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Protein

Spermatogenesis-associated protein 3

Gene

SPATA3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Spermatogenesis-associated protein 3
Alternative name(s):
Testis and spermatogenesis cell-related protein 1
Testis spermatocyte apoptosis-related protein 1
Gene namesi
Name:SPATA3
Synonyms:TSARG1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000173699.15
HGNCiHGNC:17884 SPATA3
neXtProtiNX_Q8NHX4

Pathology & Biotechi

Organism-specific databases

DisGeNETi130560
OpenTargetsiENSG00000173699
PharmGKBiPA38256

Polymorphism and mutation databases

BioMutaiSPATA3
DMDMi41704647

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000721741 – 192Spermatogenesis-associated protein 3Add BLAST192

Proteomic databases

PaxDbiQ8NHX4
PeptideAtlasiQ8NHX4
PRIDEiQ8NHX4
ProteomicsDBi73781

PTM databases

iPTMnetiQ8NHX4
PhosphoSitePlusiQ8NHX4

Expressioni

Gene expression databases

BgeeiENSG00000173699 Expressed in 61 organ(s), highest expression level in testis
ExpressionAtlasiQ8NHX4 baseline and differential
GenevisibleiQ8NHX4 HS

Interactioni

Protein-protein interaction databases

BioGridi126241, 8 interactors
STRINGi9606.ENSP00000388741

Structurei

3D structure databases

ProteinModelPortaliQ8NHX4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410JCCC Eukaryota
ENOG41113TY LUCA
GeneTreeiENSGT00390000003032
HOGENOMiHOG000276896
HOVERGENiHBG062640
InParanoidiQ8NHX4
OMAiAAPQSRK
OrthoDBiEOG091G135A
PhylomeDBiQ8NHX4
TreeFamiTF338040

Family and domain databases

InterProiView protein in InterPro
IPR026717 SPATA3
PANTHERiPTHR22234 PTHR22234, 1 hit
PfamiView protein in Pfam
PF15662 SPATA3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q8NHX4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKKVKKKRSE ARRHRDSTSQ HASSNSTSQQ PSPESTPQQP SPESTPQQPS
60 70 80 90 100
PESTPQHSSL ETTSRQPAFQ ALPAPEIRRS SCCLLSPDAN VKAAPQSRKA
110 120 130 140 150
GPLIRAGPHS CSCATCPCSS ACWRRLGLCH SRIFDVLLPR DWQMAPGRGL
160 170 180 190
PNLLTFYRKS SRKPSSHRNA CPPSPRNCGC GSGGSRSCLL HH
Length:192
Mass (Da):20,901
Last modified:April 16, 2014 - v2
Checksum:iCC2E2B60D4A2CD11
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C3E6H7C3E6_HUMAN
Spermatogenesis-associated protein ...
SPATA3
87Annotation score:
H7C283H7C283_HUMAN
Spermatogenesis-associated protein ...
SPATA3
104Annotation score:
A0A087WU50A0A087WU50_HUMAN
Spermatogenesis-associated protein ...
SPATA3
181Annotation score:
F8WDD9F8WDD9_HUMAN
Spermatogenesis-associated protein ...
SPATA3
37Annotation score:
A0A2R8Y5R0A0A2R8Y5R0_HUMAN
Spermatogenesis-associated protein ...
SPATA3
355Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti104I → T in AAH47704 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07080841 – 49Missing . 9

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY032925 mRNA Translation: AAK54455.1
AK093385 mRNA Translation: BAC04149.1
AC009407 Genomic DNA No translation available.
AC105344 Genomic DNA No translation available.
BC047704 mRNA Translation: AAH47704.1
CCDSiCCDS2481.1
RefSeqiNP_620712.2, NM_139073.3
XP_005246360.1, XM_005246303.2
XP_016858852.1, XM_017003363.1
UniGeneiHs.745178

Genome annotation databases

EnsembliENST00000424440; ENSP00000399514; ENSG00000173699
ENST00000433428; ENSP00000403804; ENSG00000173699
ENST00000452881; ENSP00000388895; ENSG00000173699
ENST00000455816; ENSP00000388741; ENSG00000173699
GeneIDi130560
KEGGihsa:130560
UCSCiuc002vri.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY032925 mRNA Translation: AAK54455.1
AK093385 mRNA Translation: BAC04149.1
AC009407 Genomic DNA No translation available.
AC105344 Genomic DNA No translation available.
BC047704 mRNA Translation: AAH47704.1
CCDSiCCDS2481.1
RefSeqiNP_620712.2, NM_139073.3
XP_005246360.1, XM_005246303.2
XP_016858852.1, XM_017003363.1
UniGeneiHs.745178

3D structure databases

ProteinModelPortaliQ8NHX4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126241, 8 interactors
STRINGi9606.ENSP00000388741

PTM databases

iPTMnetiQ8NHX4
PhosphoSitePlusiQ8NHX4

Polymorphism and mutation databases

BioMutaiSPATA3
DMDMi41704647

Proteomic databases

PaxDbiQ8NHX4
PeptideAtlasiQ8NHX4
PRIDEiQ8NHX4
ProteomicsDBi73781

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000424440; ENSP00000399514; ENSG00000173699
ENST00000433428; ENSP00000403804; ENSG00000173699
ENST00000452881; ENSP00000388895; ENSG00000173699
ENST00000455816; ENSP00000388741; ENSG00000173699
GeneIDi130560
KEGGihsa:130560
UCSCiuc002vri.5 human

Organism-specific databases

CTDi130560
DisGeNETi130560
EuPathDBiHostDB:ENSG00000173699.15
GeneCardsiSPATA3
HGNCiHGNC:17884 SPATA3
neXtProtiNX_Q8NHX4
OpenTargetsiENSG00000173699
PharmGKBiPA38256
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JCCC Eukaryota
ENOG41113TY LUCA
GeneTreeiENSGT00390000003032
HOGENOMiHOG000276896
HOVERGENiHBG062640
InParanoidiQ8NHX4
OMAiAAPQSRK
OrthoDBiEOG091G135A
PhylomeDBiQ8NHX4
TreeFamiTF338040

Miscellaneous databases

ChiTaRSiSPATA3 human
GenomeRNAii130560
PROiPR:Q8NHX4

Gene expression databases

BgeeiENSG00000173699 Expressed in 61 organ(s), highest expression level in testis
ExpressionAtlasiQ8NHX4 baseline and differential
GenevisibleiQ8NHX4 HS

Family and domain databases

InterProiView protein in InterPro
IPR026717 SPATA3
PANTHERiPTHR22234 PTHR22234, 1 hit
PfamiView protein in Pfam
PF15662 SPATA3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSPTA3_HUMAN
AccessioniPrimary (citable) accession number: Q8NHX4
Secondary accession number(s): Q86WX5, Q8N9Y6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: April 16, 2014
Last modified: September 12, 2018
This is version 104 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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