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Protein

Zinc finger protein 28 homolog

Gene

ZFP28

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation. May have a role in embryonic development.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri420 – 442C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri448 – 470C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri476 – 499C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri505 – 527C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri533 – 555C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri561 – 583C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri589 – 611C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri617 – 639C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri645 – 667C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri673 – 695C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri701 – 723C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri729 – 751C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri757 – 779C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri785 – 807C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri813 – 835C2H2-type 15; degeneratePROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 28 homolog
Short name:
Zfp-28
Alternative name(s):
Krueppel-like zinc finger factor X6
Gene namesi
Name:ZFP28
Synonyms:KIAA1431
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000196867.7
HGNCiHGNC:17801 ZFP28
neXtProtiNX_Q8NHY6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000196867
PharmGKBiPA38469

Polymorphism and mutation databases

BioMutaiZFP28
DMDMi33517131

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000472891 – 868Zinc finger protein 28 homologAdd BLAST868

Proteomic databases

MaxQBiQ8NHY6
PaxDbiQ8NHY6
PeptideAtlasiQ8NHY6
PRIDEiQ8NHY6
ProteomicsDBi73791

PTM databases

iPTMnetiQ8NHY6
PhosphoSitePlusiQ8NHY6

Expressioni

Gene expression databases

BgeeiENSG00000196867 Expressed in 139 organ(s), highest expression level in amniotic fluid
CleanExiHS_ZFP28
ExpressionAtlasiQ8NHY6 baseline and differential
GenevisibleiQ8NHY6 HS

Organism-specific databases

HPAiHPA028879

Interactioni

Protein-protein interaction databases

BioGridi126637, 5 interactors
IntActiQ8NHY6, 5 interactors
MINTiQ8NHY6
STRINGi9606.ENSP00000301318

Structurei

Secondary structure

1868
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ8NHY6
SMRiQ8NHY6
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8NHY6

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini103 – 174KRAB 1PROSITE-ProRule annotationAdd BLAST72
Domaini232 – 299KRAB 2PROSITE-ProRule annotationAdd BLAST68

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri420 – 442C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri448 – 470C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri476 – 499C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri505 – 527C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri533 – 555C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri561 – 583C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri589 – 611C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri617 – 639C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri645 – 667C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri673 – 695C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri701 – 723C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri729 – 751C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri757 – 779C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri785 – 807C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri813 – 835C2H2-type 15; degeneratePROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00840000129704
HOGENOMiHOG000234617
HOVERGENiHBG073084
InParanoidiQ8NHY6
KOiK09228
OMAiTGIYAGK
OrthoDBiEOG091G02KC
PhylomeDBiQ8NHY6
TreeFamiTF341817

Family and domain databases

CDDicd07765 KRAB_A-box, 2 hits
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 2 hits
PF00096 zf-C2H2, 11 hits
SMARTiView protein in SMART
SM00349 KRAB, 2 hits
SM00355 ZnF_C2H2, 14 hits
SUPFAMiSSF109640 SSF109640, 2 hits
SSF57667 SSF57667, 8 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 2 hits
PS00028 ZINC_FINGER_C2H2_1, 14 hits
PS50157 ZINC_FINGER_C2H2_2, 15 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8NHY6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRGAASASVR EPTPLPGRGA PRTKPRAGRG PTVGTPATLA LPARGRPRSR
60 70 80 90 100
NGLASKGQRG AAPTGPGHRA LPSRDTALPQ ERNKKLEAVG TGIEPKAMSQ
110 120 130 140 150
GLVTFGDVAV DFSQEEWEWL NPIQRNLYRK VMLENYRNLA SLGLCVSKPD
160 170 180 190 200
VISSLEQGKE PWTVKRKMTR AWCPDLKAVW KIKELPLKKD FCEGKLSQAV
210 220 230 240 250
ITERLTSYNL EYSLLGEHWD YDALFETQPG LVTIKNLAVD FRQQLHPAQK
260 270 280 290 300
NFCKNGIWEN NSDLGSAGHC VAKPDLVSLL EQEKEPWMVK RELTGSLFSG
310 320 330 340 350
QRSVHETQEL FPKQDSYAEG VTDRTSNTKL DCSSFRENWD SDYVFGRKLA
360 370 380 390 400
VGQETQFRQE PITHNKTLSK ERERTYNKSG RWFYLDDSEE KVHNRDSIKN
410 420 430 440 450
FQKSSVVIKQ TGIYAGKKLF KCNECKKTFT QSSSLTVHQR IHTGEKPYKC
460 470 480 490 500
NECGKAFSDG SSFARHQRCH TGKKPYECIE CGKAFIQNTS LIRHWRYYHT
510 520 530 540 550
GEKPFDCIDC GKAFSDHIGL NQHRRIHTGE KPYKCDVCHK SFRYGSSLTV
560 570 580 590 600
HQRIHTGEKP YECDVCRKAF SHHASLTQHQ RVHSGEKPFK CKECGKAFRQ
610 620 630 640 650
NIHLASHLRI HTGEKPFECA ECGKSFSISS QLATHQRIHT GEKPYECKVC
660 670 680 690 700
SKAFTQKAHL AQHQKTHTGE KPYECKECGK AFSQTTHLIQ HQRVHTGEKP
710 720 730 740 750
YKCMECGKAF GDNSSCTQHQ RLHTGQRPYE CIECGKAFKT KSSLICHRRS
760 770 780 790 800
HTGEKPYECS VCGKAFSHRQ SLSVHQRIHS GKKPYECKEC RKTFIQIGHL
810 820 830 840 850
NQHKRVHTGE RSYNYKKSRK VFRQTAHLAH HQRIHTGESS TCPSLPSTSN
860
PVDLFPKFLW NPSSLPSP
Length:868
Mass (Da):98,705
Last modified:October 1, 2002 - v1
Checksum:iE5959243B41CE3F3
GO
Isoform 2 (identifier: Q8NHY6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     301-349: QRSVHETQEL...DSDYVFGRKL → ECRRAWCGKS...ERKLNSGSSK
     350-868: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:349
Mass (Da):38,512
Checksum:iDC42BF404E6EDC5C
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EL00K7EL00_HUMAN
Zinc finger protein 28 homolog
ZFP28
146Annotation score:

Sequence cautioni

The sequence BAA92669 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti10R → H in AAH28416 (PubMed:15489334).Curated1
Sequence conflicti10R → H in AAH99903 (PubMed:15489334).Curated1
Sequence conflicti383F → S in BAA92669 (PubMed:10718198).Curated1
Sequence conflicti766 – 785Missing (Ref. 5) CuratedAdd BLAST20
Isoform 2 (identifier: Q8NHY6-2)
Sequence conflicti324S → F in AAH28416 (PubMed:15489334).Curated1
Sequence conflicti324S → F in AAH99903 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052738141S → W. Corresponds to variant dbSNP:rs34136271Ensembl.1
Natural variantiVAR_024190620A → V. Corresponds to variant dbSNP:rs10409531Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_055934301 – 349QRSVH…FGRKL → ECRRAWCGKSTARESGAFTK KAASSLIYSRKLYPGSLGLE RKLNSGSSK in isoform 2. 1 PublicationAdd BLAST49
Alternative sequenceiVSP_055935350 – 868Missing in isoform 2. 1 PublicationAdd BLAST519

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF507045 mRNA Translation: AAM28892.1
AB037852 mRNA Translation: BAA92669.1 Different initiation.
AC005498 Genomic DNA No translation available.
BC028416 mRNA Translation: AAH28416.1
BC099903 mRNA Translation: AAH99903.1
BC127003 mRNA Translation: AAI27004.1
AF226995 mRNA Translation: AAK28320.1
CCDSiCCDS12946.1 [Q8NHY6-1]
CCDS77363.1 [Q8NHY6-2]
RefSeqiNP_001295369.1, NM_001308440.1 [Q8NHY6-2]
NP_065879.1, NM_020828.1 [Q8NHY6-1]
UniGeneiHs.14794

Genome annotation databases

EnsembliENST00000301318; ENSP00000301318; ENSG00000196867 [Q8NHY6-1]
ENST00000591844; ENSP00000468603; ENSG00000196867 [Q8NHY6-2]
GeneIDi140612
KEGGihsa:140612
UCSCiuc002qni.4 human [Q8NHY6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF507045 mRNA Translation: AAM28892.1
AB037852 mRNA Translation: BAA92669.1 Different initiation.
AC005498 Genomic DNA No translation available.
BC028416 mRNA Translation: AAH28416.1
BC099903 mRNA Translation: AAH99903.1
BC127003 mRNA Translation: AAI27004.1
AF226995 mRNA Translation: AAK28320.1
CCDSiCCDS12946.1 [Q8NHY6-1]
CCDS77363.1 [Q8NHY6-2]
RefSeqiNP_001295369.1, NM_001308440.1 [Q8NHY6-2]
NP_065879.1, NM_020828.1 [Q8NHY6-1]
UniGeneiHs.14794

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EM2NMR-A584-616[»]
2EM3NMR-A640-672[»]
2EM4NMR-A724-756[»]
2EMJNMR-A612-644[»]
2EMKNMR-A668-700[»]
2EMLNMR-A752-784[»]
2EN9NMR-A415-447[»]
2ENHNMR-A556-588[»]
2EOHNMR-A780-812[»]
2EP0NMR-A528-560[»]
2EPXNMR-A471-504[»]
2EPZNMR-A500-532[»]
2YTMNMR-A696-728[»]
ProteinModelPortaliQ8NHY6
SMRiQ8NHY6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126637, 5 interactors
IntActiQ8NHY6, 5 interactors
MINTiQ8NHY6
STRINGi9606.ENSP00000301318

PTM databases

iPTMnetiQ8NHY6
PhosphoSitePlusiQ8NHY6

Polymorphism and mutation databases

BioMutaiZFP28
DMDMi33517131

Proteomic databases

MaxQBiQ8NHY6
PaxDbiQ8NHY6
PeptideAtlasiQ8NHY6
PRIDEiQ8NHY6
ProteomicsDBi73791

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000301318; ENSP00000301318; ENSG00000196867 [Q8NHY6-1]
ENST00000591844; ENSP00000468603; ENSG00000196867 [Q8NHY6-2]
GeneIDi140612
KEGGihsa:140612
UCSCiuc002qni.4 human [Q8NHY6-1]

Organism-specific databases

CTDi140612
EuPathDBiHostDB:ENSG00000196867.7
GeneCardsiZFP28
HGNCiHGNC:17801 ZFP28
HPAiHPA028879
neXtProtiNX_Q8NHY6
OpenTargetsiENSG00000196867
PharmGKBiPA38469
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00840000129704
HOGENOMiHOG000234617
HOVERGENiHBG073084
InParanoidiQ8NHY6
KOiK09228
OMAiTGIYAGK
OrthoDBiEOG091G02KC
PhylomeDBiQ8NHY6
TreeFamiTF341817

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

ChiTaRSiZFP28 human
EvolutionaryTraceiQ8NHY6
GenomeRNAii140612
PROiPR:Q8NHY6

Gene expression databases

BgeeiENSG00000196867 Expressed in 139 organ(s), highest expression level in amniotic fluid
CleanExiHS_ZFP28
ExpressionAtlasiQ8NHY6 baseline and differential
GenevisibleiQ8NHY6 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 2 hits
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 2 hits
PF00096 zf-C2H2, 11 hits
SMARTiView protein in SMART
SM00349 KRAB, 2 hits
SM00355 ZnF_C2H2, 14 hits
SUPFAMiSSF109640 SSF109640, 2 hits
SSF57667 SSF57667, 8 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 2 hits
PS00028 ZINC_FINGER_C2H2_1, 14 hits
PS50157 ZINC_FINGER_C2H2_2, 15 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZFP28_HUMAN
AccessioniPrimary (citable) accession number: Q8NHY6
Secondary accession number(s): A0JNV6
, K7ES88, Q8NHU8, Q9BY30, Q9P2B6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 4, 2003
Last sequence update: October 1, 2002
Last modified: October 10, 2018
This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. SIMILARITY comments
    Index of protein domains and families
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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