UniProtKB - Q8NHW5 (RLA0L_HUMAN)
Protein
60S acidic ribosomal protein P0-like
Gene
RPLP0P6
Organism
Homo sapiens (Human)
Status
Functioni
Ribosomal protein P0 is the functional equivalent of E.coli protein L10.By similarity
Caution
Could be the product of a pseudogene.Curated
GO - Molecular functioni
- large ribosomal subunit rRNA binding Source: GO_Central
- structural constituent of ribosome Source: GO_Central
GO - Biological processi
- cytoplasmic translation Source: GO_Central
- ribosomal large subunit assembly Source: GO_Central
Keywordsi
Molecular function | Ribonucleoprotein, Ribosomal protein |
Enzyme and pathway databases
PathwayCommonsi | Q8NHW5 |
Names & Taxonomyi
Protein namesi | Recommended name: 60S acidic ribosomal protein P0-likeAlternative name(s): Large ribosomal subunit protein uL10-like |
Gene namesi | Name:RPLP0P6 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:36404, RPLP0P6 |
neXtProti | NX_Q8NHW5 |
Subcellular locationi
Cytosol
- cytosolic large ribosomal subunit Source: GO_Central
Pathology & Biotechi
Miscellaneous databases
Pharosi | Q8NHW5, Tdark |
Polymorphism and mutation databases
BioMutai | HGNC:36404 |
DMDMi | 74723863 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000349111 | 1 – 317 | 60S acidic ribosomal protein P0-likeAdd BLAST | 317 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 24 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 59 | PhosphothreonineBy similarity | 1 | |
Cross-linki | 297 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity | ||
Cross-linki | 297 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity | ||
Modified residuei | 304 | PhosphoserineBy similarity | 1 | |
Modified residuei | 307 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q8NHW5 |
jPOSTi | Q8NHW5 |
MassIVEi | Q8NHW5 |
MaxQBi | Q8NHW5 |
PeptideAtlasi | Q8NHW5 |
PRIDEi | Q8NHW5 |
ProteomicsDBi | 73779 |
TopDownProteomicsi | Q8NHW5 |
PTM databases
iPTMneti | Q8NHW5 |
MetOSitei | Q8NHW5 |
PhosphoSitePlusi | Q8NHW5 |
SwissPalmi | Q8NHW5 |
Interactioni
Subunit structurei
P0 forms a pentameric complex by interaction with dimers of P1 and P2.
By similarityProtein-protein interaction databases
IntActi | Q8NHW5, 10 interactors |
MINTi | Q8NHW5 |
Miscellaneous databases
RNActi | Q8NHW5, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the universal ribosomal protein uL10 family.Curated
Phylogenomic databases
InParanoidi | Q8NHW5 |
Family and domain databases
Gene3Di | 3.30.70.1730, 1 hit 3.90.105.20, 1 hit |
InterProi | View protein in InterPro IPR030670, L10E_eukaryotes IPR043141, Ribosomal_L10-like_sf IPR001790, Ribosomal_L10P IPR043164, RL10_insert_sf IPR040637, RL10P_insert |
Pfami | View protein in Pfam PF00466, Ribosomal_L10, 1 hit PF17777, RL10P_insert, 1 hit |
PIRSFi | PIRSF039087, L10E, 1 hit |
SUPFAMi | SSF160369, SSF160369, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8NHW5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPREDRATWK SNYFLKIIQL LDDYPKCFIV GADNVGSKQM QQIRMSLRGK
60 70 80 90 100
VVVLMGKNTM MRKAIRGHLE NNPALEKLLP HIWGNVGFVF TKEDLTEIRD
110 120 130 140 150
MLLANKVPAA ARAGAIAPCE VTVPAQNTGL GPEKTSFFQA LGITTKISRG
160 170 180 190 200
TIEILSDVQL IKTGDKVGAS EATLLNMLNI SPFSFGLVIQ QVFDNGSIYN
210 220 230 240 250
PEVLDKTEET LHSRFLEGVR NVASVCLQTG YPTVASVPHS IINGYKRVLA
260 270 280 290 300
LSVETDYTFP LAENVKAFLA DPSAFVAAAP VAADTTAAPA AAAAPAKVEA
310
KEESEESDED MGFGLFD
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY064377 Genomic DNA Translation: AAL62450.1 CR596098 mRNA No translation available. CH471053 Genomic DNA Translation: EAX00373.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY064377 Genomic DNA Translation: AAL62450.1 CR596098 mRNA No translation available. CH471053 Genomic DNA Translation: EAX00373.1 |
3D structure databases
SMRi | Q8NHW5 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | Q8NHW5, 10 interactors |
MINTi | Q8NHW5 |
PTM databases
iPTMneti | Q8NHW5 |
MetOSitei | Q8NHW5 |
PhosphoSitePlusi | Q8NHW5 |
SwissPalmi | Q8NHW5 |
Polymorphism and mutation databases
BioMutai | HGNC:36404 |
DMDMi | 74723863 |
Proteomic databases
EPDi | Q8NHW5 |
jPOSTi | Q8NHW5 |
MassIVEi | Q8NHW5 |
MaxQBi | Q8NHW5 |
PeptideAtlasi | Q8NHW5 |
PRIDEi | Q8NHW5 |
ProteomicsDBi | 73779 |
TopDownProteomicsi | Q8NHW5 |
Organism-specific databases
GeneCardsi | RPLP0P6 |
HGNCi | HGNC:36404, RPLP0P6 |
neXtProti | NX_Q8NHW5 |
GenAtlasi | Search... |
Phylogenomic databases
InParanoidi | Q8NHW5 |
Enzyme and pathway databases
PathwayCommonsi | Q8NHW5 |
Miscellaneous databases
ChiTaRSi | RPLP0P6, human |
Pharosi | Q8NHW5, Tdark |
RNActi | Q8NHW5, protein |
Family and domain databases
Gene3Di | 3.30.70.1730, 1 hit 3.90.105.20, 1 hit |
InterProi | View protein in InterPro IPR030670, L10E_eukaryotes IPR043141, Ribosomal_L10-like_sf IPR001790, Ribosomal_L10P IPR043164, RL10_insert_sf IPR040637, RL10P_insert |
Pfami | View protein in Pfam PF00466, Ribosomal_L10, 1 hit PF17777, RL10P_insert, 1 hit |
PIRSFi | PIRSF039087, L10E, 1 hit |
SUPFAMi | SSF160369, SSF160369, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RLA0L_HUMAN | |
Accessioni | Q8NHW5Primary (citable) accession number: Q8NHW5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 2, 2008 |
Last sequence update: | October 1, 2002 | |
Last modified: | August 12, 2020 | |
This is version 130 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Ribosomal proteins
Ribosomal proteins families and list of entries