UniProtKB - Q8NHV1 (GIMA7_HUMAN)
Protein
GTPase IMAP family member 7
Gene
GIMAP7
Organism
Homo sapiens (Human)
Status
Functioni
The dimer has GTPase activity; the active site contains residues from both subunits.1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 37 | GTPCombined sources | 1 | |
Sitei | 103 | Important for catalytic activity | 1 | |
Binding sitei | 169 | GTPCombined sources | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 17 – 23 | GTPCombined sources | 7 | |
Nucleotide bindingi | 133 – 135 | GTPCombined sources | 3 |
GO - Molecular functioni
- GTPase activity Source: UniProtKB
- GTP binding Source: UniProtKB
- identical protein binding Source: IntAct
- protein homodimerization activity Source: UniProtKB
GO - Biological processi
- GTP metabolic process Source: UniProtKB
Keywordsi
Ligand | GTP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q8NHV1 |
Names & Taxonomyi
Protein namesi | Recommended name: GTPase IMAP family member 7Alternative name(s): Immunity-associated nucleotide 7 protein Short name: IAN-7 |
Gene namesi | Name:GIMAP7 Synonyms:IAN7 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:22404, GIMAP7 |
MIMi | 616961, gene |
neXtProti | NX_Q8NHV1 |
VEuPathDBi | HostDB:ENSG00000179144.4 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum 1 Publication
Golgi apparatus
- Golgi apparatus 1 Publication
Other locations
- Lipid droplet 1 Publication
- Cytoplasm 1 Publication
Note: Colocalizes with GIMAP2 on the surface of cytoplasmic lipid droplets.
Cytosol
- cytosol Source: HPA
Endoplasmic reticulum
- endoplasmic reticulum Source: UniProtKB-SubCell
Golgi apparatus
- Golgi apparatus Source: UniProtKB-SubCell
Other locations
- intracellular membrane-bounded organelle Source: HPA
- lipid droplet Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, Endoplasmic reticulum, Golgi apparatus, Lipid dropletPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 103 | R → D: Abolishes GTPase activity. No effect on GTP binding and on dimerization. 1 Publication | 1 | |
Mutagenesisi | 136 | E → W: Impairs dimerization and abolishes GTPase activity. No effect on GTP binding. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 168537 |
OpenTargetsi | ENSG00000179144 |
PharmGKBi | PA134915933 |
Miscellaneous databases
Pharosi | Q8NHV1, Tbio |
Genetic variation databases
BioMutai | GIMAP7 |
DMDMi | 55976538 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000190993 | 1 – 300 | GTPase IMAP family member 7Add BLAST | 300 |
Proteomic databases
jPOSTi | Q8NHV1 |
MassIVEi | Q8NHV1 |
MaxQBi | Q8NHV1 |
PaxDbi | Q8NHV1 |
PeptideAtlasi | Q8NHV1 |
PRIDEi | Q8NHV1 |
ProteomicsDBi | 73762 |
PTM databases
GlyGeni | Q8NHV1, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q8NHV1 |
PhosphoSitePlusi | Q8NHV1 |
SwissPalmi | Q8NHV1 |
Expressioni
Tissue specificityi
Most abundantly expressed in spleen, lymph nodes, and fetal kidney, but also present in the heart and the small intestine. Lower expression levels are found in lung, kidney, liver, and thyroid, salivary, and mammary glands. Also detected in the thymus (PubMed:15474311). Detected in T-cells (PubMed:23454188).2 Publications
Gene expression databases
Bgeei | ENSG00000179144, Expressed in leukocyte and 215 other tissues |
ExpressionAtlasi | Q8NHV1, baseline and differential |
Genevisiblei | Q8NHV1, HS |
Organism-specific databases
HPAi | ENSG00000179144, Tissue enhanced (blood) |
Interactioni
Subunit structurei
Monomer in the presence of bound GDP and in the absence of bound nucleotide. Homodimer in the presence of bound GTP. Heterodimer with GIMAP2.
1 PublicationBinary interactionsi
Hide detailsQ8NHV1
With | #Exp. | IntAct |
---|---|---|
GIMAP2 [Q9UG22] | 2 | EBI-16039011,EBI-15891037 |
itself | 2 | EBI-16039011,EBI-16039011 |
GO - Molecular functioni
- identical protein binding Source: IntAct
- protein homodimerization activity Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 127968, 1 interactor |
DIPi | DIP-60142N |
IntActi | Q8NHV1, 1 interactor |
STRINGi | 9606.ENSP00000315474 |
Miscellaneous databases
RNActi | Q8NHV1, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q8NHV1 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 6 – 210 | AIG1-type GPROSITE-ProRule annotationAdd BLAST | 205 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 15 – 22 | G1PROSITE-ProRule annotation | 8 | |
Regioni | 42 – 46 | G2PROSITE-ProRule annotation | 5 | |
Regioni | 63 – 66 | G3PROSITE-ProRule annotation | 4 | |
Regioni | 132 – 135 | G4PROSITE-ProRule annotation | 4 | |
Regioni | 168 – 170 | G5PROSITE-ProRule annotation | 3 |
Sequence similaritiesi
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.Curated
Phylogenomic databases
eggNOGi | ENOG502R7PE, Eukaryota |
GeneTreei | ENSGT00940000159509 |
HOGENOMi | CLU_010468_0_0_1 |
InParanoidi | Q8NHV1 |
OMAi | PHAILMV |
OrthoDBi | 1108753at2759 |
PhylomeDBi | Q8NHV1 |
TreeFami | TF330845 |
Family and domain databases
InterProi | View protein in InterPro IPR006703, G_AIG1 IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF04548, AIG1, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS51720, G_AIG1, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8NHV1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAESEDRSLR IVLVGKTGSG KSATANTILG EEIFDSRIAA QAVTKNCQKA
60 70 80 90 100
SREWQGRDLL VVDTPGLFDT KESLDTTCKE ISRCIISSCP GPHAIVLVLL
110 120 130 140 150
LGRYTEEEQK TVALIKAVFG KSAMKHMVIL FTRKEELEGQ SFHDFIADAD
160 170 180 190 200
VGLKSIVKEC GNRCCAFSNS KKTSKAEKES QVQELVELIE KMVQCNEGAY
210 220 230 240 250
FSDDIYKDTE ERLKQREEVL RKIYTDQLNE EIKLVEEDKH KSEEEKEKEI
260 270 280 290 300
KLLKLKYDEK IKNIREEAER NIFKDVFNRI WKMLSEIWHR FLSKCKFYSS
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_049534 | 83 | R → C. Corresponds to variant dbSNP:rs3735080Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC027613 mRNA Translation: AAH27613.1 |
CCDSi | CCDS5903.1 |
RefSeqi | NP_694968.1, NM_153236.3 |
Genome annotation databases
Ensembli | ENST00000313543; ENSP00000315474; ENSG00000179144 |
GeneIDi | 168537 |
KEGGi | hsa:168537 |
UCSCi | uc003whk.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC027613 mRNA Translation: AAH27613.1 |
CCDSi | CCDS5903.1 |
RefSeqi | NP_694968.1, NM_153236.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3ZJC | X-ray | 3.15 | A/B/C/D/E/F | 1-300 | [»] | |
SMRi | Q8NHV1 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 127968, 1 interactor |
DIPi | DIP-60142N |
IntActi | Q8NHV1, 1 interactor |
STRINGi | 9606.ENSP00000315474 |
PTM databases
GlyGeni | Q8NHV1, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q8NHV1 |
PhosphoSitePlusi | Q8NHV1 |
SwissPalmi | Q8NHV1 |
Genetic variation databases
BioMutai | GIMAP7 |
DMDMi | 55976538 |
Proteomic databases
jPOSTi | Q8NHV1 |
MassIVEi | Q8NHV1 |
MaxQBi | Q8NHV1 |
PaxDbi | Q8NHV1 |
PeptideAtlasi | Q8NHV1 |
PRIDEi | Q8NHV1 |
ProteomicsDBi | 73762 |
Protocols and materials databases
Antibodypediai | 18613, 113 antibodies |
DNASUi | 168537 |
Genome annotation databases
Ensembli | ENST00000313543; ENSP00000315474; ENSG00000179144 |
GeneIDi | 168537 |
KEGGi | hsa:168537 |
UCSCi | uc003whk.4, human |
Organism-specific databases
CTDi | 168537 |
DisGeNETi | 168537 |
GeneCardsi | GIMAP7 |
HGNCi | HGNC:22404, GIMAP7 |
HPAi | ENSG00000179144, Tissue enhanced (blood) |
MIMi | 616961, gene |
neXtProti | NX_Q8NHV1 |
OpenTargetsi | ENSG00000179144 |
PharmGKBi | PA134915933 |
VEuPathDBi | HostDB:ENSG00000179144.4 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502R7PE, Eukaryota |
GeneTreei | ENSGT00940000159509 |
HOGENOMi | CLU_010468_0_0_1 |
InParanoidi | Q8NHV1 |
OMAi | PHAILMV |
OrthoDBi | 1108753at2759 |
PhylomeDBi | Q8NHV1 |
TreeFami | TF330845 |
Enzyme and pathway databases
PathwayCommonsi | Q8NHV1 |
Miscellaneous databases
BioGRID-ORCSi | 168537, 1 hit in 865 CRISPR screens |
ChiTaRSi | GIMAP7, human |
GenomeRNAii | 168537 |
Pharosi | Q8NHV1, Tbio |
PROi | PR:Q8NHV1 |
RNActi | Q8NHV1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000179144, Expressed in leukocyte and 215 other tissues |
ExpressionAtlasi | Q8NHV1, baseline and differential |
Genevisiblei | Q8NHV1, HS |
Family and domain databases
InterProi | View protein in InterPro IPR006703, G_AIG1 IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF04548, AIG1, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS51720, G_AIG1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GIMA7_HUMAN | |
Accessioni | Q8NHV1Primary (citable) accession number: Q8NHV1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 23, 2004 |
Last sequence update: | October 1, 2002 | |
Last modified: | February 10, 2021 | |
This is version 135 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families