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Entry version 140 (12 Aug 2020)
Sequence version 1 (01 Oct 2002)
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Protein

NF-kappa-B inhibitor delta

Gene

NFKBID

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulates the expression of IL-2, IL-6, and other cytokines through regulation on NF-kappa-B activity. Functions in the regulation of inflammatory responses. Involved in the induction of T helper 17 cells (Th17) differentiation upon recognition of antigen by T cell antigen receptor (TCR). May also regulate TCR-induced negative selection of thymocytes.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processInflammatory response

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8NI38

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
NF-kappa-B inhibitor delta
Alternative name(s):
I-kappa-B-delta
Short name:
IkB-delta
Short name:
IkappaBdelta
IkappaBNS
T-cell activation NFKB-like protein
TA-NFKBH
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NFKBID
Synonyms:IKBNS
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000167604.13

Human Gene Nomenclature Database

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HGNCi
HGNC:15671, NFKBID

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q8NI38

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

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OpenTargetsi
ENSG00000167604

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA162397453

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
Q8NI38, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
NFKBID

Domain mapping of disease mutations (DMDM)

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DMDMi
74751323

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003311141 – 313NF-kappa-B inhibitor deltaAdd BLAST313

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q8NI38

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8NI38

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q8NI38

PeptideAtlas

More...
PeptideAtlasi
Q8NI38

PRoteomics IDEntifications database

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PRIDEi
Q8NI38

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
73829 [Q8NI38-1]
73830 [Q8NI38-2]
73831 [Q8NI38-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8NI38

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8NI38

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000167604, Expressed in blood and 136 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q8NI38, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q8NI38, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000167604, Tissue enhanced (bone)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with NFKB1, RELA and RELB; in the nucleus.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q8NI38
With#Exp.IntAct
ADAMTSL4 - isoform 3 [Q6UY14-3]3EBI-10271199,EBI-10173507
ANXA11 [P50995]3EBI-10271199,EBI-715243
ARHGEF2 [Q92974]3EBI-10271199,EBI-302405
BEX2 [Q9BXY8]3EBI-10271199,EBI-745073
C12orf66 [J3KNH0]3EBI-10271199,EBI-17269253
C1orf109 [Q9NX04]3EBI-10271199,EBI-8643161
C1orf94 [Q6P1W5]7EBI-10271199,EBI-946029
C4orf45 [Q96LM5]3EBI-10271199,EBI-12020542
CCDC36 [Q8IYA8]3EBI-10271199,EBI-8638439
CCHCR1 - isoform 3 [Q8TD31-3]3EBI-10271199,EBI-10175300
CRYBA2 [P53672]3EBI-10271199,EBI-750444
CTRC [Q99895]3EBI-10271199,EBI-10295404
CYB5R2 - isoform 2 [Q6BCY4-2]3EBI-10271199,EBI-12102608
DDX25 [Q9UHL0]3EBI-10271199,EBI-8787165
DMRT3 [Q9NQL9]3EBI-10271199,EBI-9679045
DTX3 [Q8N9I9]3EBI-10271199,EBI-2340258
EFHC2 [Q5JST6]3EBI-10271199,EBI-2349927
ELOA [Q14241]3EBI-10271199,EBI-742350
ESR2 - isoform 3 [Q92731-3]3EBI-10271199,EBI-12259414
FAAP20 - isoform 4 [Q6NZ36-4]6EBI-10271199,EBI-12013806
FAM107A - isoform 4 [O95990-4]3EBI-10271199,EBI-11977223
FARS2 [O95363]3EBI-10271199,EBI-2513774
FOXI1 - isoform 2 [Q12951-2]3EBI-10271199,EBI-12018822
GADD45GIP1 [Q8TAE8]3EBI-10271199,EBI-372506
GFAP [P14136]3EBI-10271199,EBI-744302
GIGYF1 [O75420]3EBI-10271199,EBI-947774
GLYCTK [Q8IVS8]3EBI-10271199,EBI-748515
GPANK1 [O95872]3EBI-10271199,EBI-751540
GRB10 - isoform 4 [Q13322-4]3EBI-10271199,EBI-12353035
HDAC4 - isoform 2 [P56524-2]3EBI-10271199,EBI-11953488
HNRNPF [P52597]3EBI-10271199,EBI-352986
HNRNPH1 [P31943]3EBI-10271199,EBI-351590
HOXA1 [P49639]3EBI-10271199,EBI-740785
HOXB5 [P09067]3EBI-10271199,EBI-3893317
HOXC8 [P31273]3EBI-10271199,EBI-1752118
HOXC9 [P31274]3EBI-10271199,EBI-1779423
HOXD3 [P31249]3EBI-10271199,EBI-3957655
HSBP1L1 [C9JCN9]3EBI-10271199,EBI-2685549
IKZF3 [Q9UKT9]3EBI-10271199,EBI-747204
INCA1 [Q0VD86]3EBI-10271199,EBI-6509505
IRX6 [P78412]3EBI-10271199,EBI-12100506
KRT19 [P08727]3EBI-10271199,EBI-742756
KRT34 [O76011]3EBI-10271199,EBI-1047093
KRT40 [Q6A162]3EBI-10271199,EBI-10171697
KRT75 [O95678]6EBI-10271199,EBI-2949715
KRT76 [Q01546]3EBI-10271199,EBI-2952745
KRTAP6-2 [Q3LI66]3EBI-10271199,EBI-11962084
LCK - isoform 3 [P06239-3]3EBI-10271199,EBI-13287659
LGALS14 [Q8TCE9]3EBI-10271199,EBI-10274069
LHX3 - isoform B [Q9UBR4-2]3EBI-10271199,EBI-12039345
LMO2 - isoform 3 [P25791-3]3EBI-10271199,EBI-11959475
LMO3 - isoform 4 [Q8TAP4-4]3EBI-10271199,EBI-11742507
LMO4 [P61968]3EBI-10271199,EBI-2798728
MEOX2 [Q6FHY5]3EBI-10271199,EBI-16439278
MRPL28 [Q13084]3EBI-10271199,EBI-723426
MRPL53 [Q96EL3]3EBI-10271199,EBI-2513715
MYEF2 - isoform 2 [Q9P2K5-2]3EBI-10271199,EBI-10318831
NCK2 [O43639]3EBI-10271199,EBI-713635
NDUFB7 [P17568]3EBI-10271199,EBI-1246238
NICN1 [Q9BSH3]3EBI-10271199,EBI-13324229
NUP54 [Q7Z3B4]3EBI-10271199,EBI-741048
PATL1 [Q86TB9]3EBI-10271199,EBI-2562092
PATZ1 - isoform 4 [Q9HBE1-4]3EBI-10271199,EBI-11022007
PAX6 [P26367]3EBI-10271199,EBI-747278
PKP1 - isoform 1 [Q13835-2]3EBI-10271199,EBI-9087684
PLEKHN1 - isoform 3 [Q494U1-3]3EBI-10271199,EBI-12014286
POMC [P01189]3EBI-10271199,EBI-12219503
POU4F2 [Q12837]3EBI-10271199,EBI-17236143
PRDM6 [Q9NQX0]3EBI-10271199,EBI-11320284
PRMT7 [Q9NVM4]3EBI-10271199,EBI-3215577
PSMB8 - isoform 2 [P28062-2]3EBI-10271199,EBI-372312
PTCD1 [O75127]3EBI-10271199,EBI-2560233
QARS1 [P47897]3EBI-10271199,EBI-347462
RAD51D [O75771]3EBI-10271199,EBI-1055693
RBM14 [Q96PK6]3EBI-10271199,EBI-954272
RBM41 [Q96IZ5]3EBI-10271199,EBI-740773
RBM4B [Q9BQ04]3EBI-10271199,EBI-715531
RFX2 [P48378]3EBI-10271199,EBI-746731
RING1 [Q06587]3EBI-10271199,EBI-752313
RTP5 [Q14D33]3EBI-10271199,EBI-10217913
RUNX1 - isoform AML-1G [Q01196-8]3EBI-10271199,EBI-12001422
SAMD11 [Q96NU1]3EBI-10271199,EBI-14067109
SAMD4A - isoform 3 [Q9UPU9-3]3EBI-10271199,EBI-11986417
SCNM1 [Q9BWG6]3EBI-10271199,EBI-748391
SH2D1B [O14796]3EBI-10271199,EBI-3923013
SLU7 [O95391]3EBI-10271199,EBI-750559
SMAD4 [Q13485]3EBI-10271199,EBI-347263
SMG9 [Q9H0W8]3EBI-10271199,EBI-2872322
SNAPC3 [Q92966]6EBI-10271199,EBI-1760638
SORBS3 [O60504]3EBI-10271199,EBI-741237
SS18 [Q4VAX2]3EBI-10271199,EBI-10271195
TCF19 [Q9Y242]3EBI-10271199,EBI-7413767
TCF4 - isoform SEF2-1D [P15884-3]3EBI-10271199,EBI-13636688
TCL1A [P56279]3EBI-10271199,EBI-749995
TEKT4 [Q8WW24]3EBI-10271199,EBI-750487
TEKT5 [Q96M29]3EBI-10271199,EBI-10239812
TFIP11 [Q9UBB9]3EBI-10271199,EBI-1105213
TRAF2 [Q12933]3EBI-10271199,EBI-355744
TRIM29 [Q14134]3EBI-10271199,EBI-702370
TRIM9 [Q9C026]3EBI-10271199,EBI-720828
TRIML2 [Q8N7C3]3EBI-10271199,EBI-11059915
TSEN54 [Q7Z6J9]3EBI-10271199,EBI-2559824
TSSK3 [Q96PN8]3EBI-10271199,EBI-3918381
UTP23 [Q9BRU9]3EBI-10271199,EBI-5457544
VIM [P08670]3EBI-10271199,EBI-353844
ZBTB16 [Q05516]3EBI-10271199,EBI-711925
ZC2HC1B [Q5TFG8]3EBI-10271199,EBI-12275374
ZIC1 [Q15915]3EBI-10271199,EBI-11963196

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
124269, 8 interactors

Protein interaction database and analysis system

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IntActi
Q8NI38, 114 interactors

Molecular INTeraction database

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MINTi
Q8NI38

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000380109

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8NI38, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8NI38

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati48 – 83ANK 1Add BLAST36
Repeati84 – 113ANK 2Add BLAST30
Repeati117 – 146ANK 3Add BLAST30
Repeati152 – 201ANK 4Add BLAST50
Repeati206 – 236ANK 5Add BLAST31
Repeati243 – 276ANK 6Add BLAST34

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NF-kappa-B inhibitor family.Curated

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0504, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000153695

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_046801_0_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8NI38

KEGG Orthology (KO)

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KOi
K14214

Identification of Orthologs from Complete Genome Data

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OMAi
NACDVNG

Database of Orthologous Groups

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OrthoDBi
964992at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q8NI38

TreeFam database of animal gene trees

More...
TreeFami
TF330224

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.25.40.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796, Ank_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248, ANK, 5 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF48403, SSF48403, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8NI38-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEAGPWRVSA PPSGPPQFPA VVPGPSLEVA RAHMLALGPQ QLLAQDEEGD
60 70 80 90 100
TLLHLFAARG LRWAAYAAAE VLQVYRRLDI REHKGKTPLL VAAAANQPLI
110 120 130 140 150
VEDLLNLGAE PNAADHQGRS VLHVAATYGL PGVLLAVLNS GVQVDLEARD
160 170 180 190 200
FEGLTPLHTA ILALNVAMRP SDLCPRVLST QARDRLDCVH MLLQMGANHT
210 220 230 240 250
SQEIKSNKTV LHLAVQAANP TLVQLLLELP RGDLRTFVNM KAHGNTALHM
260 270 280 290 300
AAALPPGPAQ EAIVRHLLAA GADPTLRNLE NEQPVHLLRP GPGPEGLRQL
310
LKRSRVAPPG LSS
Length:313
Mass (Da):33,481
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB986234830428320
GO
Isoform 2 (identifier: Q8NI38-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MWVCLRGILD...GQPCPFPQGM

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Length:465
Mass (Da):50,297
Checksum:i710CB1235A2AEF3E
GO
Isoform 3 (identifier: Q8NI38-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-201: Missing.
     202-202: Q → MRSCCVVQAGLQLLASSDPPSSASQSARITGVNHRTPPR

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Length:150
Mass (Da):15,921
Checksum:iEBB4EDF1D8CCCBCC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EKM2K7EKM2_HUMAN
NF-kappa-B inhibitor delta
NFKBID
292Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A286YF31A0A286YF31_HUMAN
NF-kappa-B inhibitor delta
NFKBID
455Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ENW9K7ENW9_HUMAN
NF-kappa-B inhibitor delta
NFKBID
65Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04273729V → A. Corresponds to variant dbSNP:rs8113704Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0331431 – 201Missing in isoform 3. 1 PublicationAdd BLAST201
Alternative sequenceiVSP_0331441M → MWVCLRGILDSQAFWHETLR RWECLLAEMKVSRGERSHCP TQTVKKLLEEQRRRQQQQPD AGGVQGQFLPPPEQPLTPSV NEAVTGHPPFPAHSETVGSG PSSLGFPDWDPNTHAAYTDS PYSCPASAAENFLPPDFYPP SDPGQPCPFPQGM in isoform 2. 1 Publication1
Alternative sequenceiVSP_033145202Q → MRSCCVVQAGLQLLASSDPP SSASQSARITGVNHRTPPR in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF385433 mRNA Translation: AAM43834.1
AF385434 mRNA Translation: AAM43835.1
BC006273 mRNA Translation: AAH06273.1
BC119646 mRNA Translation: AAI19647.1
BC119647 mRNA Translation: AAI19648.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS42552.1 [Q8NI38-1]

NCBI Reference Sequences

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RefSeqi
NP_640332.1, NM_139239.2 [Q8NI38-1]
XP_011525721.1, XM_011527419.2
XP_016882880.1, XM_017027391.1 [Q8NI38-1]
XP_016882881.1, XM_017027392.1 [Q8NI38-1]
XP_016882882.1, XM_017027393.1 [Q8NI38-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000396901; ENSP00000380109; ENSG00000167604 [Q8NI38-1]
ENST00000606253; ENSP00000475712; ENSG00000167604 [Q8NI38-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
84807

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:84807

UCSC genome browser

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UCSCi
uc002oci.1, human [Q8NI38-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF385433 mRNA Translation: AAM43834.1
AF385434 mRNA Translation: AAM43835.1
BC006273 mRNA Translation: AAH06273.1
BC119646 mRNA Translation: AAI19647.1
BC119647 mRNA Translation: AAI19648.1
CCDSiCCDS42552.1 [Q8NI38-1]
RefSeqiNP_640332.1, NM_139239.2 [Q8NI38-1]
XP_011525721.1, XM_011527419.2
XP_016882880.1, XM_017027391.1 [Q8NI38-1]
XP_016882881.1, XM_017027392.1 [Q8NI38-1]
XP_016882882.1, XM_017027393.1 [Q8NI38-1]

3D structure databases

SMRiQ8NI38
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi124269, 8 interactors
IntActiQ8NI38, 114 interactors
MINTiQ8NI38
STRINGi9606.ENSP00000380109

PTM databases

iPTMnetiQ8NI38
PhosphoSitePlusiQ8NI38

Polymorphism and mutation databases

BioMutaiNFKBID
DMDMi74751323

Proteomic databases

EPDiQ8NI38
MaxQBiQ8NI38
PaxDbiQ8NI38
PeptideAtlasiQ8NI38
PRIDEiQ8NI38
ProteomicsDBi73829 [Q8NI38-1]
73830 [Q8NI38-2]
73831 [Q8NI38-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
48023, 142 antibodies

Genome annotation databases

EnsembliENST00000396901; ENSP00000380109; ENSG00000167604 [Q8NI38-1]
ENST00000606253; ENSP00000475712; ENSG00000167604 [Q8NI38-2]
GeneIDi84807
KEGGihsa:84807
UCSCiuc002oci.1, human [Q8NI38-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
84807
EuPathDBiHostDB:ENSG00000167604.13

GeneCards: human genes, protein and diseases

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GeneCardsi
NFKBID
HGNCiHGNC:15671, NFKBID
HPAiENSG00000167604, Tissue enhanced (bone)
neXtProtiNX_Q8NI38
OpenTargetsiENSG00000167604
PharmGKBiPA162397453

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0504, Eukaryota
GeneTreeiENSGT00940000153695
HOGENOMiCLU_046801_0_0_1
InParanoidiQ8NI38
KOiK14214
OMAiNACDVNG
OrthoDBi964992at2759
PhylomeDBiQ8NI38
TreeFamiTF330224

Enzyme and pathway databases

PathwayCommonsiQ8NI38

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
84807, 3 hits in 874 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
NFKBID, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
84807
PharosiQ8NI38, Tbio

Protein Ontology

More...
PROi
PR:Q8NI38
RNActiQ8NI38, protein

Gene expression databases

BgeeiENSG00000167604, Expressed in blood and 136 other tissues
ExpressionAtlasiQ8NI38, baseline and differential
GenevisibleiQ8NI38, HS

Family and domain databases

Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
PfamiView protein in Pfam
PF12796, Ank_2, 1 hit
SMARTiView protein in SMART
SM00248, ANK, 5 hits
SUPFAMiSSF48403, SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIKBD_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NI38
Secondary accession number(s): Q8NI39, Q9BRG9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: October 1, 2002
Last modified: August 12, 2020
This is version 140 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families
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