The new UniProt website is here!
Take me to UniProt BETA
UniProtKB - Q8NKX1 (HASA_STRP8)
Protein
Hyaluronan synthase
Gene
hasA
Organism
Streptococcus pyogenes serotype M18 (strain MGAS8232)
Status
Functioni
Glycosaminoglycan synthesis. The hyaluronic acid capsule is involved in the pathogenicity of group A Streptococci; it may be the major virulence determinant.
Caution
It is uncertain whether Met-1 or Met-25 is the initiator.Curated
Catalytic activityi
- [hyaluronan](n) + UDP-N-acetyl-α-D-glucosamine = H+ + N-acetyl-β-D-glucosaminyl-(1→4)-[hyaluronan](n) + UDPEC:2.4.1.212
- N-acetyl-β-D-glucosaminyl-(1→4)-[hyaluronan](n) + UDP-α-D-glucuronate = [hyaluronan](n+1) + H+ + UDPEC:2.4.1.212
Cofactori
: hyaluronan biosynthesis Pathwayi
This protein is involved in the pathway hyaluronan biosynthesis, which is part of Glycan biosynthesis.View all proteins of this organism that are known to be involved in the pathway hyaluronan biosynthesis and in Glycan biosynthesis.
GO - Molecular functioni
- hyaluronan synthase activity Source: UniProtKB-EC
GO - Biological processi
- hyaluronan biosynthetic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Glycosyltransferase, Transferase |
Biological process | Capsule biogenesis/degradation, Virulence |
Enzyme and pathway databases
UniPathwayi | UPA00341 |
Protein family/group databases
CAZyi | GT2, Glycosyltransferase Family 2 |
Names & Taxonomyi
Protein namesi | Recommended name: Hyaluronan synthase (EC:2.4.1.212)Alternative name(s): Hyaluronate synthase Hyaluronic acid synthase Short name: HA synthase |
Gene namesi | Name:hasA Ordered Locus Names:spyM18_2236 |
Organismi | Streptococcus pyogenes serotype M18 (strain MGAS8232) |
Taxonomic identifieri | 186103 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus › |
Subcellular locationi
Plasma membrane
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 8 – 28 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 33 – 53 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 318 – 338 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 345 – 365 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 376 – 396 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000197168 | 1 – 419 | Hyaluronan synthaseAdd BLAST | 419 |
Family & Domainsi
Sequence similaritiesi
Belongs to the NodC/HAS family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
HOGENOMi | CLU_029695_4_0_9 |
OMAi | DVIVPCF |
Family and domain databases
Gene3Di | 3.90.550.10, 1 hit |
InterProi | View protein in InterPro IPR001173, Glyco_trans_2-like IPR029044, Nucleotide-diphossugar_trans |
Pfami | View protein in Pfam PF00535, Glycos_transf_2, 1 hit |
SUPFAMi | SSF53448, SSF53448, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8NKX1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPIFKKTLIV LSFIFLISIL IYLNMYLFGT STVGIYGVIL ITYLVIKLGL
60 70 80 90 100
SFLYEPFKGK PHDYKVAAVI PSYNEDAESL LETLKSVLAQ TYPLSEIYIV
110 120 130 140 150
DDGSSNTDAI QLIEEYVNRE VDICRNVIVH RSLVNKGKRH AQAWAFERSD
160 170 180 190 200
ADVFLTVDSD TYIYPNALEE LLKSFNDETV YAATGHLNAR NRQTNLLTRL
210 220 230 240 250
TDIRYDNAFG VERAAQSLTG NILVCSGPLS IYRREVIIPN LERYKNQTFL
260 270 280 290 300
GLPVSIGDDR CLTNYAIDLG RTVYQSTARC DTDVPFQLKS YLKQQNRWNK
310 320 330 340 350
SFFRESIISV KKILSNPIVA LWTIFEVVMF MMLIVAIGNL LFNQAIQLDL
360 370 380 390 400
IKLFAFLSII FIVALCRNVH YMVKHPASFL LSPLYGILHL FVLQPLKLYS
410
LCTIKNTEWG TRKKVTIFK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE009949 Genomic DNA Translation: AAL98667.1 |
PIRi | A53100 |
RefSeqi | WP_011018340.1, NC_003485.1 |
Genome annotation databases
KEGGi | spm:spyM18_2236 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE009949 Genomic DNA Translation: AAL98667.1 |
PIRi | A53100 |
RefSeqi | WP_011018340.1, NC_003485.1 |
3D structure databases
AlphaFoldDBi | Q8NKX1 |
SMRi | Q8NKX1 |
ModBasei | Search... |
Protein family/group databases
CAZyi | GT2, Glycosyltransferase Family 2 |
Genome annotation databases
KEGGi | spm:spyM18_2236 |
Phylogenomic databases
HOGENOMi | CLU_029695_4_0_9 |
OMAi | DVIVPCF |
Enzyme and pathway databases
UniPathwayi | UPA00341 |
Miscellaneous databases
PHI-basei | PHI:5099 |
Family and domain databases
Gene3Di | 3.90.550.10, 1 hit |
InterProi | View protein in InterPro IPR001173, Glyco_trans_2-like IPR029044, Nucleotide-diphossugar_trans |
Pfami | View protein in Pfam PF00535, Glycos_transf_2, 1 hit |
SUPFAMi | SSF53448, SSF53448, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | HASA_STRP8 | |
Accessioni | Q8NKX1Primary (citable) accession number: Q8NKX1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 30, 2005 |
Last sequence update: | October 1, 2002 | |
Last modified: | May 25, 2022 | |
This is version 102 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Documents
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families