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Entry version 151 (16 Oct 2019)
Sequence version 2 (11 Jul 2006)
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Protein

Nuclear receptor coactivator 7

Gene

NCOA7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enhances the transcriptional activities of several nuclear receptors. Involved in the coactivation of different nuclear receptors, such as ESR1, THRB, PPARG and RARA.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation

Protein family/group databases

Transport Classification Database

More...
TCDBi
8.A.126.1.1 the nuclear receptor coactivator 7 (ncoa7) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nuclear receptor coactivator 7
Alternative name(s):
140 kDa estrogen receptor-associated protein
Estrogen nuclear receptor coactivator 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NCOA7
Synonyms:ERAP140, ESNA1
ORF Names:Nbla00052, Nbla10993
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:21081 NCOA7

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
609752 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8NI08

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi511 – 517LNIHEDL → ANAHEDA: No action on the E2-induced ESR1 binding. 1 Publication7
Mutagenesisi522 – 523LI → AA: Abolishes completely the E2-induced ESR1 binding. 1 Publication2

Organism-specific databases

DisGeNET

More...
DisGeNETi
135112

Open Targets

More...
OpenTargetsi
ENSG00000111912

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134905581

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8NI08

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NCOA7

Domain mapping of disease mutations (DMDM)

More...
DMDMi
110287684

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002452291 – 942Nuclear receptor coactivator 7Add BLAST942

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei89PhosphoserineCombined sources1
Modified residuei134PhosphothreonineCombined sources1
Modified residuei179PhosphoserineCombined sources1
Modified residuei183PhosphoserineCombined sources1
Modified residuei208PhosphoserineCombined sources1
Modified residuei209PhosphoserineBy similarity1
Modified residuei211PhosphoserineCombined sources1
Modified residuei441PhosphoserineCombined sources1
Modified residuei500PhosphoserineBy similarity1
Modified residuei502PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8NI08

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8NI08

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8NI08

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8NI08

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8NI08

PeptideAtlas

More...
PeptideAtlasi
Q8NI08

PRoteomics IDEntifications database

More...
PRIDEi
Q8NI08

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
34153
73795 [Q8NI08-1]
73796 [Q8NI08-2]
73797 [Q8NI08-3]
73798 [Q8NI08-4]
73799 [Q8NI08-5]
73800 [Q8NI08-6]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8NI08

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8NI08

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q8NI08

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in brain. Weakly expressed in mammary gland, ovary, uterus, prostate, stomach, bladder, spinal cord and pancreas. Expressed in cancer cell line.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000111912 Expressed in 203 organ(s), highest expression level in visceral pleura

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8NI08 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8NI08 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA030289
HPA030290
HPA030291
HPA030292

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ESR1, ESR2A, ESR2B, THRB, PPARG and RARA in a ligand-inducible manner.

Interacts with the heterodimer AHR-ARNT.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
126419, 10 interactors

Protein interaction database and analysis system

More...
IntActi
Q8NI08, 12 interactors

Molecular INTeraction database

More...
MINTi
Q8NI08

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000376269

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8NI08

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini114 – 157LysMPROSITE-ProRule annotationAdd BLAST44
Domaini781 – 942TLDcPROSITE-ProRule annotationAdd BLAST162

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili4 – 29Sequence analysisAdd BLAST26

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the OXR1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IMGK Eukaryota
ENOG4110T63 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155141

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8NI08

Identification of Orthologs from Complete Genome Data

More...
OMAi
CSWEIIT

Database of Orthologous Groups

More...
OrthoDBi
767847at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8NI08

TreeFam database of animal gene trees

More...
TreeFami
TF313530

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00118 LysM, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.10.350.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR018392 LysM_dom
IPR036779 LysM_dom_sf
IPR006571 TLDc_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01476 LysM, 1 hit
PF07534 TLD, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00257 LysM, 1 hit
SM00584 TLDc, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51782 LYSM, 1 hit
PS51886 TLDC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 7 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8NI08-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDTKEEKKER KQSYFARLKK KKQAKQNAET ASAVATRTHT GKEDNNTVVL
60 70 80 90 100
EPDKCNIAVE EEYMTDEKKK RKSNQLKEIR RTELKRYYSI DDNQNKTHDK
110 120 130 140 150
KEKKMVVQKP HGTMEYTAGN QDTLNSIALK FNITPNKLVE LNKLFTHTIV
160 170 180 190 200
PGQVLFVPDA NSPSSTLRLS SSSPGATVSP SSSDAEYDKL PDADLARKAL
210 220 230 240 250
KPIERVLSST SEEDEPGVVK FLKMNCRYFT DGKGVVGGVM IVTPNNIMFD
260 270 280 290 300
PHKSDPLVIE NGCEEYGLIC PMEEVVSIAL YNDISHMKIK DALPSDLPQD
310 320 330 340 350
LCPLYRPGEW EDLASEKDIN PFSKFKSINK EKRQQNGEKI MTSDSRPIVP
360 370 380 390 400
LEKSTGHTPT KPSGSSVSEK LKKLDSSRET SHGSPTVTKL SKEPSDTSSA
410 420 430 440 450
FESTAKENFL GEDDDFVDLE ELSSQTGGGM HKKDTLKECL SLDPEERKKA
460 470 480 490 500
ESQINNSAVE MQVQSALAFL GTENDVELKG ALDLETCEKQ DIMPEVDKQS
510 520 530 540 550
GSPESRVENT LNIHEDLDKV KLIEYYLTKN KEGPQVSENL QKTELSDGKS
560 570 580 590 600
IEPGGIDITL SSSLSQAGDP ITEGNKEPDK TWVKKGEPLP VKLNSSTEAN
610 620 630 640 650
VIKEALDSSL ESTLDNSCQG AQMDNKSEVQ LWLLKRIQVP IEDILPSKEE
660 670 680 690 700
KSKTPPMFLC IKVGKPMRKS FATHTAAMVQ QYGKRRKQPE YWFAVPRERV
710 720 730 740 750
DHLYTFFVQW SPDVYGKDAK EQGFVVVEKE ELNMIDNFFS EPTTKSWEII
760 770 780 790 800
TVEEAKRRKS TCSYYEDEDE EVLPVLRPHS ALLENMHIEQ LARRLPARVQ
810 820 830 840 850
GYPWRLAYST LEHGTSLKTL YRKSASLDSP VLLVIKDMDN QIFGAYATHP
860 870 880 890 900
FKFSDHYYGT GETFLYTFSP HFKVFKWSGE NSYFINGDIS SLELGGGGGR
910 920 930 940
FGLWLDADLY HGRSNSCSTF NNDILSKKED FIVQDLEVWA FD
Length:942
Mass (Da):106,162
Last modified:July 11, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAFD13F06F38C6C5D
GO
Isoform 2 (identifier: Q8NI08-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     296-306: Missing.

Note: No experimental confirmation available.
Show »
Length:931
Mass (Da):104,847
Checksum:i59EF69310C7FBE9F
GO
Isoform 3 (identifier: Q8NI08-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     296-942: Missing.

Note: No experimental confirmation available.
Show »
Length:295
Mass (Da):33,145
Checksum:i698C5760DD9A3D61
GO
Isoform 4 (identifier: Q8NI08-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     234-249: GVVGGVMIVTPNNIMF → VYSNVICFLSLKSMKN
     250-942: Missing.

Note: No experimental confirmation available.
Show »
Length:249
Mass (Da):28,246
Checksum:i211C53B01C7D5AF0
GO
Isoform 5 (identifier: Q8NI08-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-723: Missing.
     724-748: FVVVEKEELNMIDNFFSEPTTKSWE → MRGQRLPLDIQIFYCARPDEEPFVK

Note: No experimental confirmation available.
Show »
Length:219
Mass (Da):25,270
Checksum:i1C0052E860872FAA
GO
Isoform 6 (identifier: Q8NI08-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     91-102: DDNQNKTHDKKE → GEYSWRYCSIFI
     103-942: Missing.

Note: No experimental confirmation available.
Show »
Length:102
Mass (Da):12,189
Checksum:iEB558581700DAE15
GO
Isoform 7 (identifier: Q8NI08-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-104: Missing.
     296-306: Missing.

Note: No experimental confirmation available.
Show »
Length:827
Mass (Da):92,472
Checksum:i37F6E9A7D3465DBF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5TF96Q5TF96_HUMAN
Nuclear receptor coactivator 7
NCOA7
191Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5TF97Q5TF97_HUMAN
Nuclear receptor coactivator 7
NCOA7
117Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5TF98Q5TF98_HUMAN
Nuclear receptor coactivator 7
NCOA7
90Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y6T0H0Y6T0_HUMAN
Nuclear receptor coactivator 7
NCOA7
159Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAD89948 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti32S → T in BAE45732 (PubMed:12880961).Curated1
Sequence conflicti118A → T in CAD89948 (PubMed:17974005).Curated1
Sequence conflicti177T → A in AAM27392 (PubMed:11971969).Curated1
Sequence conflicti228Y → H in CAD89948 (PubMed:17974005).Curated1
Sequence conflicti249F → C in AAM27392 (PubMed:11971969).Curated1
Sequence conflicti266Y → H in CAD97627 (PubMed:17974005).Curated1
Sequence conflicti278I → T in AAM27392 (PubMed:11971969).Curated1
Sequence conflicti369E → G in CAD89948 (PubMed:17974005).Curated1
Sequence conflicti723G → S in BAH11810 (PubMed:14702039).Curated1
Sequence conflicti752V → A in CAD89948 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_026965399S → A4 PublicationsCorresponds to variant dbSNP:rs6919947Ensembl.1
Natural variantiVAR_050438533G → R. Corresponds to variant dbSNP:rs35223550Ensembl.1
Natural variantiVAR_026966942D → E. Corresponds to variant dbSNP:rs1567Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0196321 – 723Missing in isoform 5. 1 PublicationAdd BLAST723
Alternative sequenceiVSP_0448591 – 104Missing in isoform 7. 1 PublicationAdd BLAST104
Alternative sequenceiVSP_01963391 – 102DDNQN…HDKKE → GEYSWRYCSIFI in isoform 6. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_019634103 – 942Missing in isoform 6. 1 PublicationAdd BLAST840
Alternative sequenceiVSP_019635234 – 249GVVGG…NNIMF → VYSNVICFLSLKSMKN in isoform 4. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_019636250 – 942Missing in isoform 4. 1 PublicationAdd BLAST693
Alternative sequenceiVSP_019637296 – 942Missing in isoform 3. 1 PublicationAdd BLAST647
Alternative sequenceiVSP_019638296 – 306Missing in isoform 2 and isoform 7. 2 PublicationsAdd BLAST11
Alternative sequenceiVSP_019639724 – 748FVVVE…TKSWE → MRGQRLPLDIQIFYCARPDE EPFVK in isoform 5. 1 PublicationAdd BLAST25

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF493978 mRNA Translation: AAM27392.1
AB074157 mRNA Translation: BAE45732.1
AK094706 mRNA Translation: BAC04402.1
AK294558 mRNA Translation: BAH11810.1
BX537385 mRNA Translation: CAD97627.1
AL832628 mRNA Translation: CAD89948.1 Frameshift.
AL035689 Genomic DNA No translation available.
AL078594 Genomic DNA No translation available.
AL136163 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48133.1
BC036461 mRNA Translation: AAH36461.1
BC071782 mRNA Translation: AAH71782.1
BC137094 mRNA Translation: AAI37095.1
BC137095 mRNA Translation: AAI37096.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS5132.1 [Q8NI08-1]
CCDS56448.1 [Q8NI08-7]
CCDS83125.1 [Q8NI08-5]

NCBI Reference Sequences

More...
RefSeqi
NP_001116314.1, NM_001122842.2 [Q8NI08-2]
NP_001186548.1, NM_001199619.1 [Q8NI08-1]
NP_001186549.1, NM_001199620.1 [Q8NI08-1]
NP_001186550.1, NM_001199621.1 [Q8NI08-7]
NP_001186551.1, NM_001199622.1 [Q8NI08-5]
NP_861447.3, NM_181782.4 [Q8NI08-1]
XP_005266879.1, XM_005266822.4 [Q8NI08-1]
XP_006715403.1, XM_006715340.3 [Q8NI08-1]
XP_011533757.1, XM_011535455.2 [Q8NI08-1]
XP_016865758.1, XM_017010269.1 [Q8NI08-1]
XP_016865759.1, XM_017010270.1 [Q8NI08-2]
XP_016865760.1, XM_017010271.1 [Q8NI08-2]
XP_016865761.1, XM_017010272.1 [Q8NI08-2]
XP_016865762.1, XM_017010273.1 [Q8NI08-2]
XP_016865763.1, XM_017010274.1 [Q8NI08-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000229634; ENSP00000229634; ENSG00000111912 [Q8NI08-7]
ENST00000368357; ENSP00000357341; ENSG00000111912 [Q8NI08-1]
ENST00000392477; ENSP00000376269; ENSG00000111912 [Q8NI08-1]
ENST00000438495; ENSP00000398268; ENSG00000111912 [Q8NI08-5]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
135112

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:135112

UCSC genome browser

More...
UCSCi
uc003qae.5 human [Q8NI08-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF493978 mRNA Translation: AAM27392.1
AB074157 mRNA Translation: BAE45732.1
AK094706 mRNA Translation: BAC04402.1
AK294558 mRNA Translation: BAH11810.1
BX537385 mRNA Translation: CAD97627.1
AL832628 mRNA Translation: CAD89948.1 Frameshift.
AL035689 Genomic DNA No translation available.
AL078594 Genomic DNA No translation available.
AL136163 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48133.1
BC036461 mRNA Translation: AAH36461.1
BC071782 mRNA Translation: AAH71782.1
BC137094 mRNA Translation: AAI37095.1
BC137095 mRNA Translation: AAI37096.1
CCDSiCCDS5132.1 [Q8NI08-1]
CCDS56448.1 [Q8NI08-7]
CCDS83125.1 [Q8NI08-5]
RefSeqiNP_001116314.1, NM_001122842.2 [Q8NI08-2]
NP_001186548.1, NM_001199619.1 [Q8NI08-1]
NP_001186549.1, NM_001199620.1 [Q8NI08-1]
NP_001186550.1, NM_001199621.1 [Q8NI08-7]
NP_001186551.1, NM_001199622.1 [Q8NI08-5]
NP_861447.3, NM_181782.4 [Q8NI08-1]
XP_005266879.1, XM_005266822.4 [Q8NI08-1]
XP_006715403.1, XM_006715340.3 [Q8NI08-1]
XP_011533757.1, XM_011535455.2 [Q8NI08-1]
XP_016865758.1, XM_017010269.1 [Q8NI08-1]
XP_016865759.1, XM_017010270.1 [Q8NI08-2]
XP_016865760.1, XM_017010271.1 [Q8NI08-2]
XP_016865761.1, XM_017010272.1 [Q8NI08-2]
XP_016865762.1, XM_017010273.1 [Q8NI08-2]
XP_016865763.1, XM_017010274.1 [Q8NI08-2]

3D structure databases

SMRiQ8NI08
ModBaseiSearch...

Protein-protein interaction databases

BioGridi126419, 10 interactors
IntActiQ8NI08, 12 interactors
MINTiQ8NI08
STRINGi9606.ENSP00000376269

Protein family/group databases

TCDBi8.A.126.1.1 the nuclear receptor coactivator 7 (ncoa7) family

PTM databases

iPTMnetiQ8NI08
PhosphoSitePlusiQ8NI08
SwissPalmiQ8NI08

Polymorphism and mutation databases

BioMutaiNCOA7
DMDMi110287684

Proteomic databases

EPDiQ8NI08
jPOSTiQ8NI08
MassIVEiQ8NI08
MaxQBiQ8NI08
PaxDbiQ8NI08
PeptideAtlasiQ8NI08
PRIDEiQ8NI08
ProteomicsDBi34153
73795 [Q8NI08-1]
73796 [Q8NI08-2]
73797 [Q8NI08-3]
73798 [Q8NI08-4]
73799 [Q8NI08-5]
73800 [Q8NI08-6]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
135112

Genome annotation databases

EnsembliENST00000229634; ENSP00000229634; ENSG00000111912 [Q8NI08-7]
ENST00000368357; ENSP00000357341; ENSG00000111912 [Q8NI08-1]
ENST00000392477; ENSP00000376269; ENSG00000111912 [Q8NI08-1]
ENST00000438495; ENSP00000398268; ENSG00000111912 [Q8NI08-5]
GeneIDi135112
KEGGihsa:135112
UCSCiuc003qae.5 human [Q8NI08-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
135112
DisGeNETi135112

GeneCards: human genes, protein and diseases

More...
GeneCardsi
NCOA7
HGNCiHGNC:21081 NCOA7
HPAiHPA030289
HPA030290
HPA030291
HPA030292
MIMi609752 gene
neXtProtiNX_Q8NI08
OpenTargetsiENSG00000111912
PharmGKBiPA134905581

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IMGK Eukaryota
ENOG4110T63 LUCA
GeneTreeiENSGT00940000155141
InParanoidiQ8NI08
OMAiCSWEIIT
OrthoDBi767847at2759
PhylomeDBiQ8NI08
TreeFamiTF313530

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
NCOA7 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
NCOA7

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
135112
PharosiQ8NI08

Protein Ontology

More...
PROi
PR:Q8NI08

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000111912 Expressed in 203 organ(s), highest expression level in visceral pleura
ExpressionAtlasiQ8NI08 baseline and differential
GenevisibleiQ8NI08 HS

Family and domain databases

CDDicd00118 LysM, 1 hit
Gene3Di3.10.350.10, 1 hit
InterProiView protein in InterPro
IPR018392 LysM_dom
IPR036779 LysM_dom_sf
IPR006571 TLDc_dom
PfamiView protein in Pfam
PF01476 LysM, 1 hit
PF07534 TLD, 1 hit
SMARTiView protein in SMART
SM00257 LysM, 1 hit
SM00584 TLDc, 1 hit
PROSITEiView protein in PROSITE
PS51782 LYSM, 1 hit
PS51886 TLDC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNCOA7_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NI08
Secondary accession number(s): B2RNS2
, B7Z2C4, B9EH71, G8JL91, Q3LID6, Q4G0V1, Q5TF95, Q6IPQ4, Q6NE83, Q86T89, Q8N1W4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: July 11, 2006
Last modified: October 16, 2019
This is version 151 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. UniProtKB entry view manual
    User manual for the UniProtKB entry view
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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