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Protein

Alanine dehydrogenase 1

Gene

ald1

Organism
Staphylococcus aureus (strain MW2)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

May play a role in cell wall synthesis as L-alanine is an important constituent of the peptidoglycan layer.By similarity

Catalytic activityi

L-alanine + H2O + NAD+ = pyruvate + NH3 + NADH.

Pathwayi: L-alanine degradation via dehydrogenase pathway

This protein is involved in step 1 of the subpathway that synthesizes NH(3) and pyruvate from L-alanine.
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine dehydrogenase 1 (ald1), Alanine dehydrogenase 2 (ald2)
This subpathway is part of the pathway L-alanine degradation via dehydrogenase pathway, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes NH(3) and pyruvate from L-alanine, the pathway L-alanine degradation via dehydrogenase pathway and in Amino-acid degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei94Sequence analysis1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi170 – 200NADBy similarityAdd BLAST31

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

UniPathwayiUPA00527; UER00585.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine dehydrogenase 1 (EC:1.4.1.1)
Gene namesi
Name:ald1
Ordered Locus Names:MW1328
OrganismiStaphylococcus aureus (strain MW2)
Taxonomic identifieri196620 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000418 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001990001 – 372Alanine dehydrogenase 1Add BLAST372

Structurei

3D structure databases

ProteinModelPortaliQ8NWQ3.
SMRiQ8NWQ3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AlaDH/PNT family.Curated

Phylogenomic databases

HOGENOMiHOG000022120.
KOiK00259.
OMAiTCFAMER.

Family and domain databases

CDDicd05305. L-AlaDH. 1 hit.
InterProiView protein in InterPro
IPR008141. Ala_DH.
IPR008143. Ala_DH/PNT_CS2.
IPR008142. AlaDH/PNT_CS1.
IPR007886. AlaDH/PNT_N.
IPR007698. AlaDH/PNT_NAD(H)-bd.
IPR036291. NAD(P)-bd_dom_sf.
PANTHERiPTHR42795. PTHR42795. 1 hit.
PfamiView protein in Pfam
PF01262. AlaDh_PNT_C. 1 hit.
PF05222. AlaDh_PNT_N. 1 hit.
PIRSFiPIRSF000183. Alanine_dh. 1 hit.
SMARTiView protein in SMART
SM01002. AlaDh_PNT_C. 1 hit.
SM01003. AlaDh_PNT_N. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR00518. alaDH. 1 hit.
PROSITEiView protein in PROSITE
PS00836. ALADH_PNT_1. 1 hit.
PS00837. ALADH_PNT_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8NWQ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVAVVKELK QGEGRVACTP ENVRKLTDAG HKVIVEKNAG IGSGFSNDMY
60 70 80 90 100
EKEGAKIVTH EQAWEADLVI KVKEPHESEY QYFKKNQIIW GFLHLASSKE
110 120 130 140 150
IVEKMQEVGV TAISGETIIK NGKAELLAPM SAIAGQRSAI MGAYYSEAQH
160 170 180 190 200
GGQGTLVTGV HENVDIPGST YVIFGGGVAA TNAANVALGL NAKVIIIELN
210 220 230 240 250
DDRIKYLQDM YAEKDVTVVK STPENLAEQI KKADVFISTI LIPGAKPPKL
260 270 280 290 300
VTREMVKSMK KGSVLIDIAI DQGGTIETIR PTTISDPVYE EEGVIHYGVP
310 320 330 340 350
NQPGAVPRTS TMALAQGNID YILEICDKGL EQAIKDNEAL STGVNIYQGQ
360 370
VTNQGLASSH DLDYKEILNV IE
Length:372
Mass (Da):40,234
Last modified:October 1, 2002 - v1
Checksum:i7FF131E5E18D4035
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000033 Genomic DNA. Translation: BAB95193.1.
RefSeqiWP_000959432.1. NC_003923.1.

Genome annotation databases

EnsemblBacteriaiBAB95193; BAB95193; BAB95193.
KEGGisam:MW1328.

Similar proteinsi

Entry informationi

Entry nameiDHA1_STAAW
AccessioniPrimary (citable) accession number: Q8NWQ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: October 1, 2002
Last modified: March 28, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome