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Entry version 115 (07 Apr 2021)
Sequence version 1 (01 Oct 2002)
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Protein

Ly6/PLAUR domain-containing protein 6B

Gene

LYPD6B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro acts on nAChRs in a subtype- and stoichiometry-dependent manner. Modulates specifically alpha-33:beta-42 nAChRs by enhancing the sensitivity to ACh, decreasing ACh-induced maximal current response and increasing the rate of desensitization to ACh; has no effect on alpha-7 homomeric nAChRs; modulates alpha-32:alpha-5:beta-42 nAChRs in the context of CHRNA5/alpha-5 variant Asn-398 but not its wild-type sequence.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8NI32

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-163125, Post-translational modification: synthesis of GPI-anchored proteins

Protein family/group databases

Transport Classification Database

More...
TCDBi
8.A.31.1.2, the ly-6 neurotoxin-like protein1 precursor (lynx1) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ly6/PLAUR domain-containing protein 6B
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LYPD6B
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:27018, LYPD6B

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8NI32

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000150556.16

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000150556

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162394734

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8NI32, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
LYPD6B

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74715711

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 39Sequence analysisAdd BLAST39
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000032195040 – 164Ly6/PLAUR domain-containing protein 6BAdd BLAST125
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_0000321951165 – 183Removed in mature formSequence analysisAdd BLAST19

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi62 ↔ 90By similarity
Disulfide bondi65 ↔ 74By similarity
Disulfide bondi83 ↔ 109By similarity
Disulfide bondi115 ↔ 134By similarity
Disulfide bondi135 ↔ 140By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi164GPI-anchor amidated serineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8NI32

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8NI32

PeptideAtlas

More...
PeptideAtlasi
Q8NI32

PRoteomics IDEntifications database

More...
PRIDEi
Q8NI32

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
73820 [Q8NI32-1]
73821 [Q8NI32-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q8NI32, 4 sites

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000150556, Expressed in skin of abdomen and 139 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8NI32, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8NI32, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000150556, Tissue enhanced (skin)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
126243, 13 interactors

Protein interaction database and analysis system

More...
IntActi
Q8NI32, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000387077

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8NI32, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8NI32

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini60 – 151UPAR/Ly6Add BLAST92

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502RXMG, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000000220

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8NI32

Identification of Orthologs from Complete Genome Data

More...
OMAi
DCNRWAE

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8NI32

TreeFam database of animal gene trees

More...
TreeFami
TF332443

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039457, LYPD6-like

The PANTHER Classification System

More...
PANTHERi
PTHR31171, PTHR31171, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8NI32-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLYKSSDRPA HKVSMLLLCH ALAIAVVQIV IFSESWAFAK NINFYNVRPP
60 70 80 90 100
LDPTPFPNSF KCFTCENAGD NYNCNRWAED KWCPQNTQYC LTVHHFTSHG
110 120 130 140 150
RSTSITKKCA SRSECHFVGC HHSRDSEHTE CRSCCEGMIC NVELPTNHTN
160 170 180
AVFAVMHAQR TSGSSAPTLY LPVLAWVFVL PLL
Length:183
Mass (Da):20,656
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i817D3D181568C5A2
GO
Isoform 2 (identifier: Q8NI32-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2-2: L → LLITLSANLFTVPERSLTTTFSFSR

Show »
Length:207
Mass (Da):23,340
Checksum:i6F760FFC205B8822
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7BXI7H7BXI7_HUMAN
Ly6/PLAUR domain-containing protein...
LYPD6B
183Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WB42F8WB42_HUMAN
Ly6/PLAUR domain-containing protein...
LYPD6B
54Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WEI1F8WEI1_HUMAN
Ly6/PLAUR domain-containing protein...
LYPD6B
50Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WCH4F8WCH4_HUMAN
Ly6/PLAUR domain-containing protein...
LYPD6B
74Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH18203 differs from that shown. Reason: Frameshift.Curated
The sequence AAH18203 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0318422L → LLITLSANLFTVPERSLTTT FSFSR in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF435957 mRNA Translation: AAM20908.1
AC009230 Genomic DNA Translation: AAY14974.1
AC073271 Genomic DNA No translation available.
CH471058 Genomic DNA Translation: EAX11541.1
CH471058 Genomic DNA Translation: EAX11542.1
CH471058 Genomic DNA Translation: EAX11543.1
BC018203 mRNA Translation: AAH18203.1 Sequence problems.
BC040176 mRNA Translation: AAH40176.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS46423.1 [Q8NI32-2]
CCDS82519.1 [Q8NI32-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001303931.1, NM_001317002.1 [Q8NI32-2]
NP_001303932.1, NM_001317003.1 [Q8NI32-1]
NP_001303933.1, NM_001317004.1 [Q8NI32-1]
NP_001303934.1, NM_001317005.1 [Q8NI32-1]
NP_001303935.1, NM_001317006.1
NP_808879.2, NM_177964.4 [Q8NI32-2]
XP_006712344.1, XM_006712281.3 [Q8NI32-1]
XP_011508925.1, XM_011510623.2 [Q8NI32-1]
XP_016858853.1, XM_017003364.1 [Q8NI32-2]
XP_016858854.1, XM_017003365.1 [Q8NI32-1]
XP_016858855.1, XM_017003366.1 [Q8NI32-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000409029; ENSP00000386650; ENSG00000150556 [Q8NI32-1]
ENST00000409642; ENSP00000387077; ENSG00000150556 [Q8NI32-2]
ENST00000409876; ENSP00000386479; ENSG00000150556 [Q8NI32-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
130576

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:130576

UCSC genome browser

More...
UCSCi
uc002twv.2, human [Q8NI32-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF435957 mRNA Translation: AAM20908.1
AC009230 Genomic DNA Translation: AAY14974.1
AC073271 Genomic DNA No translation available.
CH471058 Genomic DNA Translation: EAX11541.1
CH471058 Genomic DNA Translation: EAX11542.1
CH471058 Genomic DNA Translation: EAX11543.1
BC018203 mRNA Translation: AAH18203.1 Sequence problems.
BC040176 mRNA Translation: AAH40176.2
CCDSiCCDS46423.1 [Q8NI32-2]
CCDS82519.1 [Q8NI32-1]
RefSeqiNP_001303931.1, NM_001317002.1 [Q8NI32-2]
NP_001303932.1, NM_001317003.1 [Q8NI32-1]
NP_001303933.1, NM_001317004.1 [Q8NI32-1]
NP_001303934.1, NM_001317005.1 [Q8NI32-1]
NP_001303935.1, NM_001317006.1
NP_808879.2, NM_177964.4 [Q8NI32-2]
XP_006712344.1, XM_006712281.3 [Q8NI32-1]
XP_011508925.1, XM_011510623.2 [Q8NI32-1]
XP_016858853.1, XM_017003364.1 [Q8NI32-2]
XP_016858854.1, XM_017003365.1 [Q8NI32-1]
XP_016858855.1, XM_017003366.1 [Q8NI32-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6ZSONMR-A60-154[»]
SMRiQ8NI32
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi126243, 13 interactors
IntActiQ8NI32, 1 interactor
STRINGi9606.ENSP00000387077

Protein family/group databases

TCDBi8.A.31.1.2, the ly-6 neurotoxin-like protein1 precursor (lynx1) family

PTM databases

GlyGeniQ8NI32, 4 sites

Genetic variation databases

BioMutaiLYPD6B
DMDMi74715711

Proteomic databases

MassIVEiQ8NI32
PaxDbiQ8NI32
PeptideAtlasiQ8NI32
PRIDEiQ8NI32
ProteomicsDBi73820 [Q8NI32-1]
73821 [Q8NI32-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
62112, 27 antibodies

Genome annotation databases

EnsembliENST00000409029; ENSP00000386650; ENSG00000150556 [Q8NI32-1]
ENST00000409642; ENSP00000387077; ENSG00000150556 [Q8NI32-2]
ENST00000409876; ENSP00000386479; ENSG00000150556 [Q8NI32-1]
GeneIDi130576
KEGGihsa:130576
UCSCiuc002twv.2, human [Q8NI32-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
130576

GeneCards: human genes, protein and diseases

More...
GeneCardsi
LYPD6B
HGNCiHGNC:27018, LYPD6B
HPAiENSG00000150556, Tissue enhanced (skin)
neXtProtiNX_Q8NI32
OpenTargetsiENSG00000150556
PharmGKBiPA162394734
VEuPathDBiHostDB:ENSG00000150556.16

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502RXMG, Eukaryota
GeneTreeiENSGT00390000000220
InParanoidiQ8NI32
OMAiDCNRWAE
PhylomeDBiQ8NI32
TreeFamiTF332443

Enzyme and pathway databases

PathwayCommonsiQ8NI32
ReactomeiR-HSA-163125, Post-translational modification: synthesis of GPI-anchored proteins

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
130576, 8 hits in 979 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
LYPD6B, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
130576
PharosiQ8NI32, Tdark

Protein Ontology

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PROi
PR:Q8NI32
RNActiQ8NI32, protein

Gene expression databases

BgeeiENSG00000150556, Expressed in skin of abdomen and 139 other tissues
ExpressionAtlasiQ8NI32, baseline and differential
GenevisibleiQ8NI32, HS

Family and domain databases

InterProiView protein in InterPro
IPR039457, LYPD6-like
PANTHERiPTHR31171, PTHR31171, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLPD6B_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NI32
Secondary accession number(s): D3DP90
, Q53TK0, Q7Z747, Q8IXK7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: October 1, 2002
Last modified: April 7, 2021
This is version 115 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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