UniProtKB - Q8NI37 (PPTC7_HUMAN)
Protein
Protein phosphatase PTC7 homolog
Gene
PPTC7
Organism
Homo sapiens (Human)
Status
Functioni
Protein phosphatase which positively regulates biosynthesis of the ubiquinone, coenzyme Q (PubMed:30267671). Dephosphorylates the ubiquinone biosynthesis protein COQ7 which is likely to lead to its activation (PubMed:30267671).1 Publication
Catalytic activityi
Cofactori
Mg2+1 Publication, Mn2+1 PublicationNote: Binds 2 magnesium or manganese ions per subunit.PROSITE-ProRule annotation
Activity regulationi
Inhibited by sodium orthovanadate.1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 78 | Manganese 1By similarity | 1 | |
Metal bindingi | 78 | Manganese 2By similarity | 1 | |
Metal bindingi | 79 | Manganese 1; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 223 | Manganese 2By similarity | 1 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- protein serine/threonine phosphatase activity Source: UniProtKB
GO - Biological processi
- peptidyl-serine dephosphorylation Source: UniProtKB
- regulation of ubiquinone biosynthetic process Source: UniProtKB
Keywordsi
Molecular function | Hydrolase, Protein phosphatase |
Ligand | Magnesium, Manganese, Metal-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Protein phosphatase PTC7 homolog (EC:3.1.3.16PROSITE-ProRule annotation1 Publication)Alternative name(s): T-cell activation protein phosphatase 2C Short name: TA-PP2C T-cell activation protein phosphatase 2C-like |
Gene namesi | Name:PPTC7 Synonyms:TAPP2C |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:30695 PPTC7 |
MIMi | 609668 gene |
neXtProti | NX_Q8NI37 |
Subcellular locationi
Mitochondrion
- Mitochondrion matrix 1 Publication
Mitochondrion
- mitochondrial matrix Source: UniProtKB
- mitochondrion Source: GO_Central
Keywords - Cellular componenti
MitochondrionPathology & Biotechi
Organism-specific databases
DisGeNETi | 160760 |
OpenTargetsi | ENSG00000196850 |
PharmGKBi | PA143485580 |
Miscellaneous databases
Pharosi | Q8NI37 |
Polymorphism and mutation databases
BioMutai | PPTC7 |
DMDMi | 74715714 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 68 | MitochondrionSequence analysisAdd BLAST | 68 | |
ChainiPRO_0000328745 | 69 – 304 | Protein phosphatase PTC7 homologAdd BLAST | 236 |
Proteomic databases
EPDi | Q8NI37 |
jPOSTi | Q8NI37 |
MassIVEi | Q8NI37 |
MaxQBi | Q8NI37 |
PaxDbi | Q8NI37 |
PeptideAtlasi | Q8NI37 |
PRIDEi | Q8NI37 |
ProteomicsDBi | 73828 |
PTM databases
DEPODi | Q8NI37 |
iPTMneti | Q8NI37 |
PhosphoSitePlusi | Q8NI37 |
Expressioni
Tissue specificityi
Expressed in keratinocytes (at protein level).1 Publication
Inductioni
By hydrogen peroxide and nutrional stress (such as low glucose) (PubMed:30267671). Up-regulated during lymphocyte activation (PubMed:15177553).2 Publications
Gene expression databases
Bgeei | ENSG00000196850 Expressed in 210 organ(s), highest expression level in left ventricle myocardium |
Genevisiblei | Q8NI37 HS |
Organism-specific databases
HPAi | HPA039335 HPA040614 |
Interactioni
Binary interactionsi
With | Entry | #Exp. | IntAct | Notes |
---|---|---|---|---|
Q12983 | 7 | EBI-9089276,EBI-749464 |
Protein-protein interaction databases
BioGridi | 127764, 42 interactors |
IntActi | Q8NI37, 45 interactors |
STRINGi | 9606.ENSP00000346255 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 69 – 299 | PPM-type phosphatasePROSITE-ProRule annotationAdd BLAST | 231 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 17 – 87 | Gly-richPROSITE-ProRule annotationAdd BLAST | 71 |
Sequence similaritiesi
Belongs to the PP2C family.Curated
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG1379 Eukaryota COG0631 LUCA |
GeneTreei | ENSGT00390000011937 |
HOGENOMi | HOG000239282 |
InParanoidi | Q8NI37 |
KOi | K17508 |
OMAi | MQSIYWT |
OrthoDBi | 826926at2759 |
PhylomeDBi | Q8NI37 |
TreeFami | TF315105 |
Family and domain databases
Gene3Di | 3.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR036457 PPM-type_dom_sf IPR001932 PPM-type_phosphatase_dom IPR039123 PPTC7 |
PANTHERi | PTHR12320 PTHR12320, 1 hit |
Pfami | View protein in Pfam PF07228 SpoIIE, 1 hit |
SMARTi | View protein in SMART SM00331 PP2C_SIG, 1 hit SM00332 PP2Cc, 1 hit |
SUPFAMi | SSF81606 SSF81606, 1 hit |
PROSITEi | View protein in PROSITE PS51746 PPM_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q8NI37-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFSVLSYGRL VARAVLGGLS QTDPRAGGGG GGDYGLVTAG CGFGKDFRKG
60 70 80 90 100
LLKKGACYGD DACFVARHRS ADVLGVADGV GGWRDYGVDP SQFSGTLMRT
110 120 130 140 150
CERLVKEGRF VPSNPIGILT TSYCELLQNK VPLLGSSTAC IVVLDRTSHR
160 170 180 190 200
LHTANLGDSG FLVVRGGEVV HRSDEQQHYF NTPFQLSIAP PEAEGVVLSD
210 220 230 240 250
SPDAADSTSF DVQLGDIILT ATDGLFDNMP DYMILQELKK LKNSNYESIQ
260 270 280 290 300
QTARSIAEQA HELAYDPNYM SPFAQFACDN GLNVRGGKPD DITVLLSIVA
EYTD
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 27 | Missing in AAQ57274 (Ref. 2) Curated | 1 | |
Sequence conflicti | 124 | C → R in AAQ57274 (Ref. 2) Curated | 1 | |
Sequence conflicti | 282 | L → S in CAH18073 (PubMed:17974005).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF385435 mRNA Translation: AAM43836.1 AY357944 mRNA Translation: AAQ57274.1 AK124744 mRNA Translation: BAG54087.1 CH471054 Genomic DNA Translation: EAW97928.1 BC111551 mRNA Translation: AAI11552.1 CR749216 mRNA Translation: CAH18073.1 |
CCDSi | CCDS9149.1 |
RefSeqi | NP_644812.1, NM_139283.1 |
Genome annotation databases
Ensembli | ENST00000354300; ENSP00000346255; ENSG00000196850 |
GeneIDi | 160760 |
KEGGi | hsa:160760 |
UCSCi | uc001trh.2 human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF385435 mRNA Translation: AAM43836.1 AY357944 mRNA Translation: AAQ57274.1 AK124744 mRNA Translation: BAG54087.1 CH471054 Genomic DNA Translation: EAW97928.1 BC111551 mRNA Translation: AAI11552.1 CR749216 mRNA Translation: CAH18073.1 |
CCDSi | CCDS9149.1 |
RefSeqi | NP_644812.1, NM_139283.1 |
3D structure databases
SMRi | Q8NI37 |
ModBasei | Search... |
Protein-protein interaction databases
BioGridi | 127764, 42 interactors |
IntActi | Q8NI37, 45 interactors |
STRINGi | 9606.ENSP00000346255 |
PTM databases
DEPODi | Q8NI37 |
iPTMneti | Q8NI37 |
PhosphoSitePlusi | Q8NI37 |
Polymorphism and mutation databases
BioMutai | PPTC7 |
DMDMi | 74715714 |
Proteomic databases
EPDi | Q8NI37 |
jPOSTi | Q8NI37 |
MassIVEi | Q8NI37 |
MaxQBi | Q8NI37 |
PaxDbi | Q8NI37 |
PeptideAtlasi | Q8NI37 |
PRIDEi | Q8NI37 |
ProteomicsDBi | 73828 |
Genome annotation databases
Ensembli | ENST00000354300; ENSP00000346255; ENSG00000196850 |
GeneIDi | 160760 |
KEGGi | hsa:160760 |
UCSCi | uc001trh.2 human |
Organism-specific databases
CTDi | 160760 |
DisGeNETi | 160760 |
GeneCardsi | PPTC7 |
HGNCi | HGNC:30695 PPTC7 |
HPAi | HPA039335 HPA040614 |
MIMi | 609668 gene |
neXtProti | NX_Q8NI37 |
OpenTargetsi | ENSG00000196850 |
PharmGKBi | PA143485580 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1379 Eukaryota COG0631 LUCA |
GeneTreei | ENSGT00390000011937 |
HOGENOMi | HOG000239282 |
InParanoidi | Q8NI37 |
KOi | K17508 |
OMAi | MQSIYWT |
OrthoDBi | 826926at2759 |
PhylomeDBi | Q8NI37 |
TreeFami | TF315105 |
Miscellaneous databases
ChiTaRSi | PPTC7 human |
GenomeRNAii | 160760 |
Pharosi | Q8NI37 |
PROi | PR:Q8NI37 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000196850 Expressed in 210 organ(s), highest expression level in left ventricle myocardium |
Genevisiblei | Q8NI37 HS |
Family and domain databases
Gene3Di | 3.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR036457 PPM-type_dom_sf IPR001932 PPM-type_phosphatase_dom IPR039123 PPTC7 |
PANTHERi | PTHR12320 PTHR12320, 1 hit |
Pfami | View protein in Pfam PF07228 SpoIIE, 1 hit |
SMARTi | View protein in SMART SM00331 PP2C_SIG, 1 hit SM00332 PP2Cc, 1 hit |
SUPFAMi | SSF81606 SSF81606, 1 hit |
PROSITEi | View protein in PROSITE PS51746 PPM_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PPTC7_HUMAN | |
Accessioni | Q8NI37Primary (citable) accession number: Q8NI37 Secondary accession number(s): B3KWC5, Q68DZ7, Q6UY82 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 8, 2008 |
Last sequence update: | October 1, 2002 | |
Last modified: | October 16, 2019 | |
This is version 131 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - SIMILARITY comments
Index of protein domains and families - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot