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UniProtKB - Q8NI35 (INADL_HUMAN)

Protein

InaD-like protein

Gene

PATJ

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Scaffolding protein that may bring different proteins into adjacent positions at the cell membrane. May regulate protein targeting, cell polarity and integrity of tight junctions. May regulate the surface expression and/or function of ASIC3 in sensory neurons. May recruit ARHGEF18 to apical cell-cell boundaries (PubMed:22006950).2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • bicellular tight junction assembly Source: Reactome
  • intracellular signal transduction Source: UniProtKB
View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-420029 Tight junction interactions

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q8NI35

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q8NI35

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
InaD-like protein
Short name:
Inadl protein
Short name:
hINADL
Alternative name(s):
Pals1-associated tight junction protein
Protein associated to tight junctions
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PATJ1 PublicationImported
Synonyms:INADL
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000132849.19

Human Gene Nomenclature Database

More...HGNCi		HGNC:28881 PATJ

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		603199 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8NI35

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Membrane, Tight junction

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi19L → W: Reduces L27 domain binding affinity to MPP5 L27 domain. 1 Publication1
Mutagenesisi38F → W: Reduces L27 domain binding affinity to MPP5 L27 domain. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		10207

Open Targets

More...OpenTargetsi		ENSG00000132849

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134919267

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PATJ

Domain mapping of disease mutations (DMDM)

More...DMDMi		116242542

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000945921 – 1801InaD-like proteinAdd BLAST1801

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei455PhosphoserineCombined sources1
Modified residuei459PhosphoserineCombined sources1
Modified residuei522PhosphoserineCombined sources1
Modified residuei645PhosphoserineCombined sources1
Modified residuei1209PhosphothreonineCombined sources1
Modified residuei1212PhosphoserineCombined sources1
Modified residuei1508PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8NI35

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8NI35

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8NI35

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8NI35

PeptideAtlas

More...PeptideAtlasi		Q8NI35

PRoteomics IDEntifications database

More...PRIDEi		Q8NI35

ProteomicsDB human proteome resource

More...ProteomicsDBi		73822
73823 [Q8NI35-2]
73824 [Q8NI35-3]
73825 [Q8NI35-4]
73826 [Q8NI35-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8NI35

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8NI35

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in bladder, testis, ovary, small intestine, colon, heart, skeletal muscle, pancreas and cerebellum in the brain.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000132849 Expressed in 214 organ(s), highest expression level in cerebellar vermis

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8NI35 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8NI35 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA066352
HPA066960
HPA069079

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ASIC3, KCNJ10, KCNJ15, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NLGN2, MPP7, HTR2A and SLC6A4 (By similarity). Forms a ternary complex with MPP5, CRB1 and CRB3. Interacts with TJP3/ZO-3 and CLDN1/claudin-1. Component of a complex whose core is composed of ARHGAP17, AMOT, MPP5/PALS1, INADL/PATJ and PARD3/PAR3. Directly interacts with HTR4 (By similarity). Interacts (via PDZ domain 8) with WWC1 (via the ADDV motif). Interacts (via C-terminus) with ARHGEF18 (PubMed:22006950).By similarity6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		115502, 40 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q8NI35

Protein interaction database and analysis system

More...IntActi		Q8NI35, 37 interactors

Molecular INTeraction database

More...MINTi		Q8NI35

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000360200

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11801
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1VF6X-ray2.10A/B9-67[»]
2D92NMR-A676-770[»]
2DAZNMR-A1219-1329[»]
2DB5NMR-A114-228[»]
2DLUNMR-A238-335[»]
2DM8NMR-A1425-1527[»]
2DMZNMR-A355-470[»]
2EHRNMR-A1058-1167[»]
4Q2NX-ray2.00A/B/C/D/E/F362-452[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		Q8NI35

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8NI35

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q8NI35

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 65L27PROSITE-ProRule annotationAdd BLAST65
Domaini134 – 221PDZ 1PROSITE-ProRule annotationAdd BLAST88
Domaini248 – 328PDZ 2PROSITE-ProRule annotationAdd BLAST81
Domaini365 – 453PDZ 3PROSITE-ProRule annotationAdd BLAST89
Domaini553 – 639PDZ 4PROSITE-ProRule annotationAdd BLAST87
Domaini686 – 772PDZ 5PROSITE-ProRule annotationAdd BLAST87
Domaini1068 – 1160PDZ 6PROSITE-ProRule annotationAdd BLAST93
Domaini1239 – 1322PDZ 7PROSITE-ProRule annotationAdd BLAST84
Domaini1437 – 1520PDZ 8PROSITE-ProRule annotationAdd BLAST84
Domaini1533 – 1615PDZ 9PROSITE-ProRule annotationAdd BLAST83
Domaini1676 – 1762PDZ 10PROSITE-ProRule annotationAdd BLAST87

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The L27 domain (also called Maguk recruitment domain) is required for interaction with MPP5 and CRB3, and MPP5 localization to tight junctions.
The PDZ domain 6 mediates interaction with the C-terminus of TJP3 and is crucial for localization to the tight junctions. The PDZ domain 8 interacts with CLDN1 but is not required for proper localization.

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0708 Eukaryota
KOG3528 Eukaryota
ENOG4110362 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155136

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG080134

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8NI35

Identification of Orthologs from Complete Genome Data

More...OMAi		MKENFGI

Database of Orthologous Groups

More...OrthoDBi		1419918at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8NI35

TreeFam database of animal gene trees

More...TreeFami		TF330709

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR015132 L27_2
IPR004172 L27_dom
IPR036892 L27_dom_sf
IPR001478 PDZ
IPR036034 PDZ_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF09045 L27_2, 1 hit
PF00595 PDZ, 10 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00569 L27, 1 hit
SM00228 PDZ, 10 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF101288 SSF101288, 1 hit
SSF50156 SSF50156, 10 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51022 L27, 1 hit
PS50106 PDZ, 10 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8NI35-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPENPATDKL QVLQVLDRLK MKLQEKGDTS QNEKLSMFYE TLKSPLFNQI 
        60         70         80         90        100
LTLQQSIKQL KGQLNHIPSD CSANFDFSRK GLLVFTDGSI TNGNVHRPSN 
       110        120        130        140        150
NSTVSGLFPW TPKLGNEDFN SVIQQMAQGR QIEYIDIERP STGGLGFSVV 
       160        170        180        190        200
ALRSQNLGKV DIFVKDVQPG SVADRDQRLK ENDQILAINH TPLDQNISHQ 
       210        220        230        240        250
QAIALLQQTT GSLRLIVARE PVHTKSSTSS SLNDTTLPET VCWGHVEEVE 
       260        270        280        290        300
LINDGSGLGF GIVGGKTSGV VVRTIVPGGL ADRDGRLQTG DHILKIGGTN 
       310        320        330        340        350
VQGMTSEQVA QVLRNCGNSV RMLVARDPAG DISVTPPAPA ALPVALPTVA 
       360        370        380        390        400
SKGPGSDSSL FETYNVELVR KDGQSLGIRI VGYVGTSHTG EASGIYVKSI 
       410        420        430        440        450
IPGSAAYHNG HIQVNDKIVA VDGVNIQGFA NHDVVEVLRN AGQVVHLTLV 
       460        470        480        490        500
RRKTSSSTSP LEPPSDRGTV VEPLKPPALF LTGAVETETN VDGEDEEIKE 
       510        520        530        540        550
RIDTLKNDNI QALEKLEKVP DSPENELKSR WENLLGPDYE VMVATLDTQI 
       560        570        580        590        600
ADDAELQKYS KLLPIHTLRL GVEVDSFDGH HYISSIVSGG PVDTLGLLQP 
       610        620        630        640        650
EDELLEVNGM QLYGKSRREA VSFLKEVPPP FTLVCCRRLF DDEASVDEPR 
       660        670        680        690        700
RTETSLPETE VDHNMDVNTE EDDDGELALW SPEVKIVELV KDCKGLGFSI 
       710        720        730        740        750
LDYQDPLDPT RSVIVIRSLV ADGVAERSGG LLPGDRLVSV NEYCLDNTSL 
       760        770        780        790        800
AEAVEILKAV PPGLVHLGIC KPLVEDNEEE SCYILHSSSN EDKTEFSGTI 
       810        820        830        840        850
HDINSSLILE APKGFRDEPY FKEELVDEPF LDLGKSFHSQ QKEIEQSKEA 
       860        870        880        890        900
WEMHEFLTPR LQEMDEEREI LVDEEYELYQ DPSPSMELYP LSHIQEATPV 
       910        920        930        940        950
PSVNELHFGT QWLHDNEPSE SQEARTGRTV YSQEAQPYGY CPENVMKENF 
       960        970        980        990       1000
VMESLPSVPS TEGNSQQGRF DDLENLNSLA KTSLDLGMIP NDVQGPSLLI 
      1010       1020       1030       1040       1050
DLPVVAQRRE QEDLPLYQHQ ATRVISKASA YTGMLSSRYA TDTCELPERE 
      1060       1070       1080       1090       1100
EGEGEETPNF SHWGPPRIVE IFREPNVSLG ISIVGGQTVI KRLKNGEELK 
      1110       1120       1130       1140       1150
GIFIKQVLED SPAGKTNALK TGDKILEVSG VDLQNASHSE AVEAIKNAGN 
      1160       1170       1180       1190       1200
PVVFIVQSLS STPRVIPNVH NKANKITGNQ NQDTQEKKEK RQGTAPPPMK 
      1210       1220       1230       1240       1250
LPPPYKALTD DSDENEEEDA FTDQKIRQRY ADLPGELHII ELEKDKNGLG 
      1260       1270       1280       1290       1300
LSLAGNKDRS RMSIFVVGIN PEGPAAADGR MRIGDELLEI NNQILYGRSH 
      1310       1320       1330       1340       1350
QNASAIIKTA PSKVKLVFIR NEDAVNQMAV TPFPVPSSSP SSIEDQSGTE 
      1360       1370       1380       1390       1400
PISSEEDGSV EVGIKQLPES ESFKLAVSQM KQQKYPTKVS FSSQEIPLAP 
      1410       1420       1430       1440       1450
ASSYHSTDAD FTGYGGFQAP LSVDPATCPI VPGQEMIIEI SKGRSGLGLS 
      1460       1470       1480       1490       1500
IVGGKDTPLN AIVIHEVYEE GAAARDGRLW AGDQILEVNG VDLRNSSHEE 
      1510       1520       1530       1540       1550
AITALRQTPQ KVRLVVYRDE AHYRDEENLE IFPVDLQKKA GRGLGLSIVG 
      1560       1570       1580       1590       1600
KRNGSGVFIS DIVKGGAADL DGRLIQGDQI LSVNGEDMRN ASQETVATIL 
      1610       1620       1630       1640       1650
KCAQGLVQLE IGRLRAGSWT SARTTSQNSQ GSQQSAHSSC HPSFAPVITG 
      1660       1670       1680       1690       1700
LQNLVGTKRV SDPSQKNSGT DMEPRTVEIN RELSDALGIS IAGGRGSPLG 
      1710       1720       1730       1740       1750
DIPVFIAMIQ ASGVAARTQK LKVGDRIVSI NGQPLDGLSH ADVVNLLKNA 
      1760       1770       1780       1790       1800
YGRIILQVVA DTNISAIAAQ LENMSTGYHL GSPTAEHHPE DTEEQLQMTA 

D
Length:1,801
Mass (Da):196,368
Last modified:October 17, 2006 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i313DD1F12B6AD80A
GO
Isoform 2 (identifier: Q8NI35-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1459-1459: L → LFWRLGSPRAWSQHLVRAFMLHHPVTEVEGQ
     1553-1801: Missing.

Show »
Length:1,582
Mass (Da):173,793
Checksum:i9444B48DB84DE81E
GO
Isoform 3 (identifier: Q8NI35-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1553-1801: Missing.

Show »
Length:1,552
Mass (Da):170,238
Checksum:i646145A57C61152A
GO
Isoform 4 (identifier: Q8NI35-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1460-1487: Missing.
     1553-1801: Missing.

Show »
Length:1,524
Mass (Da):167,159
Checksum:i5203884719B4B152
GO
Isoform 5 (identifier: Q8NI35-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-541: Missing.
     1631-1675: GSQQSAHSSC...KNSGTDMEPR → SAECTQQLSS...FRHRYGTKDC
     1676-1801: Missing.

Show »
Length:1,134
Mass (Da):125,231
Checksum:i2717B2D492419866
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WUZ6A0A087WUZ6_HUMAN
InaD-like protein
PATJ
1,182Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0X1KG69A0A0X1KG69_HUMAN
InaD-like protein
PATJ
1,181Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RR46A0A0U1RR46_HUMAN
InaD-like protein
PATJ
683Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y549A0A2R8Y549_HUMAN
InaD-like protein
PATJ
1,882Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B4DE90B4DE90_HUMAN
cDNA FLJ59473, highly similar to In...
PATJ
452Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RQT2A0A0U1RQT2_HUMAN
InaD-like protein
PATJ
593Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RQR3A0A0U1RQR3_HUMAN
InaD-like protein
PATJ
139Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RQW4A0A0U1RQW4_HUMAN
InaD-like protein
PATJ
146Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RRD7A0A0U1RRD7_HUMAN
InaD-like protein
PATJ
111Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y5I3A0A2R8Y5I3_HUMAN
InaD-like protein
PATJ
666Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1443G → R in CAA04666 (PubMed:9280290).Curated1
Sequence conflicti1699L → I in AAM28433 (PubMed:11927608).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_027988303G → R. Corresponds to variant dbSNP:rs3762321Ensembl.1
Natural variantiVAR_027989362E → A. Corresponds to variant dbSNP:rs1286823Ensembl.1
Natural variantiVAR_027990400I → V. Corresponds to variant dbSNP:rs7516332Ensembl.1
Natural variantiVAR_027991599Q → H. Corresponds to variant dbSNP:rs1286812Ensembl.1
Natural variantiVAR_022695744C → R1 PublicationCorresponds to variant dbSNP:rs1134764Ensembl.1
Natural variantiVAR_027992779E → K. Corresponds to variant dbSNP:rs12141598Ensembl.1
Natural variantiVAR_027993780E → K. Corresponds to variant dbSNP:rs12141599Ensembl.1
Natural variantiVAR_027994870I → M3 PublicationsCorresponds to variant dbSNP:rs2799627Ensembl.1
Natural variantiVAR_0279951178G → S1 PublicationCorresponds to variant dbSNP:rs1056513Ensembl.1
Natural variantiVAR_0279961282R → H2 PublicationsCorresponds to variant dbSNP:rs1134767Ensembl.1
Natural variantiVAR_0279971360V → L2 PublicationsCorresponds to variant dbSNP:rs2498982Ensembl.1
Natural variantiVAR_0279981504A → P. Corresponds to variant dbSNP:rs13376115Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0142041 – 541Missing in isoform 5. 1 PublicationAdd BLAST541
Alternative sequenceiVSP_0142051459L → LFWRLGSPRAWSQHLVRAFM LHHPVTEVEGQ in isoform 2. 1 Publication1
Alternative sequenceiVSP_0142061460 – 1487Missing in isoform 4. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_0142071553 – 1801Missing in isoform 2, isoform 3 and isoform 4. 1 PublicationAdd BLAST249
Alternative sequenceiVSP_0142081631 – 1675GSQQS…DMEPR → SAECTQQLSSLLRSCHHWPA KPGWHKKSFRSFPEKFRHRY GTKDC in isoform 5. 1 PublicationAdd BLAST45
Alternative sequenceiVSP_0142091676 – 1801Missing in isoform 5. 1 PublicationAdd BLAST126

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AJ001306 mRNA Translation: CAA04666.1
AJ224747 mRNA Translation: CAA12112.1
AJ224748 mRNA Translation: CAA12113.1
AB044807 mRNA Translation: BAB19683.1
AF397170 mRNA Translation: AAM28433.1
AC097064 Genomic DNA No translation available.
AL136458 Genomic DNA No translation available.
AL353802 Genomic DNA No translation available.
AL449143 Genomic DNA No translation available.
AL590374 Genomic DNA No translation available.
BC021135 mRNA Translation: AAH21135.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS617.2 [Q8NI35-1]

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.478125

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000371158; ENSP00000360200; ENSG00000132849 [Q8NI35-1]
ENST00000484937; ENSP00000433669; ENSG00000132849 [Q8NI35-5]

UCSC genome browser

More...UCSCi		uc001dab.4 human [Q8NI35-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001306 mRNA Translation: CAA04666.1
AJ224747 mRNA Translation: CAA12112.1
AJ224748 mRNA Translation: CAA12113.1
AB044807 mRNA Translation: BAB19683.1
AF397170 mRNA Translation: AAM28433.1
AC097064 Genomic DNA No translation available.
AL136458 Genomic DNA No translation available.
AL353802 Genomic DNA No translation available.
AL449143 Genomic DNA No translation available.
AL590374 Genomic DNA No translation available.
BC021135 mRNA Translation: AAH21135.1
CCDSiCCDS617.2 [Q8NI35-1]
UniGeneiHs.478125

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1VF6X-ray2.10A/B9-67[»]
2D92NMR-A676-770[»]
2DAZNMR-A1219-1329[»]
2DB5NMR-A114-228[»]
2DLUNMR-A238-335[»]
2DM8NMR-A1425-1527[»]
2DMZNMR-A355-470[»]
2EHRNMR-A1058-1167[»]
4Q2NX-ray2.00A/B/C/D/E/F362-452[»]
ProteinModelPortaliQ8NI35
SMRiQ8NI35
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115502, 40 interactors
CORUMiQ8NI35
IntActiQ8NI35, 37 interactors
MINTiQ8NI35
STRINGi9606.ENSP00000360200

PTM databases

iPTMnetiQ8NI35
PhosphoSitePlusiQ8NI35

Polymorphism and mutation databases

BioMutaiPATJ
DMDMi116242542

Proteomic databases

EPDiQ8NI35
jPOSTiQ8NI35
MaxQBiQ8NI35
PaxDbiQ8NI35
PeptideAtlasiQ8NI35
PRIDEiQ8NI35
ProteomicsDBi73822
73823 [Q8NI35-2]
73824 [Q8NI35-3]
73825 [Q8NI35-4]
73826 [Q8NI35-5]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371158; ENSP00000360200; ENSG00000132849 [Q8NI35-1]
ENST00000484937; ENSP00000433669; ENSG00000132849 [Q8NI35-5]
UCSCiuc001dab.4 human [Q8NI35-1]

Organism-specific databases

DisGeNETi10207
EuPathDBiHostDB:ENSG00000132849.19

GeneCards: human genes, protein and diseases

More...GeneCardsi		PATJ
HGNCiHGNC:28881 PATJ
HPAiHPA066352
HPA066960
HPA069079
MIMi603199 gene
neXtProtiNX_Q8NI35
OpenTargetsiENSG00000132849
PharmGKBiPA134919267

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0708 Eukaryota
KOG3528 Eukaryota
ENOG4110362 LUCA
GeneTreeiENSGT00940000155136
HOVERGENiHBG080134
InParanoidiQ8NI35
OMAiMKENFGI
OrthoDBi1419918at2759
PhylomeDBiQ8NI35
TreeFamiTF330709

Enzyme and pathway databases

ReactomeiR-HSA-420029 Tight junction interactions
SignaLinkiQ8NI35
SIGNORiQ8NI35

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		PATJ human
EvolutionaryTraceiQ8NI35

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		INADL

Protein Ontology

More...PROi		PR:Q8NI35

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000132849 Expressed in 214 organ(s), highest expression level in cerebellar vermis
ExpressionAtlasiQ8NI35 baseline and differential
GenevisibleiQ8NI35 HS

Family and domain databases

InterProiView protein in InterPro
IPR015132 L27_2
IPR004172 L27_dom
IPR036892 L27_dom_sf
IPR001478 PDZ
IPR036034 PDZ_sf
PfamiView protein in Pfam
PF09045 L27_2, 1 hit
PF00595 PDZ, 10 hits
SMARTiView protein in SMART
SM00569 L27, 1 hit
SM00228 PDZ, 10 hits
SUPFAMiSSF101288 SSF101288, 1 hit
SSF50156 SSF50156, 10 hits
PROSITEiView protein in PROSITE
PS51022 L27, 1 hit
PS50106 PDZ, 10 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiINADL_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NI35
Secondary accession number(s): O15249
, O43742, O60833, Q5VUA5, Q5VUA6, Q5VUA7, Q5VUA8, Q5VUA9, Q5VUB0, Q8WU78, Q9H3N9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: October 17, 2006
Last modified: January 16, 2019
This is version 154 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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