Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

WD repeat-containing protein 36

Gene

WDR36

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the nucleolar processing of SSU 18S rRNA. Involved in T-cell activation and highly coregulated with IL2.1 Publication

Miscellaneous

Depletion of WDR36 mRNA in cultured cells causes apoptotic cell death and consistently associates with a reduced 21S rRNA and delay of 18S rRNA maturation.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • regulation of axon extension Source: Ensembl
  • response to stimulus Source: UniProtKB-KW
  • retina homeostasis Source: Ensembl
  • rRNA processing Source: GO_Central
  • visual perception Source: UniProtKB-KW

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processRibosome biogenesis, rRNA processing, Sensory transduction, Vision

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6790901 rRNA modification in the nucleus and cytosol
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q8NI36

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
WD repeat-containing protein 36
Alternative name(s):
T-cell activation WD repeat-containing protein
Short name:
TA-WDRP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:WDR36
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000134987.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30696 WDR36

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
609669 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8NI36

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Glaucoma 1, open angle, G (GLC1G)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of primary open angle glaucoma (POAG). POAG is characterized by a specific pattern of optic nerve and visual field defects. The angle of the anterior chamber of the eye is open, and usually the intraocular pressure is increased. However, glaucoma can occur at any intraocular pressure. The disease is generally asymptomatic until the late stages, by which time significant and irreversible optic nerve damage has already taken place.
See also OMIM:609887
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07761097Y → C in GLC1G; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs549211166Ensembl.1
Natural variantiVAR_025965216Y → P in GLC1G; unknown pathological significance; requires 2 nucleotide substitutions. 1 Publication1
Natural variantiVAR_025966355N → S in GLC1G. 1 PublicationCorresponds to variant dbSNP:rs118204022EnsemblClinVar.1
Natural variantiVAR_077612403T → A in GLC1G; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs771276992Ensembl.1
Natural variantiVAR_077613411H → L in GLC1G; unknown pathological significance. 1 Publication1
Natural variantiVAR_077614411H → Y in GLC1G; unknown pathological significance. 1 Publication1
Natural variantiVAR_077615487P → R in GLC1G; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs372059163Ensembl.1
Natural variantiVAR_025968529R → Q in GLC1G. 1 PublicationCorresponds to variant dbSNP:rs116529882EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Glaucoma

Organism-specific databases

DisGeNET

More...
DisGeNETi
134430

MalaCards human disease database

More...
MalaCardsi
WDR36
MIMi609887 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000134987

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
353225 NON RARE IN EUROPE: Primary adult open-angle glaucoma

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134933637

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
WDR36

Domain mapping of disease mutations (DMDM)

More...
DMDMi
46577504

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000513861 – 951WD repeat-containing protein 36Add BLAST951

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei438PhosphoserineCombined sources1
Modified residuei455PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8NI36

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8NI36

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8NI36

PeptideAtlas

More...
PeptideAtlasi
Q8NI36

PRoteomics IDEntifications database

More...
PRIDEi
Q8NI36

ProteomicsDB human proteome resource

More...
ProteomicsDBi
73827

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8NI36

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8NI36

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q8NI36

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in heart, placenta, liver, skeletal muscle, kidney and pancreas. In ocular tissues, strong expression in iris, sclera, ciliary muscle, ciliary body, retina and optic nerve.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000134987 Expressed in 196 organ(s), highest expression level in stomach

CleanEx database of gene expression profiles

More...
CleanExi
HS_WDR36

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8NI36 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8NI36 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA037796
HPA037797

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
126399, 78 interactors

Protein interaction database and analysis system

More...
IntActi
Q8NI36, 20 interactors

Molecular INTeraction database

More...
MINTi
Q8NI36

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000423067

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8NI36

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8NI36

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati86 – 119WD 1Add BLAST34
Repeati128 – 157WD 2Add BLAST30
Repeati166 – 199WD 3Add BLAST34
Repeati208 – 242WD 4Add BLAST35
Repeati249 – 286WD 5Add BLAST38
Repeati293 – 328WD 6Add BLAST36
Repeati333 – 376WD 7Add BLAST44
Repeati383 – 417WD 8Add BLAST35
Repeati445 – 484WD 9Add BLAST40
Repeati497 – 531WD 10Add BLAST35
Repeati542 – 578WD 11Add BLAST37
Repeati583 – 618WD 12Add BLAST36
Repeati620 – 661WD 13Add BLAST42
Repeati663 – 701WD 14Add BLAST39

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The WD repeats are grouped into two tandem seven-bladed beta-propeller regions.By similarity

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1539 Eukaryota
ENOG410XPJH LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153662

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000217777

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG059718

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8NI36

KEGG Orthology (KO)

More...
KOi
K14554

Identification of Orthologs from Complete Genome Data

More...
OMAi
EMIEYDS

Database of Orthologous Groups

More...
OrthoDBi
EOG091G02P3

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8NI36

TreeFam database of animal gene trees

More...
TreeFami
TF300606

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR024977 Apc4_WD40_dom
IPR007319 SSU_processome_Utp21
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12894 ANAPC4_WD40, 1 hit
PF04192 Utp21, 1 hit
PF00400 WD40, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00320 WD40, 8 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978 SSF50978, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 3 hits
PS50294 WD_REPEATS_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8NI36-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCCTEGSLRK RDSQRAPEAV LCLQLWQRTV PLDTLKGLGT CFPSGPELRG
60 70 80 90 100
AGIAAAMERA SERRTASALF AGFRALGLFS NDIPHVVRFS ALKRRFYVTT
110 120 130 140 150
CVGKSFHTYD VQKLSLVAVS NSVPQDICCM AADGRLVFAA YGNVFSAFAR
160 170 180 190 200
NKEIVHTFKG HKAEIHFLQP FGDHIISVDT DGILIIWHIY SEEEYLQLTF
210 220 230 240 250
DKSVFKISAI LHPSTYLNKI LLGSEQGSLQ LWNVKSNKLL YTFPGWKVGV
260 270 280 290 300
TALQQAPAVD VVAIGLMSGQ VIIHNIKFNE TLMKFRQDWG PITSISFRTD
310 320 330 340 350
GHPVMAAGSP CGHIGLWDLE DKKLINQMRN AHSTAIAGLT FLHREPLLVT
360 370 380 390 400
NGADNALRIW IFDGPTGEGR LLRFRMGHSA PLTNIRYYGQ NGQQILSASQ
410 420 430 440 450
DGTLQSFSTV HEKFNKSLGH GLINKKRVKR KGLQNTMSVR LPPITKFAAE
460 470 480 490 500
EARESDWDGI IACHQGKLSC STWNYQKSTI GAYFLKPKEL KKDDITATAV
510 520 530 540 550
DITSCGNFAV IGLSSGTVDV YNMQSGIHRG SFGKDQAHKG SVRGVAVDGL
560 570 580 590 600
NQLTVTTGSE GLLKFWNFKN KILIHSVSLS SSPNIMLLHR DSGILGLALD
610 620 630 640 650
DFSISVLDIE TRKIVREFSG HQGQINDMAF SPDGRWLISA AMDCSIRTWD
660 670 680 690 700
LPSGCLIDCF LLDSAPLNVS MSPTGDFLAT SHVDHLGIYL WSNISLYSVV
710 720 730 740 750
SLRPLPADYV PSIVMLPGTC QTQDVEVSEE TVEPSDELIE YDSPEQLNEQ
760 770 780 790 800
LVTLSLLPES RWKNLLNLDV IKKKNKPKEP PKVPKSAPFF IPTIPGLVPR
810 820 830 840 850
YAAPEQNNDP QQSKVVNLGV LAQKSDFCLK LEEGLVNNKY DTALNLLKES
860 870 880 890 900
GPSGIETELR SLSPDCGGSI EVMQSFLKMI GMMLDRKRDF ELAQAYLALF
910 920 930 940 950
LKLHLKMLPS EPVLLEEITN LSSQVEENWT HLQSLFNQSM CILNYLKSAL

L
Length:951
Mass (Da):105,322
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7C65FCB65BE91951
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MTB8A0A0A0MTB8_HUMAN
WD repeat-containing protein 36
WDR36
895Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC04527 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti371L → P in CAH18068 (PubMed:17974005).Curated1
Sequence conflicti686L → P in CAH18068 (PubMed:17974005).Curated1
Sequence conflicti918I → T in CAH18068 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02596325L → P2 PublicationsCorresponds to variant dbSNP:rs145437203EnsemblClinVar.1
Natural variantiVAR_07760831P → T1 PublicationCorresponds to variant dbSNP:rs148041801EnsemblClinVar.1
Natural variantiVAR_07760933D → E1 PublicationCorresponds to variant dbSNP:rs35629723EnsemblClinVar.1
Natural variantiVAR_07761097Y → C in GLC1G; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs549211166Ensembl.1
Natural variantiVAR_025964163A → V2 PublicationsCorresponds to variant dbSNP:rs62376783EnsemblClinVar.1
Natural variantiVAR_077611212H → P1 PublicationCorresponds to variant dbSNP:rs142088179EnsemblClinVar.1
Natural variantiVAR_025965216Y → P in GLC1G; unknown pathological significance; requires 2 nucleotide substitutions. 1 Publication1
Natural variantiVAR_024700264I → V3 PublicationsCorresponds to variant dbSNP:rs11241095EnsemblClinVar.1
Natural variantiVAR_025966355N → S in GLC1G. 1 PublicationCorresponds to variant dbSNP:rs118204022EnsemblClinVar.1
Natural variantiVAR_077612403T → A in GLC1G; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs771276992Ensembl.1
Natural variantiVAR_077613411H → L in GLC1G; unknown pathological significance. 1 Publication1
Natural variantiVAR_077614411H → Y in GLC1G; unknown pathological significance. 1 Publication1
Natural variantiVAR_025967449A → T2 PublicationsCorresponds to variant dbSNP:rs35703638EnsemblClinVar.1
Natural variantiVAR_053430454E → Q. Corresponds to variant dbSNP:rs17623803Ensembl.1
Natural variantiVAR_077615487P → R in GLC1G; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs372059163Ensembl.1
Natural variantiVAR_025968529R → Q in GLC1G. 1 PublicationCorresponds to variant dbSNP:rs116529882EnsemblClinVar.1
Natural variantiVAR_025969658D → G2 PublicationsCorresponds to variant dbSNP:rs34595252EnsemblClinVar.1
Natural variantiVAR_025970671M → V1 PublicationCorresponds to variant dbSNP:rs11956837EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF385437 mRNA Translation: AAM43838.1
BC133025 mRNA Translation: AAI33026.1
BC136517 mRNA Translation: AAI36518.1
AK095312 mRNA Translation: BAC04527.1 Different initiation.
CR749211 mRNA Translation: CAH18068.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS4102.1

NCBI Reference Sequences

More...
RefSeqi
NP_644810.1, NM_139281.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.533237

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000506538; ENSP00000423067; ENSG00000134987
ENST00000612402; ENSP00000479950; ENSG00000134987

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
134430

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:134430

UCSC genome browser

More...
UCSCi
uc003kpd.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF385437 mRNA Translation: AAM43838.1
BC133025 mRNA Translation: AAI33026.1
BC136517 mRNA Translation: AAI36518.1
AK095312 mRNA Translation: BAC04527.1 Different initiation.
CR749211 mRNA Translation: CAH18068.1
CCDSiCCDS4102.1
RefSeqiNP_644810.1, NM_139281.2
UniGeneiHs.533237

3D structure databases

ProteinModelPortaliQ8NI36
SMRiQ8NI36
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126399, 78 interactors
IntActiQ8NI36, 20 interactors
MINTiQ8NI36
STRINGi9606.ENSP00000423067

PTM databases

iPTMnetiQ8NI36
PhosphoSitePlusiQ8NI36
SwissPalmiQ8NI36

Polymorphism and mutation databases

BioMutaiWDR36
DMDMi46577504

Proteomic databases

EPDiQ8NI36
MaxQBiQ8NI36
PaxDbiQ8NI36
PeptideAtlasiQ8NI36
PRIDEiQ8NI36
ProteomicsDBi73827

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000506538; ENSP00000423067; ENSG00000134987
ENST00000612402; ENSP00000479950; ENSG00000134987
GeneIDi134430
KEGGihsa:134430
UCSCiuc003kpd.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
134430
DisGeNETi134430
EuPathDBiHostDB:ENSG00000134987.11

GeneCards: human genes, protein and diseases

More...
GeneCardsi
WDR36
HGNCiHGNC:30696 WDR36
HPAiHPA037796
HPA037797
MalaCardsiWDR36
MIMi609669 gene
609887 phenotype
neXtProtiNX_Q8NI36
OpenTargetsiENSG00000134987
Orphaneti353225 NON RARE IN EUROPE: Primary adult open-angle glaucoma
PharmGKBiPA134933637

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1539 Eukaryota
ENOG410XPJH LUCA
GeneTreeiENSGT00940000153662
HOGENOMiHOG000217777
HOVERGENiHBG059718
InParanoidiQ8NI36
KOiK14554
OMAiEMIEYDS
OrthoDBiEOG091G02P3
PhylomeDBiQ8NI36
TreeFamiTF300606

Enzyme and pathway databases

ReactomeiR-HSA-6790901 rRNA modification in the nucleus and cytosol
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
SignaLinkiQ8NI36

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
WDR36

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
134430

Protein Ontology

More...
PROi
PR:Q8NI36

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000134987 Expressed in 196 organ(s), highest expression level in stomach
CleanExiHS_WDR36
ExpressionAtlasiQ8NI36 baseline and differential
GenevisibleiQ8NI36 HS

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR024977 Apc4_WD40_dom
IPR007319 SSU_processome_Utp21
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF12894 ANAPC4_WD40, 1 hit
PF04192 Utp21, 1 hit
PF00400 WD40, 2 hits
SMARTiView protein in SMART
SM00320 WD40, 8 hits
SUPFAMiSSF50978 SSF50978, 2 hits
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 3 hits
PS50294 WD_REPEATS_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiWDR36_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NI36
Secondary accession number(s): A2RUS4, Q68E02, Q8N1Q2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: October 1, 2002
Last modified: December 5, 2018
This is version 148 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again