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Entry version 115 (12 Aug 2020)
Sequence version 2 (16 Apr 2014)
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Protein

Spermatogenesis-associated protein 3

Gene

SPATA3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8NHX4

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Spermatogenesis-associated protein 3
Alternative name(s):
Testis and spermatogenesis cell-related protein 1
Testis spermatocyte apoptosis-related protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SPATA3
Synonyms:TSARG1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000173699.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17884, SPATA3

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8NHX4

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
130560

Open Targets

More...
OpenTargetsi
ENSG00000173699

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA38256

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8NHX4, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SPATA3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
41704647

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000721741 – 192Spermatogenesis-associated protein 3Add BLAST192

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8NHX4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8NHX4

PeptideAtlas

More...
PeptideAtlasi
Q8NHX4

PRoteomics IDEntifications database

More...
PRIDEi
Q8NHX4

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
73781

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8NHX4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8NHX4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000173699, Expressed in testis and 92 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8NHX4, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8NHX4, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000173699, Tissue enriched (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
126241, 8 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000388895

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8NHX4, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502TDUQ, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000003032

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_099077_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8NHX4

Identification of Orthologs from Complete Genome Data

More...
OMAi
TFYRKPP

Database of Orthologous Groups

More...
OrthoDBi
1513172at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8NHX4

TreeFam database of animal gene trees

More...
TreeFami
TF338040

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026717, SPATA3

The PANTHER Classification System

More...
PANTHERi
PTHR22234, PTHR22234, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15662, SPATA3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q8NHX4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKKVKKKRSE ARRHRDSTSQ HASSNSTSQQ PSPESTPQQP SPESTPQQPS
60 70 80 90 100
PESTPQHSSL ETTSRQPAFQ ALPAPEIRRS SCCLLSPDAN VKAAPQSRKA
110 120 130 140 150
GPLIRAGPHS CSCATCPCSS ACWRRLGLCH SRIFDVLLPR DWQMAPGRGL
160 170 180 190
PNLLTFYRKS SRKPSSHRNA CPPSPRNCGC GSGGSRSCLL HH
Length:192
Mass (Da):20,901
Last modified:April 16, 2014 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCC2E2B60D4A2CD11
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C283H7C283_HUMAN
Spermatogenesis-associated protein ...
SPATA3
104Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C3E6H7C3E6_HUMAN
Spermatogenesis-associated protein ...
SPATA3
87Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WU50A0A087WU50_HUMAN
Spermatogenesis-associated protein ...
SPATA3
181Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y5R0A0A2R8Y5R0_HUMAN
Spermatogenesis-associated protein ...
SPATA3
355Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WDD9F8WDD9_HUMAN
Spermatogenesis-associated protein ...
SPATA3
37Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti104I → T in AAH47704 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07080841 – 49Missing . 9

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY032925 mRNA Translation: AAK54455.1
AK093385 mRNA Translation: BAC04149.1
AC009407 Genomic DNA No translation available.
AC105344 Genomic DNA No translation available.
BC047704 mRNA Translation: AAH47704.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2481.1

NCBI Reference Sequences

More...
RefSeqi
NP_620712.2, NM_139073.3
XP_005246360.1, XM_005246303.2
XP_016858852.1, XM_017003363.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000424440; ENSP00000399514; ENSG00000173699
ENST00000433428; ENSP00000403804; ENSG00000173699
ENST00000452881; ENSP00000388895; ENSG00000173699
ENST00000455816; ENSP00000388741; ENSG00000173699

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
130560

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:130560

UCSC genome browser

More...
UCSCi
uc002vri.5, human

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY032925 mRNA Translation: AAK54455.1
AK093385 mRNA Translation: BAC04149.1
AC009407 Genomic DNA No translation available.
AC105344 Genomic DNA No translation available.
BC047704 mRNA Translation: AAH47704.1
CCDSiCCDS2481.1
RefSeqiNP_620712.2, NM_139073.3
XP_005246360.1, XM_005246303.2
XP_016858852.1, XM_017003363.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi126241, 8 interactors
STRINGi9606.ENSP00000388895

PTM databases

iPTMnetiQ8NHX4
PhosphoSitePlusiQ8NHX4

Polymorphism and mutation databases

BioMutaiSPATA3
DMDMi41704647

Proteomic databases

MassIVEiQ8NHX4
PaxDbiQ8NHX4
PeptideAtlasiQ8NHX4
PRIDEiQ8NHX4
ProteomicsDBi73781

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
11837, 45 antibodies

Genome annotation databases

EnsembliENST00000424440; ENSP00000399514; ENSG00000173699
ENST00000433428; ENSP00000403804; ENSG00000173699
ENST00000452881; ENSP00000388895; ENSG00000173699
ENST00000455816; ENSP00000388741; ENSG00000173699
GeneIDi130560
KEGGihsa:130560
UCSCiuc002vri.5, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
130560
DisGeNETi130560
EuPathDBiHostDB:ENSG00000173699.15

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SPATA3
HGNCiHGNC:17884, SPATA3
HPAiENSG00000173699, Tissue enriched (testis)
neXtProtiNX_Q8NHX4
OpenTargetsiENSG00000173699
PharmGKBiPA38256

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502TDUQ, Eukaryota
GeneTreeiENSGT00390000003032
HOGENOMiCLU_099077_0_0_1
InParanoidiQ8NHX4
OMAiTFYRKPP
OrthoDBi1513172at2759
PhylomeDBiQ8NHX4
TreeFamiTF338040

Enzyme and pathway databases

PathwayCommonsiQ8NHX4

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
130560, 4 hits in 867 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SPATA3, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
130560
PharosiQ8NHX4, Tdark

Protein Ontology

More...
PROi
PR:Q8NHX4
RNActiQ8NHX4, protein

Gene expression databases

BgeeiENSG00000173699, Expressed in testis and 92 other tissues
ExpressionAtlasiQ8NHX4, baseline and differential
GenevisibleiQ8NHX4, HS

Family and domain databases

InterProiView protein in InterPro
IPR026717, SPATA3
PANTHERiPTHR22234, PTHR22234, 1 hit
PfamiView protein in Pfam
PF15662, SPATA3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSPTA3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NHX4
Secondary accession number(s): Q86WX5, Q8N9Y6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: April 16, 2014
Last modified: August 12, 2020
This is version 115 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
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