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UniProtKB - Q8NHV4 (NEDD1_HUMAN)

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Protein

Protein NEDD1

Gene

NEDD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for mitosis progression. Promotes the nucleation of microtubules from the spindle.2 Publications

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

ReactomeiR-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition
R-HSA-380259 Loss of Nlp from mitotic centrosomes
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes
R-HSA-5620912 Anchoring of the basal body to the plasma membrane
R-HSA-8854518 AURKA Activation by TPX2
SignaLinkiQ8NHV4

Names & Taxonomyi

Protein namesi
Recommended name:
Protein NEDD1
Alternative name(s):
Neural precursor cell expressed developmentally down-regulated protein 1
Short name:
NEDD-1
Gene namesi
Name:NEDD1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000139350.11
HGNCiHGNC:7723 NEDD1
MIMi600372 gene
neXtProtiNX_Q8NHV4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

DisGeNETi121441
OpenTargetsiENSG00000139350
PharmGKBiPA31531

Polymorphism and mutation databases

BioMutaiNEDD1
DMDMi74762597

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000510951 – 660Protein NEDD1Add BLAST660

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei325PhosphoserineCombined sources1
Modified residuei382Phosphothreonine; by PLK11 Publication1
Modified residuei397Phosphoserine; by PLK1Combined sources1 Publication1
Modified residuei411PhosphoserineCombined sources1
Modified residuei426Phosphoserine; by PLK11 Publication1
Modified residuei468PhosphoserineCombined sources1
Modified residuei516PhosphoserineCombined sources1
Modified residuei550Phosphothreonine; by CDK11 Publication1
Modified residuei637Phosphoserine; by PLK11 Publication1

Post-translational modificationi

During mitosis, prior phosphorylation on Thr-550 by CDK1 promotes subsequent phosphorylation by PLK1 on Thr-382, Ser-397, Ser-426 and Ser-637. Phosphorylated NEDD1 can interact with gamma-tubulin for targeting the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8NHV4
MaxQBiQ8NHV4
PaxDbiQ8NHV4
PeptideAtlasiQ8NHV4
PRIDEiQ8NHV4
ProteomicsDBi73763
73764 [Q8NHV4-2]

PTM databases

iPTMnetiQ8NHV4
PhosphoSitePlusiQ8NHV4

Expressioni

Gene expression databases

BgeeiENSG00000139350
CleanExiHS_NEDD1
ExpressionAtlasiQ8NHV4 baseline and differential
GenevisibleiQ8NHV4 HS

Organism-specific databases

HPAiHPA038591

Interactioni

Subunit structurei

Interacts with FAM29A (PubMed:19029337). Interacts with HSPA1A and HSPA1B. Interacts with gamma-tubulin in a HSPA1A/B-dependent manner (PubMed:27137183).2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
HAUS6Q7Z4H72EBI-2555055,EBI-2558196

Protein-protein interaction databases

BioGridi125728, 153 interactors
DIPiDIP-48838N
IntActiQ8NHV4, 93 interactors
STRINGi9606.ENSP00000451211

Structurei

3D structure databases

ProteinModelPortaliQ8NHV4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati1 – 31WD 1Add BLAST31
Repeati32 – 71WD 2Add BLAST40
Repeati75 – 114WD 3Add BLAST40
Repeati117 – 156WD 4Add BLAST40
Repeati160 – 200WD 5Add BLAST41
Repeati204 – 244WD 6Add BLAST41
Repeati246 – 285WD 7Add BLAST40
Repeati289 – 332WD 8Add BLAST44

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG4378 Eukaryota
ENOG410ZQNY LUCA
GeneTreeiENSGT00390000001561
HOGENOMiHOG000034642
HOVERGENiHBG055623
InParanoidiQ8NHV4
KOiK16547
OMAiRYSVNES
OrthoDBiEOG091G07XS
PhylomeDBiQ8NHV4

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 1 hit
SMARTiView protein in SMART
SM00320 WD40, 6 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NHV4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQENLRFASS GDDIKIWDAS SMTLVDKFNP HTSPHGISSI CWSSNNNFLV 
        60         70         80         90        100
TASSSGDKIV VSSCKCKPVP LLELAEGQKQ TCVNLNSTSM YLVSGGLNNT 
       110        120        130        140        150
VNIWDLKSKR VHRSLKDHKD QVTCVTYNWN DCYIASGSLS GEIILHSVTT 
       160        170        180        190        200
NLSSTPFGHG SNQSVRHLKY SLFKKSLLGS VSDNGIVTLW DVNSQSPYHN 
       210        220        230        240        250
FDSVHKAPAS GICFSPVNEL LFVTIGLDKR IILYDTSSKK LVKTLVADTP 
       260        270        280        290        300
LTAVDFMPDG ATLAIGSSRG KIYQYDLRML KSPVKTISAH KTSVQCIAFQ 
       310        320        330        340        350
YSTVLTKSSL NKGCSNKPTT VNKRSVNVNA ASGGVQNSGI VREAPATSIA 
       360        370        380        390        400
TVLPQPMTSA MGKGTVAVQE KAGLPRSINT DTLSKETDSG KNQDFSSFDD 
       410        420        430        440        450
TGKSSLGDMF SPIRDDAVVN KGSDESIGKG DGFDFLPQLN SVFPPRKNPV 
       460        470        480        490        500
TSSTSVLHSS PLNVFMGSPG KEENENRDLT AESKKIYMGK QESKDSFKQL 
       510        520        530        540        550
AKLVTSGAES GNLNTSPSSN QTRNSEKFEK PENEIEAQLI CEPPINGSST 
       560        570        580        590        600
PNPKIASSVT AGVASSLSEK IADSIGNNRQ NAPLTSIQIR FIQNMIQETL 
       610        620        630        640        650
DDFREACHRD IVNLQVEMIK QFHMQLNEMH SLLERYSVNE GLVAEIERLR 
       660
EENKRLRAHF
Length:660
Mass (Da):71,966
Last modified:October 1, 2002 - v1
Checksum:i12817A567C13098B
GO
Isoform 2 (identifier: Q8NHV4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-89: Missing.

Note: No experimental confirmation available.
Show »
Length:571
Mass (Da):62,379
Checksum:i1FBE4E895B36789B
GO
Isoform 3 (identifier: Q8NHV4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MHFTGAVM

Show »
Length:667
Mass (Da):72,710
Checksum:iCD60E653689DF81A
GO

Sequence cautioni

The sequence AAH27605 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti170Y → C in BAC04099 (PubMed:14702039).Curated1
Sequence conflicti409M → V in BAC04099 (PubMed:14702039).Curated1
Sequence conflicti649L → P in BAC04099 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0434111 – 89Missing in isoform 2. 1 PublicationAdd BLAST89
Alternative sequenceiVSP_0537941M → MHFTGAVM in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093221 mRNA Translation: BAC04099.1
AK303656 mRNA Translation: BAG64657.1
AK315821 mRNA Translation: BAF98712.1
AC007564 Genomic DNA No translation available.
AC013417 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW97577.1
CH471054 Genomic DNA Translation: EAW97579.1
CH471054 Genomic DNA Translation: EAW97580.1
BC027605 mRNA Translation: AAH27605.1 Different initiation.
CCDSiCCDS44955.1 [Q8NHV4-3]
CCDS44956.1 [Q8NHV4-2]
CCDS9063.1 [Q8NHV4-1]
RefSeqiNP_001128647.1, NM_001135175.1 [Q8NHV4-3]
NP_001128648.1, NM_001135176.1 [Q8NHV4-1]
NP_001128649.1, NM_001135177.1 [Q8NHV4-2]
NP_690869.1, NM_152905.3 [Q8NHV4-1]
XP_005268701.1, XM_005268644.2 [Q8NHV4-3]
XP_006719300.1, XM_006719237.3 [Q8NHV4-2]
XP_011536205.1, XM_011537903.2 [Q8NHV4-2]
UniGeneiHs.270084

Genome annotation databases

EnsembliENST00000266742; ENSP00000266742; ENSG00000139350 [Q8NHV4-1]
ENST00000411739; ENSP00000411307; ENSG00000139350 [Q8NHV4-2]
ENST00000429527; ENSP00000404978; ENSG00000139350 [Q8NHV4-1]
ENST00000457368; ENSP00000407964; ENSG00000139350 [Q8NHV4-2]
ENST00000557644; ENSP00000451211; ENSG00000139350 [Q8NHV4-3]
GeneIDi121441
KEGGihsa:121441
UCSCiuc001teu.5 human [Q8NHV4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiNEDD1_HUMAN
AccessioniPrimary (citable) accession number: Q8NHV4
Secondary accession number(s): B0AZN0
, B4E145, G3V3F1, Q8NA30
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: October 1, 2002
Last modified: July 18, 2018
This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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