UniProtKB - Q8NI38 (IKBD_HUMAN)
Protein
NF-kappa-B inhibitor delta
Gene
NFKBID
Organism
Homo sapiens (Human)
Status
Functioni
Regulates the expression of IL-2, IL-6, and other cytokines through regulation on NF-kappa-B activity. Functions in the regulation of inflammatory responses. Involved in the induction of T helper 17 cells (Th17) differentiation upon recognition of antigen by T cell antigen receptor (TCR). May also regulate TCR-induced negative selection of thymocytes.By similarity
GO - Molecular functioni
- NF-kappaB binding Source: Ensembl
GO - Biological processi
- inflammatory response Source: UniProtKB-KW
- negative regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
- negative regulation of NF-kappaB transcription factor activity Source: Ensembl
- negative regulation of T cell differentiation in thymus Source: Ensembl
- positive regulation of T-helper 17 cell differentiation Source: UniProtKB
- positive regulation of thymocyte apoptotic process Source: Ensembl
- regulation of transcription by RNA polymerase II Source: GO_Central
- T cell receptor signaling pathway Source: UniProtKB
Keywordsi
| Biological process | Inflammatory response |
Enzyme and pathway databases
| PathwayCommonsi | Q8NI38 |
Names & Taxonomyi
| Protein namesi | Recommended name: NF-kappa-B inhibitor deltaAlternative name(s): I-kappa-B-delta Short name: IkB-delta Short name: IkappaBdelta IkappaBNS T-cell activation NFKB-like protein TA-NFKBH |
| Gene namesi | Name:NFKBID Synonyms:IKBNS |
| Organismi | Homo sapiens (Human) |
| Taxonomic identifieri | 9606 [NCBI] |
| Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
| Proteomesi |
|
Organism-specific databases
| EuPathDBi | HostDB:ENSG00000167604.13 |
| HGNCi | HGNC:15671, NFKBID |
| neXtProti | NX_Q8NI38 |
Subcellular locationi
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
| OpenTargetsi | ENSG00000167604 |
| PharmGKBi | PA162397453 |
Miscellaneous databases
| Pharosi | Q8NI38, Tbio |
Polymorphism and mutation databases
| BioMutai | NFKBID |
| DMDMi | 74751323 |
PTM / Processingi
Molecule processing
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| ChainiPRO_0000331114 | 1 – 313 | NF-kappa-B inhibitor deltaAdd BLAST | 313 |
Proteomic databases
| EPDi | Q8NI38 |
| MaxQBi | Q8NI38 |
| PaxDbi | Q8NI38 |
| PeptideAtlasi | Q8NI38 |
| PRIDEi | Q8NI38 |
| ProteomicsDBi | 73829 [Q8NI38-1] 73830 [Q8NI38-2] 73831 [Q8NI38-3] |
PTM databases
| iPTMneti | Q8NI38 |
| PhosphoSitePlusi | Q8NI38 |
Expressioni
Gene expression databases
| Bgeei | ENSG00000167604, Expressed in blood and 136 other tissues |
| ExpressionAtlasi | Q8NI38, baseline and differential |
| Genevisiblei | Q8NI38, HS |
Organism-specific databases
| HPAi | ENSG00000167604, Tissue enhanced (bone) |
Interactioni
Subunit structurei
Interacts with NFKB1, RELA and RELB; in the nucleus.
By similarityBinary interactionsi
Q8NI38
GO - Molecular functioni
- NF-kappaB binding Source: Ensembl
Protein-protein interaction databases
| BioGRIDi | 124269, 8 interactors |
| IntActi | Q8NI38, 114 interactors |
| MINTi | Q8NI38 |
| STRINGi | 9606.ENSP00000380109 |
Miscellaneous databases
| RNActi | Q8NI38, protein |
Family & Domainsi
Domains and Repeats
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Repeati | 48 – 83 | ANK 1Add BLAST | 36 | |
| Repeati | 84 – 113 | ANK 2Add BLAST | 30 | |
| Repeati | 117 – 146 | ANK 3Add BLAST | 30 | |
| Repeati | 152 – 201 | ANK 4Add BLAST | 50 | |
| Repeati | 206 – 236 | ANK 5Add BLAST | 31 | |
| Repeati | 243 – 276 | ANK 6Add BLAST | 34 |
Sequence similaritiesi
Belongs to the NF-kappa-B inhibitor family.Curated
Keywords - Domaini
ANK repeat, RepeatPhylogenomic databases
| eggNOGi | KOG0504, Eukaryota |
| GeneTreei | ENSGT00940000153695 |
| HOGENOMi | CLU_046801_0_0_1 |
| InParanoidi | Q8NI38 |
| KOi | K14214 |
| OMAi | NACDVNG |
| OrthoDBi | 964992at2759 |
| PhylomeDBi | Q8NI38 |
| TreeFami | TF330224 |
Family and domain databases
| Gene3Di | 1.25.40.20, 1 hit |
| InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf |
| Pfami | View protein in Pfam PF12796, Ank_2, 1 hit |
| SMARTi | View protein in SMART SM00248, ANK, 5 hits |
| SUPFAMi | SSF48403, SSF48403, 1 hit |
| PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 3 hits |
Sequences (3+)i
Sequence statusi: Complete.
This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8NI38-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MEAGPWRVSA PPSGPPQFPA VVPGPSLEVA RAHMLALGPQ QLLAQDEEGD
60 70 80 90 100
TLLHLFAARG LRWAAYAAAE VLQVYRRLDI REHKGKTPLL VAAAANQPLI
110 120 130 140 150
VEDLLNLGAE PNAADHQGRS VLHVAATYGL PGVLLAVLNS GVQVDLEARD
160 170 180 190 200
FEGLTPLHTA ILALNVAMRP SDLCPRVLST QARDRLDCVH MLLQMGANHT
210 220 230 240 250
SQEIKSNKTV LHLAVQAANP TLVQLLLELP RGDLRTFVNM KAHGNTALHM
260 270 280 290 300
AAALPPGPAQ EAIVRHLLAA GADPTLRNLE NEQPVHLLRP GPGPEGLRQL
310
LKRSRVAPPG LSS
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket| K7EKM2 | K7EKM2_HUMAN | NF-kappa-B inhibitor delta | NFKBID | 292 | Annotation score: | ||
| A0A286YF31 | A0A286YF31_HUMAN | NF-kappa-B inhibitor delta | NFKBID | 455 | Annotation score: | ||
| K7ENW9 | K7ENW9_HUMAN | NF-kappa-B inhibitor delta | NFKBID | 65 | Annotation score: |
Natural variant
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Natural variantiVAR_042737 | 29 | V → A. Corresponds to variant dbSNP:rs8113704Ensembl. | 1 |
Alternative sequence
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Alternative sequenceiVSP_033143 | 1 – 201 | Missing in isoform 3. 1 PublicationAdd BLAST | 201 | |
| Alternative sequenceiVSP_033144 | 1 | M → MWVCLRGILDSQAFWHETLR RWECLLAEMKVSRGERSHCP TQTVKKLLEEQRRRQQQQPD AGGVQGQFLPPPEQPLTPSV NEAVTGHPPFPAHSETVGSG PSSLGFPDWDPNTHAAYTDS PYSCPASAAENFLPPDFYPP SDPGQPCPFPQGM in isoform 2. 1 Publication | 1 | |
| Alternative sequenceiVSP_033145 | 202 | Q → MRSCCVVQAGLQLLASSDPP SSASQSARITGVNHRTPPR in isoform 3. 1 Publication | 1 |
Sequence databases
| Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF385433 mRNA Translation: AAM43834.1 AF385434 mRNA Translation: AAM43835.1 BC006273 mRNA Translation: AAH06273.1 BC119646 mRNA Translation: AAI19647.1 BC119647 mRNA Translation: AAI19648.1 |
| CCDSi | CCDS42552.1 [Q8NI38-1] |
| RefSeqi | NP_640332.1, NM_139239.2 [Q8NI38-1] XP_011525721.1, XM_011527419.2 XP_016882880.1, XM_017027391.1 [Q8NI38-1] XP_016882881.1, XM_017027392.1 [Q8NI38-1] XP_016882882.1, XM_017027393.1 [Q8NI38-1] |
Genome annotation databases
| Ensembli | ENST00000396901; ENSP00000380109; ENSG00000167604 [Q8NI38-1] ENST00000606253; ENSP00000475712; ENSG00000167604 [Q8NI38-2] |
| GeneIDi | 84807 |
| KEGGi | hsa:84807 |
| UCSCi | uc002oci.1, human [Q8NI38-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
| Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF385433 mRNA Translation: AAM43834.1 AF385434 mRNA Translation: AAM43835.1 BC006273 mRNA Translation: AAH06273.1 BC119646 mRNA Translation: AAI19647.1 BC119647 mRNA Translation: AAI19648.1 |
| CCDSi | CCDS42552.1 [Q8NI38-1] |
| RefSeqi | NP_640332.1, NM_139239.2 [Q8NI38-1] XP_011525721.1, XM_011527419.2 XP_016882880.1, XM_017027391.1 [Q8NI38-1] XP_016882881.1, XM_017027392.1 [Q8NI38-1] XP_016882882.1, XM_017027393.1 [Q8NI38-1] |
3D structure databases
| SMRi | Q8NI38 |
| ModBasei | Search... |
Protein-protein interaction databases
| BioGRIDi | 124269, 8 interactors |
| IntActi | Q8NI38, 114 interactors |
| MINTi | Q8NI38 |
| STRINGi | 9606.ENSP00000380109 |
PTM databases
| iPTMneti | Q8NI38 |
| PhosphoSitePlusi | Q8NI38 |
Polymorphism and mutation databases
| BioMutai | NFKBID |
| DMDMi | 74751323 |
Proteomic databases
| EPDi | Q8NI38 |
| MaxQBi | Q8NI38 |
| PaxDbi | Q8NI38 |
| PeptideAtlasi | Q8NI38 |
| PRIDEi | Q8NI38 |
| ProteomicsDBi | 73829 [Q8NI38-1] 73830 [Q8NI38-2] 73831 [Q8NI38-3] |
Protocols and materials databases
| Antibodypediai | 48023, 142 antibodies |
Genome annotation databases
| Ensembli | ENST00000396901; ENSP00000380109; ENSG00000167604 [Q8NI38-1] ENST00000606253; ENSP00000475712; ENSG00000167604 [Q8NI38-2] |
| GeneIDi | 84807 |
| KEGGi | hsa:84807 |
| UCSCi | uc002oci.1, human [Q8NI38-1] |
Organism-specific databases
| CTDi | 84807 |
| EuPathDBi | HostDB:ENSG00000167604.13 |
| GeneCardsi | NFKBID |
| HGNCi | HGNC:15671, NFKBID |
| HPAi | ENSG00000167604, Tissue enhanced (bone) |
| neXtProti | NX_Q8NI38 |
| OpenTargetsi | ENSG00000167604 |
| PharmGKBi | PA162397453 |
| GenAtlasi | Search... |
Phylogenomic databases
| eggNOGi | KOG0504, Eukaryota |
| GeneTreei | ENSGT00940000153695 |
| HOGENOMi | CLU_046801_0_0_1 |
| InParanoidi | Q8NI38 |
| KOi | K14214 |
| OMAi | NACDVNG |
| OrthoDBi | 964992at2759 |
| PhylomeDBi | Q8NI38 |
| TreeFami | TF330224 |
Enzyme and pathway databases
| PathwayCommonsi | Q8NI38 |
Miscellaneous databases
| BioGRID-ORCSi | 84807, 3 hits in 874 CRISPR screens |
| ChiTaRSi | NFKBID, human |
| GenomeRNAii | 84807 |
| Pharosi | Q8NI38, Tbio |
| PROi | PR:Q8NI38 |
| RNActi | Q8NI38, protein |
Gene expression databases
| Bgeei | ENSG00000167604, Expressed in blood and 136 other tissues |
| ExpressionAtlasi | Q8NI38, baseline and differential |
| Genevisiblei | Q8NI38, HS |
Family and domain databases
| Gene3Di | 1.25.40.20, 1 hit |
| InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf |
| Pfami | View protein in Pfam PF12796, Ank_2, 1 hit |
| SMARTi | View protein in SMART SM00248, ANK, 5 hits |
| SUPFAMi | SSF48403, SSF48403, 1 hit |
| PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 3 hits |
| ProtoNeti | Search... |
| MobiDBi | Search... |
Entry informationi
| Entry namei | IKBD_HUMAN | |
| Accessioni | Q8NI38Primary (citable) accession number: Q8NI38 Secondary accession number(s): Q8NI39, Q9BRG9 | |
| Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 29, 2008 |
| Last sequence update: | October 1, 2002 | |
| Last modified: | August 12, 2020 | |
| This is version 140 of the entry and version 1 of the sequence. See complete history. | ||
| Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
| Annotation program | Chordata Protein Annotation Program | |
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - SIMILARITY comments
Index of protein domains and families
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