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Protein

Lipid A export ATP-binding/permease protein MsbA

Gene

msbA

Organism
Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi380 – 387ATPUniRule annotation8

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
Biological processLipid transport, Transport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciXCAM190485:XCC2120-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid A export ATP-binding/permease protein MsbAUniRule annotation (EC:3.6.3.-UniRule annotation)
Gene namesi
Name:msbAUniRule annotation
Ordered Locus Names:XCC2120
OrganismiXanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25)
Taxonomic identifieri190485 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas
Proteomesi
  • UP000001010 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei29 – 49HelicalUniRule annotationAdd BLAST21
Transmembranei70 – 90HelicalUniRule annotationAdd BLAST21
Transmembranei157 – 177HelicalUniRule annotationAdd BLAST21
Transmembranei261 – 281HelicalUniRule annotationAdd BLAST21
Transmembranei283 – 303HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000926071 – 589Lipid A export ATP-binding/permease protein MsbAAdd BLAST589

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi190485.XCC2120

Structurei

3D structure databases

ProteinModelPortaliQ8P8W4
SMRiQ8P8W4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 314ABC transmembrane type-1UniRule annotationAdd BLAST284
Domaini346 – 582ABC transporterUniRule annotationAdd BLAST237

Domaini

In MsbA the ATP-binding domain (NBD) and the transmembrane domain (TMD) are fused.

Sequence similaritiesi

Belongs to the ABC transporter superfamily. Lipid exporter (TC 3.A.1.106) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105BZ1 Bacteria
COG1132 LUCA
KOiK11085
OMAiAWGTYLV

Family and domain databases

Gene3Di1.20.1560.10, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR011917 ABC_transpr_lipidA
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00664 ABC_membrane, 1 hit
PF00005 ABC_tran, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF90123 SSF90123, 1 hit
TIGRFAMsiTIGR02203 MsbA_lipidA, 1 hit
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 1 hit
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 1 hit
PS51239 MSBA, 1 hit

Sequencei

Sequence statusi: Complete.

Q8P8W4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTINENAPQ VSSWQTYRRL LAFAKPYRLL LVAALIAALI EAAGTTGFLA
60 70 80 90 100
LMKPITDETF IYKNAEVSRW LPVQIILLFV IRGAAGYITD MAMGKSARSI
110 120 130 140 150
ARDLRVKVMS KYLRLPGSRF DSEPVPSMLI RLGSDSDQVA QAAVDAVKVM
160 170 180 190 200
IQQSLQVIGA LALMLWHSWQ VTLTILVLAP VLAWVMDKVA RRYRRISHSI
210 220 230 240 250
QESGAHLLQA ADQTLSSHQE VKIYGAQQSE MERYSGLADR NLRLAMKVES
260 270 280 290 300
TRGISTATVQ MIGAIGLSAL LFVAGAQALA GRLTAGDFVV LMTSMLTIIP
310 320 330 340 350
GLKQLTNVQN MVQRGLASAE RLFSVLDSPD EPDQGQVPLT RAKGLIEFRD
360 370 380 390 400
VTARYPGQAN PALADVSFVA QPGTVTAIVG RSGSGKSSLI KLIPRFYEAE
410 420 430 440 450
SGQILLDGHP VQAYALADLR RQIALVGQQV MLFDGSIAEN VAYGEMRQCD
460 470 480 490 500
AGQLERAIQG ANAMEFVAQL PEGLQSHVGT KGGRLSGGQR QRLAIARAML
510 520 530 540 550
KDAPILILDE ATAALDNESE RLVQDALHKL MPDRTTLVIA HRLSTIEHAD
560 570 580
QVLVMDQGRI VERGTHQELL ALGGLYSHLH GMQFRERQA
Length:589
Mass (Da):64,255
Last modified:October 1, 2002 - v1
Checksum:i738ED5810107E73B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008922 Genomic DNA Translation: AAM41405.1
RefSeqiNP_637481.1, NC_003902.1
WP_011037271.1, NC_003902.1

Genome annotation databases

EnsemblBacteriaiAAM41405; AAM41405; XCC2120
GeneIDi35547977
999314
KEGGixcc:XCC2120
PATRICifig|190485.4.peg.2270

Similar proteinsi

Entry informationi

Entry nameiMSBA_XANCP
AccessioniPrimary (citable) accession number: Q8P8W4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: October 1, 2002
Last modified: June 20, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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