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Protein

Anthranilate synthase component 1

Gene

trpE

Organism
Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.UniRule annotation

Catalytic activityi

Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-tryptophan from chorismate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Anthranilate synthase component 1 (trpE)
  2. Anthranilate phosphoribosyltransferase (trpD)
  3. N-(5'-phosphoribosyl)anthranilate isomerase (trpF)
  4. Indole-3-glycerol phosphate synthase (trpC)
  5. Tryptophan synthase beta chain (trpB), Tryptophan synthase alpha chain (trpA)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotation
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesisUniRule annotation
LigandMagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciXCAM190485:XCC0459-MONOMER
UniPathwayi
UPA00035;UER00040

Names & Taxonomyi

Protein namesi
Recommended name:
Anthranilate synthase component 1UniRule annotation (EC:4.1.3.27UniRule annotation)
Gene namesi
Name:trpEUniRule annotationImported
Ordered Locus Names:XCC0459Imported
OrganismiXanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25)Imported
Taxonomic identifieri190485 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas
Proteomesi
  • UP000001010 Componenti: Chromosome

Interactioni

Subunit structurei

Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).UniRule annotation

Protein-protein interaction databases

STRINGi190485.XCC0459

Structurei

3D structure databases

ProteinModelPortaliQ8PD81
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 170Anth_synt_I_NInterPro annotationAdd BLAST144
Domaini223 – 476Chorismate_bindInterPro annotationAdd BLAST254

Sequence similaritiesi

Belongs to the anthranilate synthase component I family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CRQ Bacteria
COG0147 LUCA
HOGENOMiHOG000025142
KOiK01657
OMAiIAGTFKR

Family and domain databases

Gene3Di3.60.120.10, 1 hit
InterProiView protein in InterPro
IPR005801 ADC_synthase
IPR019999 Anth_synth_I-like
IPR006805 Anth_synth_I_N
IPR005256 Anth_synth_I_PabB
IPR015890 Chorismate_C
PfamiView protein in Pfam
PF04715 Anth_synt_I_N, 1 hit
PF00425 Chorismate_bind, 1 hit
PRINTSiPR00095 ANTSNTHASEI
SUPFAMiSSF56322 SSF56322, 1 hit
TIGRFAMsiTIGR00564 trpE_most, 1 hit

Sequencei

Sequence statusi: Complete.

Q8PD81-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MITAEQFQRQ AAEGHTRIPV VREVLSDLDT PLSVYLKLAD GAYTYLFESV
60 70 80 90 100
EGGERFGRYS IIGLPARRVY SFRGHTLEVS EHGEVLETRE VADPLAEVDA
110 120 130 140 150
LRAEHSVPQL DGLPGFTGGL VGWFGFECIQ YIEPRLGSGE KPDELGTPDI
160 170 180 190 200
LLMLSEELAV FDNLKGRLYL IVHADPRQPQ AYVRANRRLD ELAHRLRQGG
210 220 230 240 250
AGYPQAQISD AIDESDFHSS FTREEYHAVV RKAQEYVRAG DIFQVVPSQR
260 270 280 290 300
LRVPFRARPV DVYRALRALN PSPYMYFLDV GGTQVVGSSP EILARLRDGV
310 320 330 340 350
VTVRPIAGTR PRGATPELDK ALEEELLADP KERAEHVMLI DLGRNDVGRV
360 370 380 390 400
AEPGTVKVGE QFVIERYSHV MHIVSEVTGT LKAGLNYSDV LRATFPAGTV
410 420 430 440 450
SGAPKIRALE IIRELEPVKR NVYSGAVGYI GWHGDADTAI AIRTAVIQDG
460 470 480 490
YLYVQAGGGV VYDSDPDLEW QETMNKGRAL FRAVAQAAKG L
Length:491
Mass (Da):54,276
Last modified:October 1, 2002 - v1
Checksum:iC8D5ECBAD56D9C4A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008922 Genomic DNA Translation: AAM39777.1
RefSeqiNP_635853.1, NC_003902.1
WP_011035712.1, NC_003902.1

Genome annotation databases

EnsemblBacteriaiAAM39777; AAM39777; XCC0459
GeneIDi1000933
35543883
KEGGixcc:XCC0459
PATRICifig|190485.4.peg.506

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008922 Genomic DNA Translation: AAM39777.1
RefSeqiNP_635853.1, NC_003902.1
WP_011035712.1, NC_003902.1

3D structure databases

ProteinModelPortaliQ8PD81
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi190485.XCC0459

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAM39777; AAM39777; XCC0459
GeneIDi1000933
35543883
KEGGixcc:XCC0459
PATRICifig|190485.4.peg.506

Phylogenomic databases

eggNOGiENOG4105CRQ Bacteria
COG0147 LUCA
HOGENOMiHOG000025142
KOiK01657
OMAiIAGTFKR

Enzyme and pathway databases

UniPathwayi
UPA00035;UER00040

BioCyciXCAM190485:XCC0459-MONOMER

Family and domain databases

Gene3Di3.60.120.10, 1 hit
InterProiView protein in InterPro
IPR005801 ADC_synthase
IPR019999 Anth_synth_I-like
IPR006805 Anth_synth_I_N
IPR005256 Anth_synth_I_PabB
IPR015890 Chorismate_C
PfamiView protein in Pfam
PF04715 Anth_synt_I_N, 1 hit
PF00425 Chorismate_bind, 1 hit
PRINTSiPR00095 ANTSNTHASEI
SUPFAMiSSF56322 SSF56322, 1 hit
TIGRFAMsiTIGR00564 trpE_most, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ8PD81_XANCP
AccessioniPrimary (citable) accession number: Q8PD81
Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2002
Last sequence update: October 1, 2002
Last modified: November 7, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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