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Entry version 139 (02 Dec 2020)
Sequence version 1 (01 Oct 2002)
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Protein
Submitted name:

Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific

Gene

Cgl2642

Organism
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei26Phosphocysteine intermediate; for EIIB activityPROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinaseARBA annotation, Transferase
Biological processPhosphotransferase systemARBA annotation, Sugar transportARBA annotation, Transport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
CORYNE:G18NG-12259-MONOMER

Protein family/group databases

Transport Classification Database

More...
TCDBi
4.A.1.2.12, the pts glucose-glucoside (glc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specificImported (EC:2.7.1.191Imported)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:Cgl2642Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCorynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri196627 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000582 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei113 – 135HelicalSequence analysisAdd BLAST23
Transmembranei155 – 176HelicalSequence analysisAdd BLAST22
Transmembranei188 – 209HelicalSequence analysisAdd BLAST22
Transmembranei229 – 248HelicalSequence analysisAdd BLAST20
Transmembranei260 – 282HelicalSequence analysisAdd BLAST23
Transmembranei302 – 320HelicalSequence analysisAdd BLAST19
Transmembranei341 – 364HelicalSequence analysisAdd BLAST24
Transmembranei376 – 396HelicalSequence analysisAdd BLAST21
Transmembranei408 – 435HelicalSequence analysisAdd BLAST28
Transmembranei441 – 464HelicalSequence analysisAdd BLAST24

GO - Cellular componenti

Keywords - Cellular componenti

Cell membraneARBA annotation, Membrane

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
196627.cg2925

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini4 – 87PTS EIIB type-1InterPro annotationAdd BLAST84
Domaini121 – 483PTS EIIC type-1InterPro annotationAdd BLAST363
Domaini519 – 627PTS EIIA type-1InterPro annotationAdd BLAST109

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG1263, Bacteria
COG1264, Bacteria
COG2190, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_012312_2_1_11

Identification of Orthologs from Complete Genome Data

More...
OMAi
LITHAGW

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00212, PTS_IIB_glc, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.70.70.10, 1 hit
3.30.1360.60, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011055, Dup_hybrid_motif
IPR036878, Glu_permease_IIB
IPR018113, PTrfase_EIIB_Cys
IPR001127, PTS_EIIA_1_perm
IPR003352, PTS_EIIC
IPR013013, PTS_EIIC_1
IPR001996, PTS_IIB_1
IPR010973, PTS_IIBC_sucr

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00358, PTS_EIIA_1, 1 hit
PF00367, PTS_EIIB, 1 hit
PF02378, PTS_EIIC, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51261, SSF51261, 1 hit
SSF55604, SSF55604, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00830, PTBA, 1 hit
TIGR01996, PTS-II-BC-sucr, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51093, PTS_EIIA_TYPE_1, 1 hit
PS51098, PTS_EIIB_TYPE_1, 1 hit
PS01035, PTS_EIIB_TYPE_1_CYS, 1 hit
PS51103, PTS_EIIC_TYPE_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8NMD6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDHKDLAQRI LRDIGGEDNI VAAAHCATRL RLVLKDTKDV DRQSLDDDPD
60 70 80 90 100
LKGTFETGGM FQIIVGPGDV DHVFKELDDA TSKDIAVSTE QLKDVVANNA
110 120 130 140 150
NWFSRAVKVL ADIFVPLIPI LVGGGLLMAI NNVLVAQDLF GPQSLVEMFP
160 170 180 190 200
QISGVAEMIN LMASAPFAFL PVLVGFTATK RFGGNEFLGA GIGMAMVFPS
210 220 230 240 250
LVNGYDVAAT MAAGEMPMWS LFGLDVAQAG YQGTVLPVLV VSWILATIEK
260 270 280 290 300
FLHKRLKGTA DFLITPVLTL LLTGFLTFIA IGPAMRWVGD VLAHGLQGLY
310 320 330 340 350
DFGGPVGGLL FGLVYSPIVI TGLHQSFPPI ELELFNQGGS FIFATASMAN
360 370 380 390 400
IAQGAACLAV FFLAKSEKLK GLAGASGVSA VLGITEPAIF GVNLRLRWPF
410 420 430 440 450
FIGIGTAAIG GALIALFNIK AVALGAAGFL GVVSIDAPDM VMFLVCAVVT
460 470 480 490 500
FFIAFGAAIA YGLYLVRRNG SIDPDATAAP VPAGTTKAEA EAPAEFSNDS
510 520 530 540 550
TIIQAPLTGE AIALSSVSDA MFASGKLGSG VAIVPTKGQL VSPVSGKIVV
560 570 580 590 600
AFPSGHAFAV RTKAEDGSNV DILMHIGFDT VNLNGTHFNP LKKQGDEVKA
610 620 630 640 650
GELLCEFDID AIKAAGYEVT TPIVVSNYKK TGPVNTYGLG EIEAGANLLN
660
VAKKEAVPAT P
Length:661
Mass (Da):69,148
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC0E5E1C7833B9F74
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BA000036 Genomic DNA Translation: BAC00036.1

NCBI Reference Sequences

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RefSeqi
NP_601842.1, NC_003450.3
WP_011015272.1, NC_006958.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
BAC00036; BAC00036; BAC00036

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
47942016

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cgl:NCgl2553

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|196627.13.peg.2578

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000036 Genomic DNA Translation: BAC00036.1
RefSeqiNP_601842.1, NC_003450.3
WP_011015272.1, NC_006958.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi196627.cg2925

Protein family/group databases

TCDBi4.A.1.2.12, the pts glucose-glucoside (glc) family

Genome annotation databases

EnsemblBacteriaiBAC00036; BAC00036; BAC00036
GeneIDi47942016
KEGGicgl:NCgl2553
PATRICifig|196627.13.peg.2578

Phylogenomic databases

eggNOGiCOG1263, Bacteria
COG1264, Bacteria
COG2190, Bacteria
HOGENOMiCLU_012312_2_1_11
OMAiLITHAGW

Enzyme and pathway databases

BioCyciCORYNE:G18NG-12259-MONOMER

Family and domain databases

CDDicd00212, PTS_IIB_glc, 1 hit
Gene3Di2.70.70.10, 1 hit
3.30.1360.60, 1 hit
InterProiView protein in InterPro
IPR011055, Dup_hybrid_motif
IPR036878, Glu_permease_IIB
IPR018113, PTrfase_EIIB_Cys
IPR001127, PTS_EIIA_1_perm
IPR003352, PTS_EIIC
IPR013013, PTS_EIIC_1
IPR001996, PTS_IIB_1
IPR010973, PTS_IIBC_sucr
PfamiView protein in Pfam
PF00358, PTS_EIIA_1, 1 hit
PF00367, PTS_EIIB, 1 hit
PF02378, PTS_EIIC, 1 hit
SUPFAMiSSF51261, SSF51261, 1 hit
SSF55604, SSF55604, 1 hit
TIGRFAMsiTIGR00830, PTBA, 1 hit
TIGR01996, PTS-II-BC-sucr, 1 hit
PROSITEiView protein in PROSITE
PS51093, PTS_EIIA_TYPE_1, 1 hit
PS51098, PTS_EIIB_TYPE_1, 1 hit
PS01035, PTS_EIIB_TYPE_1_CYS, 1 hit
PS51103, PTS_EIIC_TYPE_1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ8NMD6_CORGL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NMD6
Secondary accession number(s): Q6M2J8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2002
Last sequence update: October 1, 2002
Last modified: December 2, 2020
This is version 139 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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