UniProtKB - Q8NT39 (MENG_CORGL)
Protein
Demethylmenaquinone methyltransferase
Gene
menG
Organism
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Status
Functioni
Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).UniRule annotation
Catalytic activityi
- a 2-demethylmenaquinol + S-adenosyl-L-methionine = a menaquinol + H+ + S-adenosyl-L-homocysteineUniRule annotationEC:2.1.1.163UniRule annotation
: menaquinone biosynthesis Pathwayi
This protein is involved in step 2 of the subpathway that synthesizes menaquinol from 1,4-dihydroxy-2-naphthoate.UniRule annotationProteins known to be involved in the 2 steps of the subpathway in this organism are:
- 1,4-dihydroxy-2-naphthoate octaprenyltransferase (menA)
- Demethylmenaquinone methyltransferase (menG)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes menaquinol from 1,4-dihydroxy-2-naphthoate, the pathway menaquinone biosynthesis and in Quinol/quinone metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 62 | S-adenosyl-L-methionineUniRule annotation | 1 | |
Binding sitei | 80 | S-adenosyl-L-methionineUniRule annotation | 1 | |
Binding sitei | 117 | S-adenosyl-L-methionineUniRule annotation | 1 |
GO - Molecular functioni
- S-adenosylmethionine:2-demethylmenaquinol-7 methyltransferase activity Source: UniProtKB-EC
GO - Biological processi
- menaquinone biosynthetic process Source: UniProtKB-UniRule
Keywordsi
Molecular function | Methyltransferase, Transferase |
Biological process | Menaquinone biosynthesis |
Ligand | S-adenosyl-L-methionine |
Enzyme and pathway databases
BioCyci | CORYNE:G18NG-10028-MONOMER GCF_000196335:G1EEA-483-MONOMER |
UniPathwayi | UPA00079;UER00169 |
Names & Taxonomyi
Protein namesi | Recommended name: Demethylmenaquinone methyltransferaseUniRule annotation (EC:2.1.1.163UniRule annotation) |
Gene namesi | Name:menGUniRule annotation Ordered Locus Names:Cgl0471, cg0556 |
Organismi | Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025) |
Taxonomic identifieri | 196627 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Corynebacteriales › Corynebacteriaceae › Corynebacterium › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000193270 | 1 – 230 | Demethylmenaquinone methyltransferaseAdd BLAST | 230 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 100 – 101 | S-adenosyl-L-methionine bindingUniRule annotation | 2 |
Sequence similaritiesi
Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.UniRule annotation
Phylogenomic databases
eggNOGi | ENOG4105DDZ Bacteria COG2226 LUCA |
HOGENOMi | HOG000249464 |
KOi | K03183 |
OMAi | VRNFENL |
Family and domain databases
HAMAPi | MF_01813 MenG_UbiE_methyltr, 1 hit |
InterProi | View protein in InterPro IPR029063 SAM-dependent_MTases IPR004033 UbiE/COQ5_MeTrFase IPR023576 UbiE/COQ5_MeTrFase_CS |
Pfami | View protein in Pfam PF01209 Ubie_methyltran, 1 hit |
SUPFAMi | SSF53335 SSF53335, 1 hit |
TIGRFAMsi | TIGR01934 MenG_MenH_UbiE, 1 hit |
PROSITEi | View protein in PROSITE PS51608 SAM_MT_UBIE, 1 hit PS01183 UBIE_1, 1 hit PS01184 UBIE_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8NT39-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAKADLDKDP FDVASMFDDV GKNYDLTNTV LSFGQDRVWR KRTRQRLDLK
60 70 80 90 100
PGEKVLDLAA GTAVSTVELA KSGAFCVACD FSQGMLAAGK DRDVSKVVGD
110 120 130 140 150
GMQLPFADNS FDAVTISYGL RNIHDFRAGL KEMARVTKPG GRLTVAEFST
160 170 180 190 200
PVIPVFGTVY KEYLMRLLPQ AARAVSSNPE AYIYLADSIR AWPSQAELAR
210 220 230
EINQNGWSDC GWQNLTFGIV ALHSAIKPEN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BA000036 Genomic DNA Translation: BAB97864.1 BX927149 Genomic DNA Translation: CAF19185.1 |
RefSeqi | NP_599716.1, NC_003450.3 WP_011013674.1, NC_006958.1 |
Genome annotation databases
EnsemblBacteriai | BAB97864; BAB97864; BAB97864 CAF19185; CAF19185; cg0556 |
GeneIDi | 1021475 |
KEGGi | cgb:cg0556 cgl:NCgl0454 |
PATRICi | fig|196627.13.peg.469 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BA000036 Genomic DNA Translation: BAB97864.1 BX927149 Genomic DNA Translation: CAF19185.1 |
RefSeqi | NP_599716.1, NC_003450.3 WP_011013674.1, NC_006958.1 |
3D structure databases
SMRi | Q8NT39 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 196627.cg0556 |
Protocols and materials databases
DNASUi | 1021475 |
Genome annotation databases
EnsemblBacteriai | BAB97864; BAB97864; BAB97864 CAF19185; CAF19185; cg0556 |
GeneIDi | 1021475 |
KEGGi | cgb:cg0556 cgl:NCgl0454 |
PATRICi | fig|196627.13.peg.469 |
Phylogenomic databases
eggNOGi | ENOG4105DDZ Bacteria COG2226 LUCA |
HOGENOMi | HOG000249464 |
KOi | K03183 |
OMAi | VRNFENL |
Enzyme and pathway databases
UniPathwayi | UPA00079;UER00169 |
BioCyci | CORYNE:G18NG-10028-MONOMER GCF_000196335:G1EEA-483-MONOMER |
Family and domain databases
HAMAPi | MF_01813 MenG_UbiE_methyltr, 1 hit |
InterProi | View protein in InterPro IPR029063 SAM-dependent_MTases IPR004033 UbiE/COQ5_MeTrFase IPR023576 UbiE/COQ5_MeTrFase_CS |
Pfami | View protein in Pfam PF01209 Ubie_methyltran, 1 hit |
SUPFAMi | SSF53335 SSF53335, 1 hit |
TIGRFAMsi | TIGR01934 MenG_MenH_UbiE, 1 hit |
PROSITEi | View protein in PROSITE PS51608 SAM_MT_UBIE, 1 hit PS01183 UBIE_1, 1 hit PS01184 UBIE_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MENG_CORGL | |
Accessioni | Q8NT39Primary (citable) accession number: Q8NT39 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 10, 2003 |
Last sequence update: | October 1, 2002 | |
Last modified: | September 18, 2019 | |
This is version 99 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - PATHWAY comments
Index of metabolic and biosynthesis pathways