PPTC7

Functionⁱ

Catalytic activityⁱ

[a protein]-serine/threonine phosphate + H₂O = [a protein]-serine/threonine + phosphate.

Cofactorⁱ

Mg²⁺Curated, Mn²⁺Curated

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	78	Manganese 1By similarity	1
Metal bindingⁱ	78	Manganese 2By similarity	1
Metal bindingⁱ	79	Manganese 1; via carbonyl oxygenBy similarity	1
Metal bindingⁱ	223	Manganese 2By similarity	1

GO - Molecular functionⁱ

metal ion binding Source: UniProtKB-KW
phosphoprotein phosphatase activity Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase, Protein phosphatase
Ligand	Magnesium, Manganese, Metal-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein phosphatase PTC7 homolog (EC:3.1.3.16) Alternative name(s): T-cell activation protein phosphatase 2C Short name: TA-PP2C T-cell activation protein phosphatase 2C-like
Gene namesⁱ	Name:PPTC7 Synonyms:TAPP2C
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000196850.5
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:30695 PPTC7
MIMⁱ	609668 gene
neXtProtⁱ	NX_Q8NI37

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	160760
Open Targets More...OpenTargetsⁱ	ENSG00000196850
PharmGKBⁱ	PA143485580

Polymorphism and mutation databases

BioMutaⁱ	PPTC7
DMDMⁱ	74715714

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000328745	1 – 304	Protein phosphatase PTC7 homologAdd BLAST		304

Proteomic databases

EPDⁱ	Q8NI37
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8NI37
PaxDbⁱ	Q8NI37
PeptideAtlas More...PeptideAtlasⁱ	Q8NI37
PRIDEⁱ	Q8NI37
ProteomicsDBⁱ	73828

PTM databases

DEPODⁱ	Q8NI37
iPTMnetⁱ	Q8NI37
PhosphoSitePlusⁱ	Q8NI37

Expressionⁱ

Inductionⁱ

Up-regulated during lymphocyte activation.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000196850 Expressed in 210 organ(s), highest expression level in left ventricle myocardium
CleanExⁱ	HS_PPTC7
Genevisibleⁱ	Q8NI37 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA039335 HPA040614

HPAⁱ

HPA039335
HPA040614

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	127764, 26 interactors
IntActⁱ	Q8NI37, 32 interactors
STRINGⁱ	9606.ENSP00000346255

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8NI37
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	33 – 299	PPM-type phosphatasePROSITE-ProRule annotationAdd BLAST		267

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	17 – 87	Gly-richAdd BLAST		71

Sequence similaritiesⁱ

Belongs to the PP2C family.Curated

Phylogenomic databases

eggNOGⁱ	KOG1379 Eukaryota COG0631 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000011937
HOGENOMⁱ	HOG000239282
HOVERGENⁱ	HBG060636
InParanoidⁱ	Q8NI37
KEGG Orthology (KO) More...KOⁱ	K17508
OMAⁱ	MQSIYWT
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0G5G
PhylomeDBⁱ	Q8NI37
TreeFamⁱ	TF315105

Family and domain databases

Gene3Dⁱ	3.60.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR036457 PPM-type_dom_sf IPR001932 PPM-type_phosphatase_dom IPR039123 PPTC7
PANTHERⁱ	PTHR12320 PTHR12320, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07228 SpoIIE, 1 hit
SMARTⁱ	View protein in SMART SM00331 PP2C_SIG, 1 hit SM00332 PP2Cc, 1 hit
SUPFAMⁱ	SSF81606 SSF81606, 1 hit
PROSITEⁱ	View protein in PROSITE PS51746 PPM_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q8NI37-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MFSVLSYGRL VARAVLGGLS QTDPRAGGGG GGDYGLVTAG CGFGKDFRKG 
        60         70         80         90        100
LLKKGACYGD DACFVARHRS ADVLGVADGV GGWRDYGVDP SQFSGTLMRT 
       110        120        130        140        150
CERLVKEGRF VPSNPIGILT TSYCELLQNK VPLLGSSTAC IVVLDRTSHR 
       160        170        180        190        200
LHTANLGDSG FLVVRGGEVV HRSDEQQHYF NTPFQLSIAP PEAEGVVLSD 
       210        220        230        240        250
SPDAADSTSF DVQLGDIILT ATDGLFDNMP DYMILQELKK LKNSNYESIQ 
       260        270        280        290        300
QTARSIAEQA HELAYDPNYM SPFAQFACDN GLNVRGGKPD DITVLLSIVA 

EYTD

Length:304

Mass (Da):32,646

Last modified:October 1, 2002 - v1

Checksum:ⁱE27F2FAF8C44793B

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	27	Missing in AAQ57274 (Ref. 2) Curated	1
Sequence conflictⁱ	124	C → R in AAQ57274 (Ref. 2) Curated	1
Sequence conflictⁱ	282	L → S in CAH18073 (PubMed:17974005).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF385435 mRNA Translation: AAM43836.1 AY357944 mRNA Translation: AAQ57274.1 AK124744 mRNA Translation: BAG54087.1 CH471054 Genomic DNA Translation: EAW97928.1 BC111551 mRNA Translation: AAI11552.1 CR749216 mRNA Translation: CAH18073.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS9149.1
NCBI Reference Sequences More...RefSeqⁱ	NP_644812.1, NM_139283.1
UniGeneⁱ	Hs.13854

Genome annotation databases

Ensemblⁱ	ENST00000354300; ENSP00000346255; ENSG00000196850
GeneIDⁱ	160760
KEGGⁱ	hsa:160760
UCSC genome browser More...UCSCⁱ	uc001trh.2 human

Protein	Similar proteins		Species	Score	Length	Source
Q8NI37	PPTC7 isoform 1		PANTR		304	UniRef100_Q8NI37
Protein phosphatase PTC7 homolog		CALJA		304
PPTC7 isoform 1		PONAB		304
protein phosphatase PTC7 homolog		Enhydra lutris kenyoni		304
Uncharacterized protein		FELCA		304
+6

Protein	Similar proteins		Species	Score	Length	Source
Q8NI37	Protein phosphatase PTC7 homolog		MOUSE		310	UniRef90_Q6NVE9
Uncharacterized protein		MONDO		314
Uncharacterized protein		SARHA		207
Uncharacterized protein		SHEEP		310
Uncharacterized protein		OTOGA		308
+74

Protein	Similar proteins		Species	Score	Length	Source
Q8NI37	Protein phosphatase PTC7 homolog		MOUSE		310	UniRef50_Q6NVE9
Protein phosphatase PTC7 homolog		XENLA		297
Protein phosphatase PTC7 homolog		DANRE		297
Uncharacterized protein		MONDO		314
Uncharacterized protein		SARHA		207
+281

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF385435 mRNA Translation: AAM43836.1 AY357944 mRNA Translation: AAQ57274.1 AK124744 mRNA Translation: BAG54087.1 CH471054 Genomic DNA Translation: EAW97928.1 BC111551 mRNA Translation: AAI11552.1 CR749216 mRNA Translation: CAH18073.1
CCDSⁱ	CCDS9149.1
RefSeqⁱ	NP_644812.1, NM_139283.1
UniGeneⁱ	Hs.13854

3D structure databases

ProteinModelPortalⁱ	Q8NI37
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	127764, 26 interactors
IntActⁱ	Q8NI37, 32 interactors
STRINGⁱ	9606.ENSP00000346255

PTM databases

DEPODⁱ	Q8NI37
iPTMnetⁱ	Q8NI37
PhosphoSitePlusⁱ	Q8NI37

Polymorphism and mutation databases

BioMutaⁱ	PPTC7
DMDMⁱ	74715714

Proteomic databases

EPDⁱ	Q8NI37
MaxQBⁱ	Q8NI37
PaxDbⁱ	Q8NI37
PeptideAtlasⁱ	Q8NI37
PRIDEⁱ	Q8NI37
ProteomicsDBⁱ	73828

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000354300; ENSP00000346255; ENSG00000196850
GeneIDⁱ	160760
KEGGⁱ	hsa:160760
UCSCⁱ	uc001trh.2 human

Organism-specific databases

CTDⁱ	160760
DisGeNETⁱ	160760
EuPathDBⁱ	HostDB:ENSG00000196850.5
GeneCardsⁱ	PPTC7
HGNCⁱ	HGNC:30695 PPTC7
HPAⁱ	HPA039335 HPA040614
MIMⁱ	609668 gene
neXtProtⁱ	NX_Q8NI37
OpenTargetsⁱ	ENSG00000196850
PharmGKBⁱ	PA143485580
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1379 Eukaryota COG0631 LUCA
GeneTreeⁱ	ENSGT00390000011937
HOGENOMⁱ	HOG000239282
HOVERGENⁱ	HBG060636
InParanoidⁱ	Q8NI37
KOⁱ	K17508
OMAⁱ	MQSIYWT
OrthoDBⁱ	EOG091G0G5G
PhylomeDBⁱ	Q8NI37
TreeFamⁱ	TF315105

Miscellaneous databases

ChiTaRSⁱ	PPTC7 human
GenomeRNAiⁱ	160760
Protein Ontology More...PROⁱ	PR:Q8NI37
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000196850 Expressed in 210 organ(s), highest expression level in left ventricle myocardium
CleanExⁱ	HS_PPTC7
Genevisibleⁱ	Q8NI37 HS

Family and domain databases

Gene3Dⁱ	3.60.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR036457 PPM-type_dom_sf IPR001932 PPM-type_phosphatase_dom IPR039123 PPTC7
PANTHERⁱ	PTHR12320 PTHR12320, 1 hit
Pfamⁱ	View protein in Pfam PF07228 SpoIIE, 1 hit
SMARTⁱ	View protein in SMART SM00331 PP2C_SIG, 1 hit SM00332 PP2Cc, 1 hit
SUPFAMⁱ	SSF81606 SSF81606, 1 hit
PROSITEⁱ	View protein in PROSITE PS51746 PPM_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PPTC7_HUMAN
Accessionⁱ	Q8NI37Primary (citable) accession number: Q8NI37 Secondary accession number(s): B3KWC5, Q68DZ7, Q6UY82
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
	Last sequence update:	October 1, 2002
	Last modified:	November 7, 2018
	This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8NI37 (PPTC7_HUMAN)

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Protein phosphatase PTC7 homolog

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ