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Protein

DNA ligase 1

Gene

lig1

Organism
Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei244ATPUniRule annotation1
Active sitei246N6-AMP-lysine intermediateUniRule annotation1
Binding sitei251ATPUniRule annotation1
Binding sitei266ATPUniRule annotation1
Binding sitei296ATPUniRule annotation1
Binding sitei342ATPUniRule annotation1
Binding sitei419ATPUniRule annotation1
Binding sitei425ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processCell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMMAZ192952:G1FZI-1977-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligase 1UniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP] 1UniRule annotation
Gene namesi
Name:lig1UniRule annotation
Ordered Locus Names:MM_1895
OrganismiMethanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia)
Taxonomic identifieri192952 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina
Proteomesi
  • UP000000595 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003652591 – 579DNA ligase 1Add BLAST579

Interactioni

Protein-protein interaction databases

STRINGi192952.MM_1895

Structurei

3D structure databases

ProteinModelPortaliQ8PVR7
SMRiQ8PVR7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01347 Archaea
COG1793 LUCA
HOGENOMiHOG000036008
KOiK10747
OMAiWIKYKRD
OrthoDBiPOG093Z03L0

Family and domain databases

Gene3Di1.10.3260.10, 1 hit
HAMAPiMF_00407 DNA_ligase, 1 hit
InterProiView protein in InterPro
IPR022865 DNA_ligae_ATP-dep_bac/arc
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR016059 DNA_ligase_ATP-dep_CS
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR012340 NA-bd_OB-fold
PfamiView protein in Pfam
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit
SUPFAMiSSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00574 dnl1, 1 hit
PROSITEiView protein in PROSITE
PS00697 DNA_LIGASE_A1, 1 hit
PS50160 DNA_LIGASE_A3, 1 hit

Sequencei

Sequence statusi: Complete.

Q8PVR7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRFKELAELF EELEKTTSHR EIVRKISEFF KNLRGDEVKD SAYLFLGSTG
60 70 80 90 100
PAFENTTLGI KDMLAIRAIA GAYGVTREDV RKRYARTGDL GDVAFELSKK
110 120 130 140 150
RESSLTIEDV FQRLLQIRET SGKGSQEEKT ALFSDILQKA TPEEGKYIVR
160 170 180 190 200
LVLGRLRLGF GDQFLLEAFA IAFTGDKKHA AKIKESYSVC TDIGELAKIL
210 220 230 240 250
AENGARATGF ISIKPGRPVK SMLSQRVESF EELEKRVKGK KAAEEKYDGE
260 270 280 290 300
RVQVHKTGEG IKAFSRRLED ITSQYPEIIE DVRKTVPANE IVLDGEIVAY
310 320 330 340 350
AELERNGNRI EEFYPFQNLM QRRRKYEIEN YRKKCPVAVF FFDILYLNGE
360 370 380 390 400
PLLKRPYPER RALLEMNVVE SGIIRLSKRI VTESVEEIED FFNETIEKGL
410 420 430 440 450
EGIVVKSMSS NSYYEAGKRS WFWFKWKQEY SEGMRETFDL VVVGSYYGRG
460 470 480 490 500
RRKGSFGALL CAVLNKEGQR FETLTKVGTG FTEADAEEIN RLLSDHIVSE
510 520 530 540 550
IPKGVSIKKG MLPDIFIEPA VVIEVLGSEI TNSPGHTAGE GEEETGLALR
560 570
FPRFLRIRHD KTPYDAMTVK EVRDLKDGT
Length:579
Mass (Da):65,867
Last modified:October 1, 2002 - v1
Checksum:i9E11E66075B8DEEC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008384 Genomic DNA Translation: AAM31591.1
RefSeqiWP_011033828.1, NC_003901.1

Genome annotation databases

EnsemblBacteriaiAAM31591; AAM31591; MM_1895
GeneIDi24878633
KEGGimma:MM_1895
PATRICifig|192952.21.peg.2183

Similar proteinsi

Entry informationi

Entry nameiDNLI1_METMA
AccessioniPrimary (citable) accession number: Q8PVR7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: October 1, 2002
Last modified: September 12, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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