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Protein

Probable tRNA pseudouridine synthase D

Gene

truD

Organism
Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.UniRule annotation

Catalytic activityi

tRNA uridine(13) = tRNA pseudouridine(13).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei86NucleophileUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processtRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
Probable tRNA pseudouridine synthase DUniRule annotation (EC:5.4.99.27UniRule annotation)
Alternative name(s):
tRNA pseudouridine(13) synthaseUniRule annotation
tRNA pseudouridylate synthase DUniRule annotation
tRNA-uridine isomerase DUniRule annotation
Gene namesi
Name:truDUniRule annotation
Ordered Locus Names:MM_0114
OrganismiMethanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia)
Taxonomic identifieri192952 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaStenosarchaea groupMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina
Proteomesi
  • UP000000595 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001525431 – 438Probable tRNA pseudouridine synthase DAdd BLAST438

Interactioni

Protein-protein interaction databases

STRINGi192952.MM_0114

Structurei

Secondary structure

1438
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ8Q0M2
SMRiQ8Q0M2
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8Q0M2

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini165 – 390TRUDUniRule annotationAdd BLAST226

Sequence similaritiesi

Belongs to the pseudouridine synthase TruD family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04252 Archaea
COG0585 LUCA
HOGENOMiHOG000224849
KOiK06176
OMAiLRYERAM
OrthoDBiPOG093Z087N

Family and domain databases

HAMAPiMF_01082 TruD, 1 hit
InterProiView protein in InterPro
IPR020103 PsdUridine_synth_cat_dom_sf
IPR001656 PsdUridine_synth_TruD
IPR020119 PsdUridine_synth_TruD_CS
IPR011760 PsdUridine_synth_TruD_insert
PANTHERiPTHR13326 PTHR13326, 1 hit
PfamiView protein in Pfam
PF01142 TruD, 1 hit
PIRSFiPIRSF037016 Pseudouridin_synth_euk_prd, 1 hit
SUPFAMiSSF55120 SSF55120, 1 hit
TIGRFAMsiTIGR00094 tRNA_TruD_broad, 1 hit
PROSITEiView protein in PROSITE
PS50984 TRUD, 1 hit
PS01268 UPF0024, 1 hit

Sequencei

Sequence statusi: Complete.

Q8Q0M2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEVPEIEKQI GINLYSTDTT GLGGQLRQEI EDFIVKEITN REEGEEGKYL
60 70 80 90 100
IVELTKRDWD THHLTRTLSR ILQVSQKRIS VAGTKDKRAL TTQKISIFDT
110 120 130 140 150
DASEIEKIHL KDIELKVLGR SRKSVELGDL WGNDFRITVR NIENSPEETE
160 170 180 190 200
ALLKKTTDEI LAQGGVPNFF GIQRFGSVRP VTHLVGKAIV EGNFEKAALL
210 220 230 240 250
YIAEPFPEEP EETKNARQFV KDTLDFKEGL KTYPLRLGHE RAMMNHLIAN
260 270 280 290 300
PEDYSGSFRV LPQNLYRMFV HGYQSYIYNI ILCRRIEAGI PLNRAVEGDI
310 320 330 340 350
VCFRNEVGLP DSSKTEKVTS ETVNAMNRLL KLGRAFITAP LPGYNTEFAS
360 370 380 390 400
GIPGEIENGV LKELGVSLEG FNIEKFPEMS SKGTRREVLL EVKPKFEAGE
410 420 430
DELNPGKSKA VLEFMLPKGS YATTVLREYM KVNPLQMS
Length:438
Mass (Da):49,499
Last modified:October 1, 2002 - v1
Checksum:iD8404CC1672C0016
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008384 Genomic DNA Translation: AAM29810.1
RefSeqiWP_011032068.1, NC_003901.1

Genome annotation databases

EnsemblBacteriaiAAM29810; AAM29810; MM_0114
GeneIDi24838872
KEGGimma:MM_0114
PATRICifig|192952.21.peg.127

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008384 Genomic DNA Translation: AAM29810.1
RefSeqiWP_011032068.1, NC_003901.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Z2ZX-ray2.60A/B1-438[»]
ProteinModelPortaliQ8Q0M2
SMRiQ8Q0M2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi192952.MM_0114

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAM29810; AAM29810; MM_0114
GeneIDi24838872
KEGGimma:MM_0114
PATRICifig|192952.21.peg.127

Phylogenomic databases

eggNOGiarCOG04252 Archaea
COG0585 LUCA
HOGENOMiHOG000224849
KOiK06176
OMAiLRYERAM
OrthoDBiPOG093Z087N

Miscellaneous databases

EvolutionaryTraceiQ8Q0M2

Family and domain databases

HAMAPiMF_01082 TruD, 1 hit
InterProiView protein in InterPro
IPR020103 PsdUridine_synth_cat_dom_sf
IPR001656 PsdUridine_synth_TruD
IPR020119 PsdUridine_synth_TruD_CS
IPR011760 PsdUridine_synth_TruD_insert
PANTHERiPTHR13326 PTHR13326, 1 hit
PfamiView protein in Pfam
PF01142 TruD, 1 hit
PIRSFiPIRSF037016 Pseudouridin_synth_euk_prd, 1 hit
SUPFAMiSSF55120 SSF55120, 1 hit
TIGRFAMsiTIGR00094 tRNA_TruD_broad, 1 hit
PROSITEiView protein in PROSITE
PS50984 TRUD, 1 hit
PS01268 UPF0024, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTRUD_METMA
AccessioniPrimary (citable) accession number: Q8Q0M2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: October 1, 2002
Last modified: November 7, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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