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Entry version 142 (13 Feb 2019)
Sequence version 2 (10 Jul 2007)
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Protein

Tudor domain-containing protein 7

Gene

TDRD7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. Required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. Also required during spermatogenesis.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • mRNA binding Source: UniProtKB
  • protein N-terminus binding Source: Ensembl

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding
Biological processDifferentiation, Spermatogenesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tudor domain-containing protein 7
Alternative name(s):
PCTAIRE2-binding protein
Tudor repeat associator with PCTAIRE-2
Short name:
Trap
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TDRD7
Synonyms:PCTAIRE2BP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000196116.7

Human Gene Nomenclature Database

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HGNCi
HGNC:30831 TDRD7

Online Mendelian Inheritance in Man (OMIM)

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MIMi
611258 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8NHU6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Cataract 36 (CTRCT36)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn opacification of the crystalline lens of the eye becoming evident at birth. It frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. In general, the more posteriorly located and dense an opacity, the greater the impact on visual function.
See also OMIM:613887
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_065247618Missing in CTRCT36. 1 Publication1

Keywords - Diseasei

Cataract, Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
23424

MalaCards human disease database

More...
MalaCardsi
TDRD7
MIMi613887 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000196116

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA134937960

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TDRD7

Domain mapping of disease mutations (DMDM)

More...
DMDMi
152031705

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001831691 – 1098Tudor domain-containing protein 7Add BLAST1098

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei319PhosphoserineCombined sources1
Modified residuei859PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q8NHU6

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q8NHU6

MaxQB - The MaxQuant DataBase

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MaxQBi
Q8NHU6

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q8NHU6

PeptideAtlas

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PeptideAtlasi
Q8NHU6

PRoteomics IDEntifications database

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PRIDEi
Q8NHU6

ProteomicsDB human proteome resource

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ProteomicsDBi
73759
73760 [Q8NHU6-2]
73761 [Q8NHU6-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q8NHU6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q8NHU6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000196116 Expressed in 228 organ(s), highest expression level in testis

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q8NHU6 HS

Organism-specific databases

Human Protein Atlas

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HPAi
CAB020800
HPA022250
HPA024529

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Found in a mRNP complex, at least composed of TDRD1, TDRD6, TDRD7 and DDX4. Found in a complex containing CABLES1, CDK16 and CDK17. Interacts with CABLES1, CDK17 and PIWIL1 (By similarity).By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
116994, 9 interactors

Protein interaction database and analysis system

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IntActi
Q8NHU6, 19 interactors

Molecular INTeraction database

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MINTi
Q8NHU6

STRING: functional protein association networks

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STRINGi
9606.ENSP00000347444

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11098
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3RCOX-ray1.80A/B1-82[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q8NHU6

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8NHU6

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini3 – 76HTH OST-type 1PROSITE-ProRule annotationAdd BLAST74
Domaini233 – 302HTH OST-type 2PROSITE-ProRule annotationAdd BLAST70
Domaini337 – 406HTH OST-type 3PROSITE-ProRule annotationAdd BLAST70
Domaini513 – 570Tudor 1PROSITE-ProRule annotationAdd BLAST58
Domaini703 – 760Tudor 2PROSITE-ProRule annotationAdd BLAST58

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni861 – 1098Interaction with CDK17By similarityAdd BLAST238
Regioni893 – 1098Interaction with CABLES1By similarityAdd BLAST206

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TDRD7 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IPR1 Eukaryota
ENOG410XST4 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00890000139482

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG055704

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8NHU6

KEGG Orthology (KO)

More...
KOi
K18405

Identification of Orthologs from Complete Genome Data

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OMAi
YTYKMDE

Database of Orthologous Groups

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OrthoDBi
1276848at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q8NHU6

Family and domain databases

Conserved Domains Database

More...
CDDi
cd09974 LOTUS_3_TDRD7, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.40.50.90, 3 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR025605 OST-HTH/LOTUS_dom
IPR035437 SNase_OB-fold_sf
IPR037978 TDRD7_LOTUS_3
IPR002999 Tudor

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12872 OST-HTH, 2 hits
PF00567 TUDOR, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00333 TUDOR, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51644 HTH_OST, 3 hits
PS50304 TUDOR, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8NHU6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLEGDLVSKM LRAVLQSHKN GVALPRLQGE YRSLTGDWIP FKQLGFPTLE
60 70 80 90 100
AYLRSVPAVV RIETSRSGEI TCYAMACTET ARIAQLVARQ RSSKRKTGRQ
110 120 130 140 150
VNCQMRVKKT MPFFLEGKPK ATLRQPGFAS NFSVGKKPNP APLRDKGNSV
160 170 180 190 200
GVKPDAEMSP YMLHTTLGNE AFKDIPVQRH VTMSTNNRFS PKASLQPPLQ
210 220 230 240 250
MHLSRTSTKE MSDNLNQTVE KPNVKPPASY TYKMDEVQNR IKEILNKHNN
260 270 280 290 300
GIWISKLPHF YKELYKEDLN QGILQQFEHW PHICTVEKPC SGGQDLLLYP
310 320 330 340 350
AKRKQLLRSE LDTEKVPLSP LPGPKQTPPL KGCPTVMAGD FKEKVADLLV
360 370 380 390 400
KYTSGLWASA LPKAFEEMYK VKFPEDALKN LASLSDVCSI DYISGNPQKA
410 420 430 440 450
ILYAKLPLPT DKIQKDAGQA HGDNDIKAMV EQEYLQVEES IAESANTFME
460 470 480 490 500
DITVPPLMIP TEASPSVLVV ELSNTNEVVI RYVGKDYSAA QELMEDEMKE
510 520 530 540 550
YYSKNPKITP VQAVNVGQLL AVNAEEDAWL RAQVISTEEN KIKVCYVDYG
560 570 580 590 600
FSENVEKSKA YKLNPKFCSL SFQATKCKLA GLEVLSDDPD LVKVVESLTC
610 620 630 640 650
GKIFAVEILD KADIPLVVLY DTSGEDDINI NATCLKAICD KSLEVHLQVD
660 670 680 690 700
AMYTNVKVTN ICSDGTLYCQ VPCKGLNKLS DLLRKIEDYF HCKHMTSECF
710 720 730 740 750
VSLPFCGKIC LFHCKGKWLR VEITNVHSSR ALDVQFLDSG TVTSVKVSEL
760 770 780 790 800
REIPPRFLQE MIAIPPQAIK CCLADLPQSI GMWTPDAVLW LRDSVLNCSD
810 820 830 840 850
CSIKVTKVDE TRGIAHVYLF TPKNFPDPHR SINRQITNAD LWKHQKDVFL
860 870 880 890 900
SAISSGADSP NSKNGNMPMS GNTGENFRKN LTDVIKKSMV DHTSAFSTEE
910 920 930 940 950
LPPPVHLSKP GEHMDVYVPV ACHPGYFVIQ PWQEIHKLEV LMEEMILYYS
960 970 980 990 1000
VSEERHIAVE KDQVYAAKVE NKWHRVLLKG ILTNGLVSVY ELDYGKHELV
1010 1020 1030 1040 1050
NIRKVQPLVD MFRKLPFQAV TAQLAGVKCN QWSEEASMVF RNHVEKKPLV
1060 1070 1080 1090
ALVQTVIENA NPWDRKVVVY LVDTSLPDTD TWIHDFMSEY LIELSKVN
Length:1,098
Mass (Da):123,586
Last modified:July 10, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF27E383E5B18C428
GO
Isoform 2 (identifier: Q8NHU6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-74: Missing.

Note: No experimental confirmation available.
Show »
Length:1,024
Mass (Da):115,338
Checksum:i37280FAC875C7EE5
GO
Isoform 3 (identifier: Q8NHU6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-651: Missing.
     694-722: Missing.

Note: No experimental confirmation available.
Show »
Length:418
Mass (Da):47,539
Checksum:iADDFA5052CF8D146
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti659T → A in BAG63369 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_019070150V → A2 PublicationsCorresponds to variant dbSNP:rs2045732EnsemblClinVar.1
Natural variantiVAR_033044456P → L1 PublicationCorresponds to variant dbSNP:rs17852595Ensembl.1
Natural variantiVAR_065247618Missing in CTRCT36. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0413141 – 651Missing in isoform 3. 1 PublicationAdd BLAST651
Alternative sequenceiVSP_0413151 – 74Missing in isoform 2. 1 PublicationAdd BLAST74
Alternative sequenceiVSP_041316694 – 722Missing in isoform 3. 1 PublicationAdd BLAST29

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK294488 mRNA Translation: BAG57710.1
AK301954 mRNA Translation: BAG63369.1
AK314853 mRNA Translation: BAG37370.1
AL449464 Genomic DNA No translation available.
AL512590 Genomic DNA No translation available.
CH471105 Genomic DNA Translation: EAW58844.1
BC028694 mRNA Translation: AAH28694.1
AB025254 mRNA Translation: BAA76379.1
AL122110 mRNA Translation: CAB59271.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS6725.1 [Q8NHU6-1]

Protein sequence database of the Protein Information Resource

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PIRi
T34547

NCBI Reference Sequences

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RefSeqi
NP_001289813.1, NM_001302884.1 [Q8NHU6-2]
NP_055105.2, NM_014290.2 [Q8NHU6-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.193842

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000355295; ENSP00000347444; ENSG00000196116 [Q8NHU6-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
23424

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:23424

UCSC genome browser

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UCSCi
uc004axj.4 human [Q8NHU6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK294488 mRNA Translation: BAG57710.1
AK301954 mRNA Translation: BAG63369.1
AK314853 mRNA Translation: BAG37370.1
AL449464 Genomic DNA No translation available.
AL512590 Genomic DNA No translation available.
CH471105 Genomic DNA Translation: EAW58844.1
BC028694 mRNA Translation: AAH28694.1
AB025254 mRNA Translation: BAA76379.1
AL122110 mRNA Translation: CAB59271.1
CCDSiCCDS6725.1 [Q8NHU6-1]
PIRiT34547
RefSeqiNP_001289813.1, NM_001302884.1 [Q8NHU6-2]
NP_055105.2, NM_014290.2 [Q8NHU6-1]
UniGeneiHs.193842

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3RCOX-ray1.80A/B1-82[»]
ProteinModelPortaliQ8NHU6
SMRiQ8NHU6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116994, 9 interactors
IntActiQ8NHU6, 19 interactors
MINTiQ8NHU6
STRINGi9606.ENSP00000347444

PTM databases

iPTMnetiQ8NHU6
PhosphoSitePlusiQ8NHU6

Polymorphism and mutation databases

BioMutaiTDRD7
DMDMi152031705

Proteomic databases

EPDiQ8NHU6
jPOSTiQ8NHU6
MaxQBiQ8NHU6
PaxDbiQ8NHU6
PeptideAtlasiQ8NHU6
PRIDEiQ8NHU6
ProteomicsDBi73759
73760 [Q8NHU6-2]
73761 [Q8NHU6-3]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
23424
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355295; ENSP00000347444; ENSG00000196116 [Q8NHU6-1]
GeneIDi23424
KEGGihsa:23424
UCSCiuc004axj.4 human [Q8NHU6-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23424
DisGeNETi23424
EuPathDBiHostDB:ENSG00000196116.7

GeneCards: human genes, protein and diseases

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GeneCardsi
TDRD7

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0008211
HGNCiHGNC:30831 TDRD7
HPAiCAB020800
HPA022250
HPA024529
MalaCardsiTDRD7
MIMi611258 gene
613887 phenotype
neXtProtiNX_Q8NHU6
OpenTargetsiENSG00000196116
PharmGKBiPA134937960

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IPR1 Eukaryota
ENOG410XST4 LUCA
GeneTreeiENSGT00890000139482
HOVERGENiHBG055704
InParanoidiQ8NHU6
KOiK18405
OMAiYTYKMDE
OrthoDBi1276848at2759
PhylomeDBiQ8NHU6

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TDRD7 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
TDRD7

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
23424

Protein Ontology

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PROi
PR:Q8NHU6

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000196116 Expressed in 228 organ(s), highest expression level in testis
GenevisibleiQ8NHU6 HS

Family and domain databases

CDDicd09974 LOTUS_3_TDRD7, 1 hit
Gene3Di2.40.50.90, 3 hits
InterProiView protein in InterPro
IPR025605 OST-HTH/LOTUS_dom
IPR035437 SNase_OB-fold_sf
IPR037978 TDRD7_LOTUS_3
IPR002999 Tudor
PfamiView protein in Pfam
PF12872 OST-HTH, 2 hits
PF00567 TUDOR, 3 hits
SMARTiView protein in SMART
SM00333 TUDOR, 2 hits
PROSITEiView protein in PROSITE
PS51644 HTH_OST, 3 hits
PS50304 TUDOR, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTDRD7_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NHU6
Secondary accession number(s): A6NCI6
, B2RBX3, B4DG99, B4DXF7, E7EQD4, Q5VV27, Q96JT1, Q9UFF0, Q9Y2M3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2004
Last sequence update: July 10, 2007
Last modified: February 13, 2019
This is version 142 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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