UniProtKB - Q8PM31 (3HAO_XANAC)
Protein
3-hydroxyanthranilate 3,4-dioxygenase
Gene
nbaC
Organism
Xanthomonas axonopodis pv. citri (strain 306)
Status
Functioni
Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.UniRule annotation
Catalytic activityi
- EC:1.13.11.6UniRule annotation
Cofactori
Fe2+UniRule annotationNote: Binds 2 Fe2+ ions per subunit.UniRule annotation
: NAD(+) biosynthesis Pathwayi
This protein is involved in step 3 of the subpathway that synthesizes quinolinate from L-kynurenine.UniRule annotationProteins known to be involved in the 3 steps of the subpathway in this organism are:
- Kynurenine 3-monooxygenase (kmo)
- Kynureninase (kynU)
- 3-hydroxyanthranilate 3,4-dioxygenase (nbaC)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes quinolinate from L-kynurenine, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 44 | DioxygenUniRule annotation | 1 | |
Metal bindingi | 48 | Iron 1; catalyticUniRule annotation | 1 | |
Metal bindingi | 54 | Iron 1; catalyticUniRule annotation | 1 | |
Binding sitei | 54 | SubstrateUniRule annotation | 1 | |
Metal bindingi | 92 | Iron 1; catalyticUniRule annotation | 1 | |
Binding sitei | 96 | SubstrateUniRule annotation | 1 | |
Binding sitei | 106 | SubstrateUniRule annotation | 1 | |
Metal bindingi | 121 | Iron 2UniRule annotation | 1 | |
Metal bindingi | 124 | Iron 2UniRule annotation | 1 | |
Metal bindingi | 158 | Iron 2UniRule annotation | 1 | |
Metal bindingi | 161 | Iron 2UniRule annotation | 1 |
GO - Molecular functioni
- 3-hydroxyanthranilate 3,4-dioxygenase activity Source: UniProtKB-UniRule
- ferrous iron binding Source: UniProtKB-UniRule
GO - Biological processi
- 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-UniRule
- anthranilate metabolic process Source: UniProtKB-UniRule
- quinolinate biosynthetic process Source: UniProtKB-UniRule
- tryptophan catabolic process Source: UniProtKB-UniRule
Keywordsi
Molecular function | Dioxygenase, Oxidoreductase |
Biological process | Pyridine nucleotide biosynthesis |
Ligand | Iron, Metal-binding |
Enzyme and pathway databases
UniPathwayi | UPA00253;UER00330 |
Names & Taxonomyi
Protein namesi | Recommended name: 3-hydroxyanthranilate 3,4-dioxygenaseUniRule annotation (EC:1.13.11.6UniRule annotation)Alternative name(s): 3-hydroxyanthranilate oxygenaseUniRule annotation Short name: 3-HAOUniRule annotation 3-hydroxyanthranilic acid dioxygenaseUniRule annotation Short name: HADUniRule annotation |
Gene namesi | Name:nbaCUniRule annotation Ordered Locus Names:XAC1603 |
Organismi | Xanthomonas axonopodis pv. citri (strain 306) |
Taxonomic identifieri | 190486 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Xanthomonadales › Xanthomonadaceae › Xanthomonas › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000245479 | 1 – 176 | 3-hydroxyanthranilate 3,4-dioxygenaseAdd BLAST | 176 |
Interactioni
Subunit structurei
Homodimer.
UniRule annotationProtein-protein interaction databases
STRINGi | 190486.XAC1603 |
Family & Domainsi
Sequence similaritiesi
Belongs to the 3-HAO family.UniRule annotation
Phylogenomic databases
eggNOGi | COG0662, Bacteria |
HOGENOMi | CLU_095765_0_0_6 |
OMAi | NARKDYH |
Family and domain databases
Gene3Di | 2.60.120.10, 1 hit |
HAMAPi | MF_00825, 3_HAO, 1 hit |
InterProi | View protein in InterPro IPR010329, 3hydroanth_dOase IPR014710, RmlC-like_jellyroll IPR011051, RmlC_Cupin_sf |
PANTHERi | PTHR15497, PTHR15497, 1 hit |
Pfami | View protein in Pfam PF06052, 3-HAO, 1 hit |
SUPFAMi | SSF51182, SSF51182, 1 hit |
TIGRFAMsi | TIGR03037, anthran_nbaC, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8PM31-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLTPPINLHA WIEEHRHLLK PPVGNKCIQQ DGFIIMVVGG PNARTDYHYD
60 70 80 90 100
EGPEWFFQLE GEMVLKVQDE GVARDIPIRA GEVFLLPPKV PHSPQRADGS
110 120 130 140 150
IGLVIERERL PTEQDGLQWY CPQCNHKLYE AMFPLKNIET DFPPVFDRFY
160 170
RSPALRTCSQ CGHLHPAPER YATVEG
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE008923 Genomic DNA Translation: AAM36471.1 |
RefSeqi | WP_003485910.1, NC_003919.1 |
Genome annotation databases
EnsemblBacteriai | AAM36471; AAM36471; XAC1603 |
KEGGi | xac:XAC1603 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE008923 Genomic DNA Translation: AAM36471.1 |
RefSeqi | WP_003485910.1, NC_003919.1 |
3D structure databases
SMRi | Q8PM31 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 190486.XAC1603 |
Genome annotation databases
EnsemblBacteriai | AAM36471; AAM36471; XAC1603 |
KEGGi | xac:XAC1603 |
Phylogenomic databases
eggNOGi | COG0662, Bacteria |
HOGENOMi | CLU_095765_0_0_6 |
OMAi | NARKDYH |
Enzyme and pathway databases
UniPathwayi | UPA00253;UER00330 |
Family and domain databases
Gene3Di | 2.60.120.10, 1 hit |
HAMAPi | MF_00825, 3_HAO, 1 hit |
InterProi | View protein in InterPro IPR010329, 3hydroanth_dOase IPR014710, RmlC-like_jellyroll IPR011051, RmlC_Cupin_sf |
PANTHERi | PTHR15497, PTHR15497, 1 hit |
Pfami | View protein in Pfam PF06052, 3-HAO, 1 hit |
SUPFAMi | SSF51182, SSF51182, 1 hit |
TIGRFAMsi | TIGR03037, anthran_nbaC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | 3HAO_XANAC | |
Accessioni | Q8PM31Primary (citable) accession number: Q8PM31 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 11, 2006 |
Last sequence update: | October 1, 2002 | |
Last modified: | February 10, 2021 | |
This is version 104 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Documents
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families