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Protein

Nuclear receptor coactivator 7

Gene

NCOA7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Enhances the transcriptional activities of several nuclear receptors. Involved in the coactivation of different nuclear receptors, such as ESR1, THRB, PPARG and RARA.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear receptor coactivator 7
Alternative name(s):
140 kDa estrogen receptor-associated protein
Estrogen nuclear receptor coactivator 1
Gene namesi
Name:NCOA7
Synonyms:ERAP140, ESNA1
ORF Names:Nbla00052, Nbla10993
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000111912.19
HGNCiHGNC:21081 NCOA7
MIMi609752 gene
neXtProtiNX_Q8NI08

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi511 – 517LNIHEDL → ANAHEDA: No action on the E2-induced ESR1 binding. 1 Publication7
Mutagenesisi522 – 523LI → AA: Abolishes completely the E2-induced ESR1 binding. 1 Publication2

Organism-specific databases

DisGeNETi135112
OpenTargetsiENSG00000111912
PharmGKBiPA134905581

Polymorphism and mutation databases

BioMutaiNCOA7
DMDMi110287684

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002452291 – 942Nuclear receptor coactivator 7Add BLAST942

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei89PhosphoserineCombined sources1
Modified residuei134PhosphothreonineCombined sources1
Modified residuei179PhosphoserineCombined sources1
Modified residuei183PhosphoserineCombined sources1
Modified residuei208PhosphoserineCombined sources1
Modified residuei209PhosphoserineBy similarity1
Modified residuei211PhosphoserineCombined sources1
Modified residuei441PhosphoserineCombined sources1
Modified residuei500PhosphoserineBy similarity1
Modified residuei502PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8NI08
MaxQBiQ8NI08
PaxDbiQ8NI08
PeptideAtlasiQ8NI08
PRIDEiQ8NI08
ProteomicsDBi73795
73796 [Q8NI08-2]
73797 [Q8NI08-3]
73798 [Q8NI08-4]
73799 [Q8NI08-5]
73800 [Q8NI08-6]

PTM databases

iPTMnetiQ8NI08
PhosphoSitePlusiQ8NI08
SwissPalmiQ8NI08

Expressioni

Tissue specificityi

Highly expressed in brain. Weakly expressed in mammary gland, ovary, uterus, prostate, stomach, bladder, spinal cord and pancreas. Expressed in cancer cell line.1 Publication

Gene expression databases

BgeeiENSG00000111912 Expressed in 203 organ(s), highest expression level in visceral pleura
ExpressionAtlasiQ8NI08 baseline and differential
GenevisibleiQ8NI08 HS

Organism-specific databases

HPAiHPA030289
HPA030290
HPA030291
HPA030292

Interactioni

Subunit structurei

Interacts with ESR1, ESR2A, ESR2B, THRB, PPARG and RARA in a ligand-inducible manner. Interacts with the heterodimer AHR-ARNT.2 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi126419, 9 interactors
IntActiQ8NI08, 11 interactors
MINTiQ8NI08
STRINGi9606.ENSP00000357341

Structurei

3D structure databases

ProteinModelPortaliQ8NI08
SMRiQ8NI08
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini114 – 157LysMPROSITE-ProRule annotationAdd BLAST44
Domaini806 – 942TLDAdd BLAST137

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili4 – 29Sequence analysisAdd BLAST26

Sequence similaritiesi

Belongs to the OXR1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IMGK Eukaryota
ENOG4110T63 LUCA
GeneTreeiENSGT00410000025363
HOVERGENiHBG065488
InParanoidiQ8NI08
OMAiMSCKYFT
OrthoDBiEOG091G0L15
PhylomeDBiQ8NI08
TreeFamiTF313530

Family and domain databases

CDDicd00118 LysM, 1 hit
Gene3Di3.10.350.10, 1 hit
InterProiView protein in InterPro
IPR018392 LysM_dom
IPR036779 LysM_dom_sf
IPR006571 TLDc_dom
PfamiView protein in Pfam
PF01476 LysM, 1 hit
PF07534 TLD, 1 hit
SMARTiView protein in SMART
SM00257 LysM, 1 hit
SM00584 TLDc, 1 hit
PROSITEiView protein in PROSITE
PS51782 LYSM, 1 hit

Sequences (7+)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8NI08-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDTKEEKKER KQSYFARLKK KKQAKQNAET ASAVATRTHT GKEDNNTVVL
60 70 80 90 100
EPDKCNIAVE EEYMTDEKKK RKSNQLKEIR RTELKRYYSI DDNQNKTHDK
110 120 130 140 150
KEKKMVVQKP HGTMEYTAGN QDTLNSIALK FNITPNKLVE LNKLFTHTIV
160 170 180 190 200
PGQVLFVPDA NSPSSTLRLS SSSPGATVSP SSSDAEYDKL PDADLARKAL
210 220 230 240 250
KPIERVLSST SEEDEPGVVK FLKMNCRYFT DGKGVVGGVM IVTPNNIMFD
260 270 280 290 300
PHKSDPLVIE NGCEEYGLIC PMEEVVSIAL YNDISHMKIK DALPSDLPQD
310 320 330 340 350
LCPLYRPGEW EDLASEKDIN PFSKFKSINK EKRQQNGEKI MTSDSRPIVP
360 370 380 390 400
LEKSTGHTPT KPSGSSVSEK LKKLDSSRET SHGSPTVTKL SKEPSDTSSA
410 420 430 440 450
FESTAKENFL GEDDDFVDLE ELSSQTGGGM HKKDTLKECL SLDPEERKKA
460 470 480 490 500
ESQINNSAVE MQVQSALAFL GTENDVELKG ALDLETCEKQ DIMPEVDKQS
510 520 530 540 550
GSPESRVENT LNIHEDLDKV KLIEYYLTKN KEGPQVSENL QKTELSDGKS
560 570 580 590 600
IEPGGIDITL SSSLSQAGDP ITEGNKEPDK TWVKKGEPLP VKLNSSTEAN
610 620 630 640 650
VIKEALDSSL ESTLDNSCQG AQMDNKSEVQ LWLLKRIQVP IEDILPSKEE
660 670 680 690 700
KSKTPPMFLC IKVGKPMRKS FATHTAAMVQ QYGKRRKQPE YWFAVPRERV
710 720 730 740 750
DHLYTFFVQW SPDVYGKDAK EQGFVVVEKE ELNMIDNFFS EPTTKSWEII
760 770 780 790 800
TVEEAKRRKS TCSYYEDEDE EVLPVLRPHS ALLENMHIEQ LARRLPARVQ
810 820 830 840 850
GYPWRLAYST LEHGTSLKTL YRKSASLDSP VLLVIKDMDN QIFGAYATHP
860 870 880 890 900
FKFSDHYYGT GETFLYTFSP HFKVFKWSGE NSYFINGDIS SLELGGGGGR
910 920 930 940
FGLWLDADLY HGRSNSCSTF NNDILSKKED FIVQDLEVWA FD
Length:942
Mass (Da):106,162
Last modified:July 11, 2006 - v2
Checksum:iAFD13F06F38C6C5D
GO
Isoform 2 (identifier: Q8NI08-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     296-306: Missing.

Note: No experimental confirmation available.
Show »
Length:931
Mass (Da):104,847
Checksum:i59EF69310C7FBE9F
GO
Isoform 3 (identifier: Q8NI08-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     296-942: Missing.

Note: No experimental confirmation available.
Show »
Length:295
Mass (Da):33,145
Checksum:i698C5760DD9A3D61
GO
Isoform 4 (identifier: Q8NI08-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     234-249: GVVGGVMIVTPNNIMF → VYSNVICFLSLKSMKN
     250-942: Missing.

Note: No experimental confirmation available.
Show »
Length:249
Mass (Da):28,246
Checksum:i211C53B01C7D5AF0
GO
Isoform 5 (identifier: Q8NI08-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-723: Missing.
     724-748: FVVVEKEELNMIDNFFSEPTTKSWE → MRGQRLPLDIQIFYCARPDEEPFVK

Note: No experimental confirmation available.
Show »
Length:219
Mass (Da):25,270
Checksum:i1C0052E860872FAA
GO
Isoform 6 (identifier: Q8NI08-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     91-102: DDNQNKTHDKKE → GEYSWRYCSIFI
     103-942: Missing.

Note: No experimental confirmation available.
Show »
Length:102
Mass (Da):12,189
Checksum:iEB558581700DAE15
GO
Isoform 7 (identifier: Q8NI08-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-104: Missing.
     296-306: Missing.

Note: No experimental confirmation available.
Show »
Length:827
Mass (Da):92,472
Checksum:i37F6E9A7D3465DBF
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5TF96Q5TF96_HUMAN
Nuclear receptor coactivator 7
NCOA7
191Annotation score:
Q5TF97Q5TF97_HUMAN
Nuclear receptor coactivator 7
NCOA7
117Annotation score:
Q5TF98Q5TF98_HUMAN
Nuclear receptor coactivator 7
NCOA7
90Annotation score:
H0Y6T0H0Y6T0_HUMAN
Nuclear receptor coactivator 7
NCOA7
159Annotation score:

Sequence cautioni

The sequence CAD89948 differs from that shown. Reason: Frameshift at position 782.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti32S → T in BAE45732 (PubMed:12880961).Curated1
Sequence conflicti118A → T in CAD89948 (PubMed:17974005).Curated1
Sequence conflicti177T → A in AAM27392 (PubMed:11971969).Curated1
Sequence conflicti228Y → H in CAD89948 (PubMed:17974005).Curated1
Sequence conflicti249F → C in AAM27392 (PubMed:11971969).Curated1
Sequence conflicti266Y → H in CAD97627 (PubMed:17974005).Curated1
Sequence conflicti278I → T in AAM27392 (PubMed:11971969).Curated1
Sequence conflicti369E → G in CAD89948 (PubMed:17974005).Curated1
Sequence conflicti723G → S in BAH11810 (PubMed:14702039).Curated1
Sequence conflicti752V → A in CAD89948 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_026965399S → A4 PublicationsCorresponds to variant dbSNP:rs6919947Ensembl.1
Natural variantiVAR_050438533G → R. Corresponds to variant dbSNP:rs35223550Ensembl.1
Natural variantiVAR_026966942D → E. Corresponds to variant dbSNP:rs1567Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0196321 – 723Missing in isoform 5. 1 PublicationAdd BLAST723
Alternative sequenceiVSP_0448591 – 104Missing in isoform 7. 1 PublicationAdd BLAST104
Alternative sequenceiVSP_01963391 – 102DDNQN…HDKKE → GEYSWRYCSIFI in isoform 6. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_019634103 – 942Missing in isoform 6. 1 PublicationAdd BLAST840
Alternative sequenceiVSP_019635234 – 249GVVGG…NNIMF → VYSNVICFLSLKSMKN in isoform 4. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_019636250 – 942Missing in isoform 4. 1 PublicationAdd BLAST693
Alternative sequenceiVSP_019637296 – 942Missing in isoform 3. 1 PublicationAdd BLAST647
Alternative sequenceiVSP_019638296 – 306Missing in isoform 2 and isoform 7. 2 PublicationsAdd BLAST11
Alternative sequenceiVSP_019639724 – 748FVVVE…TKSWE → MRGQRLPLDIQIFYCARPDE EPFVK in isoform 5. 1 PublicationAdd BLAST25

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF493978 mRNA Translation: AAM27392.1
AB074157 mRNA Translation: BAE45732.1
AK094706 mRNA Translation: BAC04402.1
AK294558 mRNA Translation: BAH11810.1
BX537385 mRNA Translation: CAD97627.1
AL832628 mRNA Translation: CAD89948.1 Frameshift.
AL035689 Genomic DNA No translation available.
AL078594 Genomic DNA No translation available.
AL136163 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48133.1
BC036461 mRNA Translation: AAH36461.1
BC071782 mRNA Translation: AAH71782.1
BC137094 mRNA Translation: AAI37095.1
BC137095 mRNA Translation: AAI37096.1
CCDSiCCDS5132.1 [Q8NI08-1]
CCDS56448.1 [Q8NI08-7]
CCDS83125.1 [Q8NI08-5]
RefSeqiNP_001116314.1, NM_001122842.2 [Q8NI08-2]
NP_001186548.1, NM_001199619.1 [Q8NI08-1]
NP_001186549.1, NM_001199620.1 [Q8NI08-1]
NP_001186550.1, NM_001199621.1 [Q8NI08-7]
NP_001186551.1, NM_001199622.1 [Q8NI08-5]
NP_861447.3, NM_181782.4 [Q8NI08-1]
XP_005266879.1, XM_005266822.4 [Q8NI08-1]
XP_006715403.1, XM_006715340.3 [Q8NI08-1]
XP_011533757.1, XM_011535455.2 [Q8NI08-1]
XP_016865758.1, XM_017010269.1 [Q8NI08-1]
XP_016865759.1, XM_017010270.1 [Q8NI08-2]
XP_016865760.1, XM_017010271.1 [Q8NI08-2]
XP_016865761.1, XM_017010272.1 [Q8NI08-2]
XP_016865762.1, XM_017010273.1 [Q8NI08-2]
XP_016865763.1, XM_017010274.1 [Q8NI08-2]
UniGeneiHs.171426

Genome annotation databases

EnsembliENST00000229634; ENSP00000229634; ENSG00000111912 [Q8NI08-7]
ENST00000368357; ENSP00000357341; ENSG00000111912 [Q8NI08-1]
ENST00000392477; ENSP00000376269; ENSG00000111912 [Q8NI08-1]
ENST00000438495; ENSP00000398268; ENSG00000111912 [Q8NI08-5]
GeneIDi135112
KEGGihsa:135112
UCSCiuc003qae.5 human [Q8NI08-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF493978 mRNA Translation: AAM27392.1
AB074157 mRNA Translation: BAE45732.1
AK094706 mRNA Translation: BAC04402.1
AK294558 mRNA Translation: BAH11810.1
BX537385 mRNA Translation: CAD97627.1
AL832628 mRNA Translation: CAD89948.1 Frameshift.
AL035689 Genomic DNA No translation available.
AL078594 Genomic DNA No translation available.
AL136163 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48133.1
BC036461 mRNA Translation: AAH36461.1
BC071782 mRNA Translation: AAH71782.1
BC137094 mRNA Translation: AAI37095.1
BC137095 mRNA Translation: AAI37096.1
CCDSiCCDS5132.1 [Q8NI08-1]
CCDS56448.1 [Q8NI08-7]
CCDS83125.1 [Q8NI08-5]
RefSeqiNP_001116314.1, NM_001122842.2 [Q8NI08-2]
NP_001186548.1, NM_001199619.1 [Q8NI08-1]
NP_001186549.1, NM_001199620.1 [Q8NI08-1]
NP_001186550.1, NM_001199621.1 [Q8NI08-7]
NP_001186551.1, NM_001199622.1 [Q8NI08-5]
NP_861447.3, NM_181782.4 [Q8NI08-1]
XP_005266879.1, XM_005266822.4 [Q8NI08-1]
XP_006715403.1, XM_006715340.3 [Q8NI08-1]
XP_011533757.1, XM_011535455.2 [Q8NI08-1]
XP_016865758.1, XM_017010269.1 [Q8NI08-1]
XP_016865759.1, XM_017010270.1 [Q8NI08-2]
XP_016865760.1, XM_017010271.1 [Q8NI08-2]
XP_016865761.1, XM_017010272.1 [Q8NI08-2]
XP_016865762.1, XM_017010273.1 [Q8NI08-2]
XP_016865763.1, XM_017010274.1 [Q8NI08-2]
UniGeneiHs.171426

3D structure databases

ProteinModelPortaliQ8NI08
SMRiQ8NI08
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126419, 9 interactors
IntActiQ8NI08, 11 interactors
MINTiQ8NI08
STRINGi9606.ENSP00000357341

PTM databases

iPTMnetiQ8NI08
PhosphoSitePlusiQ8NI08
SwissPalmiQ8NI08

Polymorphism and mutation databases

BioMutaiNCOA7
DMDMi110287684

Proteomic databases

EPDiQ8NI08
MaxQBiQ8NI08
PaxDbiQ8NI08
PeptideAtlasiQ8NI08
PRIDEiQ8NI08
ProteomicsDBi73795
73796 [Q8NI08-2]
73797 [Q8NI08-3]
73798 [Q8NI08-4]
73799 [Q8NI08-5]
73800 [Q8NI08-6]

Protocols and materials databases

DNASUi135112
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000229634; ENSP00000229634; ENSG00000111912 [Q8NI08-7]
ENST00000368357; ENSP00000357341; ENSG00000111912 [Q8NI08-1]
ENST00000392477; ENSP00000376269; ENSG00000111912 [Q8NI08-1]
ENST00000438495; ENSP00000398268; ENSG00000111912 [Q8NI08-5]
GeneIDi135112
KEGGihsa:135112
UCSCiuc003qae.5 human [Q8NI08-1]

Organism-specific databases

CTDi135112
DisGeNETi135112
EuPathDBiHostDB:ENSG00000111912.19
GeneCardsiNCOA7
H-InvDBiHIX0006198
HGNCiHGNC:21081 NCOA7
HPAiHPA030289
HPA030290
HPA030291
HPA030292
MIMi609752 gene
neXtProtiNX_Q8NI08
OpenTargetsiENSG00000111912
PharmGKBiPA134905581
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IMGK Eukaryota
ENOG4110T63 LUCA
GeneTreeiENSGT00410000025363
HOVERGENiHBG065488
InParanoidiQ8NI08
OMAiMSCKYFT
OrthoDBiEOG091G0L15
PhylomeDBiQ8NI08
TreeFamiTF313530

Miscellaneous databases

ChiTaRSiNCOA7 human
GeneWikiiNCOA7
GenomeRNAii135112
PROiPR:Q8NI08
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000111912 Expressed in 203 organ(s), highest expression level in visceral pleura
ExpressionAtlasiQ8NI08 baseline and differential
GenevisibleiQ8NI08 HS

Family and domain databases

CDDicd00118 LysM, 1 hit
Gene3Di3.10.350.10, 1 hit
InterProiView protein in InterPro
IPR018392 LysM_dom
IPR036779 LysM_dom_sf
IPR006571 TLDc_dom
PfamiView protein in Pfam
PF01476 LysM, 1 hit
PF07534 TLD, 1 hit
SMARTiView protein in SMART
SM00257 LysM, 1 hit
SM00584 TLDc, 1 hit
PROSITEiView protein in PROSITE
PS51782 LYSM, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNCOA7_HUMAN
AccessioniPrimary (citable) accession number: Q8NI08
Secondary accession number(s): B2RNS2
, B7Z2C4, B9EH71, G8JL91, Q3LID6, Q4G0V1, Q5TF95, Q6IPQ4, Q6NE83, Q86T89, Q8N1W4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: July 11, 2006
Last modified: November 7, 2018
This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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