We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - Q8PUA8 (MTSA_METMA)
Protein
Methylated-thiol--coenzyme M methyltransferase
Gene
mtsA
Organism
Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia)
Status
Functioni
Methyltransferase involved in methanogenesis from methylated-thiols. Catalyzes two successive steps: mediates the transfer of a methyl group from the substrate to the cobalt cofactor of a methylated-thiol-specific corrinoid protein (MtsB), and the subsequent transfer of the methyl group from the corrinoid protein to coenzyme M (By similarity).
By similarityCatalytic activityi
- EC:2.1.1.251
Cofactori
Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 236 | ZincBy similarity | 1 | |
Metal bindingi | 238 | ZincBy similarity | 1 | |
Metal bindingi | 313 | ZincSequence analysis | 1 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- methylthiol:coenzyme M methyltransferase activity Source: UniProtKB-EC
- uroporphyrinogen decarboxylase activity Source: InterPro
GO - Biological processi
- methanogenesis Source: UniProtKB-KW
- methylation Source: UniProtKB-KW
- one-carbon metabolic process Source: InterPro
- porphyrin-containing compound biosynthetic process Source: InterPro
Keywordsi
Molecular function | Methyltransferase, Transferase |
Biological process | Methanogenesis |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Methylated-thiol--coenzyme M methyltransferase (EC:2.1.1.251)Alternative name(s): Methylthiol:coenzyme M methyltransferase 40 kDa subunit |
Gene namesi | Name:mtsA Ordered Locus Names:MM_2427 |
Organismi | Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia) |
Taxonomic identifieri | 192952 [NCBI] |
Taxonomic lineagei | Archaea › Euryarchaeota › Stenosarchaea group › Methanomicrobia › Methanosarcinales › Methanosarcinaceae › Methanosarcina › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000419107 | 1 – 367 | Methylated-thiol--coenzyme M methyltransferaseAdd BLAST | 367 |
Interactioni
Subunit structurei
Homodimer.
By similarityProtein-protein interaction databases
STRINGi | 192952.MM_2427 |
Family & Domainsi
Sequence similaritiesi
Belongs to the uroporphyrinogen decarboxylase family.Curated
Phylogenomic databases
eggNOGi | arCOG03325, Archaea |
HOGENOMi | CLU_040933_2_1_2 |
OMAi | RECILQG |
Family and domain databases
CDDi | cd03307, Mta_CmuA_like, 1 hit |
Gene3Di | 3.20.20.210, 1 hit |
InterProi | View protein in InterPro IPR006360, Mtase_MtaA_CmuA IPR038071, UROD/MetE-like_sf IPR000257, Uroporphyrinogen_deCOase |
Pfami | View protein in Pfam PF01208, URO-D, 1 hit |
SUPFAMi | SSF51726, SSF51726, 1 hit |
TIGRFAMsi | TIGR01463, mtaA_cmuA, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8PUA8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVSEMTPTRR ALAAVLGGRV DYVPPANPLA QTTTELMAIC NASWPKAHFD
60 70 80 90 100
SKMMADLAAA SYEVCGIEAA RPQFDISLEA EVLGCKLDWD KPDRPPVTGP
110 120 130 140 150
AYTNPEDVTW PDKLEETGRI PVVLGAIDEL RKRYDGMLPI IPLLTAPFTV
160 170 180 190 200
AGHIAGVENM ARWTKTDPEK AHAFIDAATD FVVAYGKLQA AYGAHILFLA
210 220 230 240 250
DPSASSSLIS AETYREFVLP AHRRLAKEIS CPQILHICGD SSKLLPYIKQ
260 270 280 290 300
SGIDCFSFDT VPVWYCRQVI GNDMSILGSL DVIDLMPNGT PEQVYNRTRE
310 320 330 340 350
CILQGTDIVG TACGVSYGTP LENLRAYVRA CKETPIPRYD DVEDLIRQIG
360
VGIGRNMKEN VLGGMQE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE008384 Genomic DNA Translation: AAM32123.1 |
RefSeqi | WP_011034351.1, NC_003901.1 |
Genome annotation databases
EnsemblBacteriai | AAM32123; AAM32123; MM_2427 |
GeneIDi | 44087800 66136066 |
KEGGi | mma:MM_2427 |
PATRICi | fig|192952.21.peg.2778 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE008384 Genomic DNA Translation: AAM32123.1 |
RefSeqi | WP_011034351.1, NC_003901.1 |
3D structure databases
SMRi | Q8PUA8 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 192952.MM_2427 |
Genome annotation databases
EnsemblBacteriai | AAM32123; AAM32123; MM_2427 |
GeneIDi | 44087800 66136066 |
KEGGi | mma:MM_2427 |
PATRICi | fig|192952.21.peg.2778 |
Phylogenomic databases
eggNOGi | arCOG03325, Archaea |
HOGENOMi | CLU_040933_2_1_2 |
OMAi | RECILQG |
Family and domain databases
CDDi | cd03307, Mta_CmuA_like, 1 hit |
Gene3Di | 3.20.20.210, 1 hit |
InterProi | View protein in InterPro IPR006360, Mtase_MtaA_CmuA IPR038071, UROD/MetE-like_sf IPR000257, Uroporphyrinogen_deCOase |
Pfami | View protein in Pfam PF01208, URO-D, 1 hit |
SUPFAMi | SSF51726, SSF51726, 1 hit |
TIGRFAMsi | TIGR01463, mtaA_cmuA, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MTSA_METMA | |
Accessioni | Q8PUA8Primary (citable) accession number: Q8PUA8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 5, 2012 |
Last sequence update: | October 1, 2002 | |
Last modified: | February 23, 2022 | |
This is version 104 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families