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Protein

NF-kappa-B inhibitor delta

Gene

NFKBID

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates the expression of IL-2, IL-6, and other cytokines through regulation on NF-kappa-B activity. Functions in the regulation of inflammatory responses. Involved in the induction of T helper 17 cells (Th17) differentiation upon recognition of antigen by T cell antigen receptor (TCR). May also regulate TCR-induced negative selection of thymocytes.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processInflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
NF-kappa-B inhibitor delta
Alternative name(s):
I-kappa-B-delta
Short name:
IkB-delta
Short name:
IkappaBdelta
IkappaBNS
T-cell activation NFKB-like protein
TA-NFKBH
Gene namesi
Name:NFKBID
Synonyms:IKBNS
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000167604.13
HGNCiHGNC:15671 NFKBID
neXtProtiNX_Q8NI38

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000167604
PharmGKBiPA162397453

Polymorphism and mutation databases

BioMutaiNFKBID
DMDMi74751323

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003311141 – 313NF-kappa-B inhibitor deltaAdd BLAST313

Proteomic databases

EPDiQ8NI38
MaxQBiQ8NI38
PaxDbiQ8NI38
PeptideAtlasiQ8NI38
PRIDEiQ8NI38
ProteomicsDBi73829
73830 [Q8NI38-2]
73831 [Q8NI38-3]

PTM databases

iPTMnetiQ8NI38
PhosphoSitePlusiQ8NI38

Expressioni

Gene expression databases

BgeeiENSG00000167604 Expressed in 113 organ(s), highest expression level in blood
CleanExiHS_NFKBID
ExpressionAtlasiQ8NI38 baseline and differential
GenevisibleiQ8NI38 HS

Organism-specific databases

HPAiHPA043573

Interactioni

Subunit structurei

Interacts with NFKB1, RELA and RELB; in the nucleus.By similarity

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi124269, 8 interactors
IntActiQ8NI38, 104 interactors
MINTiQ8NI38
STRINGi9606.ENSP00000380109

Structurei

3D structure databases

ProteinModelPortaliQ8NI38
SMRiQ8NI38
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati48 – 83ANK 1Add BLAST36
Repeati84 – 113ANK 2Add BLAST30
Repeati117 – 146ANK 3Add BLAST30
Repeati152 – 201ANK 4Add BLAST50
Repeati206 – 236ANK 5Add BLAST31
Repeati243 – 276ANK 6Add BLAST34

Sequence similaritiesi

Belongs to the NF-kappa-B inhibitor family.Curated

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00550000074527
HOGENOMiHOG000113021
HOVERGENiHBG098212
InParanoidiQ8NI38
KOiK14214
OMAiHMAAGLH
OrthoDBiEOG091G06D9
PhylomeDBiQ8NI38
TreeFamiTF330224

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
PfamiView protein in Pfam
PF00023 Ank, 1 hit
PF12796 Ank_2, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 5 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 3 hits

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8NI38-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEAGPWRVSA PPSGPPQFPA VVPGPSLEVA RAHMLALGPQ QLLAQDEEGD
60 70 80 90 100
TLLHLFAARG LRWAAYAAAE VLQVYRRLDI REHKGKTPLL VAAAANQPLI
110 120 130 140 150
VEDLLNLGAE PNAADHQGRS VLHVAATYGL PGVLLAVLNS GVQVDLEARD
160 170 180 190 200
FEGLTPLHTA ILALNVAMRP SDLCPRVLST QARDRLDCVH MLLQMGANHT
210 220 230 240 250
SQEIKSNKTV LHLAVQAANP TLVQLLLELP RGDLRTFVNM KAHGNTALHM
260 270 280 290 300
AAALPPGPAQ EAIVRHLLAA GADPTLRNLE NEQPVHLLRP GPGPEGLRQL
310
LKRSRVAPPG LSS
Length:313
Mass (Da):33,481
Last modified:October 1, 2002 - v1
Checksum:iB986234830428320
GO
Isoform 2 (identifier: Q8NI38-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MWVCLRGILD...GQPCPFPQGM

Note: No experimental confirmation available.
Show »
Length:465
Mass (Da):50,297
Checksum:i710CB1235A2AEF3E
GO
Isoform 3 (identifier: Q8NI38-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-201: Missing.
     202-202: Q → MRSCCVVQAGLQLLASSDPPSSASQSARITGVNHRTPPR

Show »
Length:150
Mass (Da):15,921
Checksum:iEBB4EDF1D8CCCBCC
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EKM2K7EKM2_HUMAN
NF-kappa-B inhibitor delta
NFKBID
292Annotation score:
A0A286YF31A0A286YF31_HUMAN
NF-kappa-B inhibitor delta
NFKBID
455Annotation score:
K7ENW9K7ENW9_HUMAN
NF-kappa-B inhibitor delta
NFKBID
65Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04273729V → A. Corresponds to variant dbSNP:rs8113704Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0331431 – 201Missing in isoform 3. 1 PublicationAdd BLAST201
Alternative sequenceiVSP_0331441M → MWVCLRGILDSQAFWHETLR RWECLLAEMKVSRGERSHCP TQTVKKLLEEQRRRQQQQPD AGGVQGQFLPPPEQPLTPSV NEAVTGHPPFPAHSETVGSG PSSLGFPDWDPNTHAAYTDS PYSCPASAAENFLPPDFYPP SDPGQPCPFPQGM in isoform 2. 1 Publication1
Alternative sequenceiVSP_033145202Q → MRSCCVVQAGLQLLASSDPP SSASQSARITGVNHRTPPR in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF385433 mRNA Translation: AAM43834.1
AF385434 mRNA Translation: AAM43835.1
BC006273 mRNA Translation: AAH06273.1
BC119646 mRNA Translation: AAI19647.1
BC119647 mRNA Translation: AAI19648.1
CCDSiCCDS42552.1 [Q8NI38-1]
RefSeqiNP_640332.1, NM_139239.2 [Q8NI38-1]
XP_011525721.1, XM_011527419.2 [Q8NI38-2]
XP_016882880.1, XM_017027391.1 [Q8NI38-1]
XP_016882881.1, XM_017027392.1 [Q8NI38-1]
XP_016882882.1, XM_017027393.1 [Q8NI38-1]
UniGeneiHs.466531

Genome annotation databases

EnsembliENST00000396901; ENSP00000380109; ENSG00000167604 [Q8NI38-1]
ENST00000606253; ENSP00000475712; ENSG00000167604 [Q8NI38-2]
GeneIDi84807
KEGGihsa:84807
UCSCiuc002oci.1 human [Q8NI38-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF385433 mRNA Translation: AAM43834.1
AF385434 mRNA Translation: AAM43835.1
BC006273 mRNA Translation: AAH06273.1
BC119646 mRNA Translation: AAI19647.1
BC119647 mRNA Translation: AAI19648.1
CCDSiCCDS42552.1 [Q8NI38-1]
RefSeqiNP_640332.1, NM_139239.2 [Q8NI38-1]
XP_011525721.1, XM_011527419.2 [Q8NI38-2]
XP_016882880.1, XM_017027391.1 [Q8NI38-1]
XP_016882881.1, XM_017027392.1 [Q8NI38-1]
XP_016882882.1, XM_017027393.1 [Q8NI38-1]
UniGeneiHs.466531

3D structure databases

ProteinModelPortaliQ8NI38
SMRiQ8NI38
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124269, 8 interactors
IntActiQ8NI38, 104 interactors
MINTiQ8NI38
STRINGi9606.ENSP00000380109

PTM databases

iPTMnetiQ8NI38
PhosphoSitePlusiQ8NI38

Polymorphism and mutation databases

BioMutaiNFKBID
DMDMi74751323

Proteomic databases

EPDiQ8NI38
MaxQBiQ8NI38
PaxDbiQ8NI38
PeptideAtlasiQ8NI38
PRIDEiQ8NI38
ProteomicsDBi73829
73830 [Q8NI38-2]
73831 [Q8NI38-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000396901; ENSP00000380109; ENSG00000167604 [Q8NI38-1]
ENST00000606253; ENSP00000475712; ENSG00000167604 [Q8NI38-2]
GeneIDi84807
KEGGihsa:84807
UCSCiuc002oci.1 human [Q8NI38-1]

Organism-specific databases

CTDi84807
EuPathDBiHostDB:ENSG00000167604.13
GeneCardsiNFKBID
H-InvDBiHIX0202751
HGNCiHGNC:15671 NFKBID
HPAiHPA043573
neXtProtiNX_Q8NI38
OpenTargetsiENSG00000167604
PharmGKBiPA162397453
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00550000074527
HOGENOMiHOG000113021
HOVERGENiHBG098212
InParanoidiQ8NI38
KOiK14214
OMAiHMAAGLH
OrthoDBiEOG091G06D9
PhylomeDBiQ8NI38
TreeFamiTF330224

Miscellaneous databases

ChiTaRSiNFKBID human
GenomeRNAii84807
PROiPR:Q8NI38

Gene expression databases

BgeeiENSG00000167604 Expressed in 113 organ(s), highest expression level in blood
CleanExiHS_NFKBID
ExpressionAtlasiQ8NI38 baseline and differential
GenevisibleiQ8NI38 HS

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
PfamiView protein in Pfam
PF00023 Ank, 1 hit
PF12796 Ank_2, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 5 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiIKBD_HUMAN
AccessioniPrimary (citable) accession number: Q8NI38
Secondary accession number(s): Q8NI39, Q9BRG9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: October 1, 2002
Last modified: September 12, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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