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Protein

Zinc finger protein 28 homolog

Gene

ZFP28

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation. May have a role in embryonic development.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri420 – 442C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri448 – 470C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri476 – 499C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri505 – 527C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri533 – 555C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri561 – 583C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri589 – 611C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri617 – 639C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri645 – 667C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri673 – 695C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri701 – 723C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri729 – 751C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri757 – 779C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri785 – 807C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri813 – 835C2H2-type 15; degeneratePROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-212436 Generic Transcription Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 28 homolog
Short name:
Zfp-28
Alternative name(s):
Krueppel-like zinc finger factor X6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZFP28
Synonyms:KIAA1431
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000196867.7

Human Gene Nomenclature Database

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HGNCi
HGNC:17801 ZFP28

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8NHY6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000196867

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA38469

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
ZFP28

Domain mapping of disease mutations (DMDM)

More...
DMDMi
33517131

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000472891 – 868Zinc finger protein 28 homologAdd BLAST868

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8NHY6

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q8NHY6

PeptideAtlas

More...
PeptideAtlasi
Q8NHY6

PRoteomics IDEntifications database

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PRIDEi
Q8NHY6

ProteomicsDB human proteome resource

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ProteomicsDBi
73791

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q8NHY6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8NHY6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000196867 Expressed in 139 organ(s), highest expression level in amniotic fluid

CleanEx database of gene expression profiles

More...
CleanExi
HS_ZFP28

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q8NHY6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q8NHY6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA028879

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
126637, 5 interactors

Protein interaction database and analysis system

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IntActi
Q8NHY6, 5 interactors

Molecular INTeraction database

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MINTi
Q8NHY6

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000301318

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1868
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q8NHY6

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8NHY6

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q8NHY6

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini103 – 174KRAB 1PROSITE-ProRule annotationAdd BLAST72
Domaini232 – 299KRAB 2PROSITE-ProRule annotationAdd BLAST68

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri420 – 442C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri448 – 470C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri476 – 499C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri505 – 527C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri533 – 555C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri561 – 583C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri589 – 611C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri617 – 639C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri645 – 667C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri673 – 695C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri701 – 723C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri729 – 751C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri757 – 779C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri785 – 807C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri813 – 835C2H2-type 15; degeneratePROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000162376

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000234617

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG073084

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8NHY6

KEGG Orthology (KO)

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KOi
K09228

Identification of Orthologs from Complete Genome Data

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OMAi
TGIYAGK

Database of Orthologous Groups

More...
OrthoDBi
EOG091G02KC

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8NHY6

TreeFam database of animal gene trees

More...
TreeFami
TF341817

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07765 KRAB_A-box, 2 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01352 KRAB, 2 hits
PF00096 zf-C2H2, 10 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00349 KRAB, 2 hits
SM00355 ZnF_C2H2, 14 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109640 SSF109640, 2 hits
SSF57667 SSF57667, 8 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50805 KRAB, 2 hits
PS00028 ZINC_FINGER_C2H2_1, 14 hits
PS50157 ZINC_FINGER_C2H2_2, 15 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8NHY6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRGAASASVR EPTPLPGRGA PRTKPRAGRG PTVGTPATLA LPARGRPRSR
60 70 80 90 100
NGLASKGQRG AAPTGPGHRA LPSRDTALPQ ERNKKLEAVG TGIEPKAMSQ
110 120 130 140 150
GLVTFGDVAV DFSQEEWEWL NPIQRNLYRK VMLENYRNLA SLGLCVSKPD
160 170 180 190 200
VISSLEQGKE PWTVKRKMTR AWCPDLKAVW KIKELPLKKD FCEGKLSQAV
210 220 230 240 250
ITERLTSYNL EYSLLGEHWD YDALFETQPG LVTIKNLAVD FRQQLHPAQK
260 270 280 290 300
NFCKNGIWEN NSDLGSAGHC VAKPDLVSLL EQEKEPWMVK RELTGSLFSG
310 320 330 340 350
QRSVHETQEL FPKQDSYAEG VTDRTSNTKL DCSSFRENWD SDYVFGRKLA
360 370 380 390 400
VGQETQFRQE PITHNKTLSK ERERTYNKSG RWFYLDDSEE KVHNRDSIKN
410 420 430 440 450
FQKSSVVIKQ TGIYAGKKLF KCNECKKTFT QSSSLTVHQR IHTGEKPYKC
460 470 480 490 500
NECGKAFSDG SSFARHQRCH TGKKPYECIE CGKAFIQNTS LIRHWRYYHT
510 520 530 540 550
GEKPFDCIDC GKAFSDHIGL NQHRRIHTGE KPYKCDVCHK SFRYGSSLTV
560 570 580 590 600
HQRIHTGEKP YECDVCRKAF SHHASLTQHQ RVHSGEKPFK CKECGKAFRQ
610 620 630 640 650
NIHLASHLRI HTGEKPFECA ECGKSFSISS QLATHQRIHT GEKPYECKVC
660 670 680 690 700
SKAFTQKAHL AQHQKTHTGE KPYECKECGK AFSQTTHLIQ HQRVHTGEKP
710 720 730 740 750
YKCMECGKAF GDNSSCTQHQ RLHTGQRPYE CIECGKAFKT KSSLICHRRS
760 770 780 790 800
HTGEKPYECS VCGKAFSHRQ SLSVHQRIHS GKKPYECKEC RKTFIQIGHL
810 820 830 840 850
NQHKRVHTGE RSYNYKKSRK VFRQTAHLAH HQRIHTGESS TCPSLPSTSN
860
PVDLFPKFLW NPSSLPSP
Length:868
Mass (Da):98,705
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE5959243B41CE3F3
GO
Isoform 2 (identifier: Q8NHY6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     301-349: QRSVHETQEL...DSDYVFGRKL → ECRRAWCGKS...ERKLNSGSSK
     350-868: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:349
Mass (Da):38,512
Checksum:iDC42BF404E6EDC5C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EL00K7EL00_HUMAN
Zinc finger protein 28 homolog
ZFP28
146Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA92669 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti10R → H in AAH28416 (PubMed:15489334).Curated1
Sequence conflicti10R → H in AAH99903 (PubMed:15489334).Curated1
Sequence conflicti383F → S in BAA92669 (PubMed:10718198).Curated1
Sequence conflicti766 – 785Missing (Ref. 5) CuratedAdd BLAST20
Isoform 2 (identifier: Q8NHY6-2)
Sequence conflicti324S → F in AAH28416 (PubMed:15489334).Curated1
Sequence conflicti324S → F in AAH99903 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_052738141S → W. Corresponds to variant dbSNP:rs34136271Ensembl.1
Natural variantiVAR_024190620A → V. Corresponds to variant dbSNP:rs10409531Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_055934301 – 349QRSVH…FGRKL → ECRRAWCGKSTARESGAFTK KAASSLIYSRKLYPGSLGLE RKLNSGSSK in isoform 2. 1 PublicationAdd BLAST49
Alternative sequenceiVSP_055935350 – 868Missing in isoform 2. 1 PublicationAdd BLAST519

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF507045 mRNA Translation: AAM28892.1
AB037852 mRNA Translation: BAA92669.1 Different initiation.
AC005498 Genomic DNA No translation available.
BC028416 mRNA Translation: AAH28416.1
BC099903 mRNA Translation: AAH99903.1
BC127003 mRNA Translation: AAI27004.1
AF226995 mRNA Translation: AAK28320.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS12946.1 [Q8NHY6-1]
CCDS77363.1 [Q8NHY6-2]

NCBI Reference Sequences

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RefSeqi
NP_001295369.1, NM_001308440.1 [Q8NHY6-2]
NP_065879.1, NM_020828.1 [Q8NHY6-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.14794

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000301318; ENSP00000301318; ENSG00000196867 [Q8NHY6-1]
ENST00000591844; ENSP00000468603; ENSG00000196867 [Q8NHY6-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
140612

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:140612

UCSC genome browser

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UCSCi
uc002qni.4 human [Q8NHY6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF507045 mRNA Translation: AAM28892.1
AB037852 mRNA Translation: BAA92669.1 Different initiation.
AC005498 Genomic DNA No translation available.
BC028416 mRNA Translation: AAH28416.1
BC099903 mRNA Translation: AAH99903.1
BC127003 mRNA Translation: AAI27004.1
AF226995 mRNA Translation: AAK28320.1
CCDSiCCDS12946.1 [Q8NHY6-1]
CCDS77363.1 [Q8NHY6-2]
RefSeqiNP_001295369.1, NM_001308440.1 [Q8NHY6-2]
NP_065879.1, NM_020828.1 [Q8NHY6-1]
UniGeneiHs.14794

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EM2NMR-A584-616[»]
2EM3NMR-A640-672[»]
2EM4NMR-A724-756[»]
2EMJNMR-A612-644[»]
2EMKNMR-A668-700[»]
2EMLNMR-A752-784[»]
2EN9NMR-A415-447[»]
2ENHNMR-A556-588[»]
2EOHNMR-A780-812[»]
2EP0NMR-A528-560[»]
2EPXNMR-A471-504[»]
2EPZNMR-A500-532[»]
2YTMNMR-A696-728[»]
ProteinModelPortaliQ8NHY6
SMRiQ8NHY6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126637, 5 interactors
IntActiQ8NHY6, 5 interactors
MINTiQ8NHY6
STRINGi9606.ENSP00000301318

PTM databases

iPTMnetiQ8NHY6
PhosphoSitePlusiQ8NHY6

Polymorphism and mutation databases

BioMutaiZFP28
DMDMi33517131

Proteomic databases

MaxQBiQ8NHY6
PaxDbiQ8NHY6
PeptideAtlasiQ8NHY6
PRIDEiQ8NHY6
ProteomicsDBi73791

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000301318; ENSP00000301318; ENSG00000196867 [Q8NHY6-1]
ENST00000591844; ENSP00000468603; ENSG00000196867 [Q8NHY6-2]
GeneIDi140612
KEGGihsa:140612
UCSCiuc002qni.4 human [Q8NHY6-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
140612
EuPathDBiHostDB:ENSG00000196867.7

GeneCards: human genes, protein and diseases

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GeneCardsi
ZFP28
HGNCiHGNC:17801 ZFP28
HPAiHPA028879
neXtProtiNX_Q8NHY6
OpenTargetsiENSG00000196867
PharmGKBiPA38469

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000162376
HOGENOMiHOG000234617
HOVERGENiHBG073084
InParanoidiQ8NHY6
KOiK09228
OMAiTGIYAGK
OrthoDBiEOG091G02KC
PhylomeDBiQ8NHY6
TreeFamiTF341817

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ZFP28 human
EvolutionaryTraceiQ8NHY6

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
140612

Protein Ontology

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PROi
PR:Q8NHY6

Gene expression databases

BgeeiENSG00000196867 Expressed in 139 organ(s), highest expression level in amniotic fluid
CleanExiHS_ZFP28
ExpressionAtlasiQ8NHY6 baseline and differential
GenevisibleiQ8NHY6 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 2 hits
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 2 hits
PF00096 zf-C2H2, 10 hits
SMARTiView protein in SMART
SM00349 KRAB, 2 hits
SM00355 ZnF_C2H2, 14 hits
SUPFAMiSSF109640 SSF109640, 2 hits
SSF57667 SSF57667, 8 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 2 hits
PS00028 ZINC_FINGER_C2H2_1, 14 hits
PS50157 ZINC_FINGER_C2H2_2, 15 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZFP28_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NHY6
Secondary accession number(s): A0JNV6
, K7ES88, Q8NHU8, Q9BY30, Q9P2B6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 4, 2003
Last sequence update: October 1, 2002
Last modified: December 5, 2018
This is version 153 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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