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Protein

DNA polymerase sliding clamp

Gene

pcn

Organism
Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processDNA replication

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase sliding clampUniRule annotation
Alternative name(s):
Proliferating cell nuclear antigen homologUniRule annotation
Short name:
PCNAUniRule annotation
Gene namesi
Name:pcnUniRule annotation
Ordered Locus Names:MM_1397
OrganismiMethanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia)
Taxonomic identifieri192952 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina
Proteomesi
  • UP000000595 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001491981 – 245DNA polymerase sliding clampAdd BLAST245

Interactioni

Subunit structurei

Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.UniRule annotation

Protein-protein interaction databases

STRINGi192952.MM_1397

Structurei

3D structure databases

ProteinModelPortaliQ8PX25
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PCNA family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00488 Archaea
COG0592 LUCA
HOGENOMiHOG000222371
KOiK04802
OMAiSDGFDKY
OrthoDBiPOG093Z0814

Family and domain databases

HAMAPiMF_00317 DNApol_clamp_arch, 1 hit
InterProiView protein in InterPro
IPR000730 Pr_cel_nuc_antig
IPR022649 Pr_cel_nuc_antig_C
IPR022659 Pr_cel_nuc_antig_CS
IPR022648 Pr_cel_nuc_antig_N
PANTHERiPTHR11352:SF0 PTHR11352:SF0, 1 hit
PfamiView protein in Pfam
PF02747 PCNA_C, 1 hit
PF00705 PCNA_N, 1 hit
PRINTSiPR00339 PCNACYCLIN
PROSITEiView protein in PROSITE
PS01251 PCNA_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q8PX25-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFKAAINAEL LKDAIASLAV IVDEVRFKIK PEGISVKAVD PANVAMGIFE
60 70 80 90 100
LGSSAFEEYS ADECEIGIDL NKITDLLGIA DRNDTVRMEL DEGSNKLLID
110 120 130 140 150
VGGLSYTLSL LDPSTIRAEP RVPQLELPAK VVLNGADLRR AVKAAEKISD
160 170 180 190 200
HMLMGVSGDT FYMEAKGDTD QVRLEMGRDQ LIDLKAGEAC SLFSLDYLTD
210 220 230 240
IVKPTNKVNE VTLSLGRDFP ILIDFEIANG AGRISYLLAP RIESD
Length:245
Mass (Da):26,650
Last modified:October 10, 2002 - v1
Checksum:i4BC2DE1551F115AA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008384 Genomic DNA Translation: AAM31093.1
RefSeqiWP_011033343.1, NC_003901.1

Genome annotation databases

EnsemblBacteriaiAAM31093; AAM31093; MM_1397
GeneIDi24883315
KEGGimma:MM_1397
PATRICifig|192952.21.peg.1619

Similar proteinsi

Entry informationi

Entry nameiPCNA_METMA
AccessioniPrimary (citable) accession number: Q8PX25
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: October 10, 2002
Last modified: July 18, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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