UniProtKB - Q8NHZ8 (CDC26_HUMAN)
Protein
Anaphase-promoting complex subunit CDC26
Gene
CDC26
Organism
Homo sapiens (Human)
Status
Functioni
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex.1 Publication
: protein ubiquitination Pathwayi
This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.
GO - Biological processi
- anaphase-promoting complex-dependent catabolic process Source: Reactome
- cell cycle Source: UniProtKB-KW
- cell division Source: UniProtKB-KW
- protein K11-linked ubiquitination Source: UniProtKB
- regulation of mitotic cell cycle Source: GO_Central
- regulation of mitotic cell cycle phase transition Source: Reactome
- regulation of mitotic metaphase/anaphase transition Source: InterPro
- ubiquitin-dependent protein catabolic process Source: Reactome
Keywordsi
Biological process | Cell cycle, Cell division, Mitosis, Ubl conjugation pathway |
Enzyme and pathway databases
PathwayCommonsi | Q8NHZ8 |
Reactomei | R-HSA-141430, Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-174048, APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174084, Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174154, APC/C:Cdc20 mediated degradation of Securin R-HSA-174178, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174184, Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-176407, Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176408, Regulation of APC/C activators between G1/S and early anaphase R-HSA-176409, APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176412, Phosphorylation of the APC/C R-HSA-179409, APC-Cdc20 mediated degradation of Nek2A R-HSA-2467813, Separation of Sister Chromatids R-HSA-2559582, Senescence-Associated Secretory Phenotype (SASP) R-HSA-69017, CDK-mediated phosphorylation and removal of Cdc6 R-HSA-8853884, Transcriptional Regulation by VENTX R-HSA-9687136, Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation |
SIGNORi | Q8NHZ8 |
UniPathwayi | UPA00143 |
Names & Taxonomyi
Protein namesi | Recommended name: Anaphase-promoting complex subunit CDC26Alternative name(s): Anaphase-promoting complex subunit 12 Short name: APC12 Cell division cycle protein 26 homolog |
Gene namesi | Name:CDC26 Synonyms:ANAPC12, C9orf17 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:17839, CDC26 |
MIMi | 614533, gene |
neXtProti | NX_Q8NHZ8 |
VEuPathDBi | HostDB:ENSG00000176386.8 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Cytosol
- cytosol Source: Reactome
Nucleus
- anaphase-promoting complex Source: UniProtKB
- nucleoplasm Source: Reactome
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 246184 |
OpenTargetsi | ENSG00000176386 |
PharmGKBi | PA25974 |
Miscellaneous databases
Pharosi | Q8NHZ8, Tbio |
Genetic variation databases
BioMutai | CDC26 |
DMDMi | 74751322 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000271194 | 1 – 85 | Anaphase-promoting complex subunit CDC26Add BLAST | 85 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 42 | PhosphoserineCombined sources | 1 | |
Modified residuei | 82 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q8NHZ8 |
jPOSTi | Q8NHZ8 |
MassIVEi | Q8NHZ8 |
MaxQBi | Q8NHZ8 |
PaxDbi | Q8NHZ8 |
PeptideAtlasi | Q8NHZ8 |
PRIDEi | Q8NHZ8 |
ProteomicsDBi | 73794 |
TopDownProteomicsi | Q8NHZ8 |
PTM databases
iPTMneti | Q8NHZ8 |
PhosphoSitePlusi | Q8NHZ8 |
Expressioni
Gene expression databases
Bgeei | ENSG00000176386, Expressed in calcaneal tendon and 118 other tissues |
ExpressionAtlasi | Q8NHZ8, baseline and differential |
Genevisiblei | Q8NHZ8, HS |
Organism-specific databases
HPAi | ENSG00000176386, Low tissue specificity |
Interactioni
Subunit structurei
V-shaped homodimer.
Interacts with CDC16. The mammalian APC/C is composed at least of 14 distinct subunits ANAPC1, ANAPC2, CDC27/APC3, ANAPC4, ANAPC5, CDC16/APC6, ANAPC7, CDC23/APC8, ANAPC10, ANAPC11, CDC26/APC12, ANAPC13, ANAPC15 and ANAPC16 that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa; APC/C interacts with FZR1 and FBXO5.
4 PublicationsBinary interactionsi
Hide detailsQ8NHZ8
With | #Exp. | IntAct |
---|---|---|
ATXN1 [P54253] | 3 | EBI-2555941,EBI-930964 |
CDC16 [Q13042] | 15 | EBI-2555941,EBI-994830 |
CDC16 - isoform 1 [Q13042-1] | 5 | EBI-2555941,EBI-15798699 |
Protein-protein interaction databases
BioGRIDi | 128878, 46 interactors |
ComplexPortali | CPX-1860, Anaphase-Promoting core complex |
DIPi | DIP-48551N |
IntActi | Q8NHZ8, 37 interactors |
STRINGi | 9606.ENSP00000363322 |
Miscellaneous databases
RNActi | Q8NHZ8, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q8NHZ8 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q8NHZ8 |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 7 – 38 | Sequence analysisAdd BLAST | 32 |
Sequence similaritiesi
Belongs to the CDC26 family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG502S5GK, Eukaryota |
GeneTreei | ENSGT00390000008457 |
HOGENOMi | CLU_190086_0_0_1 |
InParanoidi | Q8NHZ8 |
OMAi | DHKSREQ |
OrthoDBi | 1612963at2759 |
PhylomeDBi | Q8NHZ8 |
TreeFami | TF101057 |
Family and domain databases
DisProti | DP01453 |
InterProi | View protein in InterPro IPR018860, APC_suCDC26 |
PANTHERi | PTHR28579, PTHR28579, 1 hit |
Pfami | View protein in Pfam PF10471, ANAPC_CDC26, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8NHZ8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLRRKPTRLE LKLDDIEEFE NIRKDLETRK KQKEDVEVVG GSDGEGAIGL
60 70 80
SSDPKSREQM INDRIGYKPQ PKPNNRSSQF GSLEF
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF503918 mRNA Translation: AAM34207.1 AL449305 Genomic DNA No translation available. BC042534 mRNA Translation: AAH42534.1 BC066300 mRNA Translation: AAH66300.1 |
CCDSi | CCDS6790.1 |
RefSeqi | NP_644815.1, NM_139286.3 XP_016870062.1, XM_017014573.1 XP_016870063.1, XM_017014574.1 XP_016870064.1, XM_017014575.1 |
Genome annotation databases
Ensembli | ENST00000374206; ENSP00000363322; ENSG00000176386 |
GeneIDi | 246184 |
KEGGi | hsa:246184 |
UCSCi | uc004bgw.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF503918 mRNA Translation: AAM34207.1 AL449305 Genomic DNA No translation available. BC042534 mRNA Translation: AAH42534.1 BC066300 mRNA Translation: AAH66300.1 |
CCDSi | CCDS6790.1 |
RefSeqi | NP_644815.1, NM_139286.3 XP_016870062.1, XM_017014573.1 XP_016870063.1, XM_017014574.1 XP_016870064.1, XM_017014575.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3HYM | X-ray | 2.80 | A/C/E/G/I/K | 1-29 | [»] | |
4UI9 | electron microscopy | 3.60 | G/W | 1-85 | [»] | |
5A31 | electron microscopy | 4.30 | G/W | 1-85 | [»] | |
5G04 | electron microscopy | 4.00 | G/W | 1-85 | [»] | |
5G05 | electron microscopy | 3.40 | G/W | 1-85 | [»] | |
5KHR | electron microscopy | 6.10 | G/W | 1-85 | [»] | |
5KHU | electron microscopy | 4.80 | G/W | 1-85 | [»] | |
5L9T | electron microscopy | 6.40 | G/W | 1-85 | [»] | |
5L9U | electron microscopy | 6.40 | G/W | 1-85 | [»] | |
5LCW | electron microscopy | 4.00 | G/W | 1-85 | [»] | |
6Q6G | electron microscopy | 3.20 | G/W | 1-85 | [»] | |
6Q6H | electron microscopy | 3.20 | G/W | 1-85 | [»] | |
6TLJ | electron microscopy | 3.80 | G/W | 1-85 | [»] | |
6TM5 | electron microscopy | 3.90 | G/W | 1-85 | [»] | |
SMRi | Q8NHZ8 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 128878, 46 interactors |
ComplexPortali | CPX-1860, Anaphase-Promoting core complex |
DIPi | DIP-48551N |
IntActi | Q8NHZ8, 37 interactors |
STRINGi | 9606.ENSP00000363322 |
PTM databases
iPTMneti | Q8NHZ8 |
PhosphoSitePlusi | Q8NHZ8 |
Genetic variation databases
BioMutai | CDC26 |
DMDMi | 74751322 |
Proteomic databases
EPDi | Q8NHZ8 |
jPOSTi | Q8NHZ8 |
MassIVEi | Q8NHZ8 |
MaxQBi | Q8NHZ8 |
PaxDbi | Q8NHZ8 |
PeptideAtlasi | Q8NHZ8 |
PRIDEi | Q8NHZ8 |
ProteomicsDBi | 73794 |
TopDownProteomicsi | Q8NHZ8 |
Protocols and materials databases
Antibodypediai | 44232, 100 antibodies |
DNASUi | 246184 |
Genome annotation databases
Ensembli | ENST00000374206; ENSP00000363322; ENSG00000176386 |
GeneIDi | 246184 |
KEGGi | hsa:246184 |
UCSCi | uc004bgw.4, human |
Organism-specific databases
CTDi | 246184 |
DisGeNETi | 246184 |
GeneCardsi | CDC26 |
HGNCi | HGNC:17839, CDC26 |
HPAi | ENSG00000176386, Low tissue specificity |
MIMi | 614533, gene |
neXtProti | NX_Q8NHZ8 |
OpenTargetsi | ENSG00000176386 |
PharmGKBi | PA25974 |
VEuPathDBi | HostDB:ENSG00000176386.8 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S5GK, Eukaryota |
GeneTreei | ENSGT00390000008457 |
HOGENOMi | CLU_190086_0_0_1 |
InParanoidi | Q8NHZ8 |
OMAi | DHKSREQ |
OrthoDBi | 1612963at2759 |
PhylomeDBi | Q8NHZ8 |
TreeFami | TF101057 |
Enzyme and pathway databases
UniPathwayi | UPA00143 |
PathwayCommonsi | Q8NHZ8 |
Reactomei | R-HSA-141430, Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-174048, APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174084, Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174154, APC/C:Cdc20 mediated degradation of Securin R-HSA-174178, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174184, Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-176407, Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176408, Regulation of APC/C activators between G1/S and early anaphase R-HSA-176409, APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176412, Phosphorylation of the APC/C R-HSA-179409, APC-Cdc20 mediated degradation of Nek2A R-HSA-2467813, Separation of Sister Chromatids R-HSA-2559582, Senescence-Associated Secretory Phenotype (SASP) R-HSA-69017, CDK-mediated phosphorylation and removal of Cdc6 R-HSA-8853884, Transcriptional Regulation by VENTX R-HSA-9687136, Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation |
SIGNORi | Q8NHZ8 |
Miscellaneous databases
BioGRID-ORCSi | 246184, 459 hits in 853 CRISPR screens |
ChiTaRSi | CDC26, human |
EvolutionaryTracei | Q8NHZ8 |
GenomeRNAii | 246184 |
Pharosi | Q8NHZ8, Tbio |
PROi | PR:Q8NHZ8 |
RNActi | Q8NHZ8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000176386, Expressed in calcaneal tendon and 118 other tissues |
ExpressionAtlasi | Q8NHZ8, baseline and differential |
Genevisiblei | Q8NHZ8, HS |
Family and domain databases
DisProti | DP01453 |
InterProi | View protein in InterPro IPR018860, APC_suCDC26 |
PANTHERi | PTHR28579, PTHR28579, 1 hit |
Pfami | View protein in Pfam PF10471, ANAPC_CDC26, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CDC26_HUMAN | |
Accessioni | Q8NHZ8Primary (citable) accession number: Q8NHZ8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 9, 2007 |
Last sequence update: | October 1, 2002 | |
Last modified: | February 10, 2021 | |
This is version 163 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families