A

Organism
Xenopus laevis (African clawed frog)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingUniRule annotation
Biological processTranscription, Transcription regulationUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Mothers against decapentaplegic homologUniRule annotation
Short name:
MAD homologUniRule annotation
Short name:
Mothers against DPP homologUniRule annotation
Alternative name(s):
SMAD family memberUniRule annotation
Gene namesi
Name:Smad8AImported
OrganismiXenopus laevis (African clawed frog)Imported
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CytoplasmUniRule annotation, NucleusUniRule annotationSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliQ8QGG6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 140MH1InterPro annotationAdd BLAST125
Domaini272 – 466MH2InterPro annotationAdd BLAST195

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili38 – 58Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the dwarfin/SMAD family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

HOVERGENiHBG053353
KOiK16791

Family and domain databases

Gene3Di2.60.200.10, 1 hit
3.90.520.10, 1 hit
InterProiView protein in InterPro
IPR013790 Dwarfin
IPR003619 MAD_homology1_Dwarfin-type
IPR013019 MAD_homology_MH1
IPR017855 SMAD-like_dom_sf
IPR001132 SMAD_dom_Dwarfin-type
IPR008984 SMAD_FHA_dom_sf
IPR036578 SMAD_MH1_sf
PANTHERiPTHR13703 PTHR13703, 1 hit
PfamiView protein in Pfam
PF03165 MH1, 1 hit
PF03166 MH2, 1 hit
SMARTiView protein in SMART
SM00523 DWA, 1 hit
SM00524 DWB, 1 hit
SUPFAMiSSF49879 SSF49879, 1 hit
SSF56366 SSF56366, 1 hit
PROSITEiView protein in PROSITE
PS51075 MH1, 1 hit
PS51076 MH2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8QGG6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHASTPISSL FTFTSPAVKR LLGWKQGDEE EKWAEKAVDS LVKKLKKKKG
60 70 80 90 100
AMEELERALS CPGQPSKCVT IPRSLDGRLQ VSHRKGLSHV IYCRVWRWPD
110 120 130 140 150
LQSHHELKPM ECCEFPFGSK QKDVCINPYH YRRVETPVLP PVLVPRHSEF
160 170 180 190 200
NPQLSLLAKF SNTSLNNEPL MPHNATFPES FQQPPRTPFS SSPSNIFPQS
210 220 230 240 250
PNTVGYPDSP RSSTDPGSPP YQITETPPPP YNAPDLQGNQ NRPTADPAEC
260 270 280 290 300
QLVLSALNRD FRPVCYEEPL HWCSVAYYEL NNRVGETFQA SARSVLIDGF
310 320 330 340 350
TDPSNNKNRF CLGLLSNVNR NSTIENTRRH IGKGVHLYYV GGEVYAECVS
360 370 380 390 400
DSSIFVQSRN CNYQHGFHPS TVCKIPSGCS LKIFNNQLFA QLLSQSVNQG
410 420 430 440 450
FEVVYELTKM CTIRMSFVKG WGAEYHRQDV TSTPCWIEIH LHGPLQWLDK
460
VLTQMGSPHN PISSVS
Length:466
Mass (Da):52,559
Last modified:June 1, 2002 - v1
Checksum:iDC2453E9960A08B8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF464927 mRNA Translation: AAL86772.1
RefSeqiNP_001165671.1, NM_001172200.1
UniGeneiXl.741
Xl.85567

Genome annotation databases

GeneIDi100337601
KEGGixla:100337601

Similar proteinsi

Entry informationi

Entry nameiQ8QGG6_XENLA
AccessioniPrimary (citable) accession number: Q8QGG6
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2002
Last sequence update: June 1, 2002
Last modified: February 28, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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