Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

LIM domain kinase 1

Gene

LIMK1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Protein kinase which regulates actin filament dynamics. Phosphorylates and inactivates the actin binding/depolymerizing factor cofilin, thereby stabilizing the actin cytoskeleton. Required for motility of the axon growth cone.1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei375ATPPROSITE-ProRule annotation1
Active sitei467Curated1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi352 – 360ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

ReactomeiR-GGA-2029482 Regulation of actin dynamics for phagocytic cup formation
R-GGA-399954 Sema3A PAK dependent Axon repulsion
R-GGA-5627123 RHO GTPases activate PAKs

Names & Taxonomyi

Protein namesi
Recommended name:
LIM domain kinase 1 (EC:2.7.11.1)
Short name:
LIMK-1
Short name:
chLIMK1
Gene namesi
Name:LIMK1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 19

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi467D → A: Abrogates kinase activity. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000758061 – 662LIM domain kinase 1Add BLAST662

Proteomic databases

PaxDbiQ8QFP8
PRIDEiQ8QFP8

Expressioni

Tissue specificityi

Expressed predominantly in the brain.1 Publication

Gene expression databases

BgeeiENSGALG00000001076 Expressed in 10 organ(s), highest expression level in liver

Interactioni

Subunit structurei

Self-associates.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000001609

Structurei

3D structure databases

ProteinModelPortaliQ8QFP8
SMRiQ8QFP8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 83LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST60
Domaini84 – 145LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST62
Domaini166 – 259PDZPROSITE-ProRule annotationAdd BLAST94
Domaini346 – 611Protein kinasePROSITE-ProRule annotationAdd BLAST266

Sequence similaritiesi

Keywords - Domaini

LIM domain, Repeat

Phylogenomic databases

eggNOGiENOG410IEZ9 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00530000063025
HOGENOMiHOG000013121
HOVERGENiHBG052328
InParanoidiQ8QFP8
KOiK05743
OMAiCFRCCEC
OrthoDBiEOG091G03ZL
PhylomeDBiQ8QFP8

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR001478 PDZ
IPR036034 PDZ_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR001781 Znf_LIM
PfamiView protein in Pfam
PF00412 LIM, 2 hits
PF00595 PDZ, 1 hit
PF07714 Pkinase_Tyr, 1 hit
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00132 LIM, 2 hits
SM00228 PDZ, 1 hit
SUPFAMiSSF50156 SSF50156, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 2 hits
PS50023 LIM_DOMAIN_2, 2 hits
PS50106 PDZ, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

Q8QFP8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRLMLLCCTW RDEPMGEEEG TDLPVCASCG QGIFDGQYLQ ALNADWHADC
60 70 80 90 100
FRCGECGASL SHQYYEKDGR LYCKKDYWAR FGELCHGCAE QITKGLVMVA
110 120 130 140 150
GEQKYHPECF SCLNCRAFIG DGDTYALVER SKLYCGHCYY QMVVTPVIEQ
160 170 180 190 200
ILPDSPGSRI PHTVTLVSIP ACSDGKRGFS VSIDPHCGAQ GCGAEHSRTV
210 220 230 240 250
RVREVDPDCI SPDVKNSIHV GDRILEINGT PIGHVPLDEI DLLIQETSRL
260 270 280 290 300
LQLTIEHDPH EPLPRDLALP CSPLPDPHSP LRSPVPAPHG DLGTMRQRAV
310 320 330 340 350
MRSCSTDKSP GSSSVGSPAS QRKDIGRSES LRVVSRAHRI FRPSDLIHGE
360 370 380 390 400
VLGKGCFGQA IKVTHRETGE VMVMKELIRF DEETQRTFLK EVKVMRCLEH
410 420 430 440 450
PNVLKFIGVL YKEKRLNFIT EYIKGGTLRG LIKSMDSHYP WSQRVSFAKD
460 470 480 490 500
IAAGMAYLHS MNIIHRDLNS HNCLVRENKS VVVADFGLAR LMVDEKNQPE
510 520 530 540 550
HLQNLKKPDR KKRYTVVGNP YWMAPEMING RSYDEKVDIF SFGIVLCEII
560 570 580 590 600
GRVSADPDYL PRTTDFGLNV RGFLERYCPP ACPPSFFPIA ACCCDLDPEK
610 620 630 640 650
RPSFSKLEQW LETLRMHLDI RLPLSSQLEQ LTCAFWETHR RGEGGLPPHP
660
ELPDTAPHLH PL
Length:662
Mass (Da):74,445
Last modified:June 1, 2002 - v1
Checksum:iDD9FED2466C8E623
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1D5P4X1A0A1D5P4X1_CHICK
LIM domain kinase 1
LIMK1
660Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB073752 mRNA Translation: BAB88398.1
RefSeqiNP_989462.1, NM_204131.1
UniGeneiGga.3

Genome annotation databases

EnsembliENSGALT00000040584; ENSGALP00000039786; ENSGALG00000001076
GeneIDi373922
KEGGigga:373922

Similar proteinsi

Entry informationi

Entry nameiLIMK1_CHICK
AccessioniPrimary (citable) accession number: Q8QFP8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: June 1, 2002
Last modified: September 12, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again