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UniProtKB - Q8NI37 (PPTC7_HUMAN)

Entry version 132 (11 Dec 2019)
Sequence version 1 (01 Oct 2002)
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Protein

Protein phosphatase PTC7 homolog

Gene

PPTC7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Protein phosphatase which positively regulates biosynthesis of the ubiquinone, coenzyme Q (PubMed:30267671). Dephosphorylates the ubiquinone biosynthesis protein COQ7 which is likely to lead to its activation (PubMed:30267671).1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+1 Publication, Mn2+1 PublicationNote: Binds 2 magnesium or manganese ions per subunit.PROSITE-ProRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by sodium orthovanadate.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi78Manganese 1By similarity1
Metal bindingi78Manganese 2By similarity1
Metal bindingi79Manganese 1; via carbonyl oxygenBy similarity1
Metal bindingi223Manganese 2By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protein phosphatase
LigandMagnesium, Manganese, Metal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein phosphatase PTC7 homolog (EC:3.1.3.16PROSITE-ProRule annotation1 Publication)
Alternative name(s):
T-cell activation protein phosphatase 2C
Short name:
TA-PP2C
T-cell activation protein phosphatase 2C-like
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PPTC7
Synonyms:TAPP2C
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000196850.5

Human Gene Nomenclature Database

More...HGNCi		HGNC:30695 PPTC7

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		609668 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8NI37

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		160760

Open Targets

More...OpenTargetsi		ENSG00000196850

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA143485580

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8NI37 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PPTC7

Domain mapping of disease mutations (DMDM)

More...DMDMi		74715714

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 68MitochondrionSequence analysisAdd BLAST68
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000032874569 – 304Protein phosphatase PTC7 homologAdd BLAST236

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8NI37

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8NI37

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8NI37

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8NI37

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8NI37

PeptideAtlas

More...PeptideAtlasi		Q8NI37

PRoteomics IDEntifications database

More...PRIDEi		Q8NI37

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		73828

PTM databases

DEPOD human dephosphorylation database

More...DEPODi		Q8NI37

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8NI37

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8NI37

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in keratinocytes (at protein level).1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By hydrogen peroxide and nutrional stress (such as low glucose) (PubMed:30267671). Up-regulated during lymphocyte activation (PubMed:15177553).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000196850 Expressed in 210 organ(s), highest expression level in left ventricle myocardium

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8NI37 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA039335
HPA040614

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Q129837EBI-9089276,EBI-749464

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		127764, 42 interactors

Protein interaction database and analysis system

More...IntActi		Q8NI37, 45 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000346255

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8NI37 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8NI37

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini69 – 299PPM-type phosphatasePROSITE-ProRule annotationAdd BLAST231

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi17 – 87Gly-richPROSITE-ProRule annotationAdd BLAST71

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PP2C family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1379 Eukaryota
COG0631 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00390000011937

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000239282

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8NI37

KEGG Orthology (KO)

More...KOi		K17508

Identification of Orthologs from Complete Genome Data

More...OMAi		MQSIYWT

Database of Orthologous Groups

More...OrthoDBi		826926at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8NI37

TreeFam database of animal gene trees

More...TreeFami		TF315105

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.60.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR036457 PPM-type_dom_sf
IPR001932 PPM-type_phosphatase_dom
IPR039123 PPTC7

The PANTHER Classification System

More...PANTHERi		PTHR12320 PTHR12320, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF07228 SpoIIE, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00331 PP2C_SIG, 1 hit
SM00332 PP2Cc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF81606 SSF81606, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51746 PPM_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q8NI37-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFSVLSYGRL VARAVLGGLS QTDPRAGGGG GGDYGLVTAG CGFGKDFRKG 
        60         70         80         90        100
LLKKGACYGD DACFVARHRS ADVLGVADGV GGWRDYGVDP SQFSGTLMRT 
       110        120        130        140        150
CERLVKEGRF VPSNPIGILT TSYCELLQNK VPLLGSSTAC IVVLDRTSHR 
       160        170        180        190        200
LHTANLGDSG FLVVRGGEVV HRSDEQQHYF NTPFQLSIAP PEAEGVVLSD 
       210        220        230        240        250
SPDAADSTSF DVQLGDIILT ATDGLFDNMP DYMILQELKK LKNSNYESIQ 
       260        270        280        290        300
QTARSIAEQA HELAYDPNYM SPFAQFACDN GLNVRGGKPD DITVLLSIVA 

EYTD
Length:304
Mass (Da):32,646
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE27F2FAF8C44793B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti27Missing in AAQ57274 (Ref. 2) Curated1
Sequence conflicti124C → R in AAQ57274 (Ref. 2) Curated1
Sequence conflicti282L → S in CAH18073 (PubMed:17974005).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF385435 mRNA Translation: AAM43836.1
AY357944 mRNA Translation: AAQ57274.1
AK124744 mRNA Translation: BAG54087.1
CH471054 Genomic DNA Translation: EAW97928.1
BC111551 mRNA Translation: AAI11552.1
CR749216 mRNA Translation: CAH18073.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS9149.1

NCBI Reference Sequences

More...RefSeqi		NP_644812.1, NM_139283.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000354300; ENSP00000346255; ENSG00000196850

Database of genes from NCBI RefSeq genomes

More...GeneIDi		160760

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:160760

UCSC genome browser

More...UCSCi		uc001trh.2 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF385435 mRNA Translation: AAM43836.1
AY357944 mRNA Translation: AAQ57274.1
AK124744 mRNA Translation: BAG54087.1
CH471054 Genomic DNA Translation: EAW97928.1
BC111551 mRNA Translation: AAI11552.1
CR749216 mRNA Translation: CAH18073.1
CCDSiCCDS9149.1
RefSeqiNP_644812.1, NM_139283.1

3D structure databases

SMRiQ8NI37
ModBaseiSearch...

Protein-protein interaction databases

BioGridi127764, 42 interactors
IntActiQ8NI37, 45 interactors
STRINGi9606.ENSP00000346255

PTM databases

DEPODiQ8NI37
iPTMnetiQ8NI37
PhosphoSitePlusiQ8NI37

Polymorphism and mutation databases

BioMutaiPPTC7
DMDMi74715714

Proteomic databases

EPDiQ8NI37
jPOSTiQ8NI37
MassIVEiQ8NI37
MaxQBiQ8NI37
PaxDbiQ8NI37
PeptideAtlasiQ8NI37
PRIDEiQ8NI37
ProteomicsDBi73828

Genome annotation databases

EnsembliENST00000354300; ENSP00000346255; ENSG00000196850
GeneIDi160760
KEGGihsa:160760
UCSCiuc001trh.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		160760
DisGeNETi160760
EuPathDBiHostDB:ENSG00000196850.5

GeneCards: human genes, protein and diseases

More...GeneCardsi		PPTC7
HGNCiHGNC:30695 PPTC7
HPAiHPA039335
HPA040614
MIMi609668 gene
neXtProtiNX_Q8NI37
OpenTargetsiENSG00000196850
PharmGKBiPA143485580

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1379 Eukaryota
COG0631 LUCA
GeneTreeiENSGT00390000011937
HOGENOMiHOG000239282
InParanoidiQ8NI37
KOiK17508
OMAiMQSIYWT
OrthoDBi826926at2759
PhylomeDBiQ8NI37
TreeFamiTF315105

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		PPTC7 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		160760
PharosiQ8NI37 Tdark

Protein Ontology

More...PROi		PR:Q8NI37
RNActiQ8NI37 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000196850 Expressed in 210 organ(s), highest expression level in left ventricle myocardium
GenevisibleiQ8NI37 HS

Family and domain databases

Gene3Di3.60.40.10, 1 hit
InterProiView protein in InterPro
IPR036457 PPM-type_dom_sf
IPR001932 PPM-type_phosphatase_dom
IPR039123 PPTC7
PANTHERiPTHR12320 PTHR12320, 1 hit
PfamiView protein in Pfam
PF07228 SpoIIE, 1 hit
SMARTiView protein in SMART
SM00331 PP2C_SIG, 1 hit
SM00332 PP2Cc, 1 hit
SUPFAMiSSF81606 SSF81606, 1 hit
PROSITEiView protein in PROSITE
PS51746 PPM_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPPTC7_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NI37
Secondary accession number(s): B3KWC5, Q68DZ7, Q6UY82
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: October 1, 2002
Last modified: December 11, 2019
This is version 132 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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