Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 143 (29 Sep 2021)
Sequence version 1 (01 Oct 2002)
Previous versions | rss
Add a publicationFeedback
Protein

Transcription termination factor Rho

Gene

rho

Organism
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.

UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei542ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi499 – 504ATPUniRule annotation6
Nucleotide bindingi511 – 516ATPUniRule annotation6

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHelicaseUniRule annotation, Hydrolase, RNA-bindingUniRule annotationARBA annotation
Biological processTranscription, Transcription regulation, Transcription terminationUniRule annotationARBA annotation
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
CORYNE:G18NG-10772-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transcription termination factor RhoUniRule annotation (EC:3.6.4.-UniRule annotation)
Alternative name(s):
ATP-dependent helicase RhoUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:rhoUniRule annotation
Ordered Locus Names:Cgl1199Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCorynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri196627 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000582 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homohexamer. The homohexamer assembles into an open ring structure.

UniRule annotation

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
196627.cg1354

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8NR58

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini373 – 456Rho RNA-BDInterPro annotationAdd BLAST84

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni49 – 369DisorderedSequence analysisAdd BLAST321

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi67 – 97Polar residuesSequence analysisAdd BLAST31
Compositional biasi112 – 144Polar residuesSequence analysisAdd BLAST33
Compositional biasi154 – 172Polar residuesSequence analysisAdd BLAST19
Compositional biasi173 – 188Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi208 – 250Polar residuesSequence analysisAdd BLAST43
Compositional biasi251 – 275Basic and acidic residuesSequence analysisAdd BLAST25
Compositional biasi276 – 292Polar residuesSequence analysisAdd BLAST17
Compositional biasi293 – 335Basic and acidic residuesSequence analysisAdd BLAST43
Compositional biasi344 – 366Basic and acidic residuesSequence analysisAdd BLAST23

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Rho family.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG1158, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_016377_3_2_11

Identification of Orthologs from Complete Genome Data

More...
OMAi
TTDLMGA

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01128, rho_factor, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.300, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_01884, Rho, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593, AAA+_ATPase
IPR000194, ATPase_F1/V1/A1_a/bsu_nucl-bd
IPR012340, NA-bd_OB-fold
IPR027417, P-loop_NTPase
IPR041703, Rho_factor_ATP-bd
IPR011112, Rho_N
IPR011113, Rho_RNA-bd
IPR004665, Term_rho

The PANTHER Classification System

More...
PANTHERi
PTHR46425, PTHR46425, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00006, ATP-synt_ab, 1 hit
PF07498, Rho_N, 1 hit
PF07497, Rho_RNA_bind, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382, AAA, 1 hit
SM00959, Rho_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50249, SSF50249, 1 hit
SSF52540, SSF52540, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00767, rho, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51856, RHO_RNA_BD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8NR58-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTTTDNTAAN QGELTALRLP DLRKIAADLG LKGTSALRKG DLINAISAAR
60 70 80 90 100
EGKPTAAAKK TSPRKAPSRT RATQPSAPVE QAQEAPAQTS TAPASAPSEE
110 120 130 140 150
TPAAPARRGR RRVTTTATTP EPAAPAQSQP AEAQPAQTQA AQQEELPVAA
160 170 180 190 200
KESAPATENT QGQAQGQAQG QAQGDEHDDR FESRSAARRA RRNRQRQIHR
210 220 230 240 250
DGDDNANANT ESEQNTPAQN ATAQAESEQT AAPAQAEAAE QNQNDNSESS
260 270 280 290 300
ENRSDNYRNN NRRSRNNRNN RNYRDNNESS DNAGQSSNDD ADNNQARSED
310 320 330 340 350
NNDDRRSRNN RNNDRNDRND RNDRDNDDND DRRNRRGRRN RRGRNDRNDR
360 370 380 390 400
DNRDNRDNRD NSNDGDNNQQ DELQQVAGIL DIVDHNVAFV RTTGYHAAPS
410 420 430 440 450
DVFVSNQLIR RMGLRSGDAI EGQVRMNQGG GNHNNHGRNR QKYNNLVRVE
460 470 480 490 500
MVNGLPAEET RNRPEFGKLT PLYPNQRLRL ETEQKILTTR VIDLIMPIGK
510 520 530 540 550
GQRALIVSPP KAGKTTILQN IANAISTNNP ECYLMVVLVD ERPEEVTDMQ
560 570 580 590 600
RSVNGEVISS TFDRPPSEHT AVAELAIERA KRLVEQGQDV VVLLDSITRL
610 620 630 640 650
GRAYNNSSPA SGRILSGGVD SNALYPPKRF LGAARNIENG GSLTIIATAM
660 670 680 690 700
VETGSAGDTV IFEEFKGTGN AELKLDRKIS ERRVFPAVDV NPSGTRKDEL
710 720 730 740 750
LLNPDEARIM HKLRRILSAL DNQQAIDLLI KQLKKTKSNA EFLMQVASSA
760
PMAGTEKEED YS
Length:762
Mass (Da):83,968
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF73F73896D4825CF
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BA000036 Genomic DNA Translation: BAB98592.1

NCBI Reference Sequences

More...
RefSeqi
NP_600425.1, NC_003450.3
WP_011014197.1, NC_006958.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
BAB98592; BAB98592; BAB98592

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cgl:NCgl1152

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|196627.13.peg.1179

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000036 Genomic DNA Translation: BAB98592.1
RefSeqiNP_600425.1, NC_003450.3
WP_011014197.1, NC_006958.1

3D structure databases

SMRiQ8NR58
ModBaseiSearch...

Protein-protein interaction databases

STRINGi196627.cg1354

Genome annotation databases

EnsemblBacteriaiBAB98592; BAB98592; BAB98592
KEGGicgl:NCgl1152
PATRICifig|196627.13.peg.1179

Phylogenomic databases

eggNOGiCOG1158, Bacteria
HOGENOMiCLU_016377_3_2_11
OMAiTTDLMGA

Enzyme and pathway databases

BioCyciCORYNE:G18NG-10772-MONOMER

Family and domain databases

CDDicd01128, rho_factor, 1 hit
Gene3Di3.40.50.300, 1 hit
HAMAPiMF_01884, Rho, 1 hit
InterProiView protein in InterPro
IPR003593, AAA+_ATPase
IPR000194, ATPase_F1/V1/A1_a/bsu_nucl-bd
IPR012340, NA-bd_OB-fold
IPR027417, P-loop_NTPase
IPR041703, Rho_factor_ATP-bd
IPR011112, Rho_N
IPR011113, Rho_RNA-bd
IPR004665, Term_rho
PANTHERiPTHR46425, PTHR46425, 1 hit
PfamiView protein in Pfam
PF00006, ATP-synt_ab, 1 hit
PF07498, Rho_N, 1 hit
PF07497, Rho_RNA_bind, 1 hit
SMARTiView protein in SMART
SM00382, AAA, 1 hit
SM00959, Rho_N, 1 hit
SUPFAMiSSF50249, SSF50249, 1 hit
SSF52540, SSF52540, 1 hit
TIGRFAMsiTIGR00767, rho, 1 hit
PROSITEiView protein in PROSITE
PS51856, RHO_RNA_BD, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ8NR58_CORGL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NR58
Secondary accession number(s): Q6M5X9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2002
Last sequence update: October 1, 2002
Last modified: September 29, 2021
This is version 143 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again