UniProtKB - Q8NHS3 (MFSD8_HUMAN)
Protein
Major facilitator superfamily domain-containing protein 8
Gene
MFSD8
Organism
Homo sapiens (Human)
Status
Functioni
May be a carrier that transport small solutes by using chemiosmotic ion gradients.Curated
GO - Molecular functioni
- transmembrane transporter activity Source: InterPro
GO - Biological processi
- autophagosome maturation Source: Ensembl
- lysosome organization Source: Ensembl
- neuron development Source: Ensembl
- regulation of autophagy Source: Ensembl
- regulation of lysosomal protein catabolic process Source: Ensembl
- TORC1 signaling Source: Ensembl
Keywordsi
Biological process | Transport |
Enzyme and pathway databases
PathwayCommonsi | Q8NHS3 |
Protein family/group databases
TCDBi | 2.A.1.2.56, the major facilitator superfamily (mfs) |
Names & Taxonomyi
Protein namesi | Recommended name: Major facilitator superfamily domain-containing protein 8Alternative name(s): Ceroid-lipofuscinosis neuronal protein 7 |
Gene namesi | Name:MFSD8 Synonyms:CLN7 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000164073.9 |
HGNCi | HGNC:28486, MFSD8 |
MIMi | 611124, gene |
neXtProti | NX_Q8NHS3 |
Subcellular locationi
Lysosome
- Lysosome membrane 3 Publications; Multi-pass membrane protein 3 Publications
Note: Sorting to lysosomes involves tyrosine- and/or dileucine-based motifs.
Lysosome
- lysosomal membrane Source: UniProtKB
Nucleus
- nucleoplasm Source: HPA
Other locations
- integral component of membrane Source: UniProtKB-KW
- intracellular membrane-bounded organelle Source: HPA
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 40 | CytoplasmicSequence analysisAdd BLAST | 40 | |
Transmembranei | 41 – 61 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 62 – 74 | ExtracellularSequence analysisAdd BLAST | 13 | |
Transmembranei | 75 – 95 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 96 – 105 | CytoplasmicSequence analysis | 10 | |
Transmembranei | 106 – 126 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 127 – 131 | ExtracellularSequence analysis | 5 | |
Transmembranei | 132 – 152 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 153 – 173 | CytoplasmicSequence analysisAdd BLAST | 21 | |
Transmembranei | 174 – 194 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 195 – 211 | ExtracellularSequence analysisAdd BLAST | 17 | |
Transmembranei | 212 – 232 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 233 – 266 | CytoplasmicSequence analysisAdd BLAST | 34 | |
Transmembranei | 267 – 287 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 288 – 304 | ExtracellularSequence analysisAdd BLAST | 17 | |
Transmembranei | 305 – 325 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 326 – 337 | CytoplasmicSequence analysisAdd BLAST | 12 | |
Transmembranei | 338 – 358 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 359 – 412 | ExtracellularSequence analysisAdd BLAST | 54 | |
Transmembranei | 413 – 433 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 434 – 451 | CytoplasmicSequence analysisAdd BLAST | 18 | |
Transmembranei | 452 – 472 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 473 – 482 | ExtracellularSequence analysis | 10 | |
Transmembranei | 483 – 503 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 504 – 518 | CytoplasmicSequence analysisAdd BLAST | 15 |
Keywords - Cellular componenti
Lysosome, MembranePathology & Biotechi
Involvement in diseasei
Ceroid lipofuscinosis, neuronal, 7 (CLN7)7 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of neuronal ceroid lipofuscinosis with onset in early childhood. Neuronal ceroid lipofuscinoses are progressive neurodegenerative, lysosomal storage diseases characterized by intracellular accumulation of autofluorescent liposomal material, and clinically by seizures, dementia, visual loss, and/or cerebral atrophy. The lipopigment patterns observed most often in neuronal ceroid lipofuscinosis type 7 comprise mixed combinations of granular, curvilinear, fingerprint, and rectilinear profiles.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_058427 | 52 | G → R in CLN7. 1 PublicationCorresponds to variant dbSNP:rs779838200Ensembl. | 1 | |
Natural variantiVAR_058428 | 121 | Y → C in CLN7. 1 PublicationCorresponds to variant dbSNP:rs118203978EnsemblClinVar. | 1 | |
Natural variantiVAR_058429 | 139 | R → H in CLN7. 1 PublicationCorresponds to variant dbSNP:rs749704755EnsemblClinVar. | 1 | |
Natural variantiVAR_058430 | 157 | A → P in CLN7; due to a deletion-insertion mutation at nucleotide level. 2 Publications | 1 | |
Natural variantiVAR_066915 | 160 | T → I in CLN7. 1 PublicationCorresponds to variant dbSNP:rs1162750836Ensembl. | 1 | |
Natural variantiVAR_066916 | 160 | T → N in CLN7. 1 Publication | 1 | |
Natural variantiVAR_058431 | 294 | T → K in CLN7. 3 PublicationsCorresponds to variant dbSNP:rs140948465EnsemblClinVar. | 1 | |
Natural variantiVAR_037177 | 310 | G → D in CLN7; lysosomal localization. 3 PublicationsCorresponds to variant dbSNP:rs118203975EnsemblClinVar. | 1 | |
Natural variantiVAR_072674 | 412 | P → L in CLN7. 1 PublicationCorresponds to variant dbSNP:rs267607235EnsemblClinVar. | 1 | |
Natural variantiVAR_037180 | 429 | G → D in CLN7; lysosomal localization. 1 PublicationCorresponds to variant dbSNP:rs118203976EnsemblClinVar. | 1 | |
Natural variantiVAR_058432 | 447 | P → L in CLN7. 1 Publication | 1 | |
Natural variantiVAR_066917 | 458 | T → K in CLN7. 1 Publication | 1 | |
Natural variantiVAR_066918 | 465 | R → Q in CLN7. 1 PublicationCorresponds to variant dbSNP:rs1275962600Ensembl. | 1 | |
Natural variantiVAR_058433 | 465 | R → W in CLN7. 1 PublicationCorresponds to variant dbSNP:rs1043984708Ensembl. | 1 | |
Natural variantiVAR_066919 | 470 | M → V in CLN7. 1 PublicationCorresponds to variant dbSNP:rs764549054EnsemblClinVar. | 1 |
Macular dystrophy with central cone involvement (CCMD)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn ocular disease characterized by decreased visual acuity, slight pigmentary changes and color vision abnormalities, becoming apparent in the third to sixth decade of life. Fundus anomalies are variable and include bull's eye maculopathy, severe atrophy of central fovea, relatively spared fovea with surrounding atrophic ring, central retinal pigment epithelium and/or choroid changes, pale or atrophic peripapillary area, pale optic disk, relatively spared periphery, and slightly or moderately attenuated vessels.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_072673 | 336 | E → Q in CCMD. 1 PublicationCorresponds to variant dbSNP:rs150418024EnsemblClinVar. | 1 |
Keywords - Diseasei
Disease mutation, Neurodegeneration, Neuronal ceroid lipofuscinosisOrganism-specific databases
DisGeNETi | 256471 |
GeneReviewsi | MFSD8 |
MalaCardsi | MFSD8 |
MIMi | 610951, phenotype 616170, phenotype |
OpenTargetsi | ENSG00000164073 |
Orphaneti | 228366, CLN7 disease |
PharmGKBi | PA162395842 |
Miscellaneous databases
Pharosi | Q8NHS3, Tbio |
Polymorphism and mutation databases
BioMutai | MFSD8 |
DMDMi | 74730313 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000311232 | 1 – 518 | Major facilitator superfamily domain-containing protein 8Add BLAST | 518 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 371 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 376 | N-linked (GlcNAc...) asparagine1 Publication | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
EPDi | Q8NHS3 |
jPOSTi | Q8NHS3 |
MassIVEi | Q8NHS3 |
MaxQBi | Q8NHS3 |
PaxDbi | Q8NHS3 |
PeptideAtlasi | Q8NHS3 |
PRIDEi | Q8NHS3 |
ProteomicsDBi | 6392 73747 [Q8NHS3-1] |
PTM databases
GlyGeni | Q8NHS3, 2 sites |
iPTMneti | Q8NHS3 |
PhosphoSitePlusi | Q8NHS3 |
Expressioni
Tissue specificityi
Expressed at very low levels in all tissues tested.1 Publication
Gene expression databases
Bgeei | ENSG00000164073, Expressed in small intestine Peyer's patch and 212 other tissues |
ExpressionAtlasi | Q8NHS3, baseline and differential |
Genevisiblei | Q8NHS3, HS |
Organism-specific databases
HPAi | ENSG00000164073, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 129168, 28 interactors |
IntActi | Q8NHS3, 25 interactors |
STRINGi | 9606.ENSP00000296468 |
Miscellaneous databases
RNActi | Q8NHS3, protein |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 13 – 14 | Dileucine internalization motif | 2 |
Sequence similaritiesi
Belongs to the major facilitator superfamily.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2325, Eukaryota |
GeneTreei | ENSGT00530000063854 |
HOGENOMi | CLU_1712618_0_0_1 |
InParanoidi | Q8NHS3 |
OMAi | DAGKEFM |
OrthoDBi | 685352at2759 |
PhylomeDBi | Q8NHS3 |
TreeFami | TF316590 |
Family and domain databases
InterProi | View protein in InterPro IPR011701, MFS IPR020846, MFS_dom IPR036259, MFS_trans_sf |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 33 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8NHS3-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAGLRNESEQ EPLLGDTPGS REWDILETEE HYKSRWRSIR ILYLTMFLSS
60 70 80 90 100
VGFSVVMMSI WPYLQKIDPT ADTSFLGWVI ASYSLGQMVA SPIFGLWSNY
110 120 130 140 150
RPRKEPLIVS ILISVAANCL YAYLHIPASH NKYYMLVARG LLGIGAGNVA
160 170 180 190 200
VVRSYTAGAT SLQERTSSMA NISMCQALGF ILGPVFQTCF TFLGEKGVTW
210 220 230 240 250
DVIKLQINMY TTPVLLSAFL GILNIILILA ILREHRVDDS GRQCKSINFE
260 270 280 290 300
EASTDEAQVP QGNIDQVAVV AINVLFFVTL FIFALFETII TPLTMDMYAW
310 320 330 340 350
TQEQAVLYNG IILAALGVEA VVIFLGVKLL SKKIGERAIL LGGLIVVWVG
360 370 380 390 400
FFILLPWGNQ FPKIQWEDLH NNSIPNTTFG EIIIGLWKSP MEDDNERPTG
410 420 430 440 450
CSIEQAWCLY TPVIHLAQFL TSAVLIGLGY PVCNLMSYTL YSKILGPKPQ
460 470 480 490 500
GVYMGWLTAS GSGARILGPM FISQVYAHWG PRWAFSLVCG IIVLTITLLG
510
VVYKRLIALS VRYGRIQE
Isoform 2 (identifier: Q8NHS3-2) [UniParc]FASTAAdd to basket
The sequence of this isoform differs from the canonical sequence as follows:
1-45: Missing.
147-184: Missing.
233-236: REHR → SKYR
237-518: Missing.
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »Computationally mapped potential isoform sequencesi
There are 33 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A286YEW8 | A0A286YEW8_HUMAN | Major facilitator superfamily domai... | MFSD8 MGC33302, hCG_1778573 | 451 | Annotation score: | ||
A0A286YFI8 | A0A286YFI8_HUMAN | Major facilitator superfamily domai... | MFSD8 MGC33302, hCG_1778573 | 480 | Annotation score: | ||
A0A286YF73 | A0A286YF73_HUMAN | Major facilitator superfamily domai... | MFSD8 | 336 | Annotation score: | ||
A0A286YFM2 | A0A286YFM2_HUMAN | Major facilitator superfamily domai... | MFSD8 | 269 | Annotation score: | ||
A0A286YF72 | A0A286YF72_HUMAN | Major facilitator superfamily domai... | MFSD8 | 298 | Annotation score: | ||
A0A286YFF1 | A0A286YFF1_HUMAN | Major facilitator superfamily domai... | MFSD8 | 413 | Annotation score: | ||
A0A286YEV4 | A0A286YEV4_HUMAN | Major facilitator superfamily domai... | MFSD8 | 254 | Annotation score: | ||
A0A286YF51 | A0A286YF51_HUMAN | Major facilitator superfamily domai... | MFSD8 | 288 | Annotation score: | ||
A0A286YFE6 | A0A286YFE6_HUMAN | Major facilitator superfamily domai... | MFSD8 | 145 | Annotation score: | ||
A0A286YFE7 | A0A286YFE7_HUMAN | Major facilitator superfamily domai... | MFSD8 | 237 | Annotation score: | ||
There are more potential isoformsShow all |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 189 | C → Y in BAC11062 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 487 | L → R in BAC11062 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_058427 | 52 | G → R in CLN7. 1 PublicationCorresponds to variant dbSNP:rs779838200Ensembl. | 1 | |
Natural variantiVAR_037176 | 109 | V → G. Corresponds to variant dbSNP:rs11732377Ensembl. | 1 | |
Natural variantiVAR_058428 | 121 | Y → C in CLN7. 1 PublicationCorresponds to variant dbSNP:rs118203978EnsemblClinVar. | 1 | |
Natural variantiVAR_058429 | 139 | R → H in CLN7. 1 PublicationCorresponds to variant dbSNP:rs749704755EnsemblClinVar. | 1 | |
Natural variantiVAR_058430 | 157 | A → P in CLN7; due to a deletion-insertion mutation at nucleotide level. 2 Publications | 1 | |
Natural variantiVAR_066915 | 160 | T → I in CLN7. 1 PublicationCorresponds to variant dbSNP:rs1162750836Ensembl. | 1 | |
Natural variantiVAR_066916 | 160 | T → N in CLN7. 1 Publication | 1 | |
Natural variantiVAR_058431 | 294 | T → K in CLN7. 3 PublicationsCorresponds to variant dbSNP:rs140948465EnsemblClinVar. | 1 | |
Natural variantiVAR_037177 | 310 | G → D in CLN7; lysosomal localization. 3 PublicationsCorresponds to variant dbSNP:rs118203975EnsemblClinVar. | 1 | |
Natural variantiVAR_072673 | 336 | E → Q in CCMD. 1 PublicationCorresponds to variant dbSNP:rs150418024EnsemblClinVar. | 1 | |
Natural variantiVAR_037178 | 385 | G → R. Corresponds to variant dbSNP:rs11098943EnsemblClinVar. | 1 | |
Natural variantiVAR_072674 | 412 | P → L in CLN7. 1 PublicationCorresponds to variant dbSNP:rs267607235EnsemblClinVar. | 1 | |
Natural variantiVAR_037179 | 423 | A → V1 PublicationCorresponds to variant dbSNP:rs3733319EnsemblClinVar. | 1 | |
Natural variantiVAR_037180 | 429 | G → D in CLN7; lysosomal localization. 1 PublicationCorresponds to variant dbSNP:rs118203976EnsemblClinVar. | 1 | |
Natural variantiVAR_058432 | 447 | P → L in CLN7. 1 Publication | 1 | |
Natural variantiVAR_066917 | 458 | T → K in CLN7. 1 Publication | 1 | |
Natural variantiVAR_066918 | 465 | R → Q in CLN7. 1 PublicationCorresponds to variant dbSNP:rs1275962600Ensembl. | 1 | |
Natural variantiVAR_058433 | 465 | R → W in CLN7. 1 PublicationCorresponds to variant dbSNP:rs1043984708Ensembl. | 1 | |
Natural variantiVAR_066919 | 470 | M → V in CLN7. 1 PublicationCorresponds to variant dbSNP:rs764549054EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_057054 | 1 – 45 | Missing in isoform 2. 1 PublicationAdd BLAST | 45 | |
Alternative sequenceiVSP_057055 | 147 – 184 | Missing in isoform 2. 1 PublicationAdd BLAST | 38 | |
Alternative sequenceiVSP_057056 | 233 – 236 | REHR → SKYR in isoform 2. 1 Publication | 4 | |
Alternative sequenceiVSP_057057 | 237 – 518 | Missing in isoform 2. 1 PublicationAdd BLAST | 282 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK074564 mRNA Translation: BAC11062.1 AK294184 mRNA Translation: BAH11691.1 AK315596 mRNA Translation: BAG37968.1 AC099340 Genomic DNA No translation available. CH471056 Genomic DNA Translation: EAX05195.1 BC029503 mRNA Translation: AAH29503.1 |
CCDSi | CCDS3736.1 [Q8NHS3-1] |
RefSeqi | NP_689991.1, NM_152778.2 [Q8NHS3-1] XP_005262950.1, XM_005262893.1 |
Genome annotation databases
Ensembli | ENST00000296468; ENSP00000296468; ENSG00000164073 [Q8NHS3-1] ENST00000641434; ENSP00000493279; ENSG00000164073 [Q8NHS3-1] ENST00000641464; ENSP00000493438; ENSG00000164073 [Q8NHS3-2] ENST00000641686; ENSP00000493218; ENSG00000164073 [Q8NHS3-1] ENST00000641748; ENSP00000493330; ENSG00000164073 [Q8NHS3-1] ENST00000641928; ENSP00000493418; ENSG00000164073 [Q8NHS3-2] |
GeneIDi | 256471 |
KEGGi | hsa:256471 |
UCSCi | uc003ifp.4, human [Q8NHS3-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
NCL CLN7/MFSD8 Neural Ceroid Lipofuscinoses mutation db |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK074564 mRNA Translation: BAC11062.1 AK294184 mRNA Translation: BAH11691.1 AK315596 mRNA Translation: BAG37968.1 AC099340 Genomic DNA No translation available. CH471056 Genomic DNA Translation: EAX05195.1 BC029503 mRNA Translation: AAH29503.1 |
CCDSi | CCDS3736.1 [Q8NHS3-1] |
RefSeqi | NP_689991.1, NM_152778.2 [Q8NHS3-1] XP_005262950.1, XM_005262893.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 129168, 28 interactors |
IntActi | Q8NHS3, 25 interactors |
STRINGi | 9606.ENSP00000296468 |
Protein family/group databases
TCDBi | 2.A.1.2.56, the major facilitator superfamily (mfs) |
PTM databases
GlyGeni | Q8NHS3, 2 sites |
iPTMneti | Q8NHS3 |
PhosphoSitePlusi | Q8NHS3 |
Polymorphism and mutation databases
BioMutai | MFSD8 |
DMDMi | 74730313 |
Proteomic databases
EPDi | Q8NHS3 |
jPOSTi | Q8NHS3 |
MassIVEi | Q8NHS3 |
MaxQBi | Q8NHS3 |
PaxDbi | Q8NHS3 |
PeptideAtlasi | Q8NHS3 |
PRIDEi | Q8NHS3 |
ProteomicsDBi | 6392 73747 [Q8NHS3-1] |
Protocols and materials databases
Antibodypediai | 45354, 58 antibodies |
DNASUi | 256471 |
Genome annotation databases
Ensembli | ENST00000296468; ENSP00000296468; ENSG00000164073 [Q8NHS3-1] ENST00000641434; ENSP00000493279; ENSG00000164073 [Q8NHS3-1] ENST00000641464; ENSP00000493438; ENSG00000164073 [Q8NHS3-2] ENST00000641686; ENSP00000493218; ENSG00000164073 [Q8NHS3-1] ENST00000641748; ENSP00000493330; ENSG00000164073 [Q8NHS3-1] ENST00000641928; ENSP00000493418; ENSG00000164073 [Q8NHS3-2] |
GeneIDi | 256471 |
KEGGi | hsa:256471 |
UCSCi | uc003ifp.4, human [Q8NHS3-1] |
Organism-specific databases
CTDi | 256471 |
DisGeNETi | 256471 |
EuPathDBi | HostDB:ENSG00000164073.9 |
GeneCardsi | MFSD8 |
GeneReviewsi | MFSD8 |
HGNCi | HGNC:28486, MFSD8 |
HPAi | ENSG00000164073, Low tissue specificity |
MalaCardsi | MFSD8 |
MIMi | 610951, phenotype 611124, gene 616170, phenotype |
neXtProti | NX_Q8NHS3 |
OpenTargetsi | ENSG00000164073 |
Orphaneti | 228366, CLN7 disease |
PharmGKBi | PA162395842 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2325, Eukaryota |
GeneTreei | ENSGT00530000063854 |
HOGENOMi | CLU_1712618_0_0_1 |
InParanoidi | Q8NHS3 |
OMAi | DAGKEFM |
OrthoDBi | 685352at2759 |
PhylomeDBi | Q8NHS3 |
TreeFami | TF316590 |
Enzyme and pathway databases
PathwayCommonsi | Q8NHS3 |
Miscellaneous databases
BioGRID-ORCSi | 256471, 7 hits in 847 CRISPR screens |
ChiTaRSi | MFSD8, human |
GeneWikii | MFSD8 |
GenomeRNAii | 256471 |
Pharosi | Q8NHS3, Tbio |
PROi | PR:Q8NHS3 |
RNActi | Q8NHS3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000164073, Expressed in small intestine Peyer's patch and 212 other tissues |
ExpressionAtlasi | Q8NHS3, baseline and differential |
Genevisiblei | Q8NHS3, HS |
Family and domain databases
InterProi | View protein in InterPro IPR011701, MFS IPR020846, MFS_dom IPR036259, MFS_trans_sf |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MFSD8_HUMAN | |
Accessioni | Q8NHS3Primary (citable) accession number: Q8NHS3 Secondary accession number(s): B2RDM1, B7Z205, Q8N2P3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 13, 2007 |
Last sequence update: | October 1, 2002 | |
Last modified: | December 2, 2020 | |
This is version 152 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations