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Protein

Cancer/testis antigen family 45 member A3

Gene

CT45A3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • snRNA 3'-end processing Source: GO_Central

Names & Taxonomyi

Protein namesi
Recommended name:
Cancer/testis antigen family 45 member A3Imported
Alternative name(s):
Cancer/testis antigen 45-31 Publication
Cancer/testis antigen 45-41 Publication
Cancer/testis antigen 45A3Curated
Cancer/testis antigen 45A4Curated
Cancer/testis antigen family 45 member A4Imported
Gene namesi
Name:CT45A3Imported
Synonyms:CT45-31 Publication, CT45-41 Publication, CT45A4Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000269096.6
HGNCiHGNC:33268 CT45A3
MIMi300794 gene
300795 gene
neXtProtiNX_Q8NHU0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164718201

Polymorphism and mutation databases

BioMutaiCT45A3
DMDMi74751317

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003089481 – 189Cancer/testis antigen family 45 member A3Add BLAST189

Proteomic databases

MaxQBiQ8NHU0
PaxDbiQ8NHU0
PRIDEiQ8NHU0
ProteomicsDBi73752

PTM databases

iPTMnetiQ8NHU0
PhosphoSitePlusiQ8NHU0

Expressioni

Tissue specificityi

Testis specific. Expressed in cancer cell lines.1 Publication

Gene expression databases

BgeeiENSG00000269096 Expressed in 31 organ(s), highest expression level in lung
GenevisibleiQ8NHU0 HS

Organism-specific databases

HPAiHPA044735
HPA044757
HPA046872
HPA046987

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi137546, 2 interactors
IntActiQ8NHU0, 7 interactors
MINTiQ8NHU0
STRINGi9606.ENSP00000405261

Structurei

3D structure databases

ProteinModelPortaliQ8NHU0
SMRiQ8NHU0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CT45 family.

Phylogenomic databases

eggNOGiENOG410JH2S Eukaryota
ENOG41115DR LUCA
GeneTreeiENSGT00390000016655
HOGENOMiHOG000082503
HOVERGENiHBG095520
InParanoidiQ8NHU0
OrthoDBiEOG091G0L2U
PhylomeDBiQ8NHU0

Family and domain databases

InterProiView protein in InterPro
IPR029307 INT_SG_DDX_CT_C
PfamiView protein in Pfam
PF15300 INT_SG_DDX_CT_C, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NHU0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTDKTEKVAV DPETVFKRPR ECDSPSYQKR QRMALLARKQ GAGDSLIAGS
60 70 80 90 100
AMSKEKKLMT GHAIPPSQLD SQIDDFTGFS KDRMMQKPGS NAPVGGNVTS
110 120 130 140 150
SFSGDDLECR ETASSPKSQR EINADIKRKL VKELRCVGQK YEKIFEMLEG
160 170 180
VQGPTAVRKR FFESIIKEAA RCMRRDFVKH LKKKLKRMI
Length:189
Mass (Da):21,331
Last modified:October 1, 2002 - v1
Checksum:i3A86AC9CB6D6F042
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti120R → Q in AAW66467 (PubMed:15905330).Curated1
Sequence conflicti120R → Q in BAC05380 (PubMed:14702039).Curated1
Sequence conflicti120R → Q in CAI41549 (PubMed:15772651).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07589855E → A3 PublicationsCorresponds to variant dbSNP:rs200277856Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY743711 mRNA Translation: AAW66466.1
AY743712 mRNA Translation: AAW66467.1
AK098689 mRNA Translation: BAC05380.1
AC240441 Genomic DNA No translation available.
AL590618 Genomic DNA Translation: CAI41546.1
AL590618 Genomic DNA Translation: CAI41549.1
CH471107 Genomic DNA Translation: EAX11718.1
CH471107 Genomic DNA Translation: EAX11719.1
BC028711 mRNA Translation: AAH28711.1
BC140735 mRNA Translation: AAI40736.1
BC144437 mRNA Translation: AAI44438.1
BC140926 mRNA Translation: AAI40927.1
CCDSiCCDS76030.1
RefSeqiNP_001017435.1, NM_001017435.1
XP_006724821.1, XM_006724758.3
XP_011529642.1, XM_011531340.2
UniGeneiHs.535080

Genome annotation databases

EnsembliENST00000597510; ENSP00000471418; ENSG00000269096
ENST00000598716; ENSP00000471571; ENSG00000269096
GeneIDi441519
KEGGihsa:441519
UCSCiuc065bga.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY743711 mRNA Translation: AAW66466.1
AY743712 mRNA Translation: AAW66467.1
AK098689 mRNA Translation: BAC05380.1
AC240441 Genomic DNA No translation available.
AL590618 Genomic DNA Translation: CAI41546.1
AL590618 Genomic DNA Translation: CAI41549.1
CH471107 Genomic DNA Translation: EAX11718.1
CH471107 Genomic DNA Translation: EAX11719.1
BC028711 mRNA Translation: AAH28711.1
BC140735 mRNA Translation: AAI40736.1
BC144437 mRNA Translation: AAI44438.1
BC140926 mRNA Translation: AAI40927.1
CCDSiCCDS76030.1
RefSeqiNP_001017435.1, NM_001017435.1
XP_006724821.1, XM_006724758.3
XP_011529642.1, XM_011531340.2
UniGeneiHs.535080

3D structure databases

ProteinModelPortaliQ8NHU0
SMRiQ8NHU0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi137546, 2 interactors
IntActiQ8NHU0, 7 interactors
MINTiQ8NHU0
STRINGi9606.ENSP00000405261

PTM databases

iPTMnetiQ8NHU0
PhosphoSitePlusiQ8NHU0

Polymorphism and mutation databases

BioMutaiCT45A3
DMDMi74751317

Proteomic databases

MaxQBiQ8NHU0
PaxDbiQ8NHU0
PRIDEiQ8NHU0
ProteomicsDBi73752

Protocols and materials databases

DNASUi441519
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000597510; ENSP00000471418; ENSG00000269096
ENST00000598716; ENSP00000471571; ENSG00000269096
GeneIDi441519
KEGGihsa:441519
UCSCiuc065bga.1 human

Organism-specific databases

CTDi441519
EuPathDBiHostDB:ENSG00000269096.6
GeneCardsiCT45A3
HGNCiHGNC:33268 CT45A3
HPAiHPA044735
HPA044757
HPA046872
HPA046987
MIMi300794 gene
300795 gene
neXtProtiNX_Q8NHU0
PharmGKBiPA164718201
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JH2S Eukaryota
ENOG41115DR LUCA
GeneTreeiENSGT00390000016655
HOGENOMiHOG000082503
HOVERGENiHBG095520
InParanoidiQ8NHU0
OrthoDBiEOG091G0L2U
PhylomeDBiQ8NHU0

Miscellaneous databases

GenomeRNAii441520
PROiPR:Q8NHU0
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000269096 Expressed in 31 organ(s), highest expression level in lung
GenevisibleiQ8NHU0 HS

Family and domain databases

InterProiView protein in InterPro
IPR029307 INT_SG_DDX_CT_C
PfamiView protein in Pfam
PF15300 INT_SG_DDX_CT_C, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCT453_HUMAN
AccessioniPrimary (citable) accession number: Q8NHU0
Secondary accession number(s): B2RU20
, B7ZMC9, D3DTG6, P0DMU6, Q8N7B7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 1, 2002
Last modified: November 7, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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