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Protein

Potassium channel subfamily T member 1

Gene

KCNT1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Generates outwardly rectifying currents that are suppressed by elevation of intracellular calcium.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Potassium channel
Biological processIon transport, Potassium transport, Transport
LigandCalcium, Potassium

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel subfamily T member 1
Alternative name(s):
Sequence like a calcium-activated potassium channel subunit
Gene namesi
Name:KCNT1
Synonyms:SLACK
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 17

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 95CytoplasmicSequence analysisAdd BLAST95
Transmembranei96 – 116Helical; Name=Segment S1Sequence analysisAdd BLAST21
Topological domaini117 – 153ExtracellularSequence analysisAdd BLAST37
Transmembranei154 – 174Helical; Name=Segment S2Sequence analysisAdd BLAST21
Topological domaini175 – 185CytoplasmicSequence analysisAdd BLAST11
Transmembranei186 – 206Helical; Name=Segment S3Sequence analysisAdd BLAST21
Topological domaini207 – 211ExtracellularSequence analysis5
Transmembranei212 – 224Helical; Name=Segment S4Sequence analysisAdd BLAST13
Topological domaini225 – 249CytoplasmicSequence analysisAdd BLAST25
Transmembranei250 – 270Helical; Name=Segment S5Sequence analysisAdd BLAST21
Topological domaini271 – 279ExtracellularSequence analysis9
Intramembranei280 – 300Pore-formingSequence analysisAdd BLAST21
Topological domaini301 – 302ExtracellularSequence analysis2
Transmembranei303 – 323Helical; Name=Segment S6Sequence analysisAdd BLAST21
Topological domaini324 – 1201CytoplasmicSequence analysisAdd BLAST878

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000540931 – 1201Potassium channel subfamily T member 1Add BLAST1201

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi131N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi136N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8QFV0
PRIDEiQ8QFV0

Expressioni

Gene expression databases

BgeeiENSGALG00000001645 Expressed in 4 organ(s), highest expression level in brain
ExpressionAtlasiQ8QFV0 baseline

Interactioni

Protein-protein interaction databases

DIPiDIP-61789N

Structurei

3D structure databases

ProteinModelPortaliQ8QFV0
SMRiQ8QFV0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini473 – 594RCK N-terminalAdd BLAST122

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3193 Eukaryota
ENOG410XSMA LUCA
GeneTreeiENSGT00530000063026
HOGENOMiHOG000231460
HOVERGENiHBG055190
InParanoidiQ8QFV0
KOiK04946
OrthoDBiEOG091G011O
PhylomeDBiQ8QFV0

Family and domain databases

InterProiView protein in InterPro
IPR003929 K_chnl_BK_asu
IPR013099 K_chnl_dom
PfamiView protein in Pfam
PF03493 BK_channel_a, 1 hit
PF07885 Ion_trans_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8QFV0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARAKLKNSP SESNSHVKTV PPATTEDVRG VSPLLPARRM GSLGSDVGQR
60 70 80 90 100
PHAEDFSMDS SFSQVQVEFY VNENTFKERL KLFFIKNQRS SLRIRLFNFS
110 120 130 140 150
LKLLTCLLYI VRVLLDNPEE GIGCWECEKQ NYTLFNQSTK INWSHIFWVD
160 170 180 190 200
RKLPLWAVQV SIALISFLET MLLIYLSYKG NIWEQIFRIS FILEMINTVP
210 220 230 240 250
FIITIFWPPL RNLFIPVFLN CWLAKYALEN MINDLHRAIQ RTQSAMFNQV
260 270 280 290 300
LILICTLLCL VFTGTCGIQH LERAGEKLSL FKSFYFCIVT FSTVGYGDVT
310 320 330 340 350
PKIWPSQLLV VIMICVALVV LPLQFEELVY LWMERQKSGG NYSRHRAQTE
360 370 380 390 400
KHVVLCVSSL KIDLLMDFLN EFYAHPRLQD YYVVILCPTE MDIQVRRVLQ
410 420 430 440 450
IPLWSQRVIY LQGSALKDQD LMRAKMDNGE ACFILSSRNE VDRTAADHQT
460 470 480 490 500
ILRAWAVKDF APNCPLYVQI LKPENKFHVK FADHVVCEEE CKYAMLALNC
510 520 530 540 550
VCPATSTLIT LLVHTSRGQE GQESPEQWQR MYGRCSGNEV YHIRMGDSKF
560 570 580 590 600
FMEYEGKSFT YAAFHAHKKY GVCLIGIRRE ENKSILLNPG PRHIMAASDT
610 620 630 640 650
CFYINITKEE NSAFIFKQAE KQKKKGFAGR GTYDGPSRLP VHSIIASMGT
660 670 680 690 700
VAMDLQNTEC RPTNSSKLAL PAENGSGNRR PSIAPVLELA DTSSLLPCDL
710 720 730 740 750
LSDQSEDEMT QSDEEGSAVV EYVKGYPPNS PYIGSSPTLC HLLPEKAPFC
760 770 780 790 800
CLRLDKGCKH NSFEDAKAYG FKNKLIIVSA ETAGNGLYNF IVPLRAYYRS
810 820 830 840 850
RKELNPIVLL LDNKPEHHFL EAICCFPMVY YMEGTIDNLD SLLQCGIIYA
860 870 880 890 900
DNLVVVDKES TMSAEEDYMA DAKTIVNVQT MFRLFPSLSI ITELTHPSNM
910 920 930 940 950
RFMQFRAKDS YSLALSKLEK KERENGSNLA FMFRLPFAAG RVFSISMLDT
960 970 980 990 1000
LLYQSFVKDY MITITRLLLG LDTTPGSGYL CAMKITEDDL WIRTYGRLFQ
1010 1020 1030 1040 1050
KLCSSSAEIP IGIYRTESHM FATSEPHDIR AQSQISINVE DCEDTKDVKE
1060 1070 1080 1090 1100
HWGIKTGHHR NSCSSDQSEH PLLRRKSMQW ARRLSRKGNK HSGKTAEWIS
1110 1120 1130 1140 1150
QQRLSLYRRS ERQELSELVK NRMKHLGLPT TGYDEMNDHQ NTLSYVLINP
1160 1170 1180 1190 1200
PPDTRLELND IVYLIRSDPL AHVANDGHSR KSSCSNKLGP CNPETRDETQ

L
Length:1,201
Mass (Da):137,242
Last modified:June 1, 2002 - v1
Checksum:i18E18FE0CFF26E20
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E1BW18E1BW18_CHICK
Potassium channel subfamily T membe...
KCNT1
1,201Annotation score:
A0A1D5PQY5A0A1D5PQY5_CHICK
Potassium channel subfamily T membe...
KCNT1
570Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY093434 mRNA Translation: AAM18770.1
RefSeqiNP_989893.1, NM_204562.2
UniGeneiGga.37445
Gga.3757

Genome annotation databases

EnsembliENSGALT00000038919; ENSGALP00000038129; ENSGALG00000001645
GeneIDi395248
KEGGigga:395248

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY093434 mRNA Translation: AAM18770.1
RefSeqiNP_989893.1, NM_204562.2
UniGeneiGga.37445
Gga.3757

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5A6Eelectron microscopy4.50B244-337[»]
C351-1019[»]
C1141-1171[»]
5A6Felectron microscopy4.20C351-1019[»]
C1141-1171[»]
5A6Gelectron microscopy4.50B244-337[»]
5U70electron microscopy3.70A1-1201[»]
5U76electron microscopy4.20A1-1201[»]
ProteinModelPortaliQ8QFV0
SMRiQ8QFV0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-61789N

Proteomic databases

PaxDbiQ8QFV0
PRIDEiQ8QFV0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000038919; ENSGALP00000038129; ENSGALG00000001645
GeneIDi395248
KEGGigga:395248

Organism-specific databases

CTDi57582

Phylogenomic databases

eggNOGiKOG3193 Eukaryota
ENOG410XSMA LUCA
GeneTreeiENSGT00530000063026
HOGENOMiHOG000231460
HOVERGENiHBG055190
InParanoidiQ8QFV0
KOiK04946
OrthoDBiEOG091G011O
PhylomeDBiQ8QFV0

Miscellaneous databases

PROiPR:Q8QFV0

Gene expression databases

BgeeiENSGALG00000001645 Expressed in 4 organ(s), highest expression level in brain
ExpressionAtlasiQ8QFV0 baseline

Family and domain databases

InterProiView protein in InterPro
IPR003929 K_chnl_BK_asu
IPR013099 K_chnl_dom
PfamiView protein in Pfam
PF03493 BK_channel_a, 1 hit
PF07885 Ion_trans_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKCNT1_CHICK
AccessioniPrimary (citable) accession number: Q8QFV0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: June 1, 2002
Last modified: November 7, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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