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Entry version 117 (10 Apr 2019)
Sequence version 3 (11 Jan 2011)
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Protein

Clathrin heavy chain linker domain-containing protein 1

Gene

CLHC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Clathrin heavy chain linker domain-containing protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CLHC1
Synonyms:C2orf63
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000162994.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26453 CLHC1

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8NHS4

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000162994

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162379359

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CLHC1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
317373465

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003258701 – 586Clathrin heavy chain linker domain-containing protein 1Add BLAST586

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8NHS4

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8NHS4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8NHS4

PeptideAtlas

More...
PeptideAtlasi
Q8NHS4

PRoteomics IDEntifications database

More...
PRIDEi
Q8NHS4

ProteomicsDB human proteome resource

More...
ProteomicsDBi
73748
73749 [Q8NHS4-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8NHS4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8NHS4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000162994 Expressed in 137 organ(s), highest expression level in kidney

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8NHS4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8NHS4 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA045418
HPA053557

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
126226, 5 interactors

Protein interaction database and analysis system

More...
IntActi
Q8NHS4, 3 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000384869

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8NHS4

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8NHS4

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili174 – 232Sequence analysisAdd BLAST59

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0985 Eukaryota
ENOG410XPH1 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183166

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000060111

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG107579

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8NHS4

Identification of Orthologs from Complete Genome Data

More...
OMAi
ERVGCNE

Database of Orthologous Groups

More...
OrthoDBi
665507at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8NHS4

TreeFam database of animal gene trees

More...
TreeFami
TF328858

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR012331 Clathrin_H-chain_linker
IPR017212 CLHC1
IPR032755 TSNAXIP1_N

The PANTHER Classification System

More...
PANTHERi
PTHR10292:SF11 PTHR10292:SF11, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15739 TSNAXIP1_N, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF037469 Clathrin_H-chain-rel, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8NHS4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSVHQIRKHA VLPPIICRSD KEFLESVQRY IITETERLGC SEEGPADEYY
60 70 80 90 100
IIYRNVFDKV IEHITAYKSI LTSIKKEYDA FIETIKKDRR TTFCLHGKLK
110 120 130 140 150
GLAAEPTALV YYRKRTIQLE AKMRIIESNS SKIQSQIDHI KQCRAEYDTK
160 170 180 190 200
EVKYCTFSKD PSKPIPGMTL QESMNLDALT KYMKHLEDKY AEIKQAMLIK
210 220 230 240 250
YVPAQRKADL DEEMIVLLKR RDVAENLNKK LQFCHQRLQI ISQALSSWVK
260 270 280 290 300
SDMSSPFQDF VEQIQKTKYL QGDQGIVEEL MEDDPRRAKE AEIMLHYIER
310 320 330 340 350
FNELISLGEY EKAACYAANS PRRILRNIGT MNTFKAVGKI RGKPLPLLLF
360 370 380 390 400
FEALFITSHA FPCPVDAALT LEGIKCGLSE KRLDLVTNWV TQERLTFSEE
410 420 430 440 450
AGDVICDYGE QDTYNKAKCL ALAQIVYSEC GLHKKAILCL CKQGQTHRVM
460 470 480 490 500
EYIQQLKDFT TDDLLQLLMS CPQVELIQCL TKELNEKQPS LSFGLAILHL
510 520 530 540 550
FSADMKKVGI KLLQEINKGG IDAVESLMIN DSFCSIEKWQ EVANICSQNG
560 570 580
FDKLSNDITS ILRSQAAVTE ISEEDDAVNL MEHVFW
Length:586
Mass (Da):67,250
Last modified:January 11, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i52458D0C3B64468E
GO
Isoform 2 (identifier: Q8NHS4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-122: Missing.

Note: No experimental confirmation available.
Show »
Length:464
Mass (Da):52,984
Checksum:i61E2184AA48E341C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EQP3E7EQP3_HUMAN
Clathrin heavy chain linker domain-...
CLHC1
92Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EVC5E7EVC5_HUMAN
Clathrin heavy chain linker domain-...
CLHC1
80Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B5MC48B5MC48_HUMAN
Clathrin heavy chain linker domain-...
CLHC1
46Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C1D8H7C1D8_HUMAN
Clathrin heavy chain linker domain-...
CLHC1
49Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J143C9J143_HUMAN
Clathrin heavy chain linker domain-...
CLHC1
17Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_039944178A → V2 PublicationsCorresponds to variant dbSNP:rs9677948Ensembl.1
Natural variantiVAR_039945426V → I2 PublicationsCorresponds to variant dbSNP:rs6716066Ensembl.1
Natural variantiVAR_039946503A → V1 PublicationCorresponds to variant dbSNP:rs14026Ensembl.1
Natural variantiVAR_039947552D → Y. Corresponds to variant dbSNP:rs3186099Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0324611 – 122Missing in isoform 2. 1 PublicationAdd BLAST122

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK315683 mRNA Translation: BAG38048.1
AC012358 Genomic DNA No translation available.
AC093165 Genomic DNA Translation: AAY24030.1
BC029502 mRNA Translation: AAH29502.1
BC036908 mRNA Translation: AAH36908.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33201.1 [Q8NHS4-1]
CCDS46287.1 [Q8NHS4-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001129070.1, NM_001135598.1 [Q8NHS4-2]
NP_689598.2, NM_152385.2 [Q8NHS4-1]
XP_005264193.1, XM_005264136.2
XP_011530821.1, XM_011532519.2
XP_011530822.1, XM_011532520.2
XP_011530823.1, XM_011532521.2
XP_011530824.1, XM_011532522.2
XP_011530825.1, XM_011532523.2
XP_011530826.1, XM_011532524.1
XP_011530827.1, XM_011532525.2
XP_011530829.1, XM_011532527.2
XP_011530830.1, XM_011532528.1
XP_011530831.1, XM_011532529.2
XP_011530832.1, XM_011532530.1
XP_016858824.1, XM_017003335.1
XP_016858825.1, XM_017003336.1
XP_016858826.1, XM_017003337.1
XP_016858827.1, XM_017003338.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.347014

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000401408; ENSP00000384869; ENSG00000162994 [Q8NHS4-1]
ENST00000406076; ENSP00000385512; ENSG00000162994 [Q8NHS4-2]
ENST00000407122; ENSP00000385778; ENSG00000162994 [Q8NHS4-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
130162

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:130162

UCSC genome browser

More...
UCSCi
uc002ryi.3 human [Q8NHS4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK315683 mRNA Translation: BAG38048.1
AC012358 Genomic DNA No translation available.
AC093165 Genomic DNA Translation: AAY24030.1
BC029502 mRNA Translation: AAH29502.1
BC036908 mRNA Translation: AAH36908.1
CCDSiCCDS33201.1 [Q8NHS4-1]
CCDS46287.1 [Q8NHS4-2]
RefSeqiNP_001129070.1, NM_001135598.1 [Q8NHS4-2]
NP_689598.2, NM_152385.2 [Q8NHS4-1]
XP_005264193.1, XM_005264136.2
XP_011530821.1, XM_011532519.2
XP_011530822.1, XM_011532520.2
XP_011530823.1, XM_011532521.2
XP_011530824.1, XM_011532522.2
XP_011530825.1, XM_011532523.2
XP_011530826.1, XM_011532524.1
XP_011530827.1, XM_011532525.2
XP_011530829.1, XM_011532527.2
XP_011530830.1, XM_011532528.1
XP_011530831.1, XM_011532529.2
XP_011530832.1, XM_011532530.1
XP_016858824.1, XM_017003335.1
XP_016858825.1, XM_017003336.1
XP_016858826.1, XM_017003337.1
XP_016858827.1, XM_017003338.1
UniGeneiHs.347014

3D structure databases

ProteinModelPortaliQ8NHS4
SMRiQ8NHS4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126226, 5 interactors
IntActiQ8NHS4, 3 interactors
STRINGi9606.ENSP00000384869

PTM databases

iPTMnetiQ8NHS4
PhosphoSitePlusiQ8NHS4

Polymorphism and mutation databases

BioMutaiCLHC1
DMDMi317373465

Proteomic databases

EPDiQ8NHS4
jPOSTiQ8NHS4
PaxDbiQ8NHS4
PeptideAtlasiQ8NHS4
PRIDEiQ8NHS4
ProteomicsDBi73748
73749 [Q8NHS4-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000401408; ENSP00000384869; ENSG00000162994 [Q8NHS4-1]
ENST00000406076; ENSP00000385512; ENSG00000162994 [Q8NHS4-2]
ENST00000407122; ENSP00000385778; ENSG00000162994 [Q8NHS4-1]
GeneIDi130162
KEGGihsa:130162
UCSCiuc002ryi.3 human [Q8NHS4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
130162
EuPathDBiHostDB:ENSG00000162994.15

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CLHC1
HGNCiHGNC:26453 CLHC1
HPAiHPA045418
HPA053557
neXtProtiNX_Q8NHS4
OpenTargetsiENSG00000162994
PharmGKBiPA162379359

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0985 Eukaryota
ENOG410XPH1 LUCA
GeneTreeiENSGT00950000183166
HOGENOMiHOG000060111
HOVERGENiHBG107579
InParanoidiQ8NHS4
OMAiERVGCNE
OrthoDBi665507at2759
PhylomeDBiQ8NHS4
TreeFamiTF328858

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CLHC1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
130162

Protein Ontology

More...
PROi
PR:Q8NHS4

Gene expression databases

BgeeiENSG00000162994 Expressed in 137 organ(s), highest expression level in kidney
ExpressionAtlasiQ8NHS4 baseline and differential
GenevisibleiQ8NHS4 HS

Family and domain databases

Gene3Di1.25.40.30, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR012331 Clathrin_H-chain_linker
IPR017212 CLHC1
IPR032755 TSNAXIP1_N
PANTHERiPTHR10292:SF11 PTHR10292:SF11, 1 hit
PfamiView protein in Pfam
PF15739 TSNAXIP1_N, 1 hit
PIRSFiPIRSF037469 Clathrin_H-chain-rel, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCLHC1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NHS4
Secondary accession number(s): B2RDV1, Q53R93, Q8N403
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: January 11, 2011
Last modified: April 10, 2019
This is version 117 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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