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Entry version 153 (02 Jun 2021)
Sequence version 1 (01 Oct 2002)
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Protein

DNA primase

Gene

dnaG

Organism
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • SsDNA + n NTP = ssDNA/pppN(pN)(n-1) hybrid + (n-1) diphosphate.UniRule annotation EC:2.7.7.101

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per monomer.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-bindingUniRule annotationARBA annotation, NucleotidyltransferaseUniRule annotationARBA annotation, Transferase
Biological processDNA replicationUniRule annotationARBA annotation, Transcription
LigandMagnesiumARBA annotation, Metal-binding, Zinc

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
CORYNE:G18NG-11865-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA primaseUniRule annotation (EC:2.7.7.101UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:dnaGUniRule annotation
Ordered Locus Names:Cgl2268Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCorynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri196627 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000582 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

DNA-directed RNA polymeraseUniRule annotationARBA annotation, PrimosomeUniRule annotationARBA annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.

UniRule annotation

Monomer.

Interacts with DnaB.

UniRule annotation

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
196627.cg2489

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8NND6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini264 – 350ToprimInterPro annotationAdd BLAST87

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni442 – 462DisorderedSequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DnaG primase family.UniRule annotation

Keywords - Domaini

Zinc-fingerARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG0358, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_013501_3_1_11

Identification of Orthologs from Complete Genome Data

More...
OMAi
RIMFPIY

Family and domain databases

Conserved Domains Database

More...
CDDi
cd03364, TOPRIM_DnaG_primases, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.90.580.10, 1 hit
3.90.980.10, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_00974, DNA_primase_DnaG, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013264, DNA_primase_core_N
IPR037068, DNA_primase_core_N_sf
IPR019475, DNA_primase_DnaB-bd
IPR006295, DNA_primase_DnaG
IPR013173, DNA_primase_DnaG_DnaB-bd_dom
IPR036977, DNA_primase_Znf_CHC2
IPR030846, DnaG_bac
IPR034151, TOPRIM_DnaG_bac
IPR006171, TOPRIM_domain
IPR002694, Znf_CHC2

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10410, DnaB_bind, 1 hit
PF08278, DnaG_DnaB_bind, 1 hit
PF13662, Toprim_4, 1 hit
PF08275, Toprim_N, 1 hit
PF01807, zf-CHC2, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF002811, DnaG, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00766, DnaG_DnaB_bind, 1 hit
SM00493, TOPRIM, 1 hit
SM00400, ZnF_CHCC, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01391, dnaG, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50880, TOPRIM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8NND6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVMAKGRIPE SDIQAIRERT PIEEIVGDYV QLKSAGADSL KGLSPFKDEK
60 70 80 90 100
TPSFHVRPNR GYYHCFSTGK GGDVFSFLME MEHISFPEAV EVCAEKIGYQ
110 120 130 140 150
INYQGGGPGR REEPGTRQRL ILANKAAHQF YREQLETPEA QPGREFLLQR
160 170 180 190 200
GFGQQHIYHF ECGYAPAGWD TLTKHLLKKG FEFKELEAAG LSKMGKRGPI
210 220 230 240 250
DQFQRRLLWP IKNLSGDVIG FGARKLFDDD KMGKYMNTPE TLLYKKSKVL
260 270 280 290 300
FGLDSAKKAI AAGHQAVVVE GYTDVMAMHA AGIDTAVASC GTAFGEEHLQ
310 320 330 340 350
MLRRLMLDDN YFRGELIYTF DGDEAGQKAA MRAFEGDQKF TGQSFVSVAP
360 370 380 390 400
NGMDPCDLRL ERGDAAVRDL VARRIPMFEF VIQSIISEYT LDTVEGRLAA
410 420 430 440 450
LRRAVPIVAD IRDKTLQSEY ARLLSGWVGW SDPSEVLRQV HEEARRPKRD
460 470 480 490 500
KKPVRAKRFD QPLEDQSLRP TMALPNPRNP VLWQERESLK IALQYPELAG
510 520 530 540 550
SYFDGLPTDS FTNPAYRMVR DAISAAGGCE RALDGTDWLP AVSENMTDIL
560 570 580 590 600
GTSLVSELAM EPIEVEAQDL ESYTDGVLSR LQETRVGNQI AILKGQLQRM
610 620 630
RPSEDEQAYN SLFSDLVALE QARRELLARA FRG
Length:633
Mass (Da):71,041
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE2F0A85518A11903
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BA000036 Genomic DNA Translation: BAB99661.1

NCBI Reference Sequences

More...
RefSeqi
NP_601468.1, NC_003450.3
WP_003857029.1, NC_006958.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
BAB99661; BAB99661; BAB99661

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
58311283

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cgl:NCgl2188

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|196627.13.peg.2201

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000036 Genomic DNA Translation: BAB99661.1
RefSeqiNP_601468.1, NC_003450.3
WP_003857029.1, NC_006958.1

3D structure databases

SMRiQ8NND6
ModBaseiSearch...

Protein-protein interaction databases

STRINGi196627.cg2489

Genome annotation databases

EnsemblBacteriaiBAB99661; BAB99661; BAB99661
GeneIDi58311283
KEGGicgl:NCgl2188
PATRICifig|196627.13.peg.2201

Phylogenomic databases

eggNOGiCOG0358, Bacteria
HOGENOMiCLU_013501_3_1_11
OMAiRIMFPIY

Enzyme and pathway databases

BioCyciCORYNE:G18NG-11865-MONOMER

Family and domain databases

CDDicd03364, TOPRIM_DnaG_primases, 1 hit
Gene3Di3.90.580.10, 1 hit
3.90.980.10, 1 hit
HAMAPiMF_00974, DNA_primase_DnaG, 1 hit
InterProiView protein in InterPro
IPR013264, DNA_primase_core_N
IPR037068, DNA_primase_core_N_sf
IPR019475, DNA_primase_DnaB-bd
IPR006295, DNA_primase_DnaG
IPR013173, DNA_primase_DnaG_DnaB-bd_dom
IPR036977, DNA_primase_Znf_CHC2
IPR030846, DnaG_bac
IPR034151, TOPRIM_DnaG_bac
IPR006171, TOPRIM_domain
IPR002694, Znf_CHC2
PfamiView protein in Pfam
PF10410, DnaB_bind, 1 hit
PF08278, DnaG_DnaB_bind, 1 hit
PF13662, Toprim_4, 1 hit
PF08275, Toprim_N, 1 hit
PF01807, zf-CHC2, 1 hit
PIRSFiPIRSF002811, DnaG, 1 hit
SMARTiView protein in SMART
SM00766, DnaG_DnaB_bind, 1 hit
SM00493, TOPRIM, 1 hit
SM00400, ZnF_CHCC, 1 hit
TIGRFAMsiTIGR01391, dnaG, 1 hit
PROSITEiView protein in PROSITE
PS50880, TOPRIM, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ8NND6_CORGL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NND6
Secondary accession number(s): Q6M3H0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2002
Last sequence update: October 1, 2002
Last modified: June 2, 2021
This is version 153 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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