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Protein

tRNA pseudouridine synthase A

Gene

truA

Organism
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.UniRule annotation

Catalytic activityi

tRNA uridine(38-40) = tRNA pseudouridine(38-40).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei53NucleophileUniRule annotation1
Binding sitei119SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processtRNA processing

Enzyme and pathway databases

BioCyciCORYNE:G18NG-10129-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA pseudouridine synthase AUniRule annotation (EC:5.4.99.12UniRule annotation)
Alternative name(s):
tRNA pseudouridine(38-40) synthaseUniRule annotation
tRNA pseudouridylate synthase IUniRule annotation
tRNA-uridine isomerase IUniRule annotation
Gene namesi
Name:truAUniRule annotation
Ordered Locus Names:Cgl0567, cg0657
OrganismiCorynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Taxonomic identifieri196627 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium
Proteomesi
  • UP000000582 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000573701 – 289tRNA pseudouridine synthase AAdd BLAST289

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi196627.cg0657

Structurei

3D structure databases

ProteinModelPortaliQ8NSV0
SMRiQ8NSV0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tRNA pseudouridine synthase TruA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DI7 Bacteria
COG0101 LUCA
HOGENOMiHOG000248674
KOiK06173
OMAiFLYGMVR

Family and domain databases

Gene3Di3.30.70.660, 1 hit
HAMAPiMF_00171 TruA, 1 hit
InterProiView protein in InterPro
IPR020103 PsdUridine_synth_cat_dom_sf
IPR001406 PsdUridine_synth_TruA
IPR020097 PsdUridine_synth_TruA_a/b_dom
IPR020095 PsdUridine_synth_TruA_C
PANTHERiPTHR11142 PTHR11142, 1 hit
PfamiView protein in Pfam
PF01416 PseudoU_synth_1, 2 hits
PIRSFiPIRSF001430 tRNA_psdUrid_synth, 1 hit
SUPFAMiSSF55120 SSF55120, 1 hit
TIGRFAMsiTIGR00071 hisT_truA, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NSV0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRIRLDLAYD GTDFHGWAKQ GTSDLRTVQK VLEDNLSMVL RETVELTVAG
60 70 80 90 100
RTDAGVHAAG QVAHFDIPAH ALEQRSIDGD PSKLVRRLGR LLPDDIRVHG
110 120 130 140 150
VRFAEPGFDA RFSAMRRHYV YRITTHPAGA LPTRRHDTAQ WPKPVELERM
160 170 180 190 200
QLAADALLGL HDFVAFCKAK PHATTVRELQ KFAWKDVSTD IEPQVYEAHV
210 220 230 240 250
VADAFCWSMV RSLVGSCMAV GEGRRGSGFT AELLDASERS PMVPVAPAKG
260 270 280
LSLVGVDYPS ADKLQERALE TRAVREFPDA SASLKLDDE
Length:289
Mass (Da):31,992
Last modified:October 1, 2002 - v1
Checksum:iBC0D2876B61D6E2C
GO

Sequence cautioni

The sequence CAF19272 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000036 Genomic DNA Translation: BAB97960.1
BX927149 Genomic DNA Translation: CAF19272.1 Different initiation.
RefSeqiNP_599803.1, NC_003450.3

Genome annotation databases

EnsemblBacteriaiBAB97960; BAB97960; BAB97960
CAF19272; CAF19272; cg0657
GeneIDi1018571
KEGGicgb:cg0657
cgl:NCgl0542
PATRICifig|196627.13.peg.558

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000036 Genomic DNA Translation: BAB97960.1
BX927149 Genomic DNA Translation: CAF19272.1 Different initiation.
RefSeqiNP_599803.1, NC_003450.3

3D structure databases

ProteinModelPortaliQ8NSV0
SMRiQ8NSV0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi196627.cg0657

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB97960; BAB97960; BAB97960
CAF19272; CAF19272; cg0657
GeneIDi1018571
KEGGicgb:cg0657
cgl:NCgl0542
PATRICifig|196627.13.peg.558

Phylogenomic databases

eggNOGiENOG4105DI7 Bacteria
COG0101 LUCA
HOGENOMiHOG000248674
KOiK06173
OMAiFLYGMVR

Enzyme and pathway databases

BioCyciCORYNE:G18NG-10129-MONOMER

Family and domain databases

Gene3Di3.30.70.660, 1 hit
HAMAPiMF_00171 TruA, 1 hit
InterProiView protein in InterPro
IPR020103 PsdUridine_synth_cat_dom_sf
IPR001406 PsdUridine_synth_TruA
IPR020097 PsdUridine_synth_TruA_a/b_dom
IPR020095 PsdUridine_synth_TruA_C
PANTHERiPTHR11142 PTHR11142, 1 hit
PfamiView protein in Pfam
PF01416 PseudoU_synth_1, 2 hits
PIRSFiPIRSF001430 tRNA_psdUrid_synth, 1 hit
SUPFAMiSSF55120 SSF55120, 1 hit
TIGRFAMsiTIGR00071 hisT_truA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTRUA_CORGL
AccessioniPrimary (citable) accession number: Q8NSV0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: October 1, 2002
Last modified: October 10, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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