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Protein

Protein phosphatase PTC7 homolog

Gene

PPTC7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+Curated, Mn2+Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi78Manganese 1By similarity1
Metal bindingi78Manganese 2By similarity1
Metal bindingi79Manganese 1; via carbonyl oxygenBy similarity1
Metal bindingi223Manganese 2By similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protein phosphatase
LigandMagnesium, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase PTC7 homolog (EC:3.1.3.16)
Alternative name(s):
T-cell activation protein phosphatase 2C
Short name:
TA-PP2C
T-cell activation protein phosphatase 2C-like
Gene namesi
Name:PPTC7
Synonyms:TAPP2C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000196850.5
HGNCiHGNC:30695 PPTC7
MIMi609668 gene
neXtProtiNX_Q8NI37

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi160760
OpenTargetsiENSG00000196850
PharmGKBiPA143485580

Polymorphism and mutation databases

BioMutaiPPTC7
DMDMi74715714

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003287451 – 304Protein phosphatase PTC7 homologAdd BLAST304

Proteomic databases

EPDiQ8NI37
MaxQBiQ8NI37
PaxDbiQ8NI37
PeptideAtlasiQ8NI37
PRIDEiQ8NI37
ProteomicsDBi73828

PTM databases

DEPODiQ8NI37
iPTMnetiQ8NI37
PhosphoSitePlusiQ8NI37

Expressioni

Inductioni

Up-regulated during lymphocyte activation.1 Publication

Gene expression databases

BgeeiENSG00000196850 Expressed in 210 organ(s), highest expression level in left ventricle myocardium
CleanExiHS_PPTC7
GenevisibleiQ8NI37 HS

Organism-specific databases

HPAiHPA039335
HPA040614

Interactioni

Protein-protein interaction databases

BioGridi127764, 26 interactors
IntActiQ8NI37, 32 interactors
STRINGi9606.ENSP00000346255

Structurei

3D structure databases

ProteinModelPortaliQ8NI37
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 299PPM-type phosphatasePROSITE-ProRule annotationAdd BLAST267

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi17 – 87Gly-richAdd BLAST71

Sequence similaritiesi

Belongs to the PP2C family.Curated

Phylogenomic databases

eggNOGiKOG1379 Eukaryota
COG0631 LUCA
GeneTreeiENSGT00390000011937
HOGENOMiHOG000239282
HOVERGENiHBG060636
InParanoidiQ8NI37
KOiK17508
OMAiMQSIYWT
OrthoDBiEOG091G0G5G
PhylomeDBiQ8NI37
TreeFamiTF315105

Family and domain databases

Gene3Di3.60.40.10, 1 hit
InterProiView protein in InterPro
IPR036457 PPM-type_dom_sf
IPR001932 PPM-type_phosphatase_dom
IPR039123 PPTC7
PANTHERiPTHR12320 PTHR12320, 1 hit
PfamiView protein in Pfam
PF07228 SpoIIE, 1 hit
SMARTiView protein in SMART
SM00331 PP2C_SIG, 1 hit
SM00332 PP2Cc, 1 hit
SUPFAMiSSF81606 SSF81606, 1 hit
PROSITEiView protein in PROSITE
PS51746 PPM_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NI37-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFSVLSYGRL VARAVLGGLS QTDPRAGGGG GGDYGLVTAG CGFGKDFRKG
60 70 80 90 100
LLKKGACYGD DACFVARHRS ADVLGVADGV GGWRDYGVDP SQFSGTLMRT
110 120 130 140 150
CERLVKEGRF VPSNPIGILT TSYCELLQNK VPLLGSSTAC IVVLDRTSHR
160 170 180 190 200
LHTANLGDSG FLVVRGGEVV HRSDEQQHYF NTPFQLSIAP PEAEGVVLSD
210 220 230 240 250
SPDAADSTSF DVQLGDIILT ATDGLFDNMP DYMILQELKK LKNSNYESIQ
260 270 280 290 300
QTARSIAEQA HELAYDPNYM SPFAQFACDN GLNVRGGKPD DITVLLSIVA

EYTD
Length:304
Mass (Da):32,646
Last modified:October 1, 2002 - v1
Checksum:iE27F2FAF8C44793B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti27Missing in AAQ57274 (Ref. 2) Curated1
Sequence conflicti124C → R in AAQ57274 (Ref. 2) Curated1
Sequence conflicti282L → S in CAH18073 (PubMed:17974005).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF385435 mRNA Translation: AAM43836.1
AY357944 mRNA Translation: AAQ57274.1
AK124744 mRNA Translation: BAG54087.1
CH471054 Genomic DNA Translation: EAW97928.1
BC111551 mRNA Translation: AAI11552.1
CR749216 mRNA Translation: CAH18073.1
CCDSiCCDS9149.1
RefSeqiNP_644812.1, NM_139283.1
UniGeneiHs.13854

Genome annotation databases

EnsembliENST00000354300; ENSP00000346255; ENSG00000196850
GeneIDi160760
KEGGihsa:160760
UCSCiuc001trh.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF385435 mRNA Translation: AAM43836.1
AY357944 mRNA Translation: AAQ57274.1
AK124744 mRNA Translation: BAG54087.1
CH471054 Genomic DNA Translation: EAW97928.1
BC111551 mRNA Translation: AAI11552.1
CR749216 mRNA Translation: CAH18073.1
CCDSiCCDS9149.1
RefSeqiNP_644812.1, NM_139283.1
UniGeneiHs.13854

3D structure databases

ProteinModelPortaliQ8NI37
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127764, 26 interactors
IntActiQ8NI37, 32 interactors
STRINGi9606.ENSP00000346255

PTM databases

DEPODiQ8NI37
iPTMnetiQ8NI37
PhosphoSitePlusiQ8NI37

Polymorphism and mutation databases

BioMutaiPPTC7
DMDMi74715714

Proteomic databases

EPDiQ8NI37
MaxQBiQ8NI37
PaxDbiQ8NI37
PeptideAtlasiQ8NI37
PRIDEiQ8NI37
ProteomicsDBi73828

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000354300; ENSP00000346255; ENSG00000196850
GeneIDi160760
KEGGihsa:160760
UCSCiuc001trh.2 human

Organism-specific databases

CTDi160760
DisGeNETi160760
EuPathDBiHostDB:ENSG00000196850.5
GeneCardsiPPTC7
HGNCiHGNC:30695 PPTC7
HPAiHPA039335
HPA040614
MIMi609668 gene
neXtProtiNX_Q8NI37
OpenTargetsiENSG00000196850
PharmGKBiPA143485580
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1379 Eukaryota
COG0631 LUCA
GeneTreeiENSGT00390000011937
HOGENOMiHOG000239282
HOVERGENiHBG060636
InParanoidiQ8NI37
KOiK17508
OMAiMQSIYWT
OrthoDBiEOG091G0G5G
PhylomeDBiQ8NI37
TreeFamiTF315105

Miscellaneous databases

ChiTaRSiPPTC7 human
GenomeRNAii160760
PROiPR:Q8NI37
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000196850 Expressed in 210 organ(s), highest expression level in left ventricle myocardium
CleanExiHS_PPTC7
GenevisibleiQ8NI37 HS

Family and domain databases

Gene3Di3.60.40.10, 1 hit
InterProiView protein in InterPro
IPR036457 PPM-type_dom_sf
IPR001932 PPM-type_phosphatase_dom
IPR039123 PPTC7
PANTHERiPTHR12320 PTHR12320, 1 hit
PfamiView protein in Pfam
PF07228 SpoIIE, 1 hit
SMARTiView protein in SMART
SM00331 PP2C_SIG, 1 hit
SM00332 PP2Cc, 1 hit
SUPFAMiSSF81606 SSF81606, 1 hit
PROSITEiView protein in PROSITE
PS51746 PPM_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPPTC7_HUMAN
AccessioniPrimary (citable) accession number: Q8NI37
Secondary accession number(s): B3KWC5, Q68DZ7, Q6UY82
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: October 1, 2002
Last modified: November 7, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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