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Entry version 114 (08 May 2019)
Sequence version 1 (01 Oct 2002)
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Protein

Pyruvate dehydrogenase E1 component

Gene

aceE

Organism
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Is a specific component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. AceE has reductase activity with pyruvate but does not react with 2-oxoglutarate.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=0.066 mM for pyruvate1 Publication

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionOxidoreductase
    Biological processGlycolysis
    LigandMagnesium, Pyruvate, Thiamine pyrophosphate

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    CORYNE:G18NG-11842-MONOMER
    GCF_000196335:G1EEA-2217-MONOMER

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    1.2.4.1 960

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Pyruvate dehydrogenase E1 component (EC:1.2.4.1)
    Short name:
    E1p
    Short name:
    PDH E1 component
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:aceE
    Ordered Locus Names:Cgl2248, cg2466
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCorynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri196627 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000000582 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    <p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

    Cells lacking this gene display no PDH activity.1 Publication

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004205221 – 922Pyruvate dehydrogenase E1 componentAdd BLAST922

    Proteomic databases

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q8NNF6

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Homodimer (By similarity).

    Part of an unusual ODH/PDH supercomplex, consisting of AceE (E1), AceF (E2), and Lpd (E3) together with OdhA (E1+E2).

    By similarity1 Publication

    Protein-protein interaction databases

    STRING: functional protein association networks

    More...
    STRINGi
    196627.cg2466

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q8NNF6

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    ENOG4105DAQ Bacteria
    COG2609 LUCA

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000115215

    KEGG Orthology (KO)

    More...
    KOi
    K00163

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    REPWFPG

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd02017 TPP_E1_EcPDC_like, 1 hit

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.40.50.920, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR035807 PDC_E1_N
    IPR004660 PDH_E1
    IPR041621 PDH_E1_M
    IPR029061 THDP-binding
    IPR009014 Transketo_C/PFOR_II
    IPR005474 Transketolase_N

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR43825:SF3 PTHR43825:SF3, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF17831 PDH_E1_M, 1 hit
    PF00456 Transketolase_N, 1 hit

    PIRSF; a whole-protein classification database

    More...
    PIRSFi
    PIRSF000156 Pyruvate_dh_E1, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF52518 SSF52518, 2 hits
    SSF52922 SSF52922, 1 hit

    TIGRFAMs; a protein family database

    More...
    TIGRFAMsi
    TIGR00759 aceE, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    Q8NNF6-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MADQAKLGGK PSDDSNFAMI RDGVASYLND SDPEETNEWM DSLDGLLQES
    60 70 80 90 100
    SPERARYLML RLLERASAKR VSLPPMTSTD YVNTIPTSME PEFPGDEEME
    110 120 130 140 150
    KRYRRWIRWN AAIMVHRAQR PGIGVGGHIS TYAGAAPLYE VGFNHFFRGK
    160 170 180 190 200
    DHPGGGDQIF FQGHASPGMY ARAFMEGRLS EDDLDGFRQE VSREQGGIPS
    210 220 230 240 250
    YPHPHGMKDF WEFPTVSMGL GPMDAIYQAR FNRYLENRGI KDTSDQHVWA
    260 270 280 290 300
    FLGDGEMDEP ESRGLIQQAA LNNLDNLTFV VNCNLQRLDG PVRGNTKIIQ
    310 320 330 340 350
    ELESFFRGAG WSVIKVVWGR EWDELLEKDQ DGALVEIMNN TSDGDYQTFK
    360 370 380 390 400
    ANDGAYVREH FFGRDPRTAK LVENMTDEEI WKLPRGGHDY RKVYAAYKRA
    410 420 430 440 450
    LETKDRPTVI LAHTIKGYGL GHNFEGRNAT HQMKKLTLDD LKLFRDKQGI
    460 470 480 490 500
    PITDEQLEKD PYLPPYYHPG EDAPEIKYMK ERRAALGGYL PERRENYDPI
    510 520 530 540 550
    QVPPLDKLRS VRKGSGKQQI ATTMATVRTF KELMRDKGLA DRLVPIIPDE
    560 570 580 590 600
    ARTFGLDSWF PTLKIYNPHG QNYVPVDHDL MLSYREAPEG QILHEGINEA
    610 620 630 640 650
    GSVASFIAAG TSYATHGKAM IPLYIFYSMF GFQRTGDSIW AAADQMARGF
    660 670 680 690 700
    LLGATAGRTT LTGEGLQHMD GHSPVLASTN EGVETYDPSF AYEIAHLVHR
    710 720 730 740 750
    GIDRMYGPGK GEDVIYYITI YNEPTPQPAE PEGLDVEGLH KGIYLYSRGE
    760 770 780 790 800
    GTGHEANILA SGVGMQWALK AASILEADYG VRANIYSATS WVNLARDGAA
    810 820 830 840 850
    RNKAQLRNPG ADAGEAFVTT QLKQTSGPYV AVSDFSTDLP NQIREWVPGD
    860 870 880 890 900
    YTVLGADGFG FSDTRPAARR FFNIDAESIV VAVLNSLARE GKIDVSVAAQ
    910 920
    AAEKFKLDDP TSVSVDPNAP EE
    Length:922
    Mass (Da):102,826
    Last modified:October 1, 2002 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5B949B2A72B855BF
    GO

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    BA000036 Genomic DNA Translation: BAB99641.1
    BX927154 Genomic DNA Translation: CAF20589.1

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_601447.1, NC_003450.3
    WP_011014985.1, NC_006958.1

    Genome annotation databases

    Ensembl bacterial and archaeal genome annotation project

    More...
    EnsemblBacteriai
    BAB99641; BAB99641; BAB99641
    CAF20589; CAF20589; cg2466

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    1020200

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    cgb:cg2466
    cgl:NCgl2167

    Pathosystems Resource Integration Center (PATRIC)

    More...
    PATRICi
    fig|196627.13.peg.2180

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    BA000036 Genomic DNA Translation: BAB99641.1
    BX927154 Genomic DNA Translation: CAF20589.1
    RefSeqiNP_601447.1, NC_003450.3
    WP_011014985.1, NC_006958.1

    3D structure databases

    SMRiQ8NNF6
    ModBaseiSearch...

    Protein-protein interaction databases

    STRINGi196627.cg2466

    Proteomic databases

    PRIDEiQ8NNF6

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsemblBacteriaiBAB99641; BAB99641; BAB99641
    CAF20589; CAF20589; cg2466
    GeneIDi1020200
    KEGGicgb:cg2466
    cgl:NCgl2167
    PATRICifig|196627.13.peg.2180

    Phylogenomic databases

    eggNOGiENOG4105DAQ Bacteria
    COG2609 LUCA
    HOGENOMiHOG000115215
    KOiK00163
    OMAiREPWFPG

    Enzyme and pathway databases

    BioCyciCORYNE:G18NG-11842-MONOMER
    GCF_000196335:G1EEA-2217-MONOMER
    BRENDAi1.2.4.1 960

    Family and domain databases

    CDDicd02017 TPP_E1_EcPDC_like, 1 hit
    Gene3Di3.40.50.920, 1 hit
    InterProiView protein in InterPro
    IPR035807 PDC_E1_N
    IPR004660 PDH_E1
    IPR041621 PDH_E1_M
    IPR029061 THDP-binding
    IPR009014 Transketo_C/PFOR_II
    IPR005474 Transketolase_N
    PANTHERiPTHR43825:SF3 PTHR43825:SF3, 1 hit
    PfamiView protein in Pfam
    PF17831 PDH_E1_M, 1 hit
    PF00456 Transketolase_N, 1 hit
    PIRSFiPIRSF000156 Pyruvate_dh_E1, 1 hit
    SUPFAMiSSF52518 SSF52518, 2 hits
    SSF52922 SSF52922, 1 hit
    TIGRFAMsiTIGR00759 aceE, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiODP1_CORGL
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NNF6
    Secondary accession number(s): Q6M3J1
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2012
    Last sequence update: October 1, 2002
    Last modified: May 8, 2019
    This is version 114 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome
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